Click here to switch to the map view.

The map label for this gene is sdaA [H]

Identifier: 186477761

GI number: 186477761

Start: 3382282

End: 3383670

Strand: Direct

Name: sdaA [H]

Synonym: Bphy_3015

Alternate gene names: 186477761

Gene position: 3382282-3383670 (Clockwise)

Preceding gene: 186477760

Following gene: 186477762

Centisome position: 97.21

GC content: 63.57

Gene sequence:

>1389_bases
ATGGCAGTCAGCGTTTTCGATCTCTTCAAAATCGGCATCGGTCCGTCGAGTTCGCACACGGTCGGTCCCATGCGCGCAGC
GCTGATGTTCGCGCAAGGGCTCGAGCGCGATGCGCTGCTCGAGAACACGGCATCGGTGAAGGTCGACCTGTATGGATCGC
TCGGTGCAACGGGCAAAGGCCACGGCACCGATCGCGGCGTGATGCTCGGCCTGCTCGGCGACGCACCCGACACCGTCGAT
CCCGACACGATCGCGGCGCGCCTCGAACAGGTTCGCGTATCGCGCACGCTCGCGCTGCTCGGCACGCACGTCATCCCGTT
CATGCAAAAGGACCACATTTCGTTTTATCGGCAGGCGCTGCCGGAACATCCGAACGGTCTCAAGCTGCGCGCATTCGATG
CGAATGGCGAAACGCTGCGCGAAGCGACGTATCTGTCGGTGGGCGGCGGCTTTGTCGTCACTGCGGGCGCGCCTAACACG
AAGGTGCTTGCCGCCGTCGATCAGTTGCCGCATCCGTTTCGCACGGGTGCGGAGTTGCTGGAAATGTGCAAGACCACGGG
CAAGAGCATTGCGCAACTGATGTGGGACAACGAGCGCGCATGGCATACGGACGAAGAGACGCGTACGGGCCTGCTGAAAA
TCTGGAACGTGATGCAATCGTGTGTCGCGCGCGGCTGCGGAATCAACAACCCGGATGCCGAAGGCAATCTGCCCGGGCCG
TTCCAGGTGAAACGCCGCGCACCGCAGCTGTATCGCGGGTTGACGGGCAATCCGGAGCGCGCGCTGCAGGATCCGCTGTC
GATGGTCGACTGGATCAATCTGTACGCGATCGCCGTCAATGAAGAAAACGCAGCGGGCGGCCGCGTGGTCACCGCGCCGA
CCAACGGCGCTGCGGGCATCATTCCCGCCGTGCTGCACTACTACACGCGCTTCATGCCGCACGCTACCGAACAAGGCGTG
CTCGACTTTCTGATGACAGCCGCCGCGATCGGCATTCTCTACAAGCTGAATGCGTCGATTTCCGGCGCGGAAGTGGGCTG
CCAGGGCGAGGTGGGCGTCGCATGCTCGATGGCGGCGGGCGCGCTCGCGGCCGTGATGGGCGGCACGCCGTTGCAGGTCG
AGAACGCCGCCGAAATCGGCATGGAGCACAACCTGGGCCTCACGTGCGATCCCGTCGGCGGGATGGTGCAGATTCCGTGC
ATCGAGCGCAATGCGATGGCGTCCGTGAAGGCCGTGAACGCGGCGCGCATGGCGCTGCGTGGCGACGGCAGCCATTACGT
ATCGCTCGATTCCGTCATCAAGACGATGCGCGAAACGGGCGCCGACATGAAGACGAAGTACAAGGAAACGTCGCGCGGCG
GTCTCGCGGTAAACATCATCGAATGTTGA

Upstream 100 bases:

>100_bases
CTTGCCGGCGCGTTGATCACGCGCGGGGCAATGGCTCAATGAGCTGCCGCGTTACCCACGCGGTGCAGCATCCACGACAT
TCAAGCTAGCAGGAGCAGTG

Downstream 100 bases:

>100_bases
CGCTTTTGCGAATGACATTGAAGAGGGTCTCGGCGTAAGCTGTCGAAGCTCTTCTGACTGGAGGTGTGTTCGCAATGTCG
CTGTCTTCCGATGCTTCAAA

Product: L-serine dehydratase 1

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MAVSVFDLFKIGIGPSSSHTVGPMRAALMFAQGLERDALLENTASVKVDLYGSLGATGKGHGTDRGVMLGLLGDAPDTVD
PDTIAARLEQVRVSRTLALLGTHVIPFMQKDHISFYRQALPEHPNGLKLRAFDANGETLREATYLSVGGGFVVTAGAPNT
KVLAAVDQLPHPFRTGAELLEMCKTTGKSIAQLMWDNERAWHTDEETRTGLLKIWNVMQSCVARGCGINNPDAEGNLPGP
FQVKRRAPQLYRGLTGNPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYTRFMPHATEQGV
LDFLMTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAGALAAVMGGTPLQVENAAEIGMEHNLGLTCDPVGGMVQIPC
IERNAMASVKAVNAARMALRGDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIIEC

Sequences:

>Translated_462_residues
MAVSVFDLFKIGIGPSSSHTVGPMRAALMFAQGLERDALLENTASVKVDLYGSLGATGKGHGTDRGVMLGLLGDAPDTVD
PDTIAARLEQVRVSRTLALLGTHVIPFMQKDHISFYRQALPEHPNGLKLRAFDANGETLREATYLSVGGGFVVTAGAPNT
KVLAAVDQLPHPFRTGAELLEMCKTTGKSIAQLMWDNERAWHTDEETRTGLLKIWNVMQSCVARGCGINNPDAEGNLPGP
FQVKRRAPQLYRGLTGNPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYTRFMPHATEQGV
LDFLMTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAGALAAVMGGTPLQVENAAEIGMEHNLGLTCDPVGGMVQIPC
IERNAMASVKAVNAARMALRGDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIIEC
>Mature_461_residues
AVSVFDLFKIGIGPSSSHTVGPMRAALMFAQGLERDALLENTASVKVDLYGSLGATGKGHGTDRGVMLGLLGDAPDTVDP
DTIAARLEQVRVSRTLALLGTHVIPFMQKDHISFYRQALPEHPNGLKLRAFDANGETLREATYLSVGGGFVVTAGAPNTK
VLAAVDQLPHPFRTGAELLEMCKTTGKSIAQLMWDNERAWHTDEETRTGLLKIWNVMQSCVARGCGINNPDAEGNLPGPF
QVKRRAPQLYRGLTGNPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYTRFMPHATEQGVL
DFLMTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAGALAAVMGGTPLQVENAAEIGMEHNLGLTCDPVGGMVQIPCI
ERNAMASVKAVNAARMALRGDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIIEC

Specific function: Deaminates Also Threonine, Particularly When It Is Present In High Concentration. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=458, Percent_Identity=52.4017467248908, Blast_Score=470, Evalue=1e-134,
Organism=Escherichia coli, GI1789161, Length=461, Percent_Identity=52.9284164859002, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI48994925, Length=460, Percent_Identity=53.4782608695652, Blast_Score=465, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 49029; Mature: 48898

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSVFDLFKIGIGPSSSHTVGPMRAALMFAQGLERDALLENTASVKVDLYGSLGATGKG
CEEEHEEHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCEEEEEEEECCCCCCCC
HGTDRGVMLGLLGDAPDTVDPDTIAARLEQVRVSRTLALLGTHVIPFMQKDHISFYRQAL
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PEHPNGLKLRAFDANGETLREATYLSVGGGFVVTAGAPNTKVLAAVDQLPHPFRTGAELL
CCCCCCCEEEEECCCCCHHHHEEEEEECCCEEEECCCCCCCEEHHHHHCCCCHHHHHHHH
EMCKTTGKSIAQLMWDNERAWHTDEETRTGLLKIWNVMQSCVARGCGINNPDAEGNLPGP
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
FQVKRRAPQLYRGLTGNPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGI
HHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHEEEEEEEEECCCCCCCEEEECCCCCCCHH
IPAVLHYYTRFMPHATEQGVLDFLMTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHH
ALAAVMGGTPLQVENAAEIGMEHNLGLTCDPVGGMVQIPCIERNAMASVKAVNAARMALR
HHHHHHCCCCEEECCHHHCCCCCCCCEEECCCCCEEEECEECCCHHHHHHHHHHHHHEEE
GDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIIEC
CCCCCEEEHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEEC
>Mature Secondary Structure 
AVSVFDLFKIGIGPSSSHTVGPMRAALMFAQGLERDALLENTASVKVDLYGSLGATGKG
EEEHEEHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCEEEEEEEECCCCCCCC
HGTDRGVMLGLLGDAPDTVDPDTIAARLEQVRVSRTLALLGTHVIPFMQKDHISFYRQAL
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PEHPNGLKLRAFDANGETLREATYLSVGGGFVVTAGAPNTKVLAAVDQLPHPFRTGAELL
CCCCCCCEEEEECCCCCHHHHEEEEEECCCEEEECCCCCCCEEHHHHHCCCCHHHHHHHH
EMCKTTGKSIAQLMWDNERAWHTDEETRTGLLKIWNVMQSCVARGCGINNPDAEGNLPGP
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
FQVKRRAPQLYRGLTGNPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGI
HHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHEEEEEEEEECCCCCCCEEEECCCCCCCHH
IPAVLHYYTRFMPHATEQGVLDFLMTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHH
ALAAVMGGTPLQVENAAEIGMEHNLGLTCDPVGGMVQIPCIERNAMASVKAVNAARMALR
HHHHHHCCCCEEECCHHHCCCCCCCCEEECCCCCEEEECEECCCHHHHHHHHHHHHHEEE
GDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIIEC
CCCCCEEEHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]