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The map label for this gene is glmS [H]

Identifier: 186477638

GI number: 186477638

Start: 3244370

End: 3246187

Strand: Reverse

Name: glmS [H]

Synonym: Bphy_2890

Alternate gene names: 186477638

Gene position: 3246187-3244370 (Counterclockwise)

Preceding gene: 186477639

Following gene: 186477635

Centisome position: 93.3

GC content: 63.53

Gene sequence:

>1818_bases
ATGTGCGGCATTGTCGGCGCTGTTGCCCAGCGAAACATCGTTTCCGTCTTGATCGAAGGACTGCGTCGCCTCGAATATCG
CGGCTATGACTCGTGCGGCGTCGCCGTACTGGCGGACGGCGAGCCGAAGCGGGCACGCAGCGTCGCGCGCGTGGCCGATC
TCGACGACCAGGTGCGCGAGACGCGTCTCGAAGGCGCTACGGGGATCGCGCATACGCGCTGGGCCACGCACGGTGCGCCC
GTCACGGATAACGCGCATCCGATCTTCTCGCGCAACGAACTGGCGCTCGTGCACAACGGCATCATCGAGAACTACGAGTC
GCTGCGCGAGATGCTGCGCGGCAAAGGCTACGCGTTCGTCTCGCAGACCGATACGGAAGTGATCGCGCATCTCATCCATA
GCCTGTATCGCGACGATCTGTTCGCGGCCGTGCAAGAAGCGACGGCGCAGCTGCACGGCGCATATGCGATCGCCGTGTTG
CACAAGCGCCAGCCGAATACGGTGGTCGGCGCGCGCCAGGGCTCGCCGCTCGTCGTCGGTCTCGGCGAAGGCGAGAATTT
CCTCGCGTCGGACGCGCTCGCGCTGGCGGGCAGCACCGACCGTTTCATCTTCCTCGAAGAAGGCGACGTCTGCGAACTGA
CGCTGGAAAAGGTGCGCGTGTTCGATCGCGACGGCAAGCCCGCCCATCGCGAAGTGCGTCAGGTCGCGGCTTACGGCGGC
GCGGTCGAACTCGGGCCGTATCGACACTTCATGCAGAAGGAAATCTTCGAGCAGCCGCGCGCGATCACCGACACGATCCC
TCAAGCCGATGCGTTCAATGCATCGCTGTTCGGCGAAGACGCAGGAAAAGCGTTTTCCGAAATCGACAACCTGCTGATTC
TCGCGTGCGGCACGAGCTACTACTCGGGCCTGACGGCGAAGTACTGGCTCGAATCGGTGGCGAAGATTCCGACCCAGGTC
GAAATCGCCAGCGAATACCGTTATCGCGATTCGGTGCCGAATCCGAAGTCGCTGGTCGTCGTGATTTCGCAATCGGGCGA
AACGGCCGACACGCTCGCGGCGCTCAAGCATGCGCAAGCGCTGGGTCACAAGCACACGCTGTCGGTATGCAACGTCGGCA
CGAGCGCGATGGTGCGCCTCACGGAGCTGTCGTTCCTCACGCACGCCGGGCGCGAAATCGGCGTCGCATCGACGAAGGCA
TTCACGACCCAGCTCGTCGCGCTGTTTGTGCTTGCCGCGACGCTCGGCAAGATGCGCGGTCACGTCAGCGCGGCGCAGGA
AGCGGACTATATTCGCCAGTTGCGCCACCTGCCTGCCGCGCTCAACAGCGTGCTGGCGCTGGAGCCGCAGATCATCGCGT
GGTCGGAAGAATTCTCGCGCAAAGAGAACGCGCTGTTCCTCGGCCGCGGCCTGCACTATCCGATCGCACTGGAAGGCGCG
CTAAAGCTGAAGGAAATTTCGTACATTCACGCGGAGGCTTATCCGGCGGGCGAACTCAAGCATGGGCCGCTTGCGCTCGT
CACGGAAGCGATGCCCGTCGTGACGGTCGCGCCGAACGATGCGCTGCTCGAGAAGCTCAAGTCGAACATTCAGGAAGTGC
GTGCACGCGGCGGCCAACTGTATGTGTTCGCCGACGCCGACACGAAGATCGTCAACGACGAAGGGCTGCACGTGATCCGC
ATGCCGGAACACTACGGCCCGCTGTCGCCGATCCTGCATGTCGTGCCTCTGCAGATGCTCGCGTATCACACGGCTTGCGC
ACGCGGTACGGACGTCGACAAGCCGCGCAATCTCGCGAAGTCGGTGACGGTGGAGTGA

Upstream 100 bases:

>100_bases
CGGCAAAACCGGCTACGTGCGCCCAACGAAAAAGAAAAGCTAAGGGAAACGCGTGCGCGAGACGCGCCACGACCCCCAAC
TCTGCAAAGGACCATTGAAT

Downstream 100 bases:

>100_bases
GGTTGTAGTCGCTTCATACGCGTTCTGGATACGGCGCCGCAATCGCGGACGTATTCAGAACCGGCCGGTTCGAGTTCTTC
TCTTCTTCTTCCCTCCCTCA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MCGIVGAVAQRNIVSVLIEGLRRLEYRGYDSCGVAVLADGEPKRARSVARVADLDDQVRETRLEGATGIAHTRWATHGAP
VTDNAHPIFSRNELALVHNGIIENYESLREMLRGKGYAFVSQTDTEVIAHLIHSLYRDDLFAAVQEATAQLHGAYAIAVL
HKRQPNTVVGARQGSPLVVGLGEGENFLASDALALAGSTDRFIFLEEGDVCELTLEKVRVFDRDGKPAHREVRQVAAYGG
AVELGPYRHFMQKEIFEQPRAITDTIPQADAFNASLFGEDAGKAFSEIDNLLILACGTSYYSGLTAKYWLESVAKIPTQV
EIASEYRYRDSVPNPKSLVVVISQSGETADTLAALKHAQALGHKHTLSVCNVGTSAMVRLTELSFLTHAGREIGVASTKA
FTTQLVALFVLAATLGKMRGHVSAAQEADYIRQLRHLPAALNSVLALEPQIIAWSEEFSRKENALFLGRGLHYPIALEGA
LKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEVRARGGQLYVFADADTKIVNDEGLHVIR
MPEHYGPLSPILHVVPLQMLAYHTACARGTDVDKPRNLAKSVTVE

Sequences:

>Translated_605_residues
MCGIVGAVAQRNIVSVLIEGLRRLEYRGYDSCGVAVLADGEPKRARSVARVADLDDQVRETRLEGATGIAHTRWATHGAP
VTDNAHPIFSRNELALVHNGIIENYESLREMLRGKGYAFVSQTDTEVIAHLIHSLYRDDLFAAVQEATAQLHGAYAIAVL
HKRQPNTVVGARQGSPLVVGLGEGENFLASDALALAGSTDRFIFLEEGDVCELTLEKVRVFDRDGKPAHREVRQVAAYGG
AVELGPYRHFMQKEIFEQPRAITDTIPQADAFNASLFGEDAGKAFSEIDNLLILACGTSYYSGLTAKYWLESVAKIPTQV
EIASEYRYRDSVPNPKSLVVVISQSGETADTLAALKHAQALGHKHTLSVCNVGTSAMVRLTELSFLTHAGREIGVASTKA
FTTQLVALFVLAATLGKMRGHVSAAQEADYIRQLRHLPAALNSVLALEPQIIAWSEEFSRKENALFLGRGLHYPIALEGA
LKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEVRARGGQLYVFADADTKIVNDEGLHVIR
MPEHYGPLSPILHVVPLQMLAYHTACARGTDVDKPRNLAKSVTVE
>Mature_605_residues
MCGIVGAVAQRNIVSVLIEGLRRLEYRGYDSCGVAVLADGEPKRARSVARVADLDDQVRETRLEGATGIAHTRWATHGAP
VTDNAHPIFSRNELALVHNGIIENYESLREMLRGKGYAFVSQTDTEVIAHLIHSLYRDDLFAAVQEATAQLHGAYAIAVL
HKRQPNTVVGARQGSPLVVGLGEGENFLASDALALAGSTDRFIFLEEGDVCELTLEKVRVFDRDGKPAHREVRQVAAYGG
AVELGPYRHFMQKEIFEQPRAITDTIPQADAFNASLFGEDAGKAFSEIDNLLILACGTSYYSGLTAKYWLESVAKIPTQV
EIASEYRYRDSVPNPKSLVVVISQSGETADTLAALKHAQALGHKHTLSVCNVGTSAMVRLTELSFLTHAGREIGVASTKA
FTTQLVALFVLAATLGKMRGHVSAAQEADYIRQLRHLPAALNSVLALEPQIIAWSEEFSRKENALFLGRGLHYPIALEGA
LKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEVRARGGQLYVFADADTKIVNDEGLHVIR
MPEHYGPLSPILHVVPLQMLAYHTACARGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=36.2973760932945, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI205277386, Length=686, Percent_Identity=36.5889212827988, Blast_Score=388, Evalue=1e-107,
Organism=Escherichia coli, GI1790167, Length=611, Percent_Identity=55.4828150572831, Blast_Score=661, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=232, Percent_Identity=27.5862068965517, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=434, Percent_Identity=38.4792626728111, Blast_Score=277, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI17532899, Length=434, Percent_Identity=36.8663594470046, Blast_Score=269, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17532897, Length=434, Percent_Identity=36.8663594470046, Blast_Score=268, Evalue=7e-72,
Organism=Saccharomyces cerevisiae, GI6322745, Length=451, Percent_Identity=36.5853658536585, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6323731, Length=432, Percent_Identity=30.3240740740741, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=35.609756097561, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323958, Length=209, Percent_Identity=28.2296650717703, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357745, Length=685, Percent_Identity=35.4744525547445, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI28573187, Length=266, Percent_Identity=24.812030075188, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24659598, Length=269, Percent_Identity=24.907063197026, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65870; Mature: 65870

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVAQRNIVSVLIEGLRRLEYRGYDSCGVAVLADGEPKRARSVARVADLDDQVRE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHHH
TRLEGATGIAHTRWATHGAPVTDNAHPIFSRNELALVHNGIIENYESLREMLRGKGYAFV
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEE
SQTDTEVIAHLIHSLYRDDLFAAVQEATAQLHGAYAIAVLHKRQPNTVVGARQGSPLVVG
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCCCEEEE
LGEGENFLASDALALAGSTDRFIFLEEGDVCELTLEKVRVFDRDGKPAHREVRQVAAYGG
CCCCCCCHHHHHHHCCCCCCCEEEEECCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
AVELGPYRHFMQKEIFEQPRAITDTIPQADAFNASLFGEDAGKAFSEIDNLLILACGTSY
EEEECHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHCCCHHHHHHHHHCCEEEEEECCHH
YSGLTAKYWLESVAKIPTQVEIASEYRYRDSVPNPKSLVVVISQSGETADTLAALKHAQA
HCCCHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
LGHKHTLSVCNVGTSAMVRLTELSFLTHAGREIGVASTKAFTTQLVALFVLAATLGKMRG
HCCCCEEHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
HVSAAQEADYIRQLRHLPAALNSVLALEPQIIAWSEEFSRKENALFLGRGLHYPIALEGA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHCCCCCEEEEECCCCCCEEECCC
LKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEVRARGGQL
EEHHHHHEEEECCCCCCCCCCCCHHEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCEE
YVFADADTKIVNDEGLHVIRMPEHYGPLSPILHVVPLQMLAYHTACARGTDVDKPRNLAK
EEEECCCCEEECCCCEEEEECCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SVTVE
HCCCC
>Mature Secondary Structure
MCGIVGAVAQRNIVSVLIEGLRRLEYRGYDSCGVAVLADGEPKRARSVARVADLDDQVRE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHHH
TRLEGATGIAHTRWATHGAPVTDNAHPIFSRNELALVHNGIIENYESLREMLRGKGYAFV
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEE
SQTDTEVIAHLIHSLYRDDLFAAVQEATAQLHGAYAIAVLHKRQPNTVVGARQGSPLVVG
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCCCEEEE
LGEGENFLASDALALAGSTDRFIFLEEGDVCELTLEKVRVFDRDGKPAHREVRQVAAYGG
CCCCCCCHHHHHHHCCCCCCCEEEEECCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
AVELGPYRHFMQKEIFEQPRAITDTIPQADAFNASLFGEDAGKAFSEIDNLLILACGTSY
EEEECHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHCCCHHHHHHHHHCCEEEEEECCHH
YSGLTAKYWLESVAKIPTQVEIASEYRYRDSVPNPKSLVVVISQSGETADTLAALKHAQA
HCCCHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
LGHKHTLSVCNVGTSAMVRLTELSFLTHAGREIGVASTKAFTTQLVALFVLAATLGKMRG
HCCCCEEHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
HVSAAQEADYIRQLRHLPAALNSVLALEPQIIAWSEEFSRKENALFLGRGLHYPIALEGA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHCCCCCEEEEECCCCCCEEECCC
LKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEVRARGGQL
EEHHHHHEEEECCCCCCCCCCCCHHEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCEE
YVFADADTKIVNDEGLHVIRMPEHYGPLSPILHVVPLQMLAYHTACARGTDVDKPRNLAK
EEEECCCCEEECCCCEEEEECCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SVTVE
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]