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The map label for this gene is serS

Identifier: 187736593

GI number: 187736593

Start: 2577029

End: 2578309

Strand: Reverse

Name: serS

Synonym: Amuc_2115

Alternate gene names: 187736593

Gene position: 2578309-2577029 (Counterclockwise)

Preceding gene: 187736595

Following gene: 187736592

Centisome position: 96.78

GC content: 58.24

Gene sequence:

>1281_bases
ATGCTCGACATCCGTGTAATACGAGAAAATCCGGAAGAAGTGAAAGCGCGGCTAAAGCCCCGCAGCGGCGACGCGTGGAA
GCTTGTTGATGACGTTCTGGCCTGCGATGAAGCGCGCCGCAATGCCGAGACGGAAAAGCAGGCCCTGCAGTCCGAGCGCA
ATGCCACCTCCAAGCAGATCGGCATGCTCAAGAAGAAAGGGGAAGACACTTCCTCCATTGAAGCGCGCGTGCGCGAAATC
GGGGACCGCATCCGGGAACTGGACCGTGTCGCGGAGGAAAATGCAGCCCAGCTCACCTCCCTGCTGATGAACATTCCCAA
CCTGCCGCACCTGGAATGCCCCGTGGGTGCGGATGAAACGGCCAACCCGGAAATCAAGCTTTGGGGAGAAAAGCCCGCTA
TTGAAAACCCGAAGGACCATGTGGAACTGGCCGCGAATCTGGGCATGATTTCCTTTGAAGACGGAGCACGGATTACGGGC
TCCGGTTTTGTGGTGTACCGTGGGGCGGGCGCCCGTCTGGAACGTGCCCTGATCAACTTCCTGCTGAATACGCAGACCGT
GGAAAACGGTTATCAGGAAGTGGGCGTTCCTTTTGTGGTGAAAAGGGAGTGCATGGAAGGCACCGGCCAGCTTCCTAAAT
TTGAGGAAGACATGTACGGCACGGAAGACCAGCAGATGTTCCTGATTCCTACGGCGGAAGTGCCGGTCACCAACCTGTAC
CGGGATACCATTTTACAGGAAAGCGACCTGCCCATCAAGATGGCCGCGTACACGCCCTGCTTCCGCCGGGAAGCCGGAAG
CGCCGGCCGCATCAACCGCGGTATGATCCGCGTCCACCAGTTTGACAAGGTGGAACTGGTGCAGATTTTAAAGCCGGAAG
ACTCCTTCCGGGAGCTGGAAGTGCTCCGCAGCCATGCGGAATCCATCCTTCAAAAACTGGGGCTGCATTACCGGGTGATT
GAGCTCTGCACGGGAGACCTCGGTTTTTCCTCCGCCAAGACGTATGATATTGAAGTATGGGCTCCGGGACAGGGGCAGTA
TCTGGAAGTTTCTTCCTGTTCCTGCTTTACGGACTACCAGGCGCGCCGCATGCGCCTGCGTTACAAGGATGCCGACGGCA
AGAACCAGTTCTGCCACACCCTGAACGGTTCCGGCACGGCTCTGCCGCGGCTGTATGTGGCCCTTCTGGAAACTTACCAG
CAGCCGGACGGCTCCATCCGGATTCCGGAGGCGCTTGTGCCGTATTTCGGCGCGGACTGCATCCGTCCTGAACAGGCTTG
A

Upstream 100 bases:

>100_bases
TCTGCGCGCAGCGTTTTTCCGTGAAAGGGTAACGTTTTTCCATGGAAGGCCGTTCATTTGGCTTGCGTGGCGGGGGGATG
GAGTGCAAGCTGTGCGCGTT

Downstream 100 bases:

>100_bases
ACCTGCGTTTTTCCCGTCCCAACCCTGAATCAGCCCATGCCTGACGAGGGCCCTCTGGAACATTACCTGACTGTTTCCCA
TGAGCCGGAACCGGACATTC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDIRVIRENPEEVKARLKPRSGDAWKLVDDVLACDEARRNAETEKQALQSERNATSKQIGMLKKKGEDTSSIEARVREI
GDRIRELDRVAEENAAQLTSLLMNIPNLPHLECPVGADETANPEIKLWGEKPAIENPKDHVELAANLGMISFEDGARITG
SGFVVYRGAGARLERALINFLLNTQTVENGYQEVGVPFVVKRECMEGTGQLPKFEEDMYGTEDQQMFLIPTAEVPVTNLY
RDTILQESDLPIKMAAYTPCFRREAGSAGRINRGMIRVHQFDKVELVQILKPEDSFRELEVLRSHAESILQKLGLHYRVI
ELCTGDLGFSSAKTYDIEVWAPGQGQYLEVSSCSCFTDYQARRMRLRYKDADGKNQFCHTLNGSGTALPRLYVALLETYQ
QPDGSIRIPEALVPYFGADCIRPEQA

Sequences:

>Translated_426_residues
MLDIRVIRENPEEVKARLKPRSGDAWKLVDDVLACDEARRNAETEKQALQSERNATSKQIGMLKKKGEDTSSIEARVREI
GDRIRELDRVAEENAAQLTSLLMNIPNLPHLECPVGADETANPEIKLWGEKPAIENPKDHVELAANLGMISFEDGARITG
SGFVVYRGAGARLERALINFLLNTQTVENGYQEVGVPFVVKRECMEGTGQLPKFEEDMYGTEDQQMFLIPTAEVPVTNLY
RDTILQESDLPIKMAAYTPCFRREAGSAGRINRGMIRVHQFDKVELVQILKPEDSFRELEVLRSHAESILQKLGLHYRVI
ELCTGDLGFSSAKTYDIEVWAPGQGQYLEVSSCSCFTDYQARRMRLRYKDADGKNQFCHTLNGSGTALPRLYVALLETYQ
QPDGSIRIPEALVPYFGADCIRPEQA
>Mature_426_residues
MLDIRVIRENPEEVKARLKPRSGDAWKLVDDVLACDEARRNAETEKQALQSERNATSKQIGMLKKKGEDTSSIEARVREI
GDRIRELDRVAEENAAQLTSLLMNIPNLPHLECPVGADETANPEIKLWGEKPAIENPKDHVELAANLGMISFEDGARITG
SGFVVYRGAGARLERALINFLLNTQTVENGYQEVGVPFVVKRECMEGTGQLPKFEEDMYGTEDQQMFLIPTAEVPVTNLY
RDTILQESDLPIKMAAYTPCFRREAGSAGRINRGMIRVHQFDKVELVQILKPEDSFRELEVLRSHAESILQKLGLHYRVI
ELCTGDLGFSSAKTYDIEVWAPGQGQYLEVSSCSCFTDYQARRMRLRYKDADGKNQFCHTLNGSGTALPRLYVALLETYQ
QPDGSIRIPEALVPYFGADCIRPEQA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI8923421, Length=436, Percent_Identity=32.3394495412844, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI16306548, Length=434, Percent_Identity=32.9493087557604, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI225579074, Length=326, Percent_Identity=36.1963190184049, Blast_Score=209, Evalue=5e-54,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=47.5638051044084, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17539260, Length=459, Percent_Identity=31.8082788671024, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=331, Percent_Identity=31.7220543806647, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320226, Length=440, Percent_Identity=31.1363636363636, Blast_Score=206, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6321799, Length=374, Percent_Identity=30.7486631016043, Blast_Score=196, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24581334, Length=466, Percent_Identity=32.4034334763949, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17737985, Length=350, Percent_Identity=34, Blast_Score=178, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_AKKM8 (B2UPP6)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001878705.1
- GeneID:   6275481
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_2115
- HOGENOM:   HBG629391
- OMA:   FQARRIR
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47901; Mature: 47901

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 278-278 BINDING 285-285 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIRVIRENPEEVKARLKPRSGDAWKLVDDVLACDEARRNAETEKQALQSERNATSKQI
CCEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHH
GMLKKKGEDTSSIEARVREIGDRIRELDRVAEENAAQLTSLLMNIPNLPHLECPVGADET
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
ANPEIKLWGEKPAIENPKDHVELAANLGMISFEDGARITGSGFVVYRGAGARLERALINF
CCCCEEEECCCCCCCCCHHHHHHHHHCCEEEECCCCEEECCCEEEECCCCHHHHHHHHHH
LLNTQTVENGYQEVGVPFVVKRECMEGTGQLPKFEEDMYGTEDQQMFLIPTAEVPVTNLY
HHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCCCHHHHCCCCCCEEEEEECCCCCHHHHH
RDTILQESDLPIKMAAYTPCFRREAGSAGRINRGMIRVHQFDKVELVQILKPEDSFRELE
HHHHHCCCCCCEEEECCCCHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHH
VLRSHAESILQKLGLHYRVIELCTGDLGFSSAKTYDIEVWAPGQGQYLEVSSCSCFTDYQ
HHHHHHHHHHHHHCCCEEEEHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCHHHHHH
ARRMRLRYKDADGKNQFCHTLNGSGTALPRLYVALLETYQQPDGSIRIPEALVPYFGADC
HHHHEEEECCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHCCCCCEECCHHHHHHHCCCC
IRPEQA
CCCCCC
>Mature Secondary Structure
MLDIRVIRENPEEVKARLKPRSGDAWKLVDDVLACDEARRNAETEKQALQSERNATSKQI
CCEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHH
GMLKKKGEDTSSIEARVREIGDRIRELDRVAEENAAQLTSLLMNIPNLPHLECPVGADET
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
ANPEIKLWGEKPAIENPKDHVELAANLGMISFEDGARITGSGFVVYRGAGARLERALINF
CCCCEEEECCCCCCCCCHHHHHHHHHCCEEEECCCCEEECCCEEEECCCCHHHHHHHHHH
LLNTQTVENGYQEVGVPFVVKRECMEGTGQLPKFEEDMYGTEDQQMFLIPTAEVPVTNLY
HHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCCCHHHHCCCCCCEEEEEECCCCCHHHHH
RDTILQESDLPIKMAAYTPCFRREAGSAGRINRGMIRVHQFDKVELVQILKPEDSFRELE
HHHHHCCCCCCEEEECCCCHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHH
VLRSHAESILQKLGLHYRVIELCTGDLGFSSAKTYDIEVWAPGQGQYLEVSSCSCFTDYQ
HHHHHHHHHHHHHCCCEEEEHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCHHHHHH
ARRMRLRYKDADGKNQFCHTLNGSGTALPRLYVALLETYQQPDGSIRIPEALVPYFGADC
HHHHEEEECCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHCCCCCEECCHHHHHHHCCCC
IRPEQA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA