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The map label for this gene is aceA [C]

Identifier: 187927642

GI number: 187927642

Start: 580184

End: 581770

Strand: Direct

Name: aceA [C]

Synonym: Rpic_0542

Alternate gene names: 187927642

Gene position: 580184-581770 (Clockwise)

Preceding gene: 187927640

Following gene: 187927643

Centisome position: 14.72

GC content: 61.56

Gene sequence:

>1587_bases
ATGGCCCAGTATCAAGACGACATCAAGGCAGTTGCCGGTTTGAAAGAGACCCACGGCAGCGCATGGAATGCGATCAACCC
CGAGTACGCTGCCCGCATGCGTGCCCAGAACAAGTTCAAGACGGGTCTGGACATCGCCAAGTACACCGCCAAGATCATGC
GCGCGGACATGGCTGCCTACGACGCCGATCCGTCCAAGTACACGCAGTCGCTCGGTTGCTGGCACGGCTTCATCGGCCAG
CAGAAGATGATCTCCATCAAGAAGCACTTCAACAGCACCGAGCGCCGCTACCTGTATCTGTCGGGCTGGATGGTCGCTGC
GCTGCGCTCCGAGTTCGGCCCGCTGCCGGACCAGTCGATGCACGAGAAGACTTCGGTCAGCGCGCTGATTCGCGAGCTGT
ACACCTTCCTGCGCCAGGCCGATGCACGTGAACTGGGCGGTCTGTTCCGCGAGCTGGATGCTGCCAAGGACGCTAACGCT
AAGGCCGCCATCCAGGCAAAGATCGACAACCACGTCACGCACGTCGTGCCCATCATTGCCGACATCGACGCTGGTTTCGG
CAACGCAGAAGCCACGTACCTGCTGGCCAAGCAGTTCATCGAAGCGGGTGCCTGCTGTATCCAGATCGAAAATCAGGTGT
CGGACGAGAAGCAGTGCGGCCACCAGGATGGCAAGGTCACCGTGCCGCATGAGGACTTCCTCGCCAAGATCCGCGCGATC
CGCTACGCGTTCCTGGAGCTGGGTGTGGACGACGGCATCATCGTGGCCCGTACCGACTCGCTGGGCGCAGGCCTCACCAA
GCAGATCGCCGTGACCAACACGCCGGGCGACCTGGGCGACCAGTACAACGCGTTCCTCGACTGCGAAGAACTGTCGGCCG
ACCAACTGGGCAACGGTGACGTCGTCATCAAGCGCGACGGCAAGCTGCTGCGCCCGAAGCGCCTGCCGAGCAACCTGTTC
CAGTTCCGCGCCGGCACGGGCGAAGCGCGCTGCGTGCTCGATTGCATCACCTCGCTGCAAAACGGTGCCGACCTGCTGTG
GATCGAAACCGAAAAGCCGCACATCGCGCAGATCGGCGGCATGGTCAAGGAAATCCGCAAGGTCATCCCGAACGCCAAGT
TGGTGTACAACAACAGCCCGTCGTTCAACTGGACGCTGAACTTCCGCCAGCAGGTGTATGACGCGATGAAGGAAGCCGGC
AAGGATGTGTCGGCCTACGAGCGCGGCCAACTGATGAGCACGGAGTACGACGACAGCGAACTGGCAAAGCTCGCCGACGA
GAAGATCCGCACGTTCCAGGCCGATGCATCGCGTGAAGCCGGCATCTTCCACCACCTGATCACGCTGCCGACGTACCACA
CTGCCGCGCTGTCGACCGACAACCTGGCCAAGGAATACTTCGGCGACCAGGGCATGCTCGGTTATGTGGCCGGCGTGCAG
CGCAAGGAAATCCGCCAAGGCATCGCCTGCGTCAAGCACCAGAACATGTCGGGCTCGGACATCGGTGACGACCACAAGGA
ATACTTCAGCGGCGAAGCGGCACTGAAGGCTGCGGGTAAGGACAACACCATGAACCAGTTCCACTGA

Upstream 100 bases:

>100_bases
CAAAGCCGGCCTACAATAAATCCATGCTGCTCGCTTCGAATTCCGTAGCTGCACACGCAACCGATTCTTCTCAAACGCGC
TTTATTTCCAGGAAATTGAC

Downstream 100 bases:

>100_bases
TTCACGGATACAGGTCTCGCCCGAAGCAGAACGCCAACCCATTGCGGGTTGGCGTTTTTTTTGGGGGTGGGCAATTCCGA
CGCAATGCATTGCTTGAACC

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MAQYQDDIKAVAGLKETHGSAWNAINPEYAARMRAQNKFKTGLDIAKYTAKIMRADMAAYDADPSKYTQSLGCWHGFIGQ
QKMISIKKHFNSTERRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVSALIRELYTFLRQADARELGGLFRELDAAKDANA
KAAIQAKIDNHVTHVVPIIADIDAGFGNAEATYLLAKQFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIRAI
RYAFLELGVDDGIIVARTDSLGAGLTKQIAVTNTPGDLGDQYNAFLDCEELSADQLGNGDVVIKRDGKLLRPKRLPSNLF
QFRAGTGEARCVLDCITSLQNGADLLWIETEKPHIAQIGGMVKEIRKVIPNAKLVYNNSPSFNWTLNFRQQVYDAMKEAG
KDVSAYERGQLMSTEYDDSELAKLADEKIRTFQADASREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVAGVQ
RKEIRQGIACVKHQNMSGSDIGDDHKEYFSGEAALKAAGKDNTMNQFH

Sequences:

>Translated_528_residues
MAQYQDDIKAVAGLKETHGSAWNAINPEYAARMRAQNKFKTGLDIAKYTAKIMRADMAAYDADPSKYTQSLGCWHGFIGQ
QKMISIKKHFNSTERRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVSALIRELYTFLRQADARELGGLFRELDAAKDANA
KAAIQAKIDNHVTHVVPIIADIDAGFGNAEATYLLAKQFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIRAI
RYAFLELGVDDGIIVARTDSLGAGLTKQIAVTNTPGDLGDQYNAFLDCEELSADQLGNGDVVIKRDGKLLRPKRLPSNLF
QFRAGTGEARCVLDCITSLQNGADLLWIETEKPHIAQIGGMVKEIRKVIPNAKLVYNNSPSFNWTLNFRQQVYDAMKEAG
KDVSAYERGQLMSTEYDDSELAKLADEKIRTFQADASREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVAGVQ
RKEIRQGIACVKHQNMSGSDIGDDHKEYFSGEAALKAAGKDNTMNQFH
>Mature_527_residues
AQYQDDIKAVAGLKETHGSAWNAINPEYAARMRAQNKFKTGLDIAKYTAKIMRADMAAYDADPSKYTQSLGCWHGFIGQQ
KMISIKKHFNSTERRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVSALIRELYTFLRQADARELGGLFRELDAAKDANAK
AAIQAKIDNHVTHVVPIIADIDAGFGNAEATYLLAKQFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIRAIR
YAFLELGVDDGIIVARTDSLGAGLTKQIAVTNTPGDLGDQYNAFLDCEELSADQLGNGDVVIKRDGKLLRPKRLPSNLFQ
FRAGTGEARCVLDCITSLQNGADLLWIETEKPHIAQIGGMVKEIRKVIPNAKLVYNNSPSFNWTLNFRQQVYDAMKEAGK
DVSAYERGQLMSTEYDDSELAKLADEKIRTFQADASREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVAGVQR
KEIRQGIACVKHQNMSGSDIGDDHKEYFSGEAALKAAGKDNTMNQFH

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=410, Percent_Identity=27.8048780487805, Blast_Score=129, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71982926, Length=410, Percent_Identity=28.2926829268293, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17561814, Length=410, Percent_Identity=28.2926829268293, Blast_Score=124, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6320908, Length=172, Percent_Identity=31.9767441860465, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325263, Length=107, Percent_Identity=36.4485981308411, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 58466; Mature: 58335

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQYQDDIKAVAGLKETHGSAWNAINPEYAARMRAQNKFKTGLDIAKYTAKIMRADMAAY
CCCHHHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
DADPSKYTQSLGCWHGFIGQQKMISIKKHFNSTERRYLYLSGWMVAALRSEFGPLPDQSM
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCCCCHH
HEKTSVSALIRELYTFLRQADARELGGLFRELDAAKDANAKAAIQAKIDNHVTHVVPIIA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCHHHHHHHHH
DIDAGFGNAEATYLLAKQFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIRAI
CCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCEEECCHHHHHHHHHHH
RYAFLELGVDDGIIVARTDSLGAGLTKQIAVTNTPGDLGDQYNAFLDCEELSADQLGNGD
HHHHHHHCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCHHHEECHHHHCCCCCCCCC
VVIKRDGKLLRPKRLPSNLFQFRAGTGEARCVLDCITSLQNGADLLWIETEKPHIAQIGG
EEEECCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
MVKEIRKVIPNAKLVYNNSPSFNWTLNFRQQVYDAMKEAGKDVSAYERGQLMSTEYDDSE
HHHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCHHH
LAKLADEKIRTFQADASREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVAGVQ
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHCCCCCCCHHHHCCC
RKEIRQGIACVKHQNMSGSDIGDDHKEYFSGEAALKAAGKDNTMNQFH
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHEECCCCCCCCCCC
>Mature Secondary Structure 
AQYQDDIKAVAGLKETHGSAWNAINPEYAARMRAQNKFKTGLDIAKYTAKIMRADMAAY
CCHHHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
DADPSKYTQSLGCWHGFIGQQKMISIKKHFNSTERRYLYLSGWMVAALRSEFGPLPDQSM
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCCCCHH
HEKTSVSALIRELYTFLRQADARELGGLFRELDAAKDANAKAAIQAKIDNHVTHVVPIIA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCHHHHHHHHH
DIDAGFGNAEATYLLAKQFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIRAI
CCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCEEECCHHHHHHHHHHH
RYAFLELGVDDGIIVARTDSLGAGLTKQIAVTNTPGDLGDQYNAFLDCEELSADQLGNGD
HHHHHHHCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCHHHEECHHHHCCCCCCCCC
VVIKRDGKLLRPKRLPSNLFQFRAGTGEARCVLDCITSLQNGADLLWIETEKPHIAQIGG
EEEECCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
MVKEIRKVIPNAKLVYNNSPSFNWTLNFRQQVYDAMKEAGKDVSAYERGQLMSTEYDDSE
HHHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCHHH
LAKLADEKIRTFQADASREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVAGVQ
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHCCCCCCCHHHHCCC
RKEIRQGIACVKHQNMSGSDIGDDHKEYFSGEAALKAAGKDNTMNQFH
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]