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The map label for this gene is gltP [H]

Identifier: 187929183

GI number: 187929183

Start: 2219359

End: 2220636

Strand: Reverse

Name: gltP [H]

Synonym: Rpic_2104

Alternate gene names: 187929183

Gene position: 2220636-2219359 (Counterclockwise)

Preceding gene: 187929189

Following gene: 187929178

Centisome position: 56.32

GC content: 62.52

Gene sequence:

>1278_bases
TTGAACACCAAACGTCTGACCTCCCACATTGGGCTGGCAATGCTGCTGGGCATTGCCGTCGGCTGGGGTTGCCACGAATA
CGCCAAGGACGCTGCGGCGGCCAAGGACATCGCTTCGTACTTCAGCATCATCACCGACATCTTCCTGCGCATGATCAAGA
TGATCATTGCGCCGCTGGTGTTCTCGACCCTGGTGACGGGCCTGGCAAGCATGAGTGGCGGCCGTTCGGTGGGCCGCGTG
GGCCTGCGCGCGATGATCTGGTTTGTGTGCGCGTCGGCCACGTCGCTGGCGCTGGGCATGCTGCTGGTCAACTTCTTCCA
ACCCGGCATGCACATGAACCTGGCGCTGCCGGATGTGTCGGCCACGTCGGGCCTGAAGACGGGTGACTTCACCCTCAAGG
CCTTCATCACGCACGTGTTTCCGCGCAGCATCGTGGAGGCCATGGCCACCAACGAAATCCTGCAGATCTTGGTGTTTTCG
CTGTTCTTCGGCGCCGCGCTGTCGACGATGAAGAATCCGATGGACAGTGTGATCGGCCGTGGCCTGGAAGAACTGACCAA
GCTGATGTTCCGCATTACCGACTACGTGATGCGCTTTGCACCGCTGGGCGTATTTGCCGCCATGGCCGCTGCGATCACGG
TGGAAGGCGTGGGCGTGCTGTGGACCTACGGCAAGCTGATCGGCGAGTTCTACCTGGGCCTGGCACTGCTGTGGGCGATC
CTGTTCCTGGTGGGCTATGTGTTGCTGGGCCGCTCGCTGGGCCGTCTGCTTGGGCTGATTCGCGAGCCGACGCTGCTGGC
GTTCGCCACCGCAAGCAGCGAATCCGCTTACCCGAAGACGATCGAGGCGCTGGACCGGTTTGGCGTGCCCAAGCGCATCT
CCAGCTTCGTCCTGCCGCTGGGCTACTCGTTCAACCTGGATGGCTCGATGATGTACCAGGCGTTTGCGGTGCTGTTTATC
GCGCAGGCCTACAACATCGAGATGAGCTTCACGCAACAGGTCACGCTGCTGCTGGTGCTGATGCTCACGAGCAAGGGGAT
GGCCGGCGTGGCGCGTGCATCGCTGGTGGTGGTGGCGGCCACGCTGCCGATGTTCCATCTGCCCGAAGCCGGTCTGCTGC
TGATCATCGGGATCGACCAGTTCTTCGACATGGGCCGCACGGCAACCAACGTGATCGGCAACAGCCTGGCCACGGCCGTG
GTGGCAAAGTACGAGCCGGCAGAAGACGAAGTGGCGGCGGACGTTGCCGAACCGGCAGTGCAACCGACGGTTGGCTGA

Upstream 100 bases:

>100_bases
CTTTTTACAAAGCGTGATGAACTTGGGCCAGCCCTTGGCCCCATGAGATCCGCGTCTGTCGCGCGCCGCCTTCCGGCCAC
GGTATTCCTTGGAGAAAGTC

Downstream 100 bases:

>100_bases
CATTCAGCCAAGATGACAATGCGCCGCCTTTCAGGGCGGCGTTGTCCTATTCGGGCGGCGTTATTCGGGCTGGGAAGCGA
GCGACACCGCGACGGGGCTC

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MNTKRLTSHIGLAMLLGIAVGWGCHEYAKDAAAAKDIASYFSIITDIFLRMIKMIIAPLVFSTLVTGLASMSGGRSVGRV
GLRAMIWFVCASATSLALGMLLVNFFQPGMHMNLALPDVSATSGLKTGDFTLKAFITHVFPRSIVEAMATNEILQILVFS
LFFGAALSTMKNPMDSVIGRGLEELTKLMFRITDYVMRFAPLGVFAAMAAAITVEGVGVLWTYGKLIGEFYLGLALLWAI
LFLVGYVLLGRSLGRLLGLIREPTLLAFATASSESAYPKTIEALDRFGVPKRISSFVLPLGYSFNLDGSMMYQAFAVLFI
AQAYNIEMSFTQQVTLLLVLMLTSKGMAGVARASLVVVAATLPMFHLPEAGLLLIIGIDQFFDMGRTATNVIGNSLATAV
VAKYEPAEDEVAADVAEPAVQPTVG

Sequences:

>Translated_425_residues
MNTKRLTSHIGLAMLLGIAVGWGCHEYAKDAAAAKDIASYFSIITDIFLRMIKMIIAPLVFSTLVTGLASMSGGRSVGRV
GLRAMIWFVCASATSLALGMLLVNFFQPGMHMNLALPDVSATSGLKTGDFTLKAFITHVFPRSIVEAMATNEILQILVFS
LFFGAALSTMKNPMDSVIGRGLEELTKLMFRITDYVMRFAPLGVFAAMAAAITVEGVGVLWTYGKLIGEFYLGLALLWAI
LFLVGYVLLGRSLGRLLGLIREPTLLAFATASSESAYPKTIEALDRFGVPKRISSFVLPLGYSFNLDGSMMYQAFAVLFI
AQAYNIEMSFTQQVTLLLVLMLTSKGMAGVARASLVVVAATLPMFHLPEAGLLLIIGIDQFFDMGRTATNVIGNSLATAV
VAKYEPAEDEVAADVAEPAVQPTVG
>Mature_425_residues
MNTKRLTSHIGLAMLLGIAVGWGCHEYAKDAAAAKDIASYFSIITDIFLRMIKMIIAPLVFSTLVTGLASMSGGRSVGRV
GLRAMIWFVCASATSLALGMLLVNFFQPGMHMNLALPDVSATSGLKTGDFTLKAFITHVFPRSIVEAMATNEILQILVFS
LFFGAALSTMKNPMDSVIGRGLEELTKLMFRITDYVMRFAPLGVFAAMAAAITVEGVGVLWTYGKLIGEFYLGLALLWAI
LFLVGYVLLGRSLGRLLGLIREPTLLAFATASSESAYPKTIEALDRFGVPKRISSFVLPLGYSFNLDGSMMYQAFAVLFI
AQAYNIEMSFTQQVTLLLVLMLTSKGMAGVARASLVVVAATLPMFHLPEAGLLLIIGIDQFFDMGRTATNVIGNSLATAV
VAKYEPAEDEVAADVAEPAVQPTVG

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=463, Percent_Identity=28.5097192224622, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI66773030, Length=451, Percent_Identity=27.4944567627494, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI40254478, Length=473, Percent_Identity=26.0042283298097, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI21314632, Length=426, Percent_Identity=28.169014084507, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI4827012, Length=276, Percent_Identity=31.8840579710145, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI5032093, Length=387, Percent_Identity=28.1653746770026, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI262359914, Length=400, Percent_Identity=27, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI223468564, Length=273, Percent_Identity=30.4029304029304, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI223468566, Length=280, Percent_Identity=30.7142857142857, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI194239697, Length=140, Percent_Identity=38.5714285714286, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI301601644, Length=152, Percent_Identity=32.2368421052632, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1790514, Length=430, Percent_Identity=39.7674418604651, Blast_Score=278, Evalue=4e-76,
Organism=Escherichia coli, GI1789947, Length=386, Percent_Identity=40.9326424870466, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1788024, Length=414, Percent_Identity=24.1545893719807, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789473, Length=393, Percent_Identity=23.1552162849873, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17537407, Length=454, Percent_Identity=27.3127753303965, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI71996953, Length=460, Percent_Identity=27.1739130434783, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71983099, Length=432, Percent_Identity=26.1574074074074, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71983106, Length=432, Percent_Identity=26.1574074074074, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI193206654, Length=405, Percent_Identity=25.679012345679, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI193206505, Length=433, Percent_Identity=26.0969976905312, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17541374, Length=158, Percent_Identity=34.1772151898734, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24583025, Length=427, Percent_Identity=27.1662763466042, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI17137668, Length=427, Percent_Identity=27.1662763466042, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24583023, Length=427, Percent_Identity=27.1662763466042, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI281360483, Length=423, Percent_Identity=26.7139479905437, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17137666, Length=423, Percent_Identity=26.7139479905437, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281360481, Length=423, Percent_Identity=26.7139479905437, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45650; Mature: 45650

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTKRLTSHIGLAMLLGIAVGWGCHEYAKDAAAAKDIASYFSIITDIFLRMIKMIIAPLV
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSTLVTGLASMSGGRSVGRVGLRAMIWFVCASATSLALGMLLVNFFQPGMHMNLALPDVS
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
ATSGLKTGDFTLKAFITHVFPRSIVEAMATNEILQILVFSLFFGAALSTMKNPMDSVIGR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHC
GLEELTKLMFRITDYVMRFAPLGVFAAMAAAITVEGVGVLWTYGKLIGEFYLGLALLWAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LFLVGYVLLGRSLGRLLGLIREPTLLAFATASSESAYPKTIEALDRFGVPKRISSFVLPL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCC
GYSFNLDGSMMYQAFAVLFIAQAYNIEMSFTQQVTLLLVLMLTSKGMAGVARASLVVVAA
CCEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TLPMFHLPEAGLLLIIGIDQFFDMGRTATNVIGNSLATAVVAKYEPAEDEVAADVAEPAV
HCCHHCCCCCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
QPTVG
CCCCC
>Mature Secondary Structure
MNTKRLTSHIGLAMLLGIAVGWGCHEYAKDAAAAKDIASYFSIITDIFLRMIKMIIAPLV
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSTLVTGLASMSGGRSVGRVGLRAMIWFVCASATSLALGMLLVNFFQPGMHMNLALPDVS
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
ATSGLKTGDFTLKAFITHVFPRSIVEAMATNEILQILVFSLFFGAALSTMKNPMDSVIGR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHC
GLEELTKLMFRITDYVMRFAPLGVFAAMAAAITVEGVGVLWTYGKLIGEFYLGLALLWAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LFLVGYVLLGRSLGRLLGLIREPTLLAFATASSESAYPKTIEALDRFGVPKRISSFVLPL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCC
GYSFNLDGSMMYQAFAVLFIAQAYNIEMSFTQQVTLLLVLMLTSKGMAGVARASLVVVAA
CCEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TLPMFHLPEAGLLLIIGIDQFFDMGRTATNVIGNSLATAVVAKYEPAEDEVAADVAEPAV
HCCHHCCCCCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
QPTVG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]