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The map label for this gene is hitA [H]

Identifier: 186477497

GI number: 186477497

Start: 3103098

End: 3103472

Strand: Reverse

Name: hitA [H]

Synonym: Bphy_2749

Alternate gene names: 186477497

Gene position: 3103472-3103098 (Counterclockwise)

Preceding gene: 186477498

Following gene: 186477496

Centisome position: 89.2

GC content: 58.93

Gene sequence:

>375_bases
ATGAAGACCATGAGCCACCATCCGAACTGCCTTTTCTGCAAGATCGCCGCGGGAGAAATCCCCTCGACCAAAGTTCATGA
AGACGACGAGTTCATTGCGTTCCGCGACATCCGTCCCGCAGCCGAAACGCATGTGCTCGTGATTCCGCGAAAACACATAG
AAACGCTGTCCAATTGCACGGAAAGCGATTCCGTGCTGCTTGGTAAAATGTTGATATTGGTTGCACGTCTGGCCGATCAG
CTTGGCGTCGCCTACACGGGCGGCCAGACGGGCTTCCGCACGGTCATCAATACGGGGCCTGGCGGCGGTCAGGAGGTCTA
TCACCTGCACGCGCACCTGCTGGCGGGACCGCGGCCGTGGCTGAGGATGGGCTGA

Upstream 100 bases:

>100_bases
ATCAAGGGCTGGCTGTATCTGTACGACAACAAGCCGCTGACGAATCCGCGCGGCTGGTTTTGACCCACGCCGCATCGGGC
GCGCGCCGCGCTCGCCGTCC

Downstream 100 bases:

>100_bases
ACGCGGTGGCGCAGTTTGCGGGACCGGCGTGTTGCCAGCGTAGGCACGCAACCAATCGACATAGATTCGCCGCATCGGCT
TTTTGACTACGCACAATGGC

Product: histidine triad (HIT) protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 124; Mature: 124

Protein sequence:

>124_residues
MKTMSHHPNCLFCKIAAGEIPSTKVHEDDEFIAFRDIRPAAETHVLVIPRKHIETLSNCTESDSVLLGKMLILVARLADQ
LGVAYTGGQTGFRTVINTGPGGGQEVYHLHAHLLAGPRPWLRMG

Sequences:

>Translated_124_residues
MKTMSHHPNCLFCKIAAGEIPSTKVHEDDEFIAFRDIRPAAETHVLVIPRKHIETLSNCTESDSVLLGKMLILVARLADQ
LGVAYTGGQTGFRTVINTGPGGGQEVYHLHAHLLAGPRPWLRMG
>Mature_124_residues
MKTMSHHPNCLFCKIAAGEIPSTKVHEDDEFIAFRDIRPAAETHVLVIPRKHIETLSNCTESDSVLLGKMLILVARLADQ
LGVAYTGGQTGFRTVINTGPGGGQEVYHLHAHLLAGPRPWLRMG

Specific function: Unknown

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

Organism=Homo sapiens, GI4885413, Length=108, Percent_Identity=44.4444444444444, Blast_Score=96, Evalue=8e-21,
Organism=Homo sapiens, GI14211923, Length=107, Percent_Identity=39.2523364485981, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1787346, Length=111, Percent_Identity=45.045045045045, Blast_Score=88, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17506713, Length=108, Percent_Identity=44.4444444444444, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI28574010, Length=115, Percent_Identity=44.3478260869565, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24581222, Length=115, Percent_Identity=44.3478260869565, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR019808
- InterPro:   IPR001310 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 13581; Mature: 13581

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTMSHHPNCLFCKIAAGEIPSTKVHEDDEFIAFRDIRPAAETHVLVIPRKHIETLSNCT
CCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCEEEEECHHHHHHHHCCC
ESDSVLLGKMLILVARLADQLGVAYTGGQTGFRTVINTGPGGGQEVYHLHAHLLAGPRPW
CCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCCCHHHHHEEEHHHCCCCCC
LRMG
CCCC
>Mature Secondary Structure
MKTMSHHPNCLFCKIAAGEIPSTKVHEDDEFIAFRDIRPAAETHVLVIPRKHIETLSNCT
CCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCEEEEECHHHHHHHHCCC
ESDSVLLGKMLILVARLADQLGVAYTGGQTGFRTVINTGPGGGQEVYHLHAHLLAGPRPW
CCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCCCHHHHHEEEHHHCCCCCC
LRMG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA