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The map label for this gene is sglT [H]

Identifier: 187734684

GI number: 187734684

Start: 210072

End: 211634

Strand: Direct

Name: sglT [H]

Synonym: Amuc_0171

Alternate gene names: 187734684

Gene position: 210072-211634 (Clockwise)

Preceding gene: 187734683

Following gene: 187734686

Centisome position: 7.89

GC content: 57.52

Gene sequence:

>1563_bases
ATGCTCACGGACCTTTTCGTCATCGTCATTTACTTTCTTGCTATCTTCTGCATTGGCATTTATGCGGGACGAAAGCAAAA
CTCCCTGACAGACTATGCCCTGGGCAACCGCTCCCTGCCCTGGTGGGCTATTCTGGCCTCTATCCTGGCGGCGGAAATCA
GCGCGGCCACCTTCCTGGGGGCTCCCGGAGAAGGGTACCATACCCGCAACTTCACATACGCCCAGCTCTGCATCGGCACC
ATCCTGGGCCGCATCATCGTCGGCAGGCTCTTTCTCAAGCCCTATTATGACTACAAGGTTGTTTCCATCTATGAATACCT
GGAAAAAAGATTCGGGCTCCTGACGCGGCGGACAGCCTCCATGGTCTTCCTGATCAGCCGGGTGCTCGCCAGCGGAACCA
GGCTCTATTTCGCGGGCATTCTGCTGGTCATTGCCTACCAGTTCCTGACAGGCGTCACGGCAGACGCCGACCAGATTGTC
CTGCTCTACATTGCCGCCCTGGTTGCCATCTCCGTCGCCACGACAATTTATACCGCGATCGGAGGATTGAAAGCCGTCGT
CTGGACGGACGTCCTCCAGGCCGTCGTTCTGGGAGTCTCCATGCTTTCCGCCCTGTGGGTACTGTTCTCCCATATCCCCG
GAGGGTGGAGCTCCATCTCCGCCGCCATGAATGGCGGAGACGATTGGAAATTCTTCTCCTGGGGAACCGGAGAAGGCCTG
GACTTCCTCCAACAAGGCGCCCGCGTGCTGGGCCAGGAATACACGGTGTGGGCAGCCTTCCTGGGAGCAACCTTCATCAC
CATGGCTACGCATGGCACGGACCAGGACATGGTGCAGCGCATGCTGGCGGCAAAAAACAGCAAGGCGGGAACGCGTGCAG
TCATCGTATCCGGCTTGCTGGACTTCCCCATCGTCATCATTTTCCTCTTCACGGGCATTCTTCTCTATGTCTTCTACCAA
TACAACCCGGCAAACCTCCCTGCAGACACGCCGCAGCTGCATGTGTTTCCCTACTTCATCATCCATGAACTTCCCAACGG
CATCCGCGGGCTGCTGATCGCCGGACTTCTGGCGACGGCCATGGGCTCCCTCTCCACGGCTCTAAACTCCCTGGCGACTA
CCGCCACCAAGGACTGGTACCAGGGGATATTCAAACCGGAAGCCACGGAACGGCAGCTGCTCCGGTGCGTGCGCTGGGGA
ACGGCCGTTTTCTCCCTGCTGCTCATCCTCGTGGGTTCCATCACAGCGTGGTATGTGGTGCATCACCCGGAAGTCCGCAT
CATCCAAATAGCCCTGGGCATTTTCGGCTATACCTATGGCTCCCTGCTTGGCATTTTCCTGTTGGGAATGCTGACCCGCA
CCAGAGGCAGCGACTCAGGAAACATCATTGCCATGGCGGCAGGATTCTTTGTCATCGCTTTACTGACGGAACTCATCCCT
CTGCCCTCCGGCTGGCAACAATATGTTCCGGAAATAGCATTTCCGTGGCGCGTTACCATCGGAACTCTGGTTACTTTTAC
CGTCGGCTTCTGTTTCAGAAAACGCCGCCTTCCCATGCGCTGA

Upstream 100 bases:

>100_bases
TTCAGCCGCGCTGGAGCACAAGAGCCACTCCTGACCCTTTCATTAAGCCCGGGGCCTTTTCCGGAATTTCCATTCCGGAA
AAGGCCTTCTCTTTCCAGGC

Downstream 100 bases:

>100_bases
ACGGTGAACGCCGTTACTTGGCCACGTTCATGTTCCGCATTCCCCTTCAAACCGCCCCGTCAATGGGAGTAAAGGTGCAA
GCGAAAAATAGGGGATTAGG

Product: SSS sodium solute transporter superfamily

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Na(+)/glucose symporter [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MLTDLFVIVIYFLAIFCIGIYAGRKQNSLTDYALGNRSLPWWAILASILAAEISAATFLGAPGEGYHTRNFTYAQLCIGT
ILGRIIVGRLFLKPYYDYKVVSIYEYLEKRFGLLTRRTASMVFLISRVLASGTRLYFAGILLVIAYQFLTGVTADADQIV
LLYIAALVAISVATTIYTAIGGLKAVVWTDVLQAVVLGVSMLSALWVLFSHIPGGWSSISAAMNGGDDWKFFSWGTGEGL
DFLQQGARVLGQEYTVWAAFLGATFITMATHGTDQDMVQRMLAAKNSKAGTRAVIVSGLLDFPIVIIFLFTGILLYVFYQ
YNPANLPADTPQLHVFPYFIIHELPNGIRGLLIAGLLATAMGSLSTALNSLATTATKDWYQGIFKPEATERQLLRCVRWG
TAVFSLLLILVGSITAWYVVHHPEVRIIQIALGIFGYTYGSLLGIFLLGMLTRTRGSDSGNIIAMAAGFFVIALLTELIP
LPSGWQQYVPEIAFPWRVTIGTLVTFTVGFCFRKRRLPMR

Sequences:

>Translated_520_residues
MLTDLFVIVIYFLAIFCIGIYAGRKQNSLTDYALGNRSLPWWAILASILAAEISAATFLGAPGEGYHTRNFTYAQLCIGT
ILGRIIVGRLFLKPYYDYKVVSIYEYLEKRFGLLTRRTASMVFLISRVLASGTRLYFAGILLVIAYQFLTGVTADADQIV
LLYIAALVAISVATTIYTAIGGLKAVVWTDVLQAVVLGVSMLSALWVLFSHIPGGWSSISAAMNGGDDWKFFSWGTGEGL
DFLQQGARVLGQEYTVWAAFLGATFITMATHGTDQDMVQRMLAAKNSKAGTRAVIVSGLLDFPIVIIFLFTGILLYVFYQ
YNPANLPADTPQLHVFPYFIIHELPNGIRGLLIAGLLATAMGSLSTALNSLATTATKDWYQGIFKPEATERQLLRCVRWG
TAVFSLLLILVGSITAWYVVHHPEVRIIQIALGIFGYTYGSLLGIFLLGMLTRTRGSDSGNIIAMAAGFFVIALLTELIP
LPSGWQQYVPEIAFPWRVTIGTLVTFTVGFCFRKRRLPMR
>Mature_520_residues
MLTDLFVIVIYFLAIFCIGIYAGRKQNSLTDYALGNRSLPWWAILASILAAEISAATFLGAPGEGYHTRNFTYAQLCIGT
ILGRIIVGRLFLKPYYDYKVVSIYEYLEKRFGLLTRRTASMVFLISRVLASGTRLYFAGILLVIAYQFLTGVTADADQIV
LLYIAALVAISVATTIYTAIGGLKAVVWTDVLQAVVLGVSMLSALWVLFSHIPGGWSSISAAMNGGDDWKFFSWGTGEGL
DFLQQGARVLGQEYTVWAAFLGATFITMATHGTDQDMVQRMLAAKNSKAGTRAVIVSGLLDFPIVIIFLFTGILLYVFYQ
YNPANLPADTPQLHVFPYFIIHELPNGIRGLLIAGLLATAMGSLSTALNSLATTATKDWYQGIFKPEATERQLLRCVRWG
TAVFSLLLILVGSITAWYVVHHPEVRIIQIALGIFGYTYGSLLGIFLLGMLTRTRGSDSGNIIAMAAGFFVIALLTELIP
LPSGWQQYVPEIAFPWRVTIGTLVTFTVGFCFRKRRLPMR

Specific function: Actively transports glucose into cells by Na(+) cotransport [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI4507035, Length=455, Percent_Identity=26.1538461538462, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI256985183, Length=522, Percent_Identity=27.0114942528736, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI167466278, Length=466, Percent_Identity=26.6094420600858, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI157671931, Length=434, Percent_Identity=25.3456221198157, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI4507031, Length=449, Percent_Identity=27.1714922048998, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI14140236, Length=496, Percent_Identity=24.3951612903226, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI17941285, Length=416, Percent_Identity=24.7596153846154, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4507033, Length=421, Percent_Identity=26.603325415677, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI110835708, Length=426, Percent_Identity=25.5868544600939, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI109659836, Length=447, Percent_Identity=25.503355704698, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI109659839, Length=465, Percent_Identity=25.5913978494624, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI206597483, Length=414, Percent_Identity=25.3623188405797, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI206597487, Length=438, Percent_Identity=23.5159817351598, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI87082237, Length=492, Percent_Identity=25.2032520325203, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790113, Length=413, Percent_Identity=22.0338983050847, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1787251, Length=397, Percent_Identity=23.1738035264484, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533094, Length=478, Percent_Identity=23.6401673640167, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI115533096, Length=336, Percent_Identity=23.8095238095238, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI28573698, Length=458, Percent_Identity=27.0742358078603, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI221459584, Length=448, Percent_Identity=27.6785714285714, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24645928, Length=461, Percent_Identity=28.1995661605206, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24651739, Length=458, Percent_Identity=26.6375545851528, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24641117, Length=492, Percent_Identity=27.0325203252033, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI221459588, Length=465, Percent_Identity=27.3118279569892, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161076631, Length=461, Percent_Identity=28.4164859002169, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24651741, Length=487, Percent_Identity=24.2299794661191, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221459586, Length=474, Percent_Identity=25.3164556962025, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24650192, Length=446, Percent_Identity=26.2331838565022, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24640370, Length=480, Percent_Identity=25.8333333333333, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19920916, Length=452, Percent_Identity=26.5486725663717, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221379702, Length=445, Percent_Identity=25.3932584269663, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281362054, Length=476, Percent_Identity=23.7394957983193, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281362052, Length=476, Percent_Identity=23.7394957983193, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281362050, Length=476, Percent_Identity=23.7394957983193, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24648056, Length=476, Percent_Identity=23.7394957983193, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356827, Length=476, Percent_Identity=23.7394957983193, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281364280, Length=465, Percent_Identity=24.5161290322581, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574994, Length=467, Percent_Identity=23.7687366167024, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281362918, Length=507, Percent_Identity=24.2603550295858, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI221459582, Length=444, Percent_Identity=24.5495495495495, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 57236; Mature: 57236

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS00501 SPASE_I_1 ; PS00211 ABC_TRANSPORTER_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure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CCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8652595; 10835424; 10757971 [H]