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The map label for this gene is rnd [H]

Identifier: 187735079

GI number: 187735079

Start: 670610

End: 671668

Strand: Direct

Name: rnd [H]

Synonym: Amuc_0573

Alternate gene names: 187735079

Gene position: 670610-671668 (Clockwise)

Preceding gene: 187735077

Following gene: 187735080

Centisome position: 25.17

GC content: 57.98

Gene sequence:

>1059_bases
ATGATTAGCGAGAAAGAGGAATTACTGGAATGGCGCAAACGCGCCGCCGCACAGCCCGCGGGACGGGTAGTCCTGGATCT
GGAGGCAGACAGCCTGCACCGCTATCAGGAAAAAATCTGCCTGATCCAATATGCGGACGAAACGGGTTCCTGCCTGATTG
ACCCTCTCTCTATCGAAGATATGGGGCCTTTCTACAACTGGCTGAAAGAAACGGAAGTCTGGATGCACGGAGCGGACTAC
GATATGAGCCTCTTTCAAAACGCCTGGGAAACGCTGCCCGCCATGATCTGGGATACGCAGACGGCGGCGCGCCTGCTGGG
CTTCCGCCAGTTCGGGCTGGCAGCCCTGGTGGAACACTTCCACGGCATCACCCTGAGCAAATCTTCCCAAAAGGCGGACT
GGGCGCGGCGCCCCCTTTCCCCAACCATGGTCACTTACGCCCTGAACGACGTAAATTACATGCTGGACATGGCGGACAAA
CTGACGGCCGCCCTCCGGAAAAAAGGACGCATGGGCTGGTTTGAAGAAATTTGCAGACATTCCATGGAACGCGCCCGGGA
ACGCCATCTGGCAGGCCATCAGGACCCCTGGCGCATCCAGGGCTGCGGCAAATTGAACAGGAAGGGGCTGGCCGCCCTCC
GGGAAATGTGGACCTGGCGTGATGCGGAAGCCAAAACGTGGGACAAACCCGCGTTCATGGTTTGCTCCAATGCTGACCTC
ATCCAGTGGAGCGTGGCTCTCCAGGAACAGCGCACCGTGGCGCCCCCGCCCCGTTTTCATGCCCACAGGCGCAGCCGGTT
CATGAATGCGCTCCAGAAATTCTACCTGCTGGATGAAGAAGACTACCCATGCCGGCCCCGCATTCAGCGCCGGCAACATT
CCGACCAATTTGAGGACAATCTGGCCCGCCTGTGCAAACTCAGGGATGAAAAAGCTGAAGAACTGGGCATGGAAGGCTCC
TTCCTGATTACCCGGGCCTCTCTGGAAGCTATTGCGGAAGACAGGGAAAAAGGCGTTTCCACCCTGTTGAACTGGCAGAA
GGAAGCCCTGGGTTTTTAA

Upstream 100 bases:

>100_bases
GGGAAATAGGCAATACATGATTGCCCCATCAGCACTTTTTTTGCATTTCCAGTTGCCCGGCGTCCGGATACATGGTTCAA
TCCCGCTCCGTTGCAATAAG

Downstream 100 bases:

>100_bases
ACGGTCCTTTCTGCAAAGGAAAAACATCCGGACGGAAGCACCAAGGCCCGGAAAGTCCGTTGTCCCCCTCTTTCCCCATT
CACCCAGCATCATCGCCCAT

Product: 3'-5' exonuclease

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MISEKEELLEWRKRAAAQPAGRVVLDLEADSLHRYQEKICLIQYADETGSCLIDPLSIEDMGPFYNWLKETEVWMHGADY
DMSLFQNAWETLPAMIWDTQTAARLLGFRQFGLAALVEHFHGITLSKSSQKADWARRPLSPTMVTYALNDVNYMLDMADK
LTAALRKKGRMGWFEEICRHSMERARERHLAGHQDPWRIQGCGKLNRKGLAALREMWTWRDAEAKTWDKPAFMVCSNADL
IQWSVALQEQRTVAPPPRFHAHRRSRFMNALQKFYLLDEEDYPCRPRIQRRQHSDQFEDNLARLCKLRDEKAEELGMEGS
FLITRASLEAIAEDREKGVSTLLNWQKEALGF

Sequences:

>Translated_352_residues
MISEKEELLEWRKRAAAQPAGRVVLDLEADSLHRYQEKICLIQYADETGSCLIDPLSIEDMGPFYNWLKETEVWMHGADY
DMSLFQNAWETLPAMIWDTQTAARLLGFRQFGLAALVEHFHGITLSKSSQKADWARRPLSPTMVTYALNDVNYMLDMADK
LTAALRKKGRMGWFEEICRHSMERARERHLAGHQDPWRIQGCGKLNRKGLAALREMWTWRDAEAKTWDKPAFMVCSNADL
IQWSVALQEQRTVAPPPRFHAHRRSRFMNALQKFYLLDEEDYPCRPRIQRRQHSDQFEDNLARLCKLRDEKAEELGMEGS
FLITRASLEAIAEDREKGVSTLLNWQKEALGF
>Mature_352_residues
MISEKEELLEWRKRAAAQPAGRVVLDLEADSLHRYQEKICLIQYADETGSCLIDPLSIEDMGPFYNWLKETEVWMHGADY
DMSLFQNAWETLPAMIWDTQTAARLLGFRQFGLAALVEHFHGITLSKSSQKADWARRPLSPTMVTYALNDVNYMLDMADK
LTAALRKKGRMGWFEEICRHSMERARERHLAGHQDPWRIQGCGKLNRKGLAALREMWTWRDAEAKTWDKPAFMVCSNADL
IQWSVALQEQRTVAPPPRFHAHRRSRFMNALQKFYLLDEEDYPCRPRIQRRQHSDQFEDNLARLCKLRDEKAEELGMEGS
FLITRASLEAIAEDREKGVSTLLNWQKEALGF

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=248, Percent_Identity=26.6129032258064, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI50301240, Length=248, Percent_Identity=26.6129032258064, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1788105, Length=250, Percent_Identity=31.2, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17531757, Length=257, Percent_Identity=28.4046692607004, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324574, Length=234, Percent_Identity=26.0683760683761, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI161078302, Length=238, Percent_Identity=26.4705882352941, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 40981; Mature: 40981

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISEKEELLEWRKRAAAQPAGRVVLDLEADSLHRYQEKICLIQYADETGSCLIDPLSIED
CCCCHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHEEEEEECCCCCCEEECCCCCCC
MGPFYNWLKETEVWMHGADYDMSLFQNAWETLPAMIWDTQTAARLLGFRQFGLAALVEHF
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
HGITLSKSSQKADWARRPLSPTMVTYALNDVNYMLDMADKLTAALRKKGRMGWFEEICRH
CCCEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SMERARERHLAGHQDPWRIQGCGKLNRKGLAALREMWTWRDAEAKTWDKPAFMVCSNADL
HHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCH
IQWSVALQEQRTVAPPPRFHAHRRSRFMNALQKFYLLDEEDYPCRPRIQRRQHSDQFEDN
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHH
LARLCKLRDEKAEELGMEGSFLITRASLEAIAEDREKGVSTLLNWQKEALGF
HHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MISEKEELLEWRKRAAAQPAGRVVLDLEADSLHRYQEKICLIQYADETGSCLIDPLSIED
CCCCHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHEEEEEECCCCCCEEECCCCCCC
MGPFYNWLKETEVWMHGADYDMSLFQNAWETLPAMIWDTQTAARLLGFRQFGLAALVEHF
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
HGITLSKSSQKADWARRPLSPTMVTYALNDVNYMLDMADKLTAALRKKGRMGWFEEICRH
CCCEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SMERARERHLAGHQDPWRIQGCGKLNRKGLAALREMWTWRDAEAKTWDKPAFMVCSNADL
HHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCH
IQWSVALQEQRTVAPPPRFHAHRRSRFMNALQKFYLLDEEDYPCRPRIQRRQHSDQFEDN
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHH
LARLCKLRDEKAEELGMEGSFLITRASLEAIAEDREKGVSTLLNWQKEALGF
HHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]