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The map label for this gene is ung [H]

Identifier: 187917932

GI number: 187917932

Start: 49033

End: 49704

Strand: Direct

Name: ung [H]

Synonym: BH0053

Alternate gene names: 187917932

Gene position: 49033-49704 (Clockwise)

Preceding gene: 187917930

Following gene: 187917941

Centisome position: 5.32

GC content: 29.76

Gene sequence:

>672_bases
GTGGAAGTAAAAATCGAAGAATCTTGGAAAGAAATATTAAAAGCTGAATTTTGCAAAGGATATTTCAAAAGACTTGTAAA
TTTCATAAAAAATGAATATAAAACTAAAAAGGGTAAAATATTTCCACCTCCAAAGTTAATATTCAATGCATTTGATTCTT
TGCCATTTAAAGACATAAAAGTAGTAATACTCGGGCAAGATCCGTATCATGGTAAAAGACAGGCTAATGGTTTAGCCTTT
TCTGTTAATTCAGATATCAAAATACCTCCATCACTACAAAATATTTTTAAAGAAATAGAGAGAAGTTTAAAAATTCAAAC
TATTCCAAACGGAGACCTAACACGATGGGCAACGCAAGGCGTATTTTTACTAAATTCAATATTAACAGTAGAAGAAAGCC
GTCCATCATCTCACAAAGACATTGGTTGGGAAATTTTTACAAACGAAGTAATAAAAATTATTTCAAAAAACCTAAATAAT
ATTGTGTTTATGTTATGGGGTAATTTTGCAAGAGGAAAAAAAGAATTGATAGATGCATCAAGACATTTAATTCTTGAAAC
AAGTCATCCATCCCCTTATTCCGCACATAATGGCTTTTTAGGATCAAATCACTTTAGTCAAGCTTTAAGATATCTAAAAG
AACACAATAAAAGTCCAATAGACTTTCAATAA

Upstream 100 bases:

>100_bases
TTAAATGTATCATCGCTCACAAAATATAATTTTAGATAAAAAACCAATAAAATCCAATTAAAATGTTAAAAAATAAATTA
TTTTTTATATAATATTAAAA

Downstream 100 bases:

>100_bases
CACCGACTTGCCTAATAACGCATCAAGCAAGTCATTTAATTATTTTTCTTTATCTGAAGTATCCTCATCAAGAGTATCTT
TATCTTGCTTTATGTCATCG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MEVKIEESWKEILKAEFCKGYFKRLVNFIKNEYKTKKGKIFPPPKLIFNAFDSLPFKDIKVVILGQDPYHGKRQANGLAF
SVNSDIKIPPSLQNIFKEIERSLKIQTIPNGDLTRWATQGVFLLNSILTVEESRPSSHKDIGWEIFTNEVIKIISKNLNN
IVFMLWGNFARGKKELIDASRHLILETSHPSPYSAHNGFLGSNHFSQALRYLKEHNKSPIDFQ

Sequences:

>Translated_223_residues
MEVKIEESWKEILKAEFCKGYFKRLVNFIKNEYKTKKGKIFPPPKLIFNAFDSLPFKDIKVVILGQDPYHGKRQANGLAF
SVNSDIKIPPSLQNIFKEIERSLKIQTIPNGDLTRWATQGVFLLNSILTVEESRPSSHKDIGWEIFTNEVIKIISKNLNN
IVFMLWGNFARGKKELIDASRHLILETSHPSPYSAHNGFLGSNHFSQALRYLKEHNKSPIDFQ
>Mature_223_residues
MEVKIEESWKEILKAEFCKGYFKRLVNFIKNEYKTKKGKIFPPPKLIFNAFDSLPFKDIKVVILGQDPYHGKRQANGLAF
SVNSDIKIPPSLQNIFKEIERSLKIQTIPNGDLTRWATQGVFLLNSILTVEESRPSSHKDIGWEIFTNEVIKIISKNLNN
IVFMLWGNFARGKKELIDASRHLILETSHPSPYSAHNGFLGSNHFSQALRYLKEHNKSPIDFQ

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI6224979, Length=224, Percent_Identity=45.9821428571429, Blast_Score=211, Evalue=4e-55,
Organism=Homo sapiens, GI19718751, Length=224, Percent_Identity=45.9821428571429, Blast_Score=211, Evalue=4e-55,
Organism=Escherichia coli, GI1788934, Length=218, Percent_Identity=46.7889908256881, Blast_Score=207, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17556304, Length=218, Percent_Identity=46.3302752293578, Blast_Score=200, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6323620, Length=217, Percent_Identity=41.0138248847926, Blast_Score=159, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25688; Mature: 25688

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVKIEESWKEILKAEFCKGYFKRLVNFIKNEYKTKKGKIFPPPKLIFNAFDSLPFKDIK
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEE
VVILGQDPYHGKRQANGLAFSVNSDIKIPPSLQNIFKEIERSLKIQTIPNGDLTRWATQG
EEEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHEEEEECCCCCHHHHHHHH
VFLLNSILTVEESRPSSHKDIGWEIFTNEVIKIISKNLNNIVFMLWGNFARGKKELIDAS
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
RHLILETSHPSPYSAHNGFLGSNHFSQALRYLKEHNKSPIDFQ
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEVKIEESWKEILKAEFCKGYFKRLVNFIKNEYKTKKGKIFPPPKLIFNAFDSLPFKDIK
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEE
VVILGQDPYHGKRQANGLAFSVNSDIKIPPSLQNIFKEIERSLKIQTIPNGDLTRWATQG
EEEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHEEEEECCCCCHHHHHHHH
VFLLNSILTVEESRPSSHKDIGWEIFTNEVIKIISKNLNNIVFMLWGNFARGKKELIDAS
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
RHLILETSHPSPYSAHNGFLGSNHFSQALRYLKEHNKSPIDFQ
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA