Definition Ralstonia pickettii 12J chromosome chromosome 1, complete sequence.
Accession NC_010682
Length 3,942,557

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The map label for this gene is dxr

Identifier: 187928373

GI number: 187928373

Start: 1378882

End: 1380072

Strand: Direct

Name: dxr

Synonym: Rpic_1284

Alternate gene names: 187928373

Gene position: 1378882-1380072 (Clockwise)

Preceding gene: 187928372

Following gene: 187928374

Centisome position: 34.97

GC content: 64.82

Gene sequence:

>1191_bases
ATGATGCGTTTGACCGTTCTTGGCGCCACTGGCTCCATTGGCGACAGCACGCTCGACGTGGTGCGCCGTCATCCCGACAA
ATACAGCGTTTTTGCGCTGACCGCCAACGCGCAGGCCGACAAGCTCGCGGTGCTCTGCCGTGAGTTTCGCCCGAAGATGG
CGGTGCTCGGTTCGGCGGCTGCGGCGGATGCATTGCGTGACCAACTGGGCACAGAAGCTGCCGGCATCGAAATCTGTTCT
GGCACCAAGGCGCTGGAAGAGGCCGCCGCCCACCCTGACTGCGATGCCGTGATGGCCGCCATCGTTGGGGCGGCAGGTTT
GCGCCCGACGCTTGCCGCCGTGCGCGCCGGCAAGCGCGTGCTCCTGGCCAACAAGGAGGCGCTGGTGATGTCCGGCGCGC
TCTTCATGGACGCCGTGCGTGAGCATGGCGCCACCGTGCTCCCGATCGACAGCGAGCACAACGCCATCTTCCAATGCCTT
CCTCAGCAAGTTCCGCAGTTCGGGCGCGGCGTGTCGCGCATCGTCCTGACGGCATCAGGTGGTCCGTTCCGTACGCGTGC
CGTTGATTCGCTTGCTGATGTCACGCCCGATCAGGCTTGCGCGCATCCGAACTGGGTGATGGGGCGCAAGATCTCCGTTG
ACTCCGCCACCATGATGAACAAGGGGCTGGAGGTGATCGAGGCGTACTGGCTGTTTGGCGTGCCGGTCGAGCATCTCGAA
GTGCTGATCCACCCGCAGAGTGTCATCCATTCGATGGTCGGCTACGACGATGGCTCCGTGCTGGCGCAGCTGGGCAATCC
GGACATGCGCACGCCGATTGCCTACGGCTTGGCCTACCCTGAGCGCATTGAGGCCGGTGTTCCGCTGCTCGATCTCGTGA
CCACAGGTGCACTGACGTTCGAGGCGCCGGATCTGCGCCGCTTCCCGTGTCTGGCGCTGGCCTTTGATGCACTGCGCGCC
GGTGGTACGGCACCTGCTGCTCTGAACGCGGCCAACGAGGTGGCTGTCGAAGCATTTTTACAGCGCCGCATCCGGTTCAC
CGAGATTGCTGCCGTGGTGGGTGACACGCTCGCCCGTACTTCTATCGTGCCCGCCGACTCGCTCGACACCGTATTTGCGG
CCGACGCCCAAGCGCGTCAGCAGGCGGAGCGCTATATCGCGACCGCATGCGCGCAACTGCCGGCCGCCTGA

Upstream 100 bases:

>100_bases
GCCGCCTGTTGCCCGGCCACGGCGGTGTGCTCGATCGTATCGACGCACTGCTGCCAGTGTTTCCGCTGGCTGCGCTGCTG
ATTTCCTGAGGCGTCTGAAC

Downstream 100 bases:

>100_bases
AAGCGCCCCGTCAGAGCAAGCGGGTAACATAGCGGCTTCGCGCGGGGTCAACCAGCGCGTGCCCTTCAGTGCATCCGGAG
AAGGTTTTGCAGACCGTTTT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MMRLTVLGATGSIGDSTLDVVRRHPDKYSVFALTANAQADKLAVLCREFRPKMAVLGSAAAADALRDQLGTEAAGIEICS
GTKALEEAAAHPDCDAVMAAIVGAAGLRPTLAAVRAGKRVLLANKEALVMSGALFMDAVREHGATVLPIDSEHNAIFQCL
PQQVPQFGRGVSRIVLTASGGPFRTRAVDSLADVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAYWLFGVPVEHLE
VLIHPQSVIHSMVGYDDGSVLAQLGNPDMRTPIAYGLAYPERIEAGVPLLDLVTTGALTFEAPDLRRFPCLALAFDALRA
GGTAPAALNAANEVAVEAFLQRRIRFTEIAAVVGDTLARTSIVPADSLDTVFAADAQARQQAERYIATACAQLPAA

Sequences:

>Translated_396_residues
MMRLTVLGATGSIGDSTLDVVRRHPDKYSVFALTANAQADKLAVLCREFRPKMAVLGSAAAADALRDQLGTEAAGIEICS
GTKALEEAAAHPDCDAVMAAIVGAAGLRPTLAAVRAGKRVLLANKEALVMSGALFMDAVREHGATVLPIDSEHNAIFQCL
PQQVPQFGRGVSRIVLTASGGPFRTRAVDSLADVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAYWLFGVPVEHLE
VLIHPQSVIHSMVGYDDGSVLAQLGNPDMRTPIAYGLAYPERIEAGVPLLDLVTTGALTFEAPDLRRFPCLALAFDALRA
GGTAPAALNAANEVAVEAFLQRRIRFTEIAAVVGDTLARTSIVPADSLDTVFAADAQARQQAERYIATACAQLPAA
>Mature_396_residues
MMRLTVLGATGSIGDSTLDVVRRHPDKYSVFALTANAQADKLAVLCREFRPKMAVLGSAAAADALRDQLGTEAAGIEICS
GTKALEEAAAHPDCDAVMAAIVGAAGLRPTLAAVRAGKRVLLANKEALVMSGALFMDAVREHGATVLPIDSEHNAIFQCL
PQQVPQFGRGVSRIVLTASGGPFRTRAVDSLADVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAYWLFGVPVEHLE
VLIHPQSVIHSMVGYDDGSVLAQLGNPDMRTPIAYGLAYPERIEAGVPLLDLVTTGALTFEAPDLRRFPCLALAFDALRA
GGTAPAALNAANEVAVEAFLQRRIRFTEIAAVVGDTLARTSIVPADSLDTVFAADAQARQQAERYIATACAQLPAA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=393, Percent_Identity=55.470737913486, Blast_Score=411, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_RALPJ (B2UB12)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001898860.1
- ProteinModelPortal:   B2UB12
- SMR:   B2UB12
- GeneID:   6289310
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_1284
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41790; Mature: 41790

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: BINDING 125-125 BINDING 152-152 BINDING 179-179 BINDING 202-202 BINDING 224-224

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MMRLTVLGATGSIGDSTLDVVRRHPDKYSVFALTANAQADKLAVLCREFRPKMAVLGSAA
CEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHH
AADALRDQLGTEAAGIEICSGTKALEEAAAHPDCDAVMAAIVGAAGLRPTLAAVRAGKRV
HHHHHHHHHCCCCCCEEEECCCHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCEE
LLANKEALVMSGALFMDAVREHGATVLPIDSEHNAIFQCLPQQVPQFGRGVSRIVLTASG
EEECCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECC
GPFRTRAVDSLADVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAYWLFGVPVEHLE
CCCHHHHHHHHHHCCCHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCHHHHH
VLIHPQSVIHSMVGYDDGSVLAQLGNPDMRTPIAYGLAYPERIEAGVPLLDLVTTGALTF
EEECCHHHHHHHHCCCCCHHHEECCCCCCCCCHHHHCCCHHHHHCCCCHHHHHHCCCEEE
EAPDLRRFPCLALAFDALRAGGTAPAALNAANEVAVEAFLQRRIRFTEIAAVVGDTLART
CCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIVPADSLDTVFAADAQARQQAERYIATACAQLPAA
CCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMRLTVLGATGSIGDSTLDVVRRHPDKYSVFALTANAQADKLAVLCREFRPKMAVLGSAA
CEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHH
AADALRDQLGTEAAGIEICSGTKALEEAAAHPDCDAVMAAIVGAAGLRPTLAAVRAGKRV
HHHHHHHHHCCCCCCEEEECCCHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCEE
LLANKEALVMSGALFMDAVREHGATVLPIDSEHNAIFQCLPQQVPQFGRGVSRIVLTASG
EEECCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECC
GPFRTRAVDSLADVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAYWLFGVPVEHLE
CCCHHHHHHHHHHCCCHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCHHHHH
VLIHPQSVIHSMVGYDDGSVLAQLGNPDMRTPIAYGLAYPERIEAGVPLLDLVTTGALTF
EEECCHHHHHHHHCCCCCHHHEECCCCCCCCCHHHHCCCHHHHHCCCCHHHHHHCCCEEE
EAPDLRRFPCLALAFDALRAGGTAPAALNAANEVAVEAFLQRRIRFTEIAAVVGDTLART
CCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIVPADSLDTVFAADAQARQQAERYIATACAQLPAA
CCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA