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The map label for this gene is mutL [H]

Identifier: 186477234

GI number: 186477234

Start: 2793941

End: 2796016

Strand: Direct

Name: mutL [H]

Synonym: Bphy_2485

Alternate gene names: 186477234

Gene position: 2793941-2796016 (Clockwise)

Preceding gene: 186477232

Following gene: 186477235

Centisome position: 80.3

GC content: 67.44

Gene sequence:

>2076_bases
ATGTCCGCGATCCCCGAATCTTCCGAAACGCGCGCCGACGCGCCCGCCGCTCACGCGGCTGCGAGCCGCGACGCCGGCGC
AGCCGACAACGCCCTCACGCCGCGTCCGCCGCGCGCCATCCAGCCGCTGCCCGACCAGTTGATCAGCCAGATCGCGGCGG
GCGAAGTGGTCGAGCGGCCGGCGTCCGTCGTCAAGGAACTGCTGGAGAACGCGCTCGACGCGGGCGCGACGGCGCTGCGC
ATCCTGCTCGACGAAGGCGGCGTCAAGCGCATTTCGATCACCGACGACGGCTGCGGCATTCCCGAAGGGGAACTGGCGCT
CGCGCTGATGCGCCACGCGACGAGCAAGATCCGCTCGCTCGCGGAACTCGAAGCAGTCGCGACACTCGGGTTTCGCGGCG
AAGCGCTGGCATCGATCGCGTCGGTGTCGGAAATGCACATCACGAGCCGCACTGAGACCGTTTCGCACGCGACGCGCATC
GATGCGCAGACGGGCGCGCTCTCGCCGGCAGCGGGCACGCGCGGCACGACGATCGAAGTGCGCGAGCTTTATTTCAATAC
GCCCGCGCGCCGCAAATTCCTCAAGAGCGAGCAGACGGAGCTCGGCCATTGCCTCGAGATGATCCGGCGCGCAGCGCTCG
CGCGGCCTGACGTCGCGATTTCAGTGCTGCATAACGGGCGCGCCGTTGAGCACTGGAACGCAAGCGATCCCGCGACGCGC
GTCGCGAAGATCCTTGGCGAGACGTTCGCAAGTGCGCATCTGCCGCTCGACGAATCGGCGGGACCGCTCGCCGTGTACGG
CTGCGCCGGCCTGCCGACCGCGAGCCGCGGACGCGCGGATCAGCAGTATTTCTTCGTCAACGGCCGCTTCGTGCGCGACA
AGCTGCTCACGCATGCGGTCCGCGCCGCGTATGAGGACGTTCTGCATGGCGATCGCTATCCGTCCTATGTGCTGTTCCTC
GATCTGCCGCCCGAGGCCGTCGACGTGAACGTGCATCCGTCGAAAATCGAGGTGCGCTTCCGCGACTCGCGCTCGATTCA
CCAGTTCGTGTTCCATGCCGTGCAGCGCGCGCTGGCCAGACACGCGGGCGCATCGCCGGAAACGACGTCGGGCGGTCATG
CTGCGCGTATCGAACCGATGCCATCCGCGTCGCCCGTGTCGACTTTTTCGACCGGCACGCCTGCTTCGTTCGGCTCCGCG
CCGCTCGGTGCCGGCTTCAGGGTCGGCGACGGCGGCGGCTCGCAGCCGGGCAACACGTGGATGCGCCAGGCGCGCATGAC
GCAGGGCACGCTGCCCGTCGCACAGCCGCTCGCGCTTTACGACGCGCTATTCGGCCGCAAAGATTCAGGCGCCGGCACAT
CGCAAGGCACGACCTCCCTCGAATTGCGCGATGCCGCGGACGCGGCTGACGGCGCGGTTGCGCCCTTGCCTTTCGGGAGC
TTCGCAACCGCCCAGCCGTTTGCAGCAGCGCAGAGTTTCAATCCGCACGACGAGCAGCCGCTCGGCTTCGCGCTTGGCCA
GATCCACGGTATCTATGTGCTCGCGCAGAACGCGCGTGGACTCGTGATCGTCGACATGCACGCGGCGCATGAACGCATCC
TGTACGAGCAGTTCAAGAATGCGCTCGCCGATCGCGCGATCGCGGTGCAGCCGCTGCTGATTCCCGTTTCGATGACAGCG
GACGCCGTCGAAATCGGCGTGGTCGAAGAAGAGCGTGAGACGCTCGATGCGCTCGGCTTCGATCTCGCCGTGCTGTCGCC
GACGACCATCGCGATCCGCGCCGTCCCTGCGCTCCTGAAGGACGCGGATCTGCAGGCGCTGGCGCGCGCGGTCCTGTCCG
ATCTGCATGCGTACGGCGGCTCGCGCGTGCTGACTGAGCGCCAGCATGAATTGCTGGGCACGCTCGCGTGCCATCACGCC
GTGCGCGCGAACCGGCGGCTGACGCTCGATGAAATGAATGCGCTGTTGCGGCAGATGGAAGCGACGGAACGCGCCGATCA
ATGCAATCACGGGCGCCCGACGTGGTATCAGCTGACGCTCGCCGATCTCGACCGGCTGTTCATGCGCGGTCAGTGA

Upstream 100 bases:

>100_bases
TGACCGCGCCATGATACCGAAAGTGCCATGACCTCTTGAAAAAAAGTCGCCGGCGGTTTCCCCGTTCAGACGGTTTGCGA
CGAATCGCTATAATTTCGCC

Downstream 100 bases:

>100_bases
GCGGCTCCGTTTCTTTCATTCGCTCACGCTTTTCATGATGCAGCGCGCACCGCAACCCATCGCCTGTCTTCTCGGCCCGA
CCGCCTCCGGCAAGACGGCG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 691; Mature: 690

Protein sequence:

>691_residues
MSAIPESSETRADAPAAHAAASRDAGAADNALTPRPPRAIQPLPDQLISQIAAGEVVERPASVVKELLENALDAGATALR
ILLDEGGVKRISITDDGCGIPEGELALALMRHATSKIRSLAELEAVATLGFRGEALASIASVSEMHITSRTETVSHATRI
DAQTGALSPAAGTRGTTIEVRELYFNTPARRKFLKSEQTELGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASDPATR
VAKILGETFASAHLPLDESAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFL
DLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTSGGHAARIEPMPSASPVSTFSTGTPASFGSA
PLGAGFRVGDGGGSQPGNTWMRQARMTQGTLPVAQPLALYDALFGRKDSGAGTSQGTTSLELRDAADAADGAVAPLPFGS
FATAQPFAAAQSFNPHDEQPLGFALGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKNALADRAIAVQPLLIPVSMTA
DAVEIGVVEEERETLDALGFDLAVLSPTTIAIRAVPALLKDADLQALARAVLSDLHAYGGSRVLTERQHELLGTLACHHA
VRANRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLADLDRLFMRGQ

Sequences:

>Translated_691_residues
MSAIPESSETRADAPAAHAAASRDAGAADNALTPRPPRAIQPLPDQLISQIAAGEVVERPASVVKELLENALDAGATALR
ILLDEGGVKRISITDDGCGIPEGELALALMRHATSKIRSLAELEAVATLGFRGEALASIASVSEMHITSRTETVSHATRI
DAQTGALSPAAGTRGTTIEVRELYFNTPARRKFLKSEQTELGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASDPATR
VAKILGETFASAHLPLDESAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFL
DLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTSGGHAARIEPMPSASPVSTFSTGTPASFGSA
PLGAGFRVGDGGGSQPGNTWMRQARMTQGTLPVAQPLALYDALFGRKDSGAGTSQGTTSLELRDAADAADGAVAPLPFGS
FATAQPFAAAQSFNPHDEQPLGFALGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKNALADRAIAVQPLLIPVSMTA
DAVEIGVVEEERETLDALGFDLAVLSPTTIAIRAVPALLKDADLQALARAVLSDLHAYGGSRVLTERQHELLGTLACHHA
VRANRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLADLDRLFMRGQ
>Mature_690_residues
SAIPESSETRADAPAAHAAASRDAGAADNALTPRPPRAIQPLPDQLISQIAAGEVVERPASVVKELLENALDAGATALRI
LLDEGGVKRISITDDGCGIPEGELALALMRHATSKIRSLAELEAVATLGFRGEALASIASVSEMHITSRTETVSHATRID
AQTGALSPAAGTRGTTIEVRELYFNTPARRKFLKSEQTELGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASDPATRV
AKILGETFASAHLPLDESAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLD
LPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTSGGHAARIEPMPSASPVSTFSTGTPASFGSAP
LGAGFRVGDGGGSQPGNTWMRQARMTQGTLPVAQPLALYDALFGRKDSGAGTSQGTTSLELRDAADAADGAVAPLPFGSF
ATAQPFAAAQSFNPHDEQPLGFALGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKNALADRAIAVQPLLIPVSMTAD
AVEIGVVEEERETLDALGFDLAVLSPTTIAIRAVPALLKDADLQALARAVLSDLHAYGGSRVLTERQHELLGTLACHHAV
RANRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLADLDRLFMRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=34.5454545454545, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI4505911, Length=351, Percent_Identity=28.7749287749288, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI189458898, Length=351, Percent_Identity=28.7749287749288, Blast_Score=144, Evalue=4e-34,
Organism=Homo sapiens, GI4505913, Length=340, Percent_Identity=26.7647058823529, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI310128478, Length=340, Percent_Identity=26.7647058823529, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI189458896, Length=341, Percent_Identity=29.0322580645161, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI310128480, Length=300, Percent_Identity=24, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=31.063829787234, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1790612, Length=582, Percent_Identity=38.8316151202749, Blast_Score=333, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=34.375, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17562796, Length=411, Percent_Identity=25.0608272506083, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=407, Percent_Identity=30.7125307125307, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324247, Length=355, Percent_Identity=25.3521126760563, Blast_Score=114, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6325093, Length=718, Percent_Identity=20.1949860724234, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=146, Percent_Identity=29.4520547945205, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17136968, Length=312, Percent_Identity=34.9358974358974, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI17136970, Length=356, Percent_Identity=25.561797752809, Blast_Score=104, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 73792; Mature: 73661

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIPESSETRADAPAAHAAASRDAGAADNALTPRPPRAIQPLPDQLISQIAAGEVVERP
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ASVVKELLENALDAGATALRILLDEGGVKRISITDDGCGIPEGELALALMRHATSKIRSL
HHHHHHHHHHHHHCCHHEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
AELEAVATLGFRGEALASIASVSEMHITSRTETVSHATRIDAQTGALSPAAGTRGTTIEV
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
RELYFNTPARRKFLKSEQTELGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASDPATR
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHH
VAKILGETFASAHLPLDESAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAV
HHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHH
RAAYEDVLHGDRYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALAR
HHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHH
HAGASPETTSGGHAARIEPMPSASPVSTFSTGTPASFGSAPLGAGFRVGDGGGSQPGNTW
HCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHH
MRQARMTQGTLPVAQPLALYDALFGRKDSGAGTSQGTTSLELRDAADAADGAVAPLPFGS
HHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
FATAQPFAAAQSFNPHDEQPLGFALGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKN
CCCCCCHHHHCCCCCCCCCCHHHHHHHHCEEEEEEECCCCEEEEECHHHHHHHHHHHHHH
ALADRAIAVQPLLIPVSMTADAVEIGVVEEERETLDALGFDLAVLSPTTIAIRAVPALLK
HHHHCCEEECEEEEEEECCCCCEEEEEEHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHH
DADLQALARAVLSDLHAYGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQME
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
ATERADQCNHGRPTWYQLTLADLDRLFMRGQ
HHHHHHHCCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
SAIPESSETRADAPAAHAAASRDAGAADNALTPRPPRAIQPLPDQLISQIAAGEVVERP
CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ASVVKELLENALDAGATALRILLDEGGVKRISITDDGCGIPEGELALALMRHATSKIRSL
HHHHHHHHHHHHHCCHHEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
AELEAVATLGFRGEALASIASVSEMHITSRTETVSHATRIDAQTGALSPAAGTRGTTIEV
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
RELYFNTPARRKFLKSEQTELGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASDPATR
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHH
VAKILGETFASAHLPLDESAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAV
HHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHH
RAAYEDVLHGDRYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALAR
HHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHH
HAGASPETTSGGHAARIEPMPSASPVSTFSTGTPASFGSAPLGAGFRVGDGGGSQPGNTW
HCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHH
MRQARMTQGTLPVAQPLALYDALFGRKDSGAGTSQGTTSLELRDAADAADGAVAPLPFGS
HHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
FATAQPFAAAQSFNPHDEQPLGFALGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKN
CCCCCCHHHHCCCCCCCCCCHHHHHHHHCEEEEEEECCCCEEEEECHHHHHHHHHHHHHH
ALADRAIAVQPLLIPVSMTADAVEIGVVEEERETLDALGFDLAVLSPTTIAIRAVPALLK
HHHHCCEEECEEEEEEECCCCCEEEEEEHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHH
DADLQALARAVLSDLHAYGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQME
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
ATERADQCNHGRPTWYQLTLADLDRLFMRGQ
HHHHHHHCCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]