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The map label for this gene is uppS [H]

Identifier: 187928371

GI number: 187928371

Start: 1377272

End: 1378048

Strand: Direct

Name: uppS [H]

Synonym: Rpic_1282

Alternate gene names: 187928371

Gene position: 1377272-1378048 (Clockwise)

Preceding gene: 187928370

Following gene: 187928372

Centisome position: 34.93

GC content: 64.99

Gene sequence:

>777_bases
ATGCATATCAGTTCCACACTGGCGGTGCCCGACACCGCCGATACGCCGCGCCACGTTGCCGTCATCATGGACGGTAACGG
CCGCTGGGCCACCGAACGGCATCTGCCGCGCGTGGCCGGGCATAGCCGCGGCCTCGACGCCGTGCGTGCAACCGTTGAAG
CGGCGGCACGCCGAGGCGTCGGTTACCTGACGCTGTTTGCGTTCAGCTCCGAAAACTGGCGTCGTCCGGCCGAGGAAGTC
ACCTTCCTCATGAAGCTGTTCATGACGGCGCTGCGCCGCGAGGTCAGCAAGCTGCACGACAACGGCATCCGCTTGCGCGT
GGTGGGCGATCTGTCTGCGTTCAGCCCGCGCATCCAGCTCTTGATTCGCGAAGCTGAGGCCAAGACGGCTGCCAATCCCG
GTCTGACCGTCACGATCCTCGCCAACTACGGCGGGCGCTGGGACATCCTGCAAGCCATGCGCGCCTTGTTGACGGCAAAG
CCCGGCATTGCACCCGACGCCATCACCGAAGAGATGCTCGCGCCGTACATGGCGCTGTCCTACGCGCCGGAGCCGGATTT
GTTCATCCGCACCGGTGGCGAGCAACGCATCAGCAACTTTCTGCTCTGGCAGCTTGCGTATTCCGAGCTGTACTTCACCG
ATCGCTACTGGCCCGATTTCGATGCCGCAGAACTCGATCGCGCCTTTGCGTGGTATCGCAACCGCGAGCGCCGCTTCGGC
CGCACAAGCGCCCAGCTCGAGCCCGATGTTCCCCCCGCGCTATCCGCCGGAGCCTGA

Upstream 100 bases:

>100_bases
ATCGACAAGCTGGTCGCCGAGAAAGACAAGGAAATCATGACGGTGTAAGGCCGTCTCCCGCCGCCGGCGCATTGGGCGCA
TGCGGTGGGAAGCCCGATTC

Downstream 100 bases:

>100_bases
CACATGCTGCTGACTCGCGTCATTACCGCTGTCTGCCTGCTGATTGTCATCCTGCCCATTCTGTTCTTTGCGCCGCCCGC
CGGCCTGGCCGGGCTCGTGA

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MHISSTLAVPDTADTPRHVAVIMDGNGRWATERHLPRVAGHSRGLDAVRATVEAAARRGVGYLTLFAFSSENWRRPAEEV
TFLMKLFMTALRREVSKLHDNGIRLRVVGDLSAFSPRIQLLIREAEAKTAANPGLTVTILANYGGRWDILQAMRALLTAK
PGIAPDAITEEMLAPYMALSYAPEPDLFIRTGGEQRISNFLLWQLAYSELYFTDRYWPDFDAAELDRAFAWYRNRERRFG
RTSAQLEPDVPPALSAGA

Sequences:

>Translated_258_residues
MHISSTLAVPDTADTPRHVAVIMDGNGRWATERHLPRVAGHSRGLDAVRATVEAAARRGVGYLTLFAFSSENWRRPAEEV
TFLMKLFMTALRREVSKLHDNGIRLRVVGDLSAFSPRIQLLIREAEAKTAANPGLTVTILANYGGRWDILQAMRALLTAK
PGIAPDAITEEMLAPYMALSYAPEPDLFIRTGGEQRISNFLLWQLAYSELYFTDRYWPDFDAAELDRAFAWYRNRERRFG
RTSAQLEPDVPPALSAGA
>Mature_258_residues
MHISSTLAVPDTADTPRHVAVIMDGNGRWATERHLPRVAGHSRGLDAVRATVEAAARRGVGYLTLFAFSSENWRRPAEEV
TFLMKLFMTALRREVSKLHDNGIRLRVVGDLSAFSPRIQLLIREAEAKTAANPGLTVTILANYGGRWDILQAMRALLTAK
PGIAPDAITEEMLAPYMALSYAPEPDLFIRTGGEQRISNFLLWQLAYSELYFTDRYWPDFDAAELDRAFAWYRNRERRFG
RTSAQLEPDVPPALSAGA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=210, Percent_Identity=34.7619047619048, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI45580742, Length=210, Percent_Identity=34.7619047619048, Blast_Score=131, Evalue=6e-31,
Organism=Escherichia coli, GI1786371, Length=246, Percent_Identity=52.8455284552846, Blast_Score=256, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI71993029, Length=228, Percent_Identity=35.0877192982456, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=217, Percent_Identity=34.5622119815668, Blast_Score=119, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6319474, Length=212, Percent_Identity=34.4339622641509, Blast_Score=108, Evalue=6e-25,
Organism=Drosophila melanogaster, GI18857969, Length=207, Percent_Identity=36.231884057971, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28890; Mature: 28890

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHISSTLAVPDTADTPRHVAVIMDGNGRWATERHLPRVAGHSRGLDAVRATVEAAARRGV
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHCCHHHHCCCCCHHHHHHHHHHHHHCCC
GYLTLFAFSSENWRRPAEEVTFLMKLFMTALRREVSKLHDNGIRLRVVGDLSAFSPRIQL
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHCHHHHH
LIREAEAKTAANPGLTVTILANYGGRWDILQAMRALLTAKPGIAPDAITEEMLAPYMALS
HHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
YAPEPDLFIRTGGEQRISNFLLWQLAYSELYFTDRYWPDFDAAELDRAFAWYRNRERRFG
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
RTSAQLEPDVPPALSAGA
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHISSTLAVPDTADTPRHVAVIMDGNGRWATERHLPRVAGHSRGLDAVRATVEAAARRGV
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHCCHHHHCCCCCHHHHHHHHHHHHHCCC
GYLTLFAFSSENWRRPAEEVTFLMKLFMTALRREVSKLHDNGIRLRVVGDLSAFSPRIQL
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHCHHHHH
LIREAEAKTAANPGLTVTILANYGGRWDILQAMRALLTAKPGIAPDAITEEMLAPYMALS
HHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
YAPEPDLFIRTGGEQRISNFLLWQLAYSELYFTDRYWPDFDAAELDRAFAWYRNRERRFG
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
RTSAQLEPDVPPALSAGA
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]