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The map label for this gene is alr

Identifier: 187928333

GI number: 187928333

Start: 1332075

End: 1333199

Strand: Direct

Name: alr

Synonym: Rpic_1244

Alternate gene names: 187928333

Gene position: 1332075-1333199 (Clockwise)

Preceding gene: 187928331

Following gene: 187928334

Centisome position: 33.79

GC content: 67.38

Gene sequence:

>1125_bases
ATGCCAAGACCCATCCAGGCCGTCATCCACGGCCCAGCACTTGCCAATAATCTCCAGATTGCCCGCCGTCATGCGCCCAA
CTCGCGCGTGTGGGCTGTCGTCAAAGCCAACGCGTACGGCCACGGTATCGAACGCGTGTATGAAGGCCTGCGCCAGACCG
ACGGTTTCGGTCTGCTCGATCTGGACGAGGCCGTCCGCCTGCGCCAACTCGGCTGGCAGGGGCCGGTCCTCCTGCTCGAA
GGCTTTTTCAAGCCGGAAGACCTGGCCATCGTCGAGCAGTACCGCCTGACGACCACCGTCCACTGCGAAGAGCAACTGCG
CATGCTGGAACTGGCGCGCCTGAAAGGGCCCACCAGCGTGCAGCTCAAGATCAATACGGGCATGAGCCGACTCGGCTTCG
CGCCCGCCGCCTACCGCGCCGCATGGGAGCGCGCCCGCGCCATTTCAGGCGTCGGCACGATCGTCCACATGACGCATTTT
TCGGATGCCGACGGCCCGCGTGGCATCGAGCATCAACTCGCGGCGTTTGAGCGCGCCACGCAAGGTTTGCCGGGCGAAGC
GTCGCTGTCCAACTCCGCGGCCACGCTGTGGCATCCGAAGGCGCATCGCGACTGGGTGCGCCCAGGCGTGATCATGTACG
GCGCATCGCCGACGGGCGTGGCGGCGGATATTGACGGCACAGGCCTGATGCCCGCCATGTCGCTCAAGAGCGAGCTGATC
GCCATCCAGGATCTGCAGCCGGGCGCGACGATCGGTTACGGCTCGCGCTTTACCGTGGAGCACCCGATGCGCATCGGCGT
CGTCGCGTGCGGTTATGCCGACGGCTACCCGCGCCATGCGCCGGGCTGGGACGGCAACCATACGCCGGTGCTGGTCGACG
GCGTGCGCACGCACATCGTGGGCCGCGTGTCGATGGACATGATCACCGTGGATCTGGCCGGCGTGCCCGAGGCGCGTGTC
GGCACGCCCGTCACGCTGTGGGGCGAGGGCTTGCCGATCGACGACGTCGCACAGGCCTCCGGCACGGTTGGCTATGAGTT
GATGTGCGCACTGGCGCCGCGCGTGCCGGTATTGGTCGAGCCCGTCGGCACGGCAGAGGCCGGCGACCTGGGCAAGGCTG
CCTGA

Upstream 100 bases:

>100_bases
GGCGCACCGGCCTCCGCACAGTCAATTTGCCTGTTGCACTGCAGCACCGACGCCGCGCCACGAGCGCGCCATCGCATTCA
CGTTTTGCAGGTTTGCCGTC

Downstream 100 bases:

>100_bases
GCGCCGCATCGTTAATACAAAGATCAAGCGGCGGTCGCCCATGCGCGGCGCCGTAAGCAGGGGGTTGTTTGGCCAAGAGC
AAGACGGTCTATACGTGCAC

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MPRPIQAVIHGPALANNLQIARRHAPNSRVWAVVKANAYGHGIERVYEGLRQTDGFGLLDLDEAVRLRQLGWQGPVLLLE
GFFKPEDLAIVEQYRLTTTVHCEEQLRMLELARLKGPTSVQLKINTGMSRLGFAPAAYRAAWERARAISGVGTIVHMTHF
SDADGPRGIEHQLAAFERATQGLPGEASLSNSAATLWHPKAHRDWVRPGVIMYGASPTGVAADIDGTGLMPAMSLKSELI
AIQDLQPGATIGYGSRFTVEHPMRIGVVACGYADGYPRHAPGWDGNHTPVLVDGVRTHIVGRVSMDMITVDLAGVPEARV
GTPVTLWGEGLPIDDVAQASGTVGYELMCALAPRVPVLVEPVGTAEAGDLGKAA

Sequences:

>Translated_374_residues
MPRPIQAVIHGPALANNLQIARRHAPNSRVWAVVKANAYGHGIERVYEGLRQTDGFGLLDLDEAVRLRQLGWQGPVLLLE
GFFKPEDLAIVEQYRLTTTVHCEEQLRMLELARLKGPTSVQLKINTGMSRLGFAPAAYRAAWERARAISGVGTIVHMTHF
SDADGPRGIEHQLAAFERATQGLPGEASLSNSAATLWHPKAHRDWVRPGVIMYGASPTGVAADIDGTGLMPAMSLKSELI
AIQDLQPGATIGYGSRFTVEHPMRIGVVACGYADGYPRHAPGWDGNHTPVLVDGVRTHIVGRVSMDMITVDLAGVPEARV
GTPVTLWGEGLPIDDVAQASGTVGYELMCALAPRVPVLVEPVGTAEAGDLGKAA
>Mature_373_residues
PRPIQAVIHGPALANNLQIARRHAPNSRVWAVVKANAYGHGIERVYEGLRQTDGFGLLDLDEAVRLRQLGWQGPVLLLEG
FFKPEDLAIVEQYRLTTTVHCEEQLRMLELARLKGPTSVQLKINTGMSRLGFAPAAYRAAWERARAISGVGTIVHMTHFS
DADGPRGIEHQLAAFERATQGLPGEASLSNSAATLWHPKAHRDWVRPGVIMYGASPTGVAADIDGTGLMPAMSLKSELIA
IQDLQPGATIGYGSRFTVEHPMRIGVVACGYADGYPRHAPGWDGNHTPVLVDGVRTHIVGRVSMDMITVDLAGVPEARVG
TPVTLWGEGLPIDDVAQASGTVGYELMCALAPRVPVLVEPVGTAEAGDLGKAA

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=358, Percent_Identity=58.1005586592179, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1790487, Length=351, Percent_Identity=45.8689458689459, Blast_Score=281, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_RALPJ (B2UAX2)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001898820.1
- ProteinModelPortal:   B2UAX2
- SMR:   B2UAX2
- GeneID:   6289337
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_1244
- HOGENOM:   HBG712172
- OMA:   MCAVAGR
- ProtClustDB:   PRK00053
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 40066; Mature: 39935

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 35-35 ACT_SITE 253-253

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPIQAVIHGPALANNLQIARRHAPNSRVWAVVKANAYGHGIERVYEGLRQTDGFGLLD
CCCCCEEEEECCHHHCCHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEE
LDEAVRLRQLGWQGPVLLLEGFFKPEDLAIVEQYRLTTTVHCEEQLRMLELARLKGPTSV
HHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHEEEEEEEEHHHHHHHHHHHHCCCCCEE
QLKINTGMSRLGFAPAAYRAAWERARAISGVGTIVHMTHFSDADGPRGIEHQLAAFERAT
EEEECCCCHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHH
QGLPGEASLSNSAATLWHPKAHRDWVRPGVIMYGASPTGVAADIDGTGLMPAMSLKSELI
CCCCCCCCCCCCCEEEECCCHHHHHCCCCEEEECCCCCCEEEECCCCCCCHHHHHHHHEE
AIQDLQPGATIGYGSRFTVEHPMRIGVVACGYADGYPRHAPGWDGNHTPVLVDGVRTHIV
EEEECCCCCEECCCCEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHEE
GRVSMDMITVDLAGVPEARVGTPVTLWGEGLPIDDVAQASGTVGYELMCALAPRVPVLVE
EEEEEEEEEEEECCCCCCCCCCCEEECCCCCCHHHHHHHCCCCCHHHHEECCCCCCEEEE
PVGTAEAGDLGKAA
CCCCCCCCCCCCCC
>Mature Secondary Structure 
PRPIQAVIHGPALANNLQIARRHAPNSRVWAVVKANAYGHGIERVYEGLRQTDGFGLLD
CCCCEEEEECCHHHCCHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEE
LDEAVRLRQLGWQGPVLLLEGFFKPEDLAIVEQYRLTTTVHCEEQLRMLELARLKGPTSV
HHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHEEEEEEEEHHHHHHHHHHHHCCCCCEE
QLKINTGMSRLGFAPAAYRAAWERARAISGVGTIVHMTHFSDADGPRGIEHQLAAFERAT
EEEECCCCHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHH
QGLPGEASLSNSAATLWHPKAHRDWVRPGVIMYGASPTGVAADIDGTGLMPAMSLKSELI
CCCCCCCCCCCCCEEEECCCHHHHHCCCCEEEECCCCCCEEEECCCCCCCHHHHHHHHEE
AIQDLQPGATIGYGSRFTVEHPMRIGVVACGYADGYPRHAPGWDGNHTPVLVDGVRTHIV
EEEECCCCCEECCCCEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHEE
GRVSMDMITVDLAGVPEARVGTPVTLWGEGLPIDDVAQASGTVGYELMCALAPRVPVLVE
EEEEEEEEEEEECCCCCCCCCCCEEECCCCCCHHHHHHHCCCCCHHHHEECCCCCCEEEE
PVGTAEAGDLGKAA
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA