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The map label for this gene is mprA

Identifier: 187734035

GI number: 187734035

Start: 2981569

End: 2982099

Strand: Reverse

Name: mprA

Synonym: SbBS512_E3192

Alternate gene names: 187734035

Gene position: 2982099-2981569 (Counterclockwise)

Preceding gene: 187733596

Following gene: 187730269

Centisome position: 64.6

GC content: 49.15

Gene sequence:

>531_bases
ATGGATAGTTCGTTTACGCCCATTGAACAAATGCTAAAATTTCGCGCCAGCCGCCACGAAGATTTTCCTTATCAGGAGAT
CCTTCTGACTCGTCTTTGCATGCACATGCAAAGCAAGCTGCTGGAGAACCGCAATAAAATGCTGAAGGCTCAGGGGATTA
ACGAGACGTTGTTTATGGCGTTGATTACGCTGGAGTCTCAGGAAAACCACAGTATTCAGCCTTCTGAATTAAGTTGTGCT
CTTGGATCATCCCGTACCAACGCGACGCGTATTGCCGATGAACTGGAAAAACGCGGTTGGATCGAACGTCGTGAAAGCGA
TAACGATCGCCGCTGCCTGCATCTGCAATTAACGGAAAAAGGTCACGAGTTTTTGCGCGAGGTTTTACCACCGCAGCATA
ACTGCCTGCATCAACTCTGGTCCGCGCTCAGCACAACAGAAAAAGATCAGCTCGAGCAAATCACCCGCAAATTGCTCTCC
CGTCTCGACCAGATGGAACAAGACGGTGTGGTTCTCGAAGCGATGAGCTAA

Upstream 100 bases:

>100_bases
GATTATATAACCCACAAGAATCATTTTTCTAAAACAATACATTTACTTTATTTGTCACTGTTGTTACTATATCGGCTGAA
ATTAATGAGGTCATACCCAA

Downstream 100 bases:

>100_bases
CGCGTCATCTCGCTCAAAAATCCAGATTTATAAAAGAAAAAATGACCGGCCAGCATCGCAACATGCTGGCCTTTTTGGCA
AGCAGGTCGGCTCAGCCGAT

Product: transcriptional repressor MprA

Products: NA

Alternate protein names: Protein emrR

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCA
LGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLS
RLDQMEQDGVVLEAMS

Sequences:

>Translated_176_residues
MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCA
LGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLS
RLDQMEQDGVVLEAMS
>Mature_176_residues
MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCA
LGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLS
RLDQMEQDGVVLEAMS

Specific function: Negative regulator of the multidrug operon emrAB

COG id: COG1846

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH marR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1789040, Length=176, Percent_Identity=100, Blast_Score=361, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MPRA_ECO57 (P0ACS1)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B91072
- RefSeq:   NP_289235.1
- RefSeq:   NP_311573.1
- ProteinModelPortal:   P0ACS1
- SMR:   P0ACS1
- EnsemblBacteria:   EBESCT00000027807
- EnsemblBacteria:   EBESCT00000058171
- GeneID:   914738
- GeneID:   958137
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z3985
- KEGG:   ecs:ECs3546
- GeneTree:   EBGT00050000010973
- HOGENOM:   HBG752581
- OMA:   MRKLLVR
- ProtClustDB:   PRK10870
- BioCyc:   ECOL83334:ECS3546-MONOMER
- GO:   GO:0005622
- InterPro:   IPR000835
- InterPro:   IPR023187
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00598
- SMART:   SM00347

Pfam domain/function: PF01047 MarR

EC number: NA

Molecular weight: Translated: 20564; Mature: 20564

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS01117 HTH_MARR_1; PS50995 HTH_MARR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMA
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEK
HHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCCCCEEEEEEEHHH
GHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLSRLDQMEQDGVVLEAMS
HHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECC
>Mature Secondary Structure
MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMA
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEK
HHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCCCCEEEEEEEHHH
GHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLSRLDQMEQDGVVLEAMS
HHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796