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The map label for this gene is nuoF2 [H]

Identifier: 187932967

GI number: 187932967

Start: 2378637

End: 2380517

Strand: Reverse

Name: nuoF2 [H]

Synonym: CLL_A2308

Alternate gene names: 187932967

Gene position: 2380517-2378637 (Counterclockwise)

Preceding gene: 187934365

Following gene: 187932399

Centisome position: 62.64

GC content: 33.81

Gene sequence:

>1881_bases
ATGAGAATTAATACTAGAGAAGAATTAAATTCTTCAATAAAAAAATGTAAGTTAGCTTTAGGCAAGCAATCTAAACAAAT
ATTAATTTGTGGTGGAACTGGTTGTGTAGCTAGTGGCTCTTTAAAAATCTATGATAGATTAAAGGAGTTAATAGAGCAAA
GAGGACTTGAAGTTAGTATCTCATTAGAAGATGAACCTCATGATAATAGTGTTGGTTTAAAGAAAAGTGGATGTCATGGA
TTTTGTGAAATGGGTCCTCTTTTAAGAATAGAACCAGAAGGTATATTATATATAAAAGTTAAATTAGAAGATTGTGAAGA
AATTGTTGAAAAAAGTATAATTTCAAATGAAGTAATAGAACATCTTATTTATAAAAATGAAGAGAGAAGCTATAGTAAGC
AAGAGGAGATTCCTTTTTATGCAAGACAAACACGTGTTGCATTGGAACATTGTGGACATATAAATGCAGAATCTATTGAA
GAATACTTAGCAGCTGATGGGTATACTGCTGTAGAAAAGGCACTTTTTGATATGACACCTGAAGAAGTTGTAGATGAAAT
ATCTGAATCTTATCTTCGTGGAAGAGGAGGCGGTGGTTTCCAAACAGGAAAAAAATGGTGTCAAGTATTACAACAAGCTG
AAAAACAAAAATATATAGTATGTAATGGCGATGAGGGAGATCCAGGAGCATTTATGGATAGAAGTATGATGGAAGGTGAT
CCTCATAGAGTAATTGAAGGAATGCTTATAGCTGGAATTGCAACTAAGGCAAGTTATGGATATATATATGTCCGTGCTGA
ATATCCACTTGCAGTTAAGAGATTGCAAATGGCTATAGACCAAGCTACTAAAGTGGGACTTTTAGGAAAGAATATTTTAA
ACTCTGGATTTGATTTTGACTTACATATAAGTCAAGGAGCTGGAGCATTTGTTTGTGGCGAGGGCAGTGCTCTTACAGCA
TCAATAGAAGGAAATAGAGGCATGCCAAGAGTTAAACCACCTAGAACTGTTGAAAAGGGATTATTTGAAAAACCAACTGT
ATTAAATAATGTTGAAACATTTTGTAATGTTCCAAGCATAATTAATAAAGGTTCAAAGTGGTATAAGAGTATTGGTACTG
AAAAGAATTATGGAACTAAGGCTTTTGCACTTACTGGAAATGTAAAACACACAGGTTTAATAGAAGTTCCTATGGGAACA
AAATTAAAAGAGGTAATATTTGATATTGGTGGTGGAGTAAAAGAAGGAAAGTTTAAAGCGGTTCAAATTGGAGGTCCATC
TGGTGGGTGCCTTTGCGTAGGTGAAAATCATTTAGAACTACCATTAGATTTTGATTCACTTAAAAAAGTTGGAGCCATGA
TTGGTAGCGGTGGATTAGTTGTAATGAATGATAAAAGTTGTATGGTGGAAGTAGCTCGTTTCTTCATGAATTTTACTCAA
AACGAATCTTGTGGTAAATGTATACCTTGCAGGGAAGGTACAAAAAGAATGTTAGAAATTTTAACTGACATTGTAGAAGG
ACGAGGAACCTTAGAACACCTAGATATGTTAGAAGAATTATCAGATACTATATCTGCGACAGCACTTTGTGGTCTTGGTA
AGAGTGCATCTTTGCCAGTAAAGAGTACTTTGAAATACTTTAGAGAAGAATATATAGCTCATGTTGTAGATAAAAAATGT
CCAGGTGGAGTATGTAAATCTTTAATGTCTTATGAAATAGACAAGGATAAATGTAAAGGCTGTTCTAAGTGTGCAAGAAT
GTGTCCAGCAGGAGCTATTACAGGAGAAATAAAAAAACCTTATACCATTGATCAATCAAAATGTATAAAATGTGGTGCTT
GTATGGATGGATGTGCATTTAAAGCAATCCAGTTGGTTTAA

Upstream 100 bases:

>100_bases
GGATTAGCACCTGTCTGTACTGTAAACGATGTAGTATATCCTAGTATGACTCAGCAAAAGGCTAGAGACATAATAAAAAA
GTTAAAGGAGGAAGCATCTA

Downstream 100 bases:

>100_bases
TAGCTCACAACGTATGAATTAGTGAAAGGAAGGTATAAAGTTATGTCAAAATATATGATAATTGATGGTAACAGGGTAGA
ATTTGATAATGAAAAAAATA

Product: iron hydrogenase, electron-transfer subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MRINTREELNSSIKKCKLALGKQSKQILICGGTGCVASGSLKIYDRLKELIEQRGLEVSISLEDEPHDNSVGLKKSGCHG
FCEMGPLLRIEPEGILYIKVKLEDCEEIVEKSIISNEVIEHLIYKNEERSYSKQEEIPFYARQTRVALEHCGHINAESIE
EYLAADGYTAVEKALFDMTPEEVVDEISESYLRGRGGGGFQTGKKWCQVLQQAEKQKYIVCNGDEGDPGAFMDRSMMEGD
PHRVIEGMLIAGIATKASYGYIYVRAEYPLAVKRLQMAIDQATKVGLLGKNILNSGFDFDLHISQGAGAFVCGEGSALTA
SIEGNRGMPRVKPPRTVEKGLFEKPTVLNNVETFCNVPSIINKGSKWYKSIGTEKNYGTKAFALTGNVKHTGLIEVPMGT
KLKEVIFDIGGGVKEGKFKAVQIGGPSGGCLCVGENHLELPLDFDSLKKVGAMIGSGGLVVMNDKSCMVEVARFFMNFTQ
NESCGKCIPCREGTKRMLEILTDIVEGRGTLEHLDMLEELSDTISATALCGLGKSASLPVKSTLKYFREEYIAHVVDKKC
PGGVCKSLMSYEIDKDKCKGCSKCARMCPAGAITGEIKKPYTIDQSKCIKCGACMDGCAFKAIQLV

Sequences:

>Translated_626_residues
MRINTREELNSSIKKCKLALGKQSKQILICGGTGCVASGSLKIYDRLKELIEQRGLEVSISLEDEPHDNSVGLKKSGCHG
FCEMGPLLRIEPEGILYIKVKLEDCEEIVEKSIISNEVIEHLIYKNEERSYSKQEEIPFYARQTRVALEHCGHINAESIE
EYLAADGYTAVEKALFDMTPEEVVDEISESYLRGRGGGGFQTGKKWCQVLQQAEKQKYIVCNGDEGDPGAFMDRSMMEGD
PHRVIEGMLIAGIATKASYGYIYVRAEYPLAVKRLQMAIDQATKVGLLGKNILNSGFDFDLHISQGAGAFVCGEGSALTA
SIEGNRGMPRVKPPRTVEKGLFEKPTVLNNVETFCNVPSIINKGSKWYKSIGTEKNYGTKAFALTGNVKHTGLIEVPMGT
KLKEVIFDIGGGVKEGKFKAVQIGGPSGGCLCVGENHLELPLDFDSLKKVGAMIGSGGLVVMNDKSCMVEVARFFMNFTQ
NESCGKCIPCREGTKRMLEILTDIVEGRGTLEHLDMLEELSDTISATALCGLGKSASLPVKSTLKYFREEYIAHVVDKKC
PGGVCKSLMSYEIDKDKCKGCSKCARMCPAGAITGEIKKPYTIDQSKCIKCGACMDGCAFKAIQLV
>Mature_626_residues
MRINTREELNSSIKKCKLALGKQSKQILICGGTGCVASGSLKIYDRLKELIEQRGLEVSISLEDEPHDNSVGLKKSGCHG
FCEMGPLLRIEPEGILYIKVKLEDCEEIVEKSIISNEVIEHLIYKNEERSYSKQEEIPFYARQTRVALEHCGHINAESIE
EYLAADGYTAVEKALFDMTPEEVVDEISESYLRGRGGGGFQTGKKWCQVLQQAEKQKYIVCNGDEGDPGAFMDRSMMEGD
PHRVIEGMLIAGIATKASYGYIYVRAEYPLAVKRLQMAIDQATKVGLLGKNILNSGFDFDLHISQGAGAFVCGEGSALTA
SIEGNRGMPRVKPPRTVEKGLFEKPTVLNNVETFCNVPSIINKGSKWYKSIGTEKNYGTKAFALTGNVKHTGLIEVPMGT
KLKEVIFDIGGGVKEGKFKAVQIGGPSGGCLCVGENHLELPLDFDSLKKVGAMIGSGGLVVMNDKSCMVEVARFFMNFTQ
NESCGKCIPCREGTKRMLEILTDIVEGRGTLEHLDMLEELSDTISATALCGLGKSASLPVKSTLKYFREEYIAHVVDKKC
PGGVCKSLMSYEIDKDKCKGCSKCARMCPAGAITGEIKKPYTIDQSKCIKCGACMDGCAFKAIQLV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=376, Percent_Identity=40.1595744680851, Blast_Score=284, Evalue=2e-76,
Organism=Homo sapiens, GI260656005, Length=376, Percent_Identity=40.1595744680851, Blast_Score=284, Evalue=2e-76,
Organism=Escherichia coli, GI1788620, Length=400, Percent_Identity=42, Blast_Score=336, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI17531727, Length=374, Percent_Identity=39.3048128342246, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI19920794, Length=373, Percent_Identity=38.8739946380697, Blast_Score=281, Evalue=7e-76,
Organism=Drosophila melanogaster, GI45550452, Length=369, Percent_Identity=39.8373983739837, Blast_Score=275, Evalue=8e-74,
Organism=Drosophila melanogaster, GI24653819, Length=379, Percent_Identity=32.4538258575198, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24653817, Length=350, Percent_Identity=31.1428571428571, Blast_Score=182, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68417; Mature: 68417

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00645 COMPLEX1_51K_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRINTREELNSSIKKCKLALGKQSKQILICGGTGCVASGSLKIYDRLKELIEQRGLEVSI
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEE
SLEDEPHDNSVGLKKSGCHGFCEMGPLLRIEPEGILYIKVKLEDCEEIVEKSIISNEVIE
EECCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHH
HLIYKNEERSYSKQEEIPFYARQTRVALEHCGHINAESIEEYLAADGYTAVEKALFDMTP
HHHHCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCCH
EEVVDEISESYLRGRGGGGFQTGKKWCQVLQQAEKQKYIVCNGDEGDPGAFMDRSMMEGD
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCC
PHRVIEGMLIAGIATKASYGYIYVRAEYPLAVKRLQMAIDQATKVGLLGKNILNSGFDFD
HHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LHISQGAGAFVCGEGSALTASIEGNRGMPRVKPPRTVEKGLFEKPTVLNNVETFCNVPSI
EEEECCCCEEEECCCCEEEEEECCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCHH
INKGSKWYKSIGTEKNYGTKAFALTGNVKHTGLIEVPMGTKLKEVIFDIGGGVKEGKFKA
HHCCHHHHHHCCCCCCCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCEEE
VQIGGPSGGCLCVGENHLELPLDFDSLKKVGAMIGSGGLVVMNDKSCMVEVARFFMNFTQ
EEECCCCCCEEEECCCCEECCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCC
NESCGKCIPCREGTKRMLEILTDIVEGRGTLEHLDMLEELSDTISATALCGLGKSASLPV
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
KSTLKYFREEYIAHVVDKKCPGGVCKSLMSYEIDKDKCKGCSKCARMCPAGAITGEIKKP
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
YTIDQSKCIKCGACMDGCAFKAIQLV
EECCHHHHHHHCCCCCCHHHHHEECC
>Mature Secondary Structure
MRINTREELNSSIKKCKLALGKQSKQILICGGTGCVASGSLKIYDRLKELIEQRGLEVSI
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEE
SLEDEPHDNSVGLKKSGCHGFCEMGPLLRIEPEGILYIKVKLEDCEEIVEKSIISNEVIE
EECCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHH
HLIYKNEERSYSKQEEIPFYARQTRVALEHCGHINAESIEEYLAADGYTAVEKALFDMTP
HHHHCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCCH
EEVVDEISESYLRGRGGGGFQTGKKWCQVLQQAEKQKYIVCNGDEGDPGAFMDRSMMEGD
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCC
PHRVIEGMLIAGIATKASYGYIYVRAEYPLAVKRLQMAIDQATKVGLLGKNILNSGFDFD
HHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LHISQGAGAFVCGEGSALTASIEGNRGMPRVKPPRTVEKGLFEKPTVLNNVETFCNVPSI
EEEECCCCEEEECCCCEEEEEECCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCHH
INKGSKWYKSIGTEKNYGTKAFALTGNVKHTGLIEVPMGTKLKEVIFDIGGGVKEGKFKA
HHCCHHHHHHCCCCCCCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCEEE
VQIGGPSGGCLCVGENHLELPLDFDSLKKVGAMIGSGGLVVMNDKSCMVEVARFFMNFTQ
EEECCCCCCEEEECCCCEECCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCC
NESCGKCIPCREGTKRMLEILTDIVEGRGTLEHLDMLEELSDTISATALCGLGKSASLPV
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
KSTLKYFREEYIAHVVDKKCPGGVCKSLMSYEIDKDKCKGCSKCARMCPAGAITGEIKKP
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
YTIDQSKCIKCGACMDGCAFKAIQLV
EECCHHHHHHHCCCCCCHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]