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The map label for this gene is betA [H]

Identifier: 186477130

GI number: 186477130

Start: 2671855

End: 2673570

Strand: Reverse

Name: betA [H]

Synonym: Bphy_2379

Alternate gene names: 186477130

Gene position: 2673570-2671855 (Counterclockwise)

Preceding gene: 186477131

Following gene: 186477128

Centisome position: 76.84

GC content: 57.58

Gene sequence:

>1716_bases
ATGTCAGCAGAAAAGATCGACGGAACCCGATCGAAGCAATCGTCCGGCGAGTTCGACTACATCGTGATCGGAGCAGGTAC
GGCCGGCTGCGTGGTCGCCAGTCGCCTGAGCGAAGATAATGACGTGTCTGTGCTGCTGGTAGAGGCGGGCGGAAAGGATA
ACTATCACTGGATTCATATACCGGTGGGTTATCTCTACTGCATCGGGAATCCACGGACCGACTGGCGTTACAAGACATCC
GAGGAGCCGGGGCTCAACGGCAGGGCGCTGGCTTATCCGCGAGGCCGGGTGCTGGGCGGCTGCTCGTCGATCAACGGCAT
GATCTACATGCGCGGTCAACGGGAGGACTACGACGATTGGGCTCGTATAACGGGCGACCACTCATGGGGATGGGATTCGG
TTCTCGACGCATTCAAGAAGAGCGAGGACTATCACGGGGGCGCAAGCGATGCTCATGGTGCAGGCGGCCCGTGGCGCGTG
GAAAAGCAACGATTGAAATGGGACATTCTCGAATCGTTTGCACAAGCCGCACAACAGACCGGCATACCCGCAACGGACGA
TTTCAATTGTGGAGACAATACCGGCGTCGGGTATTTCGATGTCAATCAGAGGCATGGCATCCGGTGGAATGCGTCGAAGG
CATACCTGCGCCCTGCCGCAAATCGGAAGAATCTGACTATCCTCACGAATGCGCAGACGCAGCGACTCGTGTTCAAGAAC
CAGCGCTGTTCCGGCATTGAGTTCCGCGTTGGTGACGAGTACCGTGTGGCCAGGGCGCGGCATGAAGTGATCTTGTGCGC
CGGTGCCGTCAATTCGCCTCAATTGCTTGAGTTGTCAGGGATTGGGGACATCAATCGTCTGGCAAAGCTTGGCATCGAAG
TGATAAAAGATCTGCGCGGTGTGGGTGAGAATTTGCAGGATCATCTGCAATTGCGCACAGCCTTCAGGGTGGACGGTGTG
CGGACCTTGAACACCCTCAGCGCTCACTGGTGGGGCAAATTAATGATCGGCTTCGAATATGGGCTCTTCAGAAGCGGGCC
GATGGCGATGGCGCCTTCGCAGCTTGGCGTCTTTGCGAAGTCGGATCCGGACGATAAGACGCTGAGGCGCCCCGATGTGC
AGTACCATGTCCAGCCGCTTTCGCTCGAACGGTTCGGCGAGCCGCTGCATTCGTTCGACGCGTTTACGGCGTCAGTTTGT
CATTTGCGGCCGTCGTCACGGGGCAGTGTACACATCACGTCGAGTGATCCCGAGACGGCACCCAGAATTGCGCCCAACTA
TCTTTCCACGGAGCACGATCTTCATGTTGCGGCCAACGCACTGCGATTGACGAGGCGTATTGTTGCGGCGTCGGCCCTGG
AACGGTTTCGTCCTCGGGAGGTCCTTCCTGGGATCCAGTTTCAGACCGAAGAAGAATTGCGGCATGCGGCTGGCAATGTC
GGAACCACCATCTTTCATCCGGTGGGAACCTGCCGAATGGGAAGAGGAGATGATCCGGACTCGGTGGTAGATTCCCGTCT
ACGCGTGCATGGTGTATGTGGCTTACGGGTGGTCGATGCTTCAATCATGCCGGTCATCACGTCGGGCAATACCAACTCGC
CGACGTTAATGATCGCCGAACGCGCCAGCGAGATGATCCGGGCGGACAGAATGCGAAAAGATACGAGCGCAGAGGCATAT
TCGCGGGAGGTTCTCGACGTGAAGAACGCGTACTGA

Upstream 100 bases:

>100_bases
AGTTGACGATGTCGGGGATTGCGATCGTCGAACCGGCTTTCGAGGCCGCAGGCGTTGCGCAACAGAGTGAAATCGATATG
CACAACAAGCAGGAGGCGTG

Downstream 100 bases:

>100_bases
CCGAGTACTCGCACGGCAAGGCCGCTGGGTGTCGGGGATACGTGTACCGGATAGCGGCCAACCCAGCCTGTACGGAGATT
TCATGCACATTCAGATGGCG

Product: glucose-methanol-choline oxidoreductase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 571; Mature: 570

Protein sequence:

>571_residues
MSAEKIDGTRSKQSSGEFDYIVIGAGTAGCVVASRLSEDNDVSVLLVEAGGKDNYHWIHIPVGYLYCIGNPRTDWRYKTS
EEPGLNGRALAYPRGRVLGGCSSINGMIYMRGQREDYDDWARITGDHSWGWDSVLDAFKKSEDYHGGASDAHGAGGPWRV
EKQRLKWDILESFAQAAQQTGIPATDDFNCGDNTGVGYFDVNQRHGIRWNASKAYLRPAANRKNLTILTNAQTQRLVFKN
QRCSGIEFRVGDEYRVARARHEVILCAGAVNSPQLLELSGIGDINRLAKLGIEVIKDLRGVGENLQDHLQLRTAFRVDGV
RTLNTLSAHWWGKLMIGFEYGLFRSGPMAMAPSQLGVFAKSDPDDKTLRRPDVQYHVQPLSLERFGEPLHSFDAFTASVC
HLRPSSRGSVHITSSDPETAPRIAPNYLSTEHDLHVAANALRLTRRIVAASALERFRPREVLPGIQFQTEEELRHAAGNV
GTTIFHPVGTCRMGRGDDPDSVVDSRLRVHGVCGLRVVDASIMPVITSGNTNSPTLMIAERASEMIRADRMRKDTSAEAY
SREVLDVKNAY

Sequences:

>Translated_571_residues
MSAEKIDGTRSKQSSGEFDYIVIGAGTAGCVVASRLSEDNDVSVLLVEAGGKDNYHWIHIPVGYLYCIGNPRTDWRYKTS
EEPGLNGRALAYPRGRVLGGCSSINGMIYMRGQREDYDDWARITGDHSWGWDSVLDAFKKSEDYHGGASDAHGAGGPWRV
EKQRLKWDILESFAQAAQQTGIPATDDFNCGDNTGVGYFDVNQRHGIRWNASKAYLRPAANRKNLTILTNAQTQRLVFKN
QRCSGIEFRVGDEYRVARARHEVILCAGAVNSPQLLELSGIGDINRLAKLGIEVIKDLRGVGENLQDHLQLRTAFRVDGV
RTLNTLSAHWWGKLMIGFEYGLFRSGPMAMAPSQLGVFAKSDPDDKTLRRPDVQYHVQPLSLERFGEPLHSFDAFTASVC
HLRPSSRGSVHITSSDPETAPRIAPNYLSTEHDLHVAANALRLTRRIVAASALERFRPREVLPGIQFQTEEELRHAAGNV
GTTIFHPVGTCRMGRGDDPDSVVDSRLRVHGVCGLRVVDASIMPVITSGNTNSPTLMIAERASEMIRADRMRKDTSAEAY
SREVLDVKNAY
>Mature_570_residues
SAEKIDGTRSKQSSGEFDYIVIGAGTAGCVVASRLSEDNDVSVLLVEAGGKDNYHWIHIPVGYLYCIGNPRTDWRYKTSE
EPGLNGRALAYPRGRVLGGCSSINGMIYMRGQREDYDDWARITGDHSWGWDSVLDAFKKSEDYHGGASDAHGAGGPWRVE
KQRLKWDILESFAQAAQQTGIPATDDFNCGDNTGVGYFDVNQRHGIRWNASKAYLRPAANRKNLTILTNAQTQRLVFKNQ
RCSGIEFRVGDEYRVARARHEVILCAGAVNSPQLLELSGIGDINRLAKLGIEVIKDLRGVGENLQDHLQLRTAFRVDGVR
TLNTLSAHWWGKLMIGFEYGLFRSGPMAMAPSQLGVFAKSDPDDKTLRRPDVQYHVQPLSLERFGEPLHSFDAFTASVCH
LRPSSRGSVHITSSDPETAPRIAPNYLSTEHDLHVAANALRLTRRIVAASALERFRPREVLPGIQFQTEEELRHAAGNVG
TTIFHPVGTCRMGRGDDPDSVVDSRLRVHGVCGLRVVDASIMPVITSGNTNSPTLMIAERASEMIRADRMRKDTSAEAYS
REVLDVKNAY

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=570, Percent_Identity=39.8245614035088, Blast_Score=388, Evalue=1e-108,
Organism=Escherichia coli, GI1786503, Length=559, Percent_Identity=39.1771019677996, Blast_Score=372, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17532301, Length=552, Percent_Identity=34.6014492753623, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24642055, Length=572, Percent_Identity=37.2377622377622, Blast_Score=331, Evalue=7e-91,
Organism=Drosophila melanogaster, GI45549471, Length=571, Percent_Identity=36.2521891418564, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI45551458, Length=571, Percent_Identity=36.2521891418564, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24642042, Length=572, Percent_Identity=36.8881118881119, Blast_Score=321, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24642059, Length=570, Percent_Identity=36.140350877193, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI17137792, Length=563, Percent_Identity=36.056838365897, Blast_Score=296, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24642035, Length=574, Percent_Identity=34.6689895470383, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24642048, Length=583, Percent_Identity=32.4185248713551, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI18859995, Length=572, Percent_Identity=35.8391608391608, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI24650267, Length=568, Percent_Identity=34.6830985915493, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI18859993, Length=571, Percent_Identity=32.9246935201401, Blast_Score=271, Evalue=7e-73,
Organism=Drosophila melanogaster, GI24642039, Length=570, Percent_Identity=34.0350877192982, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24642037, Length=571, Percent_Identity=32.9246935201401, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24642051, Length=574, Percent_Identity=33.4494773519164, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24645930, Length=591, Percent_Identity=29.1032148900169, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24642057, Length=592, Percent_Identity=27.8716216216216, Blast_Score=150, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 63211; Mature: 63080

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAEKIDGTRSKQSSGEFDYIVIGAGTAGCVVASRLSEDNDVSVLLVEAGGKDNYHWIHI
CCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEE
PVGYLYCIGNPRTDWRYKTSEEPGLNGRALAYPRGRVLGGCSSINGMIYMRGQREDYDDW
EEEEEEECCCCCCCCEEECCCCCCCCCCEEECCCCCEEECCCCCCCEEEEECCCCCCHHH
ARITGDHSWGWDSVLDAFKKSEDYHGGASDAHGAGGPWRVEKQRLKWDILESFAQAAQQT
HHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GIPATDDFNCGDNTGVGYFDVNQRHGIRWNASKAYLRPAANRKNLTILTNAQTQRLVFKN
CCCCCCCCCCCCCCCCEEEECCCCCCEEECCCHHEECCCCCCCCEEEEECCCCEEEEECC
QRCSGIEFRVGDEYRVARARHEVILCAGAVNSPQLLELSGIGDINRLAKLGIEVIKDLRG
CCCCCCEEEECCCHHHHHCCCEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
VGENLQDHLQLRTAFRVDGVRTLNTLSAHWWGKLMIGFEYGLFRSGPMAMAPSQLGVFAK
HCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCCHHCCEEEC
SDPDDKTLRRPDVQYHVQPLSLERFGEPLHSFDAFTASVCHLRPSSRGSVHITSSDPETA
CCCCCCCCCCCCCEEEEEECCHHHHCCHHHHHHHHHHHHEEECCCCCCCEEEECCCCCCC
PRIAPNYLSTEHDLHVAANALRLTRRIVAASALERFRPREVLPGIQFQTEEELRHAAGNV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHCCCC
GTTIFHPVGTCRMGRGDDPDSVVDSRLRVHGVCGLRVVDASIMPVITSGNTNSPTLMIAE
CCEEECCCCCEECCCCCCHHHHHHCCCEEEEECCEEEECCCEEEEEECCCCCCCEEEEHH
RASEMIRADRMRKDTSAEAYSREVLDVKNAY
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAEKIDGTRSKQSSGEFDYIVIGAGTAGCVVASRLSEDNDVSVLLVEAGGKDNYHWIHI
CCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEE
PVGYLYCIGNPRTDWRYKTSEEPGLNGRALAYPRGRVLGGCSSINGMIYMRGQREDYDDW
EEEEEEECCCCCCCCEEECCCCCCCCCCEEECCCCCEEECCCCCCCEEEEECCCCCCHHH
ARITGDHSWGWDSVLDAFKKSEDYHGGASDAHGAGGPWRVEKQRLKWDILESFAQAAQQT
HHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GIPATDDFNCGDNTGVGYFDVNQRHGIRWNASKAYLRPAANRKNLTILTNAQTQRLVFKN
CCCCCCCCCCCCCCCCEEEECCCCCCEEECCCHHEECCCCCCCCEEEEECCCCEEEEECC
QRCSGIEFRVGDEYRVARARHEVILCAGAVNSPQLLELSGIGDINRLAKLGIEVIKDLRG
CCCCCCEEEECCCHHHHHCCCEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
VGENLQDHLQLRTAFRVDGVRTLNTLSAHWWGKLMIGFEYGLFRSGPMAMAPSQLGVFAK
HCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCCHHCCEEEC
SDPDDKTLRRPDVQYHVQPLSLERFGEPLHSFDAFTASVCHLRPSSRGSVHITSSDPETA
CCCCCCCCCCCCCEEEEEECCHHHHCCHHHHHHHHHHHHEEECCCCCCCEEEECCCCCCC
PRIAPNYLSTEHDLHVAANALRLTRRIVAASALERFRPREVLPGIQFQTEEELRHAAGNV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHCCCC
GTTIFHPVGTCRMGRGDDPDSVVDSRLRVHGVCGLRVVDASIMPVITSGNTNSPTLMIAE
CCEEECCCCCEECCCCCCHHHHHHCCCEEEEECCEEEECCCEEEEEECCCCCCCEEEEHH
RASEMIRADRMRKDTSAEAYSREVLDVKNAY
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10708384 [H]