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The map label for this gene is proC [H]

Identifier: 186477266

GI number: 186477266

Start: 2836565

End: 2837380

Strand: Direct

Name: proC [H]

Synonym: Bphy_2518

Alternate gene names: 186477266

Gene position: 2836565-2837380 (Clockwise)

Preceding gene: 186477265

Following gene: 186477272

Centisome position: 81.53

GC content: 66.3

Gene sequence:

>816_bases
ATGAAAATTGCCTTCATCGGCGGCGGCAACATGGCCGCCGCGCTCATCGGCGGAATGATCAAGCGCGGCGTGGCGCCGGC
TGATATTCTCGCGATCGATCCCAACGAAGACGCGCGCAAGCGCAACGAACAGCAGTTCGGCATCGGCACGGGCGCTTCGG
CGGATGCGTCGCTGAAATCGTTCGATGCCGTCGTGCTTGCCGTGAAACCGCAAATCGTCAAAGACGTCGCTGCCGCGCTC
GCGCCGCATCTGTCGCCTTCGCAACTCGTCATCAGCATCGTCGCGGGCATTCGCAGCGCGGACCTTTCGCGCTGGCTCGG
CGGCCACGCGCGCGTCGCGCGCACGATGCCGAACACGCCAGCGCTGATCGGCATGGGCGTGACAGGTCTGGTGGCGACGG
AAGGCGTCGATGAAGCGGGACGCGATCTGGCGTCCCAGGTGCTCGGCGCAGTCGGGCAAACGGTGTGGTTCGACAACGAA
GCGAAGATCGATGCCGTCACCGCGATCTCCGGCAGCGGGCCTGCCTACGTGTTCTACTTCATCGAAGCCATGCAGGAAGC
GGCGCGGCAACTCGGCATGGACGACGAGCAAGGCCGTGCACTGGCTGTCGCCACGTTCACTGGCGCGGCGCAGCTCGCCG
CGCAATCGGGCGAACCGGCTAGCGTGCTGCGCGAGCGCGTGACGTCGAAGGGCGGCACGACAGCGGCAGCGCTCGCCTCA
TTCGACGCGCAAGGCGTGAAGGACGCGATCGTACGCGGCGCGTTGGCCGCGGATGCTCGTGCGCGCGAGATGGGAGAGGA
ATTCGGCAAGCAATGA

Upstream 100 bases:

>100_bases
GCGATCTCGAAGCGGCCGTGCTCGAAGGCGCGACTATCGTACGCGTCGGCACCGCGATCTTCGGCGCCCGCGATTACTCT
CACTGAACTTCACGAACATC

Downstream 100 bases:

>100_bases
TGTTGCTTGCCTGAACCGGTCGGCAGACGGTGCACGCGTTATGCGGGCCTCGTCGCGCCGATAAAGGGAGGCTCATAACG
CCGCGGGAAACAAGACTCAG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MKIAFIGGGNMAAALIGGMIKRGVAPADILAIDPNEDARKRNEQQFGIGTGASADASLKSFDAVVLAVKPQIVKDVAAAL
APHLSPSQLVISIVAGIRSADLSRWLGGHARVARTMPNTPALIGMGVTGLVATEGVDEAGRDLASQVLGAVGQTVWFDNE
AKIDAVTAISGSGPAYVFYFIEAMQEAARQLGMDDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALAS
FDAQGVKDAIVRGALAADARAREMGEEFGKQ

Sequences:

>Translated_271_residues
MKIAFIGGGNMAAALIGGMIKRGVAPADILAIDPNEDARKRNEQQFGIGTGASADASLKSFDAVVLAVKPQIVKDVAAAL
APHLSPSQLVISIVAGIRSADLSRWLGGHARVARTMPNTPALIGMGVTGLVATEGVDEAGRDLASQVLGAVGQTVWFDNE
AKIDAVTAISGSGPAYVFYFIEAMQEAARQLGMDDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALAS
FDAQGVKDAIVRGALAADARAREMGEEFGKQ
>Mature_271_residues
MKIAFIGGGNMAAALIGGMIKRGVAPADILAIDPNEDARKRNEQQFGIGTGASADASLKSFDAVVLAVKPQIVKDVAAAL
APHLSPSQLVISIVAGIRSADLSRWLGGHARVARTMPNTPALIGMGVTGLVATEGVDEAGRDLASQVLGAVGQTVWFDNE
AKIDAVTAISGSGPAYVFYFIEAMQEAARQLGMDDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALAS
FDAQGVKDAIVRGALAADARAREMGEEFGKQ

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=31.4393939393939, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24797095, Length=270, Percent_Identity=30.3703703703704, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI24797097, Length=270, Percent_Identity=30.3703703703704, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI21361454, Length=270, Percent_Identity=28.8888888888889, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=34.8148148148148, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=33.0855018587361, Blast_Score=134, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17540664, Length=283, Percent_Identity=28.6219081272085, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320861, Length=227, Percent_Identity=29.9559471365639, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=35.4716981132075, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24648116, Length=277, Percent_Identity=29.6028880866426, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=36.6863905325444, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27746; Mature: 27746

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAFIGGGNMAAALIGGMIKRGVAPADILAIDPNEDARKRNEQQFGIGTGASADASLKS
CEEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCHHHHCCCHHCCCCCCCCCCCHHHH
FDAVVLAVKPQIVKDVAAALAPHLSPSQLVISIVAGIRSADLSRWLGGHARVARTMPNTP
HCEEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCC
ALIGMGVTGLVATEGVDEAGRDLASQVLGAVGQTVWFDNEAKIDAVTAISGSGPAYVFYF
CEEECCCHHHHHCCCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEECCCCCCHHHHH
IEAMQEAARQLGMDDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALAS
HHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHH
FDAQGVKDAIVRGALAADARAREMGEEFGKQ
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAFIGGGNMAAALIGGMIKRGVAPADILAIDPNEDARKRNEQQFGIGTGASADASLKS
CEEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCHHHHCCCHHCCCCCCCCCCCHHHH
FDAVVLAVKPQIVKDVAAALAPHLSPSQLVISIVAGIRSADLSRWLGGHARVARTMPNTP
HCEEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCC
ALIGMGVTGLVATEGVDEAGRDLASQVLGAVGQTVWFDNEAKIDAVTAISGSGPAYVFYF
CEEECCCHHHHHCCCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEECCCCCCHHHHH
IEAMQEAARQLGMDDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALAS
HHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHH
FDAQGVKDAIVRGALAADARAREMGEEFGKQ
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]