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The map label for this gene is cyp18 [H]

Identifier: 187928099

GI number: 187928099

Start: 1063146

End: 1063727

Strand: Reverse

Name: cyp18 [H]

Synonym: Rpic_1006

Alternate gene names: 187928099

Gene position: 1063727-1063146 (Counterclockwise)

Preceding gene: 187928100

Following gene: 187928098

Centisome position: 26.98

GC content: 59.28

Gene sequence:

>582_bases
ATGCTCCGTATTCGCTCCCTCTTTGCCGGGCTCGTGTGTGCACTGGCCGTAACCGCCACCGCAGCCACGGCAGCCACCGC
GTCCGCGCCGCGCATCCAGTTCAAGACATCGATGGGTAACTTCACCGTTGAGGTGTATCCGGACAAGGCGCCCAAGACGG
TCGCCAACTTCCTGCAGTACGTGAAGGACGGCTTCTACAAGGGCACGATTTTCCACCGCGTGATGGACGGCTTCATGATC
CAGGGCGGCGGCTTCACGCCCGACATGAAACAGAAGGACACGCGCCCGCCGGTCGAGATCGAATCGAAGAACGGCCTGAA
GAACGACAAGTACACGATCGCCATGGCACGCACCATGGACCCGAACTCCGCCACGGCGCAGTTCTATGTGAACGTGGTCG
ACAACAACATGCTGAACTACCCTGGTCAGGACGGTTACGGCTATACCGTCTTCGGCAAGGTGGTTGACGGCACTGACACC
ATCGACAAGATAAAGGCGGTGGAAACCACCACCAAGTTCCCGCACCAGAACGTGCCCGTGAAGCCGATCGTGATTGAATC
GGCCACCGTCGTCTCCAAGTAA

Upstream 100 bases:

>100_bases
CTGCCTGCAGCCAGCGGTGTGACTGCCAAGCCGGCGAAGCGTCAATAAGAAGACGCGGCCCGATCCTGCTTTCCCACCCA
CAAGCTCTCTCTTCCTGACC

Downstream 100 bases:

>100_bases
CGCATTTTTGCCCCACCCAAGGAATTCACCATGACCCAAGTCAAGCTGCACACCAACCACGGCGACATCACCCTGGCCCT
GGACGCTGAGAAGGCACCCA

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MLRIRSLFAGLVCALAVTATAATAATASAPRIQFKTSMGNFTVEVYPDKAPKTVANFLQYVKDGFYKGTIFHRVMDGFMI
QGGGFTPDMKQKDTRPPVEIESKNGLKNDKYTIAMARTMDPNSATAQFYVNVVDNNMLNYPGQDGYGYTVFGKVVDGTDT
IDKIKAVETTTKFPHQNVPVKPIVIESATVVSK

Sequences:

>Translated_193_residues
MLRIRSLFAGLVCALAVTATAATAATASAPRIQFKTSMGNFTVEVYPDKAPKTVANFLQYVKDGFYKGTIFHRVMDGFMI
QGGGFTPDMKQKDTRPPVEIESKNGLKNDKYTIAMARTMDPNSATAQFYVNVVDNNMLNYPGQDGYGYTVFGKVVDGTDT
IDKIKAVETTTKFPHQNVPVKPIVIESATVVSK
>Mature_193_residues
MLRIRSLFAGLVCALAVTATAATAATASAPRIQFKTSMGNFTVEVYPDKAPKTVANFLQYVKDGFYKGTIFHRVMDGFMI
QGGGFTPDMKQKDTRPPVEIESKNGLKNDKYTIAMARTMDPNSATAQFYVNVVDNNMLNYPGQDGYGYTVFGKVVDGTDT
IDKIKAVETTTKFPHQNVPVKPIVIESATVVSK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=175, Percent_Identity=30.2857142857143, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI19557636, Length=160, Percent_Identity=30.625, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI7706339, Length=164, Percent_Identity=33.5365853658537, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI22547212, Length=161, Percent_Identity=29.8136645962733, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI7657473, Length=161, Percent_Identity=29.8136645962733, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI22547215, Length=161, Percent_Identity=29.8136645962733, Blast_Score=68, Evalue=4e-12,
Organism=Escherichia coli, GI1786736, Length=161, Percent_Identity=55.9006211180124, Blast_Score=194, Evalue=3e-51,
Organism=Escherichia coli, GI1789763, Length=188, Percent_Identity=50.531914893617, Blast_Score=184, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71980594, Length=144, Percent_Identity=31.9444444444444, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71980590, Length=144, Percent_Identity=31.9444444444444, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17539496, Length=145, Percent_Identity=33.1034482758621, Blast_Score=73, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=162, Percent_Identity=32.0987654320988, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=161, Percent_Identity=27.3291925465839, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=194, Percent_Identity=31.4432989690722, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19922376, Length=162, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17986117, Length=161, Percent_Identity=31.055900621118, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17136360, Length=203, Percent_Identity=32.0197044334975, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24652460, Length=161, Percent_Identity=27.3291925465839, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922912, Length=134, Percent_Identity=33.5820895522388, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21106; Mature: 21106

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIRSLFAGLVCALAVTATAATAATASAPRIQFKTSMGNFTVEVYPDKAPKTVANFLQY
CEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHH
VKDGFYKGTIFHRVMDGFMIQGGGFTPDMKQKDTRPPVEIESKNGLKNDKYTIAMARTMD
HHCCCCCHHHHHHHHHCEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEECC
PNSATAQFYVNVVDNNMLNYPGQDGYGYTVFGKVVDGTDTIDKIKAVETTTKFPHQNVPV
CCCCEEEEEEEEECCCEECCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCC
KPIVIESATVVSK
CEEEEECEEECCC
>Mature Secondary Structure
MLRIRSLFAGLVCALAVTATAATAATASAPRIQFKTSMGNFTVEVYPDKAPKTVANFLQY
CEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHH
VKDGFYKGTIFHRVMDGFMIQGGGFTPDMKQKDTRPPVEIESKNGLKNDKYTIAMARTMD
HHCCCCCHHHHHHHHHCEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEECC
PNSATAQFYVNVVDNNMLNYPGQDGYGYTVFGKVVDGTDTIDKIKAVETTTKFPHQNVPV
CCCCEEEEEEEEECCCEECCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCC
KPIVIESATVVSK
CEEEEECEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]