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The map label for this gene is metC [H]

Identifier: 187928988

GI number: 187928988

Start: 2012235

End: 2013446

Strand: Reverse

Name: metC [H]

Synonym: Rpic_1908

Alternate gene names: 187928988

Gene position: 2013446-2012235 (Counterclockwise)

Preceding gene: 187928989

Following gene: 187928983

Centisome position: 51.07

GC content: 63.2

Gene sequence:

>1212_bases
GTGAACGACGACACCAAGCTCCCGCCCATGTTTCCCGCGACCCAGGCTGTGCATCCGGAATTGCATATCCCACCGGGCTT
CACGGCGTTCTCGCATGCCACGCATCGTGCGTCGACGGTGGTGTTCAAGAATCTCGCAGACATGCGTGCCTTCGGTAGCG
GCAGTGTGGTGCACTGGCGCTACGGCCTGCATGCCACGCCGACATCCGACACGCTGTGCCAGGCGCTGGCGCAGATCGAG
GGCGGCTCACACACGCTGCTGCTCCCATCAGGGCTGGCGGCGATTTCGCTGGTGTACTTCACGCTCGTCAAATCCGGCGA
CGACGTGTTGATTCCGGACAACGCCTACGGTCCGAACCGCGACCATGGCGAGTGGATGGCACGCCAGTTCGGCATCACCG
TGCGCTATTACGATCCGATGATCGGCGCCGGCATTGCCGACCTGATCCGTCACAACACCAAACTCGTGTGGCTCGAAGCG
CCGGGTTCGGTGACGATGGAGGTGCCCGATTGCACGGCCATCGCCGAGGTGGCGCGCAAGGCCGGCGCCATTACGGCAAT
CGACAACACCTGGAGCGGTGGCGTGTATTACCAGCCGTTCGAGCACGGCATCGACATCTCTGTGCAGGCGCTGACCAAGT
ACCAATCGGGTGGCAGCGACGTGCTCATGGGCGCCGCCATCACCAACGACGAAGCGCTGCACTATAAGCTGCTTGCCACA
CGCATGCGCATGGGTTGGGGCGTTTCGGCGGACGATTGCTATTTCGTGTTGCGTGGCATGCCGAGCCTGCCAACGCGCCT
GGCTGCACACGATGCACACGCCCGCGAAGTGGCCGAATGGCTGGCGGATCGGCCCGAAATCGTGCGCGTTCTGCACCCGG
CACTGCCTGATTGTCCGGGCCACGAAAACTGGAAGCGCGACTTTACCGGCGCGAGCGGCTTGTTCTCGATCGTGCTGCAC
GAGCGCTATTCGCAGGCGCAGATCGACGCCTTTATCGAAGGGTTGCGCTACTTCGCGATCGGTTTTTCGTGGGGCGGGGC
CCACAGCCTGGCGTTGCCGTACAACATTCCGTCGATGCGCACGGCGACCGCCTGGCCGCCGGCCGATTGGGAAAACGCGG
GCGGTTTCGTGCGTCTGTATATCGGGCTGGAAGATCCGCGTGATTTGATTGCGGATTTGAAGCAGGCGATGGAGGCGCAC
CTGCGGGCTTGA

Upstream 100 bases:

>100_bases
GGCCTGGTCAGATTGCACCACCGGCCGGCAGTCCAACACGATCAAGCGCGCACTGGTAAGCGGCCGCAAAACGCTCATAC
GCCATCAAACAGGAAACCAC

Downstream 100 bases:

>100_bases
CCTTTCAAGCTTCAGGCGGCGGTGATGGCGGGGCGTGCGAGTTGATCGTGGCGCCCCGTTTTCAATCGTCGTGGCTACAG
CGTTTCAAGCAGGCGCGCAA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MNDDTKLPPMFPATQAVHPELHIPPGFTAFSHATHRASTVVFKNLADMRAFGSGSVVHWRYGLHATPTSDTLCQALAQIE
GGSHTLLLPSGLAAISLVYFTLVKSGDDVLIPDNAYGPNRDHGEWMARQFGITVRYYDPMIGAGIADLIRHNTKLVWLEA
PGSVTMEVPDCTAIAEVARKAGAITAIDNTWSGGVYYQPFEHGIDISVQALTKYQSGGSDVLMGAAITNDEALHYKLLAT
RMRMGWGVSADDCYFVLRGMPSLPTRLAAHDAHAREVAEWLADRPEIVRVLHPALPDCPGHENWKRDFTGASGLFSIVLH
ERYSQAQIDAFIEGLRYFAIGFSWGGAHSLALPYNIPSMRTATAWPPADWENAGGFVRLYIGLEDPRDLIADLKQAMEAH
LRA

Sequences:

>Translated_403_residues
MNDDTKLPPMFPATQAVHPELHIPPGFTAFSHATHRASTVVFKNLADMRAFGSGSVVHWRYGLHATPTSDTLCQALAQIE
GGSHTLLLPSGLAAISLVYFTLVKSGDDVLIPDNAYGPNRDHGEWMARQFGITVRYYDPMIGAGIADLIRHNTKLVWLEA
PGSVTMEVPDCTAIAEVARKAGAITAIDNTWSGGVYYQPFEHGIDISVQALTKYQSGGSDVLMGAAITNDEALHYKLLAT
RMRMGWGVSADDCYFVLRGMPSLPTRLAAHDAHAREVAEWLADRPEIVRVLHPALPDCPGHENWKRDFTGASGLFSIVLH
ERYSQAQIDAFIEGLRYFAIGFSWGGAHSLALPYNIPSMRTATAWPPADWENAGGFVRLYIGLEDPRDLIADLKQAMEAH
LRA
>Mature_403_residues
MNDDTKLPPMFPATQAVHPELHIPPGFTAFSHATHRASTVVFKNLADMRAFGSGSVVHWRYGLHATPTSDTLCQALAQIE
GGSHTLLLPSGLAAISLVYFTLVKSGDDVLIPDNAYGPNRDHGEWMARQFGITVRYYDPMIGAGIADLIRHNTKLVWLEA
PGSVTMEVPDCTAIAEVARKAGAITAIDNTWSGGVYYQPFEHGIDISVQALTKYQSGGSDVLMGAAITNDEALHYKLLAT
RMRMGWGVSADDCYFVLRGMPSLPTRLAAHDAHAREVAEWLADRPEIVRVLHPALPDCPGHENWKRDFTGASGLFSIVLH
ERYSQAQIDAFIEGLRYFAIGFSWGGAHSLALPYNIPSMRTATAWPPADWENAGGFVRLYIGLEDPRDLIADLKQAMEAH
LRA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=345, Percent_Identity=33.3333333333333, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI299473759, Length=288, Percent_Identity=34.0277777777778, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI25453487, Length=344, Percent_Identity=29.9418604651163, Blast_Score=132, Evalue=4e-31,
Organism=Escherichia coli, GI1789383, Length=386, Percent_Identity=39.6373056994819, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1790375, Length=390, Percent_Identity=28.7179487179487, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560056, Length=346, Percent_Identity=34.393063583815, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17538055, Length=344, Percent_Identity=33.7209302325581, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71980708, Length=374, Percent_Identity=28.8770053475936, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321170, Length=312, Percent_Identity=42.9487179487179, Blast_Score=256, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6319307, Length=348, Percent_Identity=29.0229885057471, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6323333, Length=410, Percent_Identity=23.4146341463415, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321904, Length=341, Percent_Identity=25.5131964809384, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI19922554, Length=350, Percent_Identity=34, Blast_Score=199, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44147; Mature: 44147

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDDTKLPPMFPATQAVHPELHIPPGFTAFSHATHRASTVVFKNLADMRAFGSGSVVHWR
CCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
YGLHATPTSDTLCQALAQIEGGSHTLLLPSGLAAISLVYFTLVKSGDDVLIPDNAYGPNR
ECCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCC
DHGEWMARQFGITVRYYDPMIGAGIADLIRHNTKLVWLEAPGSVTMEVPDCTAIAEVARK
CHHHHHHHHHCCEEEEECCHHHCCHHHHHHCCCEEEEEECCCCEEEECCCHHHHHHHHHH
AGAITAIDNTWSGGVYYQPFEHGIDISVQALTKYQSGGSDVLMGAAITNDEALHYKLLAT
CCCEEEECCCCCCCEEECCHHCCCCEEEEEEHHHCCCCCCEEEEEEECCCCHHHHHHHHH
RMRMGWGVSADDCYFVLRGMPSLPTRLAAHDAHAREVAEWLADRPEIVRVLHPALPDCPG
HHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
HENWKRDFTGASGLFSIVLHERYSQAQIDAFIEGLRYFAIGFSWGGAHSLALPYNIPSMR
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEECCCCCCCC
TATAWPPADWENAGGFVRLYIGLEDPRDLIADLKQAMEAHLRA
CCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNDDTKLPPMFPATQAVHPELHIPPGFTAFSHATHRASTVVFKNLADMRAFGSGSVVHWR
CCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
YGLHATPTSDTLCQALAQIEGGSHTLLLPSGLAAISLVYFTLVKSGDDVLIPDNAYGPNR
ECCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCC
DHGEWMARQFGITVRYYDPMIGAGIADLIRHNTKLVWLEAPGSVTMEVPDCTAIAEVARK
CHHHHHHHHHCCEEEEECCHHHCCHHHHHHCCCEEEEEECCCCEEEECCCHHHHHHHHHH
AGAITAIDNTWSGGVYYQPFEHGIDISVQALTKYQSGGSDVLMGAAITNDEALHYKLLAT
CCCEEEECCCCCCCEEECCHHCCCCEEEEEEHHHCCCCCCEEEEEEECCCCHHHHHHHHH
RMRMGWGVSADDCYFVLRGMPSLPTRLAAHDAHAREVAEWLADRPEIVRVLHPALPDCPG
HHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
HENWKRDFTGASGLFSIVLHERYSQAQIDAFIEGLRYFAIGFSWGGAHSLALPYNIPSMR
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEECCCCCCCC
TATAWPPADWENAGGFVRLYIGLEDPRDLIADLKQAMEAHLRA
CCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]