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The map label for this gene is pyrG [H]

Identifier: 187734683

GI number: 187734683

Start: 208398

End: 210005

Strand: Direct

Name: pyrG [H]

Synonym: Amuc_0170

Alternate gene names: 187734683

Gene position: 208398-210005 (Clockwise)

Preceding gene: 187734682

Following gene: 187734684

Centisome position: 7.82

GC content: 57.71

Gene sequence:

>1608_bases
ATGAAATATATCTTCGTCACAGGCGGTGTTGTCTCCTCTCTCGGCAAAGGACTGGCGGCGGCATCCATCGGCACGCTGCT
GGAACGCTGCGGACTCAAGGTAACCCTTCAAAAATTCGACCCCTACCTGAATGTGGACCCCGGAACGATGAGCCCGTTCC
AGCACGGGGAAGTGTACGTCTTGAACGACGGAGCGGAAACGGACCTGGACCTGGGCCATTACGAACGCTTCGTCCATTGC
AGCCTCTCCCGGCTCAACAACCTCACTTCCGGACAGGTCTTTGAAAGCGTGCTGCGGAAGGAACGCCGGGGAGACTATCT
GGGAAAAACGGTTCAATACATTCCGCATGTCACGGATGAAATCAAAAACCGCCTCTATGAAGTCACGGAAAAATCAGACG
TGGACATCATCATCACGGAAATCGGCGGCACGGTCGGGGACATGGAAGGCCACATTTTCCTGGAAGCCCTGCGCCAATTC
GCCCTGGAAGTGGGCCGTGACAACGTCTGCTTCATTCACGTCACCCTGCTCCCCTATATCAAGGCCGCCGGGGAAATGAA
AACGAAGCCCACCCAGCAATCCGTCGCCAAGCTCCGGGAAATCGGCATCCAGCCGGACGTGATCATCTGCCGGACGGAAT
ACGACATGAGTGAAGACGAACGCCGCAAAATCGCCATGTTCTGCAACGTGGAAGCCAAAAACGTCATTGCCTTCCGCGAC
GTCAAAAACACCATCTACGAATGCCCCCTGGATCTCAGCCAGGATAAAATAGACCGCATTGTCACCAGGCGGCTGGGACT
GGACGTTCCGGCGCCCAATCTGGCGGACTGGCAGCGTTACGTCGGCAGGGTCATCAGCCCCAGCCACTCCATCAGGATTG
CCGTAGTAGGTAAATACATCGCTCTCCAGGACGCCTACAAATCCATCTATGAATCCTTCACTCACGCCGGTGCGGAAAAT
GACGCCCGCGTGGAAATTCTCCGGATAGACGCGGAAGAAATTGAGGAAAAGGGCGCGGAGGCCATGATTGGCTCCGTGGA
CGGCATTCTGGTGCCGGGCGGCTTTGGAGACCGCGGCATTGAAGGAAAAATCCAGACGGTGGAATACGCGCGCACCAAAG
GAATCCCGTTCCTGGGCATTTGCCTGGGCATGCAGGTGGCCGTCATTGAGTACGCACGCCACATCTGCGGCATGGATGAC
GCCAACTCCACGGAATTCGACCAGAAAACCACCCACCCAGTCATCAGCCTCCAGGAAGAGCAAAAAGGCATCAAGGCCAT
GGGAGCCACCATGCGCCTGGGCGCCTACAAGGCCCTGATCCAGCCCGGAACGCTGGCGCACAAGCTTTACGGCAAGGACA
GCGTTACGGAACGCCACCGCCACCGGTACGAATTCAACCCGGCCTACCGCGACGAACTGGAAAACGCGGGGCTGGTCATC
AGCGCCGTCAATGACGAACACGGACTGGTGGAAGTCGTGGAACTTCCCGATCATCCCTTCTTCATCGCCTGCCAGTACCA
TCCGGAATTCCAGTCCGCTCCCAACCGGGCCCACCCGCTCTTTTCCGGCCTGGTTTCAGCCGCGCTGGAGCACAAGAGCC
ACTCCTGA

Upstream 100 bases:

>100_bases
CGGGTCATCCTGACGGACCACGTCAGTGTGGGCGTGGATACGCCGGAACAGGCGGAACAGGTGGAACAAATCTTATTAAA
CATACACTAGGAAGCAAATC

Downstream 100 bases:

>100_bases
CCCTTTCATTAAGCCCGGGGCCTTTTCCGGAATTTCCATTCCGGAAAAGGCCTTCTCTTTCCAGGCATGCTCACGGACCT
TTTCGTCATCGTCATTTACT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MKYIFVTGGVVSSLGKGLAAASIGTLLERCGLKVTLQKFDPYLNVDPGTMSPFQHGEVYVLNDGAETDLDLGHYERFVHC
SLSRLNNLTSGQVFESVLRKERRGDYLGKTVQYIPHVTDEIKNRLYEVTEKSDVDIIITEIGGTVGDMEGHIFLEALRQF
ALEVGRDNVCFIHVTLLPYIKAAGEMKTKPTQQSVAKLREIGIQPDVIICRTEYDMSEDERRKIAMFCNVEAKNVIAFRD
VKNTIYECPLDLSQDKIDRIVTRRLGLDVPAPNLADWQRYVGRVISPSHSIRIAVVGKYIALQDAYKSIYESFTHAGAEN
DARVEILRIDAEEIEEKGAEAMIGSVDGILVPGGFGDRGIEGKIQTVEYARTKGIPFLGICLGMQVAVIEYARHICGMDD
ANSTEFDQKTTHPVISLQEEQKGIKAMGATMRLGAYKALIQPGTLAHKLYGKDSVTERHRHRYEFNPAYRDELENAGLVI
SAVNDEHGLVEVVELPDHPFFIACQYHPEFQSAPNRAHPLFSGLVSAALEHKSHS

Sequences:

>Translated_535_residues
MKYIFVTGGVVSSLGKGLAAASIGTLLERCGLKVTLQKFDPYLNVDPGTMSPFQHGEVYVLNDGAETDLDLGHYERFVHC
SLSRLNNLTSGQVFESVLRKERRGDYLGKTVQYIPHVTDEIKNRLYEVTEKSDVDIIITEIGGTVGDMEGHIFLEALRQF
ALEVGRDNVCFIHVTLLPYIKAAGEMKTKPTQQSVAKLREIGIQPDVIICRTEYDMSEDERRKIAMFCNVEAKNVIAFRD
VKNTIYECPLDLSQDKIDRIVTRRLGLDVPAPNLADWQRYVGRVISPSHSIRIAVVGKYIALQDAYKSIYESFTHAGAEN
DARVEILRIDAEEIEEKGAEAMIGSVDGILVPGGFGDRGIEGKIQTVEYARTKGIPFLGICLGMQVAVIEYARHICGMDD
ANSTEFDQKTTHPVISLQEEQKGIKAMGATMRLGAYKALIQPGTLAHKLYGKDSVTERHRHRYEFNPAYRDELENAGLVI
SAVNDEHGLVEVVELPDHPFFIACQYHPEFQSAPNRAHPLFSGLVSAALEHKSHS
>Mature_535_residues
MKYIFVTGGVVSSLGKGLAAASIGTLLERCGLKVTLQKFDPYLNVDPGTMSPFQHGEVYVLNDGAETDLDLGHYERFVHC
SLSRLNNLTSGQVFESVLRKERRGDYLGKTVQYIPHVTDEIKNRLYEVTEKSDVDIIITEIGGTVGDMEGHIFLEALRQF
ALEVGRDNVCFIHVTLLPYIKAAGEMKTKPTQQSVAKLREIGIQPDVIICRTEYDMSEDERRKIAMFCNVEAKNVIAFRD
VKNTIYECPLDLSQDKIDRIVTRRLGLDVPAPNLADWQRYVGRVISPSHSIRIAVVGKYIALQDAYKSIYESFTHAGAEN
DARVEILRIDAEEIEEKGAEAMIGSVDGILVPGGFGDRGIEGKIQTVEYARTKGIPFLGICLGMQVAVIEYARHICGMDD
ANSTEFDQKTTHPVISLQEEQKGIKAMGATMRLGAYKALIQPGTLAHKLYGKDSVTERHRHRYEFNPAYRDELENAGLVI
SAVNDEHGLVEVVELPDHPFFIACQYHPEFQSAPNRAHPLFSGLVSAALEHKSHS

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=556, Percent_Identity=45.863309352518, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI28559085, Length=550, Percent_Identity=44.3636363636364, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI28559083, Length=550, Percent_Identity=44.3636363636364, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI221316689, Length=550, Percent_Identity=44.3636363636364, Blast_Score=471, Evalue=1e-133,
Organism=Escherichia coli, GI1789142, Length=541, Percent_Identity=51.9408502772643, Blast_Score=568, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI25148299, Length=602, Percent_Identity=38.2059800664452, Blast_Score=416, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6322563, Length=566, Percent_Identity=43.8162544169611, Blast_Score=456, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319432, Length=562, Percent_Identity=42.7046263345196, Blast_Score=448, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24664469, Length=552, Percent_Identity=44.7463768115942, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI21357815, Length=496, Percent_Identity=42.5403225806452, Blast_Score=395, Evalue=1e-110,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59585; Mature: 59585

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYIFVTGGVVSSLGKGLAAASIGTLLERCGLKVTLQKFDPYLNVDPGTMSPFQHGEVYV
CEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCEECCCCCCCCCCCCEEEE
LNDGAETDLDLGHYERFVHCSLSRLNNLTSGQVFESVLRKERRGDYLGKTVQYIPHVTDE
ECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHH
IKNRLYEVTEKSDVDIIITEIGGTVGDMEGHIFLEALRQFALEVGRDNVCFIHVTLLPYI
HHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHHH
KAAGEMKTKPTQQSVAKLREIGIQPDVIICRTEYDMSEDERRKIAMFCNVEAKNVIAFRD
HHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEHH
VKNTIYECPLDLSQDKIDRIVTRRLGLDVPAPNLADWQRYVGRVISPSHSIRIAVVGKYI
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHH
ALQDAYKSIYESFTHAGAENDARVEILRIDAEEIEEKGAEAMIGSVDGILVPGGFGDRGI
HHHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHCCHHHEEECCCCEEECCCCCCCCC
EGKIQTVEYARTKGIPFLGICLGMQVAVIEYARHICGMDDANSTEFDQKTTHPVISLQEE
CCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHH
QKGIKAMGATMRLGAYKALIQPGTLAHKLYGKDSVTERHRHRYEFNPAYRDELENAGLVI
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHCCCCEEE
SAVNDEHGLVEVVELPDHPFFIACQYHPEFQSAPNRAHPLFSGLVSAALEHKSHS
EEECCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKYIFVTGGVVSSLGKGLAAASIGTLLERCGLKVTLQKFDPYLNVDPGTMSPFQHGEVYV
CEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCEECCCCCCCCCCCCEEEE
LNDGAETDLDLGHYERFVHCSLSRLNNLTSGQVFESVLRKERRGDYLGKTVQYIPHVTDE
ECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHH
IKNRLYEVTEKSDVDIIITEIGGTVGDMEGHIFLEALRQFALEVGRDNVCFIHVTLLPYI
HHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHHH
KAAGEMKTKPTQQSVAKLREIGIQPDVIICRTEYDMSEDERRKIAMFCNVEAKNVIAFRD
HHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEHH
VKNTIYECPLDLSQDKIDRIVTRRLGLDVPAPNLADWQRYVGRVISPSHSIRIAVVGKYI
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHH
ALQDAYKSIYESFTHAGAENDARVEILRIDAEEIEEKGAEAMIGSVDGILVPGGFGDRGI
HHHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHCCHHHEEECCCCEEECCCCCCCCC
EGKIQTVEYARTKGIPFLGICLGMQVAVIEYARHICGMDDANSTEFDQKTTHPVISLQEE
CCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHH
QKGIKAMGATMRLGAYKALIQPGTLAHKLYGKDSVTERHRHRYEFNPAYRDELENAGLVI
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHCCCCEEE
SAVNDEHGLVEVVELPDHPFFIACQYHPEFQSAPNRAHPLFSGLVSAALEHKSHS
EEECCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA