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The map label for this gene is ppiB [H]

Identifier: 187928098

GI number: 187928098

Start: 1062609

End: 1063115

Strand: Reverse

Name: ppiB [H]

Synonym: Rpic_1005

Alternate gene names: 187928098

Gene position: 1063115-1062609 (Counterclockwise)

Preceding gene: 187928099

Following gene: 187928097

Centisome position: 26.97

GC content: 60.95

Gene sequence:

>507_bases
ATGACCCAAGTCAAGCTGCACACCAACCACGGCGACATCACCCTGGCCCTGGACGCTGAGAAGGCACCCAAGTCGGTTGC
CAACTTCGTCGCCTATGTGAAGGATGGCCACTACAACGGCACGGTGTTCCACCGCGTCATCAAGGGCTTCATGATCCAGG
GCGGCGGATTCGAGCCGGGCGAGAAGATGAGCCAGAAGCCCACCAAGGCGCCGATCGACAACGAAGCCAACAACGGACTG
AAGAACGAGCGCGGCACCATTGCCATGGCTCGCACCAACGACCCGCACTCGGCCACGGCGCAGTTCTTCATCAACACGGT
CGACAACGACTTCCTGAACCACACCTCGCCGACGCCGCAAGGCTGGGGCTACGCCGTGTTCGGCAAAGTGACCGAAGGCA
TGGATGTGGTCGACAAAATCCGCTCGGTGCGCACGGGCAACCGCGGCTTCCACCAGGACGTGCCGATGGAAGACGTGATC
ATCGAAAGCGCCGAAGTGATCGAATGA

Upstream 100 bases:

>100_bases
CAAGTTCCCGCACCAGAACGTGCCCGTGAAGCCGATCGTGATTGAATCGGCCACCGTCGTCTCCAAGTAACGCATTTTTG
CCCCACCCAAGGAATTCACC

Downstream 100 bases:

>100_bases
TCGACGCAGCGCACGCCGCACAGGCCTCCGCGCTGAAGACACCGGTCCGGGTTTCCGGGCCGGTGTTTTTTATTTCGGAT
CTGCACCTCACGGCCAGCAT

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MTQVKLHTNHGDITLALDAEKAPKSVANFVAYVKDGHYNGTVFHRVIKGFMIQGGGFEPGEKMSQKPTKAPIDNEANNGL
KNERGTIAMARTNDPHSATAQFFINTVDNDFLNHTSPTPQGWGYAVFGKVTEGMDVVDKIRSVRTGNRGFHQDVPMEDVI
IESAEVIE

Sequences:

>Translated_168_residues
MTQVKLHTNHGDITLALDAEKAPKSVANFVAYVKDGHYNGTVFHRVIKGFMIQGGGFEPGEKMSQKPTKAPIDNEANNGL
KNERGTIAMARTNDPHSATAQFFINTVDNDFLNHTSPTPQGWGYAVFGKVTEGMDVVDKIRSVRTGNRGFHQDVPMEDVI
IESAEVIE
>Mature_167_residues
TQVKLHTNHGDITLALDAEKAPKSVANFVAYVKDGHYNGTVFHRVIKGFMIQGGGFEPGEKMSQKPTKAPIDNEANNGLK
NERGTIAMARTNDPHSATAQFFINTVDNDFLNHTSPTPQGWGYAVFGKVTEGMDVVDKIRSVRTGNRGFHQDVPMEDVII
ESAEVIE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=164, Percent_Identity=32.3170731707317, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI24308049, Length=157, Percent_Identity=35.031847133758, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI22547212, Length=165, Percent_Identity=31.5151515151515, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI7657473, Length=165, Percent_Identity=31.5151515151515, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI22547215, Length=165, Percent_Identity=31.5151515151515, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4758950, Length=162, Percent_Identity=37.6543209876543, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI7706339, Length=162, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI64276486, Length=130, Percent_Identity=34.6153846153846, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI310110104, Length=141, Percent_Identity=35.4609929078014, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI310129267, Length=153, Percent_Identity=32.0261437908497, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310120620, Length=153, Percent_Identity=32.0261437908497, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI5031987, Length=136, Percent_Identity=36.7647058823529, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI10863927, Length=142, Percent_Identity=34.5070422535211, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1786736, Length=165, Percent_Identity=67.8787878787879, Blast_Score=232, Evalue=9e-63,
Organism=Escherichia coli, GI1789763, Length=164, Percent_Identity=59.7560975609756, Blast_Score=184, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=35.6164383561644, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=35.6164383561644, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17532641, Length=171, Percent_Identity=33.9181286549708, Blast_Score=83, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=147, Percent_Identity=34.6938775510204, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17552780, Length=158, Percent_Identity=34.8101265822785, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506307, Length=158, Percent_Identity=34.1772151898734, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17551282, Length=160, Percent_Identity=31.875, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=160, Percent_Identity=31.875, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=144, Percent_Identity=31.25, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=145, Percent_Identity=35.8620689655172, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17565860, Length=149, Percent_Identity=33.5570469798658, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71997782, Length=136, Percent_Identity=34.5588235294118, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=177, Percent_Identity=34.4632768361582, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=161, Percent_Identity=32.2981366459627, Blast_Score=61, Evalue=8e-11,
Organism=Drosophila melanogaster, GI19922376, Length=175, Percent_Identity=30.2857142857143, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19922912, Length=164, Percent_Identity=35.9756097560976, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24652460, Length=164, Percent_Identity=30.4878048780488, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=30.0613496932515, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17136360, Length=163, Percent_Identity=33.7423312883436, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20130249, Length=158, Percent_Identity=33.5443037974684, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357249, Length=175, Percent_Identity=32, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18443; Mature: 18312

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVKLHTNHGDITLALDAEKAPKSVANFVAYVKDGHYNGTVFHRVIKGFMIQGGGFEPG
CCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCCC
EKMSQKPTKAPIDNEANNGLKNERGTIAMARTNDPHSATAQFFINTVDNDFLNHTSPTPQ
HHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHEEEEECCCCHHHCCCCCCCC
GWGYAVFGKVTEGMDVVDKIRSVRTGNRGFHQDVPMEDVIIESAEVIE
CCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCHHHHCC
>Mature Secondary Structure 
TQVKLHTNHGDITLALDAEKAPKSVANFVAYVKDGHYNGTVFHRVIKGFMIQGGGFEPG
CEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCCC
EKMSQKPTKAPIDNEANNGLKNERGTIAMARTNDPHSATAQFFINTVDNDFLNHTSPTPQ
HHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHEEEEECCCCHHHCCCCCCCC
GWGYAVFGKVTEGMDVVDKIRSVRTGNRGFHQDVPMEDVIIESAEVIE
CCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]