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The map label for this gene is phbA [H]

Identifier: 187928995

GI number: 187928995

Start: 2019908

End: 2021089

Strand: Reverse

Name: phbA [H]

Synonym: Rpic_1915

Alternate gene names: 187928995

Gene position: 2021089-2019908 (Counterclockwise)

Preceding gene: 187928996

Following gene: 187928994

Centisome position: 51.26

GC content: 65.74

Gene sequence:

>1182_bases
ATGACCGATGTTGTGATCGTATCGGCGGTACGCACCGCCGTGGGCAAGTTTGGTGGCTCGCTGGCGAAGATCGCTGCGCC
TGAGCTTGGCGCGGCCGTTATCCGTGAAGCGCTGGCGCGCGCCAAGGTGGCGCCGGACCAGGTGAGCGAAGTCATCATGG
GCCAGGTGCTGACGGCAGGCTCGGGTCAGAACCCGGCGCGCCAGGCCGTCATCAAGGCTGGGCTGCCGAACATGGTGCCT
GGCCTGACCATCAACAAGGTGTGCGGCTCGGGCCTGAAGGCCGTGATGCTGGCCGCCAACGCCATCATCGCGGGCGATGC
CGAGATCGTCGTGGCTGGCGGCCAGGAAAACATGTCCGCCGCGCCGCACGTCCTGCCAGGCTCGCGCGACGGTTTCCGCA
TGGGCGACGCCAAGCTGATCGATTCGATGATTGTGGATGGGCTATGGGACGTCTACAACCAGTACCACATGGGCATCACG
GCCGAGAACGTCGCCAAGGAATACGGCATCACGCGTGAAGCGCAGGACGAGTTTGCCGTGGCTTCGCAGAACAAGGCGGA
AGCTGCGCAGAAGTCGGGCCGCTTCAATGACGAAATCGTTCCGATCCTGATCCCGCAGCGCAAGGGCGATCCGATTGCCT
TCTCGCAGGACGAGTTCGTTCGCCATGGTGCCACGCTCGAGTCGATGGCTGGCCTGAAGCCCGCCTTCGACAAGGCAGGT
ACGGTGACGGCGGCCAACGCCTCGGGCCTGAACGATGGCGCCGCCGCAGTCGTGGTGATGTCGGCCGCCAAGGCCAAGGA
ACTGGGCCTGACGCCACTGGCCACCATCCGTGCTTACGCGAGCGCCGGCCTGGACCCGAAGGTCATGGGCATGGGGCCGG
TGCCGGCATCCAAACGCTGCCTGTCGCGCGCCGGCTGGTCGGTGGGCGACCTGGACCTGATGGAGATCAACGAGGCGTTC
GCCGCTCAGGCGCTGGCCGTGCATCAGCAGATGGGCTGGGACACGTCCAAGATCAACGTCAACGGCGGTGCGATTGCGAT
CGGTCACCCGATCGGCGCGTCGGGCTGCCGCATCCTGGTCACGCTGCTGCACGAAATGCAGAAGCGCGATGCGAAGAAGG
GCCTGGCTTCGCTGTGTATCGGCGGTGGCATGGGCGTGGCGCTGGCCGTTGAGCGCCCGTAA

Upstream 100 bases:

>100_bases
AGAAAGCGTAAGATCGCGCGCATGAACCCCCGTTGCCGTCGCGGCTTCGGCCGCTGACGGTATCCAACGACCCTCTCTTT
CGACAGTGGAAGGTAAGCAA

Downstream 100 bases:

>100_bases
GTTTTTTGCAGTGGGATTGGCGTGAATCGGAACGAATGCCTGACGCGCCAATCCGAGACACCTGAGCATTTGCCGCCCGG
CAAGAGGCCGGGCGATTCTA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDVVIVSAVRTAVGKFGGSLAKIAAPELGAAVIREALARAKVAPDQVSEVIMGQVLTAGSGQNPARQAVIKAGLPNMVP
GLTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLIDSMIVDGLWDVYNQYHMGIT
AENVAKEYGITREAQDEFAVASQNKAEAAQKSGRFNDEIVPILIPQRKGDPIAFSQDEFVRHGATLESMAGLKPAFDKAG
TVTAANASGLNDGAAAVVVMSAAKAKELGLTPLATIRAYASAGLDPKVMGMGPVPASKRCLSRAGWSVGDLDLMEINEAF
AAQALAVHQQMGWDTSKINVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKKGLASLCIGGGMGVALAVERP

Sequences:

>Translated_393_residues
MTDVVIVSAVRTAVGKFGGSLAKIAAPELGAAVIREALARAKVAPDQVSEVIMGQVLTAGSGQNPARQAVIKAGLPNMVP
GLTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLIDSMIVDGLWDVYNQYHMGIT
AENVAKEYGITREAQDEFAVASQNKAEAAQKSGRFNDEIVPILIPQRKGDPIAFSQDEFVRHGATLESMAGLKPAFDKAG
TVTAANASGLNDGAAAVVVMSAAKAKELGLTPLATIRAYASAGLDPKVMGMGPVPASKRCLSRAGWSVGDLDLMEINEAF
AAQALAVHQQMGWDTSKINVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKKGLASLCIGGGMGVALAVERP
>Mature_392_residues
TDVVIVSAVRTAVGKFGGSLAKIAAPELGAAVIREALARAKVAPDQVSEVIMGQVLTAGSGQNPARQAVIKAGLPNMVPG
LTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLIDSMIVDGLWDVYNQYHMGITA
ENVAKEYGITREAQDEFAVASQNKAEAAQKSGRFNDEIVPILIPQRKGDPIAFSQDEFVRHGATLESMAGLKPAFDKAGT
VTAANASGLNDGAAAVVVMSAAKAKELGLTPLATIRAYASAGLDPKVMGMGPVPASKRCLSRAGWSVGDLDLMEINEAFA
AQALAVHQQMGWDTSKINVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKKGLASLCIGGGMGVALAVERP

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=55.7544757033248, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=44.8717948717949, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=43.0025445292621, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=41.8136020151133, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=32.0754716981132, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI194353979, Length=394, Percent_Identity=30.9644670050761, Blast_Score=156, Evalue=4e-38,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=59.6938775510204, Blast_Score=480, Evalue=1e-137,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=61.0687022900763, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=44.0594059405941, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=42.643391521197, Blast_Score=274, Evalue=6e-75,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=35.2078239608802, Blast_Score=216, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=45.8974358974359, Blast_Score=329, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=41.343669250646, Blast_Score=291, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI17535921, Length=397, Percent_Identity=40.5541561712846, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=31.5420560747664, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17535917, Length=397, Percent_Identity=31.4861460957179, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6325229, Length=395, Percent_Identity=42.2784810126582, Blast_Score=295, Evalue=6e-81,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=38.3838383838384, Blast_Score=229, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=57.1428571428571, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=45.5470737913486, Blast_Score=320, Evalue=7e-88,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=44.6153846153846, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.5294117647059, Blast_Score=185, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40467; Mature: 40336

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVVIVSAVRTAVGKFGGSLAKIAAPELGAAVIREALARAKVAPDQVSEVIMGQVLTAG
CCCEEEHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
SGQNPARQAVIKAGLPNMVPGLTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCEEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLIDSMIVDGLWDVYNQYHMGITAENVAKEYGITREAQDEFAV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHH
ASQNKAEAAQKSGRFNDEIVPILIPQRKGDPIAFSQDEFVRHGATLESMAGLKPAFDKAG
HCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCHHHHHCCCCCCCCCC
TVTAANASGLNDGAAAVVVMSAAKAKELGLTPLATIRAYASAGLDPKVMGMGPVPASKRC
CEEECCCCCCCCCCCEEEEEHHHHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHH
LSRAGWSVGDLDLMEINEAFAAQALAVHQQMGWDTSKINVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMQKRDAKKGLASLCIGGGMGVALAVERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure 
TDVVIVSAVRTAVGKFGGSLAKIAAPELGAAVIREALARAKVAPDQVSEVIMGQVLTAG
CCEEEHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
SGQNPARQAVIKAGLPNMVPGLTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCEEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLIDSMIVDGLWDVYNQYHMGITAENVAKEYGITREAQDEFAV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHH
ASQNKAEAAQKSGRFNDEIVPILIPQRKGDPIAFSQDEFVRHGATLESMAGLKPAFDKAG
HCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCHHHHHCCCCCCCCCC
TVTAANASGLNDGAAAVVVMSAAKAKELGLTPLATIRAYASAGLDPKVMGMGPVPASKRC
CEEECCCCCCCCCCCEEEEEHHHHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHH
LSRAGWSVGDLDLMEINEAFAAQALAVHQQMGWDTSKINVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMQKRDAKKGLASLCIGGGMGVALAVERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]