Click here to switch to the map view.

The map label for this gene is proY [H]

Identifier: 187927929

GI number: 187927929

Start: 880774

End: 882156

Strand: Direct

Name: proY [H]

Synonym: Rpic_0834

Alternate gene names: 187927929

Gene position: 880774-882156 (Clockwise)

Preceding gene: 187927928

Following gene: 187927930

Centisome position: 22.34

GC content: 64.06

Gene sequence:

>1383_bases
TTGGAACACCTTCAACGCAACCTGCGCGCGCGGCATATCCGCTTTCTCGCGCTCGGTTCGGCCATCGGCACGGGCCTTTT
CTACGGGTCCGCTTCGGCCATCCAGTTGGCCGGGCCGGCCGTGATCCTTGCATACATCATCGGCGGCGCGGCCGTCTACA
TGGTCATGCGCGCGCTCGGCGAGATGGCGGTGCGCCAGCCGGTCTCCGGTTCGTTCGGGCGTTATGCGCGCGACAACCTC
GGTCCGCTCGCCGGCTTTCTCACCGGCTGGACGTACATCCTCGAAATGGTGATCGTCTGCCTGGCCGACGTGACCGCCTT
CGGCATCTACATGGGCTTCTGGTTTCCCGAGGTGCCGCAATGGCTCTGGGTGCTCGGCATCGTCATGCTCATCTGCGGCC
TGAACCTCTGCAACGTCAAGGTGTTCGGCGAGATGGAATTCTGGCTCGCACTGATCAAGATCGTAGCGATTGGCGCCATG
ATCGTCGGCGGCACCGTCATCCTGTTCCTCGGCGTGAAGATGAACGGCGAGCACGCGTCGGGCCTCAGCAATCTCTGGTC
GCATGGCGGTTTCCTGCCGCACGGCGTGGGCGGCCTCGTGGCGTCGTTTGCCGTGGTGATGTTCGCGTATGGCGGCGTCG
AGATCATCGGCATCACCGGCGGTGAGGCGCAGAACCCCGACAAGGTCATCCCGAAGGCCATCAACGCCGTACCGGCGCGC
ATCCTGCTGTTCTACGTGCTGACCATGTGCGTGCTGATGGCGATCTTCCCGTGGACAGGCATCGACGGCCAGGGCAGCCC
GTTCGTGCAGATCTTCTCAGGGCTGGGTATCCAGTCGGCGGCGGCAATCCTCAACCTCATCGTCATTTCGGCAGCCATCT
CGGCCATCAACAGCAACATCTTTGGAGCGGGCCGGATGATGTACGGCATGGCGGAGCAGGGCCAGGCGCCGCGCATCTTT
GCGGCCACGTCGCGTCACGGTGTGCCCTGGGTGACGGTGCTGTTCATGGCCGGTGCGCTGTTGTGCGGCGTGGTGCTGAA
CTACCTGATCCCCGAAAACGTCTTCGTGATCATCGCGTCGATCGCCACGTTCGCCACCGTGTGGGTCTGGCTGATGATCC
TGTTGTCGCAGGTGGCGATGCGCCGTCGCCTGTCGGCCGAAGAAGTGCGTGCGCTCAAGTTCAAGGTGCCGCTGTGGCCC
GTGGGGCCGGCCCTTGCCATCGCGTTCATGCTCTTCGTGATCGGCGTGCTGGGCACCATGGAAGACACCCGGGTGGCGCT
TTACGTCGGCGCAGGCTGGGTGCTGCTCATGTCGGCAGCGTGGTATCTGCGCGTGAAGCCCAACGCAGCAGCCGTTCTGG
CTGAAGAGGCAAGCGGGGTGTGA

Upstream 100 bases:

>100_bases
ATCAACGCGATGTTGTCTGTATGTGAACTCCGGTCCGTTCGACGCCTGCGTCCCGCCCGGAACTGCGCCGACAGCCTTGC
CGACATAAAGAGGAGACAGT

Downstream 100 bases:

>100_bases
GCCCCGCCCGCCCGCAAAGACAAGACAAGTTTCGGAGACACCCCATGTCGAACCAAACCTCTGCGCCGTCGTACGCCGGC
CGCGCCGATGCGCAGGCGAC

Product: amino acid permease-associated protein

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MEHLQRNLRARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYIIGGAAVYMVMRALGEMAVRQPVSGSFGRYARDNL
GPLAGFLTGWTYILEMVIVCLADVTAFGIYMGFWFPEVPQWLWVLGIVMLICGLNLCNVKVFGEMEFWLALIKIVAIGAM
IVGGTVILFLGVKMNGEHASGLSNLWSHGGFLPHGVGGLVASFAVVMFAYGGVEIIGITGGEAQNPDKVIPKAINAVPAR
ILLFYVLTMCVLMAIFPWTGIDGQGSPFVQIFSGLGIQSAAAILNLIVISAAISAINSNIFGAGRMMYGMAEQGQAPRIF
AATSRHGVPWVTVLFMAGALLCGVVLNYLIPENVFVIIASIATFATVWVWLMILLSQVAMRRRLSAEEVRALKFKVPLWP
VGPALAIAFMLFVIGVLGTMEDTRVALYVGAGWVLLMSAAWYLRVKPNAAAVLAEEASGV

Sequences:

>Translated_460_residues
MEHLQRNLRARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYIIGGAAVYMVMRALGEMAVRQPVSGSFGRYARDNL
GPLAGFLTGWTYILEMVIVCLADVTAFGIYMGFWFPEVPQWLWVLGIVMLICGLNLCNVKVFGEMEFWLALIKIVAIGAM
IVGGTVILFLGVKMNGEHASGLSNLWSHGGFLPHGVGGLVASFAVVMFAYGGVEIIGITGGEAQNPDKVIPKAINAVPAR
ILLFYVLTMCVLMAIFPWTGIDGQGSPFVQIFSGLGIQSAAAILNLIVISAAISAINSNIFGAGRMMYGMAEQGQAPRIF
AATSRHGVPWVTVLFMAGALLCGVVLNYLIPENVFVIIASIATFATVWVWLMILLSQVAMRRRLSAEEVRALKFKVPLWP
VGPALAIAFMLFVIGVLGTMEDTRVALYVGAGWVLLMSAAWYLRVKPNAAAVLAEEASGV
>Mature_460_residues
MEHLQRNLRARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYIIGGAAVYMVMRALGEMAVRQPVSGSFGRYARDNL
GPLAGFLTGWTYILEMVIVCLADVTAFGIYMGFWFPEVPQWLWVLGIVMLICGLNLCNVKVFGEMEFWLALIKIVAIGAM
IVGGTVILFLGVKMNGEHASGLSNLWSHGGFLPHGVGGLVASFAVVMFAYGGVEIIGITGGEAQNPDKVIPKAINAVPAR
ILLFYVLTMCVLMAIFPWTGIDGQGSPFVQIFSGLGIQSAAAILNLIVISAAISAINSNIFGAGRMMYGMAEQGQAPRIF
AATSRHGVPWVTVLFMAGALLCGVVLNYLIPENVFVIIASIATFATVWVWLMILLSQVAMRRRLSAEEVRALKFKVPLWP
VGPALAIAFMLFVIGVLGTMEDTRVALYVGAGWVLLMSAAWYLRVKPNAAAVLAEEASGV

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=338, Percent_Identity=28.4023668639053, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI110347453, Length=350, Percent_Identity=27.4285714285714, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI114326544, Length=351, Percent_Identity=23.3618233618234, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI114326550, Length=351, Percent_Identity=23.3618233618234, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1786602, Length=455, Percent_Identity=58.9010989010989, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI1786302, Length=454, Percent_Identity=43.3920704845815, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1786789, Length=445, Percent_Identity=44.0449438202247, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1790653, Length=451, Percent_Identity=39.2461197339246, Blast_Score=347, Evalue=8e-97,
Organism=Escherichia coli, GI48994972, Length=441, Percent_Identity=42.8571428571429, Blast_Score=329, Evalue=3e-91,
Organism=Escherichia coli, GI87081915, Length=401, Percent_Identity=37.9052369077307, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI87081708, Length=453, Percent_Identity=37.3068432671082, Blast_Score=286, Evalue=3e-78,
Organism=Escherichia coli, GI1789017, Length=412, Percent_Identity=37.378640776699, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1788480, Length=446, Percent_Identity=35.6502242152466, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87081869, Length=194, Percent_Identity=25.2577319587629, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082023, Length=287, Percent_Identity=23.6933797909408, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17532491, Length=340, Percent_Identity=24.4117647058824, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540018, Length=454, Percent_Identity=24.4493392070485, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324061, Length=439, Percent_Identity=33.0296127562642, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320772, Length=440, Percent_Identity=31.3636363636364, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324990, Length=420, Percent_Identity=31.1904761904762, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6324924, Length=446, Percent_Identity=32.0627802690583, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6324553, Length=397, Percent_Identity=30.9823677581864, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321629, Length=406, Percent_Identity=26.8472906403941, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6322892, Length=416, Percent_Identity=28.6057692307692, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6324059, Length=451, Percent_Identity=29.490022172949, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6319824, Length=433, Percent_Identity=27.2517321016166, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320717, Length=436, Percent_Identity=27.2935779816514, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=419, Percent_Identity=27.2076372315036, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320251, Length=401, Percent_Identity=25.9351620947631, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319543, Length=398, Percent_Identity=25.8793969849246, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=401, Percent_Identity=25.1870324189526, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=404, Percent_Identity=27.2277227722772, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319608, Length=382, Percent_Identity=30.6282722513089, Blast_Score=129, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6320364, Length=499, Percent_Identity=25.6513026052104, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324981, Length=397, Percent_Identity=25.6926952141058, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24667468, Length=331, Percent_Identity=25.3776435045317, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI161077963, Length=328, Percent_Identity=27.7439024390244, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49208; Mature: 49208

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHLQRNLRARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYIIGGAAVYMVMRALG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHH
EMAVRQPVSGSFGRYARDNLGPLAGFLTGWTYILEMVIVCLADVTAFGIYMGFWFPEVPQ
HHHHCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLWVLGIVMLICGLNLCNVKVFGEMEFWLALIKIVAIGAMIVGGTVILFLGVKMNGEHAS
HHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHEEEHEECEECCCHHH
GLSNLWSHGGFLPHGVGGLVASFAVVMFAYGGVEIIGITGGEAQNPDKVIPKAINAVPAR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
ILLFYVLTMCVLMAIFPWTGIDGQGSPFVQIFSGLGIQSAAAILNLIVISAAISAINSNI
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
FGAGRMMYGMAEQGQAPRIFAATSRHGVPWVTVLFMAGALLCGVVLNYLIPENVFVIIAS
CCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
IATFATVWVWLMILLSQVAMRRRLSAEEVRALKFKVPLWPVGPALAIAFMLFVIGVLGTM
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHCCC
EDTRVALYVGAGWVLLMSAAWYLRVKPNAAAVLAEEASGV
CCCEEEEEECCHHHHHHHHHHEEEECCCHHHEEECCCCCC
>Mature Secondary Structure
MEHLQRNLRARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYIIGGAAVYMVMRALG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHH
EMAVRQPVSGSFGRYARDNLGPLAGFLTGWTYILEMVIVCLADVTAFGIYMGFWFPEVPQ
HHHHCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLWVLGIVMLICGLNLCNVKVFGEMEFWLALIKIVAIGAMIVGGTVILFLGVKMNGEHAS
HHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHEEEHEECEECCCHHH
GLSNLWSHGGFLPHGVGGLVASFAVVMFAYGGVEIIGITGGEAQNPDKVIPKAINAVPAR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
ILLFYVLTMCVLMAIFPWTGIDGQGSPFVQIFSGLGIQSAAAILNLIVISAAISAINSNI
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
FGAGRMMYGMAEQGQAPRIFAATSRHGVPWVTVLFMAGALLCGVVLNYLIPENVFVIIAS
CCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
IATFATVWVWLMILLSQVAMRRRLSAEEVRALKFKVPLWPVGPALAIAFMLFVIGVLGTM
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHCCC
EDTRVALYVGAGWVLLMSAAWYLRVKPNAAAVLAEEASGV
CCCEEEEEECCHHHHHHHHHHEEEECCCHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]