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The map label for this gene is mmgC [H]

Identifier: 187927802

GI number: 187927802

Start: 742083

End: 743276

Strand: Reverse

Name: mmgC [H]

Synonym: Rpic_0706

Alternate gene names: 187927802

Gene position: 743276-742083 (Counterclockwise)

Preceding gene: 187927804

Following gene: 187927801

Centisome position: 18.85

GC content: 62.73

Gene sequence:

>1194_bases
GTGACCGCTCGCAACGCCTTCAATTGGGCCGACCCCCTGCTGCTCGACCAACAACTGACCGACGACGAACGCATGGTGCG
CGACGCCGCCGCGTCGTACTGCCAGGACAAGCTGATGCCGCGCGTACTGGAGTCGTTCCGGCATGAGAAGACCGACGCAT
CGATCTTTCGTGAGATGGGCGAGCTGGGCCTGCTGGGCCCGACGATTCCCGAGCAGTACGGCGGCCCGGGCCTGAACTAC
GTCAGCTACGGCCTGATCGCACGTGAAGTCGAACGGGTGGATTCAGGCTACCGCTCGATGATGAGCGTGCAGTCGTCGCT
CGTAATGGTGCCGATCTACGAATTCGGCAGCGAGGCGCAAAAGCAGAAATACCTGCCGAAGCTGGCGACCGGCGAGTGGA
TCGGCTGCTTTGGCCTGACTGAGCCGAACCACGGTTCCGACCCGGCCTCGATGATCACGCGCGCCAGGAAGGTCGACGGC
GGCTACTCGCTGTCGGGCGCCAAGATGTGGATCACCAACTCGCCCATCGCCGATGTGTTTGTCGTGTGGGCCAAGCTGCC
GAACGACAACGGCGAGGACGAAATCCGCGGCTTCATCCTGGAGAAAGGATGGAAGGGTCTGACGGCGCCTGCCATCCACG
GCAAGGTTGGCCTGCGTACGTCGATCACCGGTGAAATCGTGCTGGACGAAGTGTTCGTGCCGGAAGAGAACTTGATGCCG
GGCGTGCGCGGCCTGAAGGGTCCGTTCACGTGCCTGAACTCGGCACGCTACGGCATCGCGTGGGGCGCACTGGGCGCAGC
AGAAGCCTGCTGGCACATCGCACGCCAGTACGTACTGGATCGCAAGCAGTTCGGCCGCCCACTCGCCGCCAACCAACTCG
TGCAGAAAAAACTGGCCGACATGCAGACCGAAATCACGCTTGGCCTGCAAGGTTGCCTGCGCCTGGGCCGCATGAAGGAC
GAAGGCACGGCCGCGGTCGAAATCACCTCGATCATGAAGCGCAACTCATGCGGCAAGTCGCTCGACATCGCCCGTGTGGC
ACGCGACATGCTGGGCGGCAACGGCATCTCGGATGAGTTTGGCGTGATCCGCCACGTGGTGAACCTGGAAGTGGTGAACA
CATACGAAGGCACGCACGATATCCACGCGCTGATCCTCGGCCGCGCACAGACCGGCATTCAGGCTTTCTTCTGA

Upstream 100 bases:

>100_bases
AAAAAAGCCCTGGAAATCGTCGGCGGTTGCGCTATGATAGCCCTAAATTTCGAAACTGTGTTCCGTATATCGGAACAACA
ACGACTCGGAGACGACCGCC

Downstream 100 bases:

>100_bases
TTGCGCTTTGCTTTTTCGGCGAGTTGCAGCACACTCGTGCACAACTCGCCACACGCCTTGCCGCATCTCTCGCCCGTCCT
GGGCACCGTTGTTCTCCTTC

Product: acyl-CoA dehydrogenase domain-containing protein

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MTARNAFNWADPLLLDQQLTDDERMVRDAAASYCQDKLMPRVLESFRHEKTDASIFREMGELGLLGPTIPEQYGGPGLNY
VSYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGSEAQKQKYLPKLATGEWIGCFGLTEPNHGSDPASMITRARKVDG
GYSLSGAKMWITNSPIADVFVVWAKLPNDNGEDEIRGFILEKGWKGLTAPAIHGKVGLRTSITGEIVLDEVFVPEENLMP
GVRGLKGPFTCLNSARYGIAWGALGAAEACWHIARQYVLDRKQFGRPLAANQLVQKKLADMQTEITLGLQGCLRLGRMKD
EGTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEFGVIRHVVNLEVVNTYEGTHDIHALILGRAQTGIQAFF

Sequences:

>Translated_397_residues
MTARNAFNWADPLLLDQQLTDDERMVRDAAASYCQDKLMPRVLESFRHEKTDASIFREMGELGLLGPTIPEQYGGPGLNY
VSYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGSEAQKQKYLPKLATGEWIGCFGLTEPNHGSDPASMITRARKVDG
GYSLSGAKMWITNSPIADVFVVWAKLPNDNGEDEIRGFILEKGWKGLTAPAIHGKVGLRTSITGEIVLDEVFVPEENLMP
GVRGLKGPFTCLNSARYGIAWGALGAAEACWHIARQYVLDRKQFGRPLAANQLVQKKLADMQTEITLGLQGCLRLGRMKD
EGTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEFGVIRHVVNLEVVNTYEGTHDIHALILGRAQTGIQAFF
>Mature_396_residues
TARNAFNWADPLLLDQQLTDDERMVRDAAASYCQDKLMPRVLESFRHEKTDASIFREMGELGLLGPTIPEQYGGPGLNYV
SYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGSEAQKQKYLPKLATGEWIGCFGLTEPNHGSDPASMITRARKVDGG
YSLSGAKMWITNSPIADVFVVWAKLPNDNGEDEIRGFILEKGWKGLTAPAIHGKVGLRTSITGEIVLDEVFVPEENLMPG
VRGLKGPFTCLNSARYGIAWGALGAAEACWHIARQYVLDRKQFGRPLAANQLVQKKLADMQTEITLGLQGCLRLGRMKDE
GTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEFGVIRHVVNLEVVNTYEGTHDIHALILGRAQTGIQAFF

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=397, Percent_Identity=65.9949622166247, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI7669494, Length=377, Percent_Identity=64.4562334217507, Blast_Score=500, Evalue=1e-141,
Organism=Homo sapiens, GI226958412, Length=379, Percent_Identity=32.7176781002639, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI4557233, Length=372, Percent_Identity=31.1827956989247, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI226958414, Length=347, Percent_Identity=33.1412103746398, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=29.1553133514986, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI4557235, Length=347, Percent_Identity=32.5648414985591, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI76496475, Length=347, Percent_Identity=32.5648414985591, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=29.8666666666667, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=29.8666666666667, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI21361497, Length=348, Percent_Identity=31.8965517241379, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI7656849, Length=380, Percent_Identity=28.1578947368421, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI4501857, Length=379, Percent_Identity=27.7044854881267, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1786223, Length=337, Percent_Identity=24.3323442136499, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87081958, Length=341, Percent_Identity=26.6862170087977, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17534353, Length=391, Percent_Identity=63.9386189258312, Blast_Score=515, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17538396, Length=374, Percent_Identity=32.3529411764706, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17508101, Length=367, Percent_Identity=31.6076294277929, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=29.8630136986301, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17569725, Length=375, Percent_Identity=30.9333333333333, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI71990804, Length=274, Percent_Identity=35.4014598540146, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71985184, Length=370, Percent_Identity=31.0810810810811, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17534899, Length=376, Percent_Identity=29.7872340425532, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=280, Percent_Identity=33.5714285714286, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=28.7598944591029, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=30.4029304029304, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=32.4675324675325, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17533517, Length=373, Percent_Identity=24.9329758713137, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17551932, Length=380, Percent_Identity=23.9473684210526, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17505929, Length=396, Percent_Identity=23.989898989899, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19920834, Length=394, Percent_Identity=62.9441624365482, Blast_Score=493, Evalue=1e-140,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=30.9973045822102, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=32.0547945205479, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=30.6451612903226, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=30.4232804232804, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=30.952380952381, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI281363737, Length=356, Percent_Identity=30.8988764044944, Blast_Score=154, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43661; Mature: 43529

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARNAFNWADPLLLDQQLTDDERMVRDAAASYCQDKLMPRVLESFRHEKTDASIFREMG
CCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ELGLLGPTIPEQYGGPGLNYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGSEAQ
HCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHCCHHH
KQKYLPKLATGEWIGCFGLTEPNHGSDPASMITRARKVDGGYSLSGAKMWITNSPIADVF
HHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEECCCEEEEECCCHHHHH
VVWAKLPNDNGEDEIRGFILEKGWKGLTAPAIHGKVGLRTSITGEIVLDEVFVPEENLMP
HHEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCEEEEEEECCCHHCCC
GVRGLKGPFTCLNSARYGIAWGALGAAEACWHIARQYVLDRKQFGRPLAANQLVQKKLAD
CCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
MQTEITLGLQGCLRLGRMKDEGTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEF
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHH
GVIRHVVNLEVVNTYEGTHDIHALILGRAQTGIQAFF
HHHHHHHHHEEEECCCCCHHHHHHEEHHHHCCHHHCC
>Mature Secondary Structure 
TARNAFNWADPLLLDQQLTDDERMVRDAAASYCQDKLMPRVLESFRHEKTDASIFREMG
CCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ELGLLGPTIPEQYGGPGLNYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGSEAQ
HCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHCCHHH
KQKYLPKLATGEWIGCFGLTEPNHGSDPASMITRARKVDGGYSLSGAKMWITNSPIADVF
HHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEECCCEEEEECCCHHHHH
VVWAKLPNDNGEDEIRGFILEKGWKGLTAPAIHGKVGLRTSITGEIVLDEVFVPEENLMP
HHEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCEEEEEEECCCHHCCC
GVRGLKGPFTCLNSARYGIAWGALGAAEACWHIARQYVLDRKQFGRPLAANQLVQKKLAD
CCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
MQTEITLGLQGCLRLGRMKDEGTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEF
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHH
GVIRHVVNLEVVNTYEGTHDIHALILGRAQTGIQAFF
HHHHHHHHHEEEECCCCCHHHHHHEEHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]