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The map label for this gene is cysH1 [H]

Identifier: 187929758

GI number: 187929758

Start: 2798941

End: 2799744

Strand: Reverse

Name: cysH1 [H]

Synonym: Rpic_2687

Alternate gene names: 187929758

Gene position: 2799744-2798941 (Counterclockwise)

Preceding gene: 187929759

Following gene: 187929757

Centisome position: 71.01

GC content: 65.92

Gene sequence:

>804_bases
ATGAGCGAGTTCCAAGAGGCTGCCCTGTCCGAGGTGCCGGTGTCCGCTATCGGGCGCCCGGTGCTGTGGACGCGTCCGGT
CTACACCGGCACGGCTGAAGCCCTCGCTGCGAAGGAAGCCGCGCTGTTCGAGCGCCTGGCCGAGATTGCCGCCAGGCACG
GCGTGGCAAAGTTCGCCACCAGCCTGGCAGCCGAAGACATGGTCGTGACCGATGCGATCCTGCGCAGCCCCCAGGCCGTG
CGGGCGCACCTGCCGATCTTCACGCTGCAGACCGGCCGTCTGCACGCCGAAACGCTGGCGATGCTCGAGCGCATCCGCGA
GCACTACGGTTATGTGATCGAGCAATACGCACCGGATGCCCGCGCAGTGGAAGCCTACGTCCGTGACCACGGCCTGAACG
CCTTCTACGACAGCATCGAACTGCGCAAGGCCTGCTGCAACATCCGCAAGGTGGTGCCGCTGAATCGCGCGCTCAAAGAT
GCCGACGCATGGCTGACGGGCCAGCGACGCGAGCAGGCCGTCACCCGTGCCGACCTGCCGTTTGCTGAAGACGACGACGC
CCGCGGCATCGCCAAGTACAACCCGCTGTTCGACTGGTCCGAGCCTGAAGTCTGGGCCTACCTCGAGCAGCACAACGTGC
CCACCAACGCGCTGCACGACAAGGGCTATCCCAGCATTGGCTGCGAGCCTTGCACGCGTGCGGTGCGCGCTGGTGAGGAT
GTGCGCGCCGGCCGCTGGTGGTGGGAATCGCGCGACAGCAAGGAATGCGGTCTGCATGCGACGAATCTGTCGCAAAAGAG
CTAA

Upstream 100 bases:

>100_bases
CACTGAACGGCTTCGGCGAGATCAGCGTGCGCTACCAAGGCGCCGTCGACGAGCCGCGTCCGTTGTTCCGCCGCGAGCGT
GCTACCGAGGCGAGCGCAGT

Downstream 100 bases:

>100_bases
GGAAAGGAACATGGGAGTCATGAGCGAAATCCCCGGCACGGCATTGACGCCTGTGCAGAACGAGCACCTCGACTGGCTGG
AAGCCGAGTCGATCTACATC

Product: phosphoadenosine phosphosulfate reductase

Products: NA

Alternate protein names: 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAPS sulfotransferase; PAdoPS reductase [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSEFQEAALSEVPVSAIGRPVLWTRPVYTGTAEALAAKEAALFERLAEIAARHGVAKFATSLAAEDMVVTDAILRSPQAV
RAHLPIFTLQTGRLHAETLAMLERIREHYGYVIEQYAPDARAVEAYVRDHGLNAFYDSIELRKACCNIRKVVPLNRALKD
ADAWLTGQRREQAVTRADLPFAEDDDARGIAKYNPLFDWSEPEVWAYLEQHNVPTNALHDKGYPSIGCEPCTRAVRAGED
VRAGRWWWESRDSKECGLHATNLSQKS

Sequences:

>Translated_267_residues
MSEFQEAALSEVPVSAIGRPVLWTRPVYTGTAEALAAKEAALFERLAEIAARHGVAKFATSLAAEDMVVTDAILRSPQAV
RAHLPIFTLQTGRLHAETLAMLERIREHYGYVIEQYAPDARAVEAYVRDHGLNAFYDSIELRKACCNIRKVVPLNRALKD
ADAWLTGQRREQAVTRADLPFAEDDDARGIAKYNPLFDWSEPEVWAYLEQHNVPTNALHDKGYPSIGCEPCTRAVRAGED
VRAGRWWWESRDSKECGLHATNLSQKS
>Mature_266_residues
SEFQEAALSEVPVSAIGRPVLWTRPVYTGTAEALAAKEAALFERLAEIAARHGVAKFATSLAAEDMVVTDAILRSPQAVR
AHLPIFTLQTGRLHAETLAMLERIREHYGYVIEQYAPDARAVEAYVRDHGLNAFYDSIELRKACCNIRKVVPLNRALKDA
DAWLTGQRREQAVTRADLPFAEDDDARGIAKYNPLFDWSEPEVWAYLEQHNVPTNALHDKGYPSIGCEPCTRAVRAGEDV
RAGRWWWESRDSKECGLHATNLSQKS

Specific function: Reduction of activated sulfate into sulfite [H]

COG id: COG0175

COG function: function code EH; 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAPS reductase family. CysH subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789121, Length=182, Percent_Identity=31.3186813186813, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325425, Length=208, Percent_Identity=31.25, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011798
- InterPro:   IPR004511
- InterPro:   IPR002500
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01507 PAPS_reduct [H]

EC number: =1.8.4.8 [H]

Molecular weight: Translated: 29889; Mature: 29758

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFQEAALSEVPVSAIGRPVLWTRPVYTGTAEALAAKEAALFERLAEIAARHGVAKFAT
CCHHHHHHHHHCCHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAAEDMVVTDAILRSPQAVRAHLPIFTLQTGRLHAETLAMLERIREHYGYVIEQYAPDA
HHHHHHHHHHHHHHHCCHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
RAVEAYVRDHGLNAFYDSIELRKACCNIRKVVPLNRALKDADAWLTGQRREQAVTRADLP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
FAEDDDARGIAKYNPLFDWSEPEVWAYLEQHNVPTNALHDKGYPSIGCEPCTRAVRAGED
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHCCCC
VRAGRWWWESRDSKECGLHATNLSQKS
CCCCCCCCCCCCCCCCCCEECCCCCCC
>Mature Secondary Structure 
SEFQEAALSEVPVSAIGRPVLWTRPVYTGTAEALAAKEAALFERLAEIAARHGVAKFAT
CHHHHHHHHHCCHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAAEDMVVTDAILRSPQAVRAHLPIFTLQTGRLHAETLAMLERIREHYGYVIEQYAPDA
HHHHHHHHHHHHHHHCCHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
RAVEAYVRDHGLNAFYDSIELRKACCNIRKVVPLNRALKDADAWLTGQRREQAVTRADLP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
FAEDDDARGIAKYNPLFDWSEPEVWAYLEQHNVPTNALHDKGYPSIGCEPCTRAVRAGED
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHCCCC
VRAGRWWWESRDSKECGLHATNLSQKS
CCCCCCCCCCCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]