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The map label for this gene is emrA

Identifier: 187730269

GI number: 187730269

Start: 2980270

End: 2981442

Strand: Reverse

Name: emrA

Synonym: SbBS512_E3191

Alternate gene names: 187730269

Gene position: 2981442-2980270 (Counterclockwise)

Preceding gene: 187734035

Following gene: 187730572

Centisome position: 64.59

GC content: 52.77

Gene sequence:

>1173_bases
ATGAGCGCAAATGCGGAGACTCAAACCCCGCAGCAACCGGTAAAGAAGAGCGGCAAACGTAAGCGTCTGCTCCTCCTTCT
CACCTTGCTCTTTATAATTATTGCCGTAGCGATAGGGATTTATTGGTTTTTGGTACTGCGTCATTTCGAAGAAACCGATG
ACGCATACGTGGCAGGGAATCAGATTCAAATTATGTCTCAGGTGTCTGGCAGCGTGACGAAAGTCTGGGCCGATAACACC
GATTTTGTAAAAGAAGGCGATGTTCTGGTCACTCTCGACCCGACAGATGCTCGCCAGGCGTTTGAAAAAGCCAAAACTGC
ACTGGCTTCCAGCGTTCGCCAAACCTACCAGCTGATGATTAACAGCAAACAGTTACAGGCGAATATTGAGGTGCAAAAAA
TCGCCCTCGCGAAAGCACAAAGCGACTACAACCGCCGTGTGCCGCTGGGCAATGCCAACCTGATTGGTCGCGAAGAGCTG
CAACACGCCCGCGACGCCGTCACCAGTGCCCAGGCGCAACTGGACGTCGCTATTCAACAATACAATGCCAATCAGGCGAT
GATTCTGGGGACTAAACTGGAAGATCAGCCTGCCGTGCAACAGGCTGCCACCGAAGTACGTAACGCCTGGCTGGCGCTGG
AGCGTACCCGTATTGTCAGTCCGATGACCGCTTATGTCTCCCGCCGCGCGGTACAGCCTGGGGCGCAAATTAGCCCAACG
ACGCCGCTGATGGCGGTCGTTCCAGCCACCAATATGTGGGTGGATGCCAACTTTAAAGAGACGCAGATTGCCAATATGCG
TATCGGTCAGCCGGTCACTATCACCACGGATATTTACGGCGATGATGTGAAATACACCGGTAAAGTGGTTGGTCTGGATA
TGGGCACAGGTAGCGCATTCTCACTGCTTCCGGCGCAAAATGCGACCGGTAACTGGATCAAAGTCGTTCAGCGTCTACCT
GTGCGTATCGAACTGGACCAGAAACAGCTGGAGCAATACTCGCTGCGCATTGGTTTGTCCACGCTGGTGAGCGTCAATAC
CACTAACCGTGACGGTCAGGTACTGGCAAATAAAGTACGTTCAACACCGGTCGCGGTAAGTACCGCGCGTGAAATCAGCC
TGGCACCTGTCAATAAACTGATCGACGATATCGTAAAAGCTAACGCTGGCTAA

Upstream 100 bases:

>100_bases
TTTATAAAAGAAAAAATGACCGGCCAGCATCGCAACATGCTGGCCTTTTTGGCAAGCAGGTCGGCTCAGCCGATGAGTTA
AGAAGATCGTGGAGAACAAT

Downstream 100 bases:

>100_bases
TCCAGAGGTGCGTGTGATGCAACAGCAAAAACCGCTGGAAGGCGCGCAACTGGTCATTATGACGATTGCGCTGTCACTGG
CGACATTCATGCAGGTGCTG

Product: multidrug resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSANAETQTPQQPVKKSGKRKRLLLLLTLLFIIIAVAIGIYWFLVLRHFEETDDAYVAGNQIQIMSQVSGSVTKVWADNT
DFVKEGDVLVTLDPTDARQAFEKAKTALASSVRQTYQLMINSKQLQANIEVQKIALAKAQSDYNRRVPLGNANLIGREEL
QHARDAVTSAQAQLDVAIQQYNANQAMILGTKLEDQPAVQQAATEVRNAWLALERTRIVSPMTAYVSRRAVQPGAQISPT
TPLMAVVPATNMWVDANFKETQIANMRIGQPVTITTDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP
VRIELDQKQLEQYSLRIGLSTLVSVNTTNRDGQVLANKVRSTPVAVSTAREISLAPVNKLIDDIVKANAG

Sequences:

>Translated_390_residues
MSANAETQTPQQPVKKSGKRKRLLLLLTLLFIIIAVAIGIYWFLVLRHFEETDDAYVAGNQIQIMSQVSGSVTKVWADNT
DFVKEGDVLVTLDPTDARQAFEKAKTALASSVRQTYQLMINSKQLQANIEVQKIALAKAQSDYNRRVPLGNANLIGREEL
QHARDAVTSAQAQLDVAIQQYNANQAMILGTKLEDQPAVQQAATEVRNAWLALERTRIVSPMTAYVSRRAVQPGAQISPT
TPLMAVVPATNMWVDANFKETQIANMRIGQPVTITTDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP
VRIELDQKQLEQYSLRIGLSTLVSVNTTNRDGQVLANKVRSTPVAVSTAREISLAPVNKLIDDIVKANAG
>Mature_389_residues
SANAETQTPQQPVKKSGKRKRLLLLLTLLFIIIAVAIGIYWFLVLRHFEETDDAYVAGNQIQIMSQVSGSVTKVWADNTD
FVKEGDVLVTLDPTDARQAFEKAKTALASSVRQTYQLMINSKQLQANIEVQKIALAKAQSDYNRRVPLGNANLIGREELQ
HARDAVTSAQAQLDVAIQQYNANQAMILGTKLEDQPAVQQAATEVRNAWLALERTRIVSPMTAYVSRRAVQPGAQISPTT
PLMAVVPATNMWVDANFKETQIANMRIGQPVTITTDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPV
RIELDQKQLEQYSLRIGLSTLVSVNTTNRDGQVLANKVRSTPVAVSTAREISLAPVNKLIDDIVKANAG

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=390, Percent_Identity=98.974358974359, Blast_Score=783, Evalue=0.0,
Organism=Escherichia coli, GI1788711, Length=378, Percent_Identity=48.9417989417989, Blast_Score=360, Evalue=1e-101,
Organism=Escherichia coli, GI1790519, Length=310, Percent_Identity=29.6774193548387, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87081951, Length=314, Percent_Identity=27.0700636942675, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789637, Length=312, Percent_Identity=25.9615384615385, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42753; Mature: 42621

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANAETQTPQQPVKKSGKRKRLLLLLTLLFIIIAVAIGIYWFLVLRHFEETDDAYVAGN
CCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECC
QIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAKTALASSVRQTYQLMI
EEEEEEHHCCCEEEEECCCCCCEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
NSKQLQANIEVQKIALAKAQSDYNRRVPLGNANLIGREELQHARDAVTSAQAQLDVAIQQ
CCHHHEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YNANQAMILGTKLEDQPAVQQAATEVRNAWLALERTRIVSPMTAYVSRRAVQPGAQISPT
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TPLMAVVPATNMWVDANFKETQIANMRIGQPVTITTDIYGDDVKYTGKVVGLDMGTGSAF
CCEEEEECCCCEEEECCCCCCEEECEECCCCEEEEEECCCCCCEECCEEEEEECCCCCCE
SLLPAQNATGNWIKVVQRLPVRIELDQKQLEQYSLRIGLSTLVSVNTTNRDGQVLANKVR
EEECCCCCCCHHHHHHHHCCCEEEECHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHHHH
STPVAVSTAREISLAPVNKLIDDIVKANAG
CCCEEEEHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SANAETQTPQQPVKKSGKRKRLLLLLTLLFIIIAVAIGIYWFLVLRHFEETDDAYVAGN
CCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECC
QIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAKTALASSVRQTYQLMI
EEEEEEHHCCCEEEEECCCCCCEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
NSKQLQANIEVQKIALAKAQSDYNRRVPLGNANLIGREELQHARDAVTSAQAQLDVAIQQ
CCHHHEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YNANQAMILGTKLEDQPAVQQAATEVRNAWLALERTRIVSPMTAYVSRRAVQPGAQISPT
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TPLMAVVPATNMWVDANFKETQIANMRIGQPVTITTDIYGDDVKYTGKVVGLDMGTGSAF
CCEEEEECCCCEEEECCCCCCEEECEECCCCEEEEEECCCCCCEECCEEEEEECCCCCCE
SLLPAQNATGNWIKVVQRLPVRIELDQKQLEQYSLRIGLSTLVSVNTTNRDGQVLANKVR
EEECCCCCCCHHHHHHHHCCCEEEECHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHHHH
STPVAVSTAREISLAPVNKLIDDIVKANAG
CCCEEEEHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]