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The map label for this gene is glmU

Identifier: 186477639

GI number: 186477639

Start: 3246245

End: 3247606

Strand: Reverse

Name: glmU

Synonym: Bphy_2891

Alternate gene names: 186477639

Gene position: 3247606-3246245 (Counterclockwise)

Preceding gene: 186477640

Following gene: 186477638

Centisome position: 93.34

GC content: 63.44

Gene sequence:

>1362_bases
ATGAACATCGTGATTCTGGCGGCAGGCACCGGCAAGCGCATGCGCTCGGCATTGCCAAAGGTGCTTCATCCCCTGGCCGG
TCGGCCGCTTCTCGCTCACGTCATCGACACTGCCCGCACGCTGAATCCGACGCGACTGGTCGTCGTGGTCGGTCATGGTG
CCGATCAGGTGCGCACGGCGGTGGCCGCGTCCGACGTGCAATTTGCGTTGCAGGAACAGCAGCTTGGCACGGGCCACGCG
GTGCAGCAGGCGCTGCCGCTGCTCGATCCGTCGGCGCCGACGCTCGTGCTGTACGGCGACGTGCCGCTCACGAAGGCAAG
CACGCTCAAGCGTCTGACGGACGCGGCGGGCCATGACGGCTACGGCGTGCTGACCGTGACGCTCGACGATCCCACGGGCT
ACGGCCGCATCGTGCGCGACGCGCAAGGCAAGGTCGAGCGCATCGTCGAACAGAAGGACGCGACGGCCGAACAGCAGAAG
ATCGCAGAGATCAACACGGGCATCGTCGTGATGCCGACGAAGCGTCTCGACGGCTGGTTGTCTTCGCTGAAGAACGAGAA
TGCGCAGGGCGAGTTCTATCTGACCGACGTCGTCGAACTGGCTATCGAAGCGGGCATCGAAGTCGTCACCGCGCAGCCCG
ATGAAGAATGGGAGACGCTCGGCGTCAACAGCAAGCAGCAGCTTGCCGAACTCGAACGCATTCATCAGCGCAACGTCGCG
GACGATCTTCTTGTGGCGGGCGTGACGATTGCCGACCCGGCGCGCATCGACGTGCGCGGTACGCTCGAATGCGGCCGCGA
CGTGTCGATCGACGTGAACTGCGTGTTCGAAGGCAAGGTGACGCTGGGGGACAACGTATCGATCGGGCCGAACTGCGTGA
TCCGCAATGCGACGATTGGCGCGGGTACGCGCATCGACGCCTACACGCATATCGAAGGCGCGCAAGTCGGCGCGCAAGCC
GTGCTTGGTCCGTATGCGCGCCTGCGTCCGGGCGCAACGCTGTCGGACGAGACGCACATCGGCAATTTCGTCGAAGTGAA
GAACGCGGTGCTCGGTCATGGTTCGAAGGCGAATCACTTGTCGTACATCGGCGATTCAGATGTCGGCGCGCGAGTGAACA
TCGGCGCGGGCACGATCACCTGCAACTACGACGGTGCGAACAAGTTCCGCACGATCATCGAAGACGATGTGTTCGTCGGC
TCGGATACGCAACTGGTGGCGCCCGTGCGCGTCGGCCGCGGTGTGACGATCGCGGCGGGCACGACGGTCTGGAAGGATGT
CGAAGAAGGCCTGCTGGTGCTCAACGAAAAGACCCAGATCGGCAAAACCGGCTACGTGCGCCCAACGAAAAAGAAAAGCT
AA

Upstream 100 bases:

>100_bases
CTCCCCGCAAAGCCTTTGAAAACAGGCATTTGCGGGGCGATGCAGACACATCCAGCGTGCTAAAATCGCGCACTCCAAAC
TCGTCAAATACGCCCACGTC

Downstream 100 bases:

>100_bases
GGGAAACGCGTGCGCGAGACGCGCCACGACCCCCAACTCTGCAAAGGACCATTGAATATGTGCGGCATTGTCGGCGCTGT
TGCCCAGCGAAACATCGTTT

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MNIVILAAGTGKRMRSALPKVLHPLAGRPLLAHVIDTARTLNPTRLVVVVGHGADQVRTAVAASDVQFALQEQQLGTGHA
VQQALPLLDPSAPTLVLYGDVPLTKASTLKRLTDAAGHDGYGVLTVTLDDPTGYGRIVRDAQGKVERIVEQKDATAEQQK
IAEINTGIVVMPTKRLDGWLSSLKNENAQGEFYLTDVVELAIEAGIEVVTAQPDEEWETLGVNSKQQLAELERIHQRNVA
DDLLVAGVTIADPARIDVRGTLECGRDVSIDVNCVFEGKVTLGDNVSIGPNCVIRNATIGAGTRIDAYTHIEGAQVGAQA
VLGPYARLRPGATLSDETHIGNFVEVKNAVLGHGSKANHLSYIGDSDVGARVNIGAGTITCNYDGANKFRTIIEDDVFVG
SDTQLVAPVRVGRGVTIAAGTTVWKDVEEGLLVLNEKTQIGKTGYVRPTKKKS

Sequences:

>Translated_453_residues
MNIVILAAGTGKRMRSALPKVLHPLAGRPLLAHVIDTARTLNPTRLVVVVGHGADQVRTAVAASDVQFALQEQQLGTGHA
VQQALPLLDPSAPTLVLYGDVPLTKASTLKRLTDAAGHDGYGVLTVTLDDPTGYGRIVRDAQGKVERIVEQKDATAEQQK
IAEINTGIVVMPTKRLDGWLSSLKNENAQGEFYLTDVVELAIEAGIEVVTAQPDEEWETLGVNSKQQLAELERIHQRNVA
DDLLVAGVTIADPARIDVRGTLECGRDVSIDVNCVFEGKVTLGDNVSIGPNCVIRNATIGAGTRIDAYTHIEGAQVGAQA
VLGPYARLRPGATLSDETHIGNFVEVKNAVLGHGSKANHLSYIGDSDVGARVNIGAGTITCNYDGANKFRTIIEDDVFVG
SDTQLVAPVRVGRGVTIAAGTTVWKDVEEGLLVLNEKTQIGKTGYVRPTKKKS
>Mature_453_residues
MNIVILAAGTGKRMRSALPKVLHPLAGRPLLAHVIDTARTLNPTRLVVVVGHGADQVRTAVAASDVQFALQEQQLGTGHA
VQQALPLLDPSAPTLVLYGDVPLTKASTLKRLTDAAGHDGYGVLTVTLDDPTGYGRIVRDAQGKVERIVEQKDATAEQQK
IAEINTGIVVMPTKRLDGWLSSLKNENAQGEFYLTDVVELAIEAGIEVVTAQPDEEWETLGVNSKQQLAELERIHQRNVA
DDLLVAGVTIADPARIDVRGTLECGRDVSIDVNCVFEGKVTLGDNVSIGPNCVIRNATIGAGTRIDAYTHIEGAQVGAQA
VLGPYARLRPGATLSDETHIGNFVEVKNAVLGHGSKANHLSYIGDSDVGARVNIGAGTITCNYDGANKFRTIIEDDVFVG
SDTQLVAPVRVGRGVTIAAGTTVWKDVEEGLLVLNEKTQIGKTGYVRPTKKKS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=452, Percent_Identity=55.9734513274336, Blast_Score=498, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_BURP8 (B2JIL7)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001859109.1
- ProteinModelPortal:   B2JIL7
- SMR:   B2JIL7
- GeneID:   6244374
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_2891
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   CLSK930247
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00132 Hexapep; PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 48184; Mature: 48184

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 359-359 BINDING 71-71 BINDING 135-135 BINDING 150-150 BINDING 165-165 BINDING 383-383 BINDING 401-401 BINDING 419-419

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVILAAGTGKRMRSALPKVLHPLAGRPLLAHVIDTARTLNPTRLVVVVGHGADQVRTA
CEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHH
VAASDVQFALQEQQLGTGHAVQQALPLLDPSAPTLVLYGDVPLTKASTLKRLTDAAGHDG
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
YGVLTVTLDDPTGYGRIVRDAQGKVERIVEQKDATAEQQKIAEINTGIVVMPTKRLDGWL
EEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECHHHHHHH
SSLKNENAQGEFYLTDVVELAIEAGIEVVTAQPDEEWETLGVNSKQQLAELERIHQRNVA
HHHCCCCCCCCEEHHHHHHHHHHCCCEEEECCCCCCHHHCCCCCHHHHHHHHHHHHCCCC
DDLLVAGVTIADPARIDVRGTLECGRDVSIDVNCVFEGKVTLGDNVSIGPNCVIRNATIG
CHHHEECEEECCCCEEEEEEECCCCCCCEEEEEEEEECEEEECCCCCCCCCEEEEECCCC
AGTRIDAYTHIEGAQVGAQAVLGPYARLRPGATLSDETHIGNFVEVKNAVLGHGSKANHL
CCCEEEEEEECCCHHHCHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCE
SYIGDSDVGARVNIGAGTITCNYDGANKFRTIIEDDVFVGSDTQLVAPVRVGRGVTIAAG
EECCCCCCCCEEEECCEEEEEECCCCHHHHHHHCCCEEECCCCEEEEEEECCCCEEEEEC
TTVWKDVEEGLLVLNEKTQIGKTGYVRPTKKKS
CHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNIVILAAGTGKRMRSALPKVLHPLAGRPLLAHVIDTARTLNPTRLVVVVGHGADQVRTA
CEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHH
VAASDVQFALQEQQLGTGHAVQQALPLLDPSAPTLVLYGDVPLTKASTLKRLTDAAGHDG
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
YGVLTVTLDDPTGYGRIVRDAQGKVERIVEQKDATAEQQKIAEINTGIVVMPTKRLDGWL
EEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECHHHHHHH
SSLKNENAQGEFYLTDVVELAIEAGIEVVTAQPDEEWETLGVNSKQQLAELERIHQRNVA
HHHCCCCCCCCEEHHHHHHHHHHCCCEEEECCCCCCHHHCCCCCHHHHHHHHHHHHCCCC
DDLLVAGVTIADPARIDVRGTLECGRDVSIDVNCVFEGKVTLGDNVSIGPNCVIRNATIG
CHHHEECEEECCCCEEEEEEECCCCCCCEEEEEEEEECEEEECCCCCCCCCEEEEECCCC
AGTRIDAYTHIEGAQVGAQAVLGPYARLRPGATLSDETHIGNFVEVKNAVLGHGSKANHL
CCCEEEEEEECCCHHHCHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCE
SYIGDSDVGARVNIGAGTITCNYDGANKFRTIIEDDVFVGSDTQLVAPVRVGRGVTIAAG
EECCCCCCCCEEEECCEEEEEECCCCHHHHHHHCCCEEECCCCEEEEEEECCCCEEEEEC
TTVWKDVEEGLLVLNEKTQIGKTGYVRPTKKKS
CHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA