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The map label for this gene is galM [H]

Identifier: 186477095

GI number: 186477095

Start: 2630663

End: 2631754

Strand: Direct

Name: galM [H]

Synonym: Bphy_2344

Alternate gene names: 186477095

Gene position: 2630663-2631754 (Clockwise)

Preceding gene: 186477094

Following gene: 186477096

Centisome position: 75.61

GC content: 67.03

Gene sequence:

>1092_bases
ATGAATCTCGCCGACATGCACAGCACCGACACTTCTCTCTCCCCCAGCGTCCAGGTCGAACGCTGGGGCACGTTGCCCGG
TCTTGGCGACGTCCGGCTGTTCACGCTGCGCAACGCGCACGGCATGCGCGCGGCCATTAGCGACCTGGGTGCCACGCTCG
TTTCGTGGCATGCGCCCGACCGCGCCGGCCGCGTTGCCGATGTGCTGCTCGGCCACGACACGCCCGCCGACTATCTCGCG
AGCCGATGGTTCTTCGGCTCGACCATCGGCCGCTGGGCGAACCGTATCGCGCAGGCGCGCTTCACGCTCGACGGCGTGAC
CTATCAGCTCGACCGCAACGACGGCGACAATCTGCTGCACGGCGGCGCAAGCGGCTTTCACAAGGCGTTGTGGCAGGCGC
GCGAAGTGGATGGCGCGCTCGTGCTGTCGCATGAATCGCCTGAAGGCGACGCGGGCTTTCCGGGTGCGGTGTCGGCTACC
GTGCGCTATGCGCTCGACGACGACGGCGCACTCACGATCGACTACGACGCGACAGCCGATGCGCCCACACCCGTCAGCCT
GACGAATCACGCGTACTTCAACCTGTCGGGCGACGCGCTCGCCGAGGCGCCGGACATTCGCGGCCATGTGATTTCGATCG
ATGCCGACGCGTTCTTCGCGGTCGACGATACGATGATTCCCATCGAACGCAGGGAGGTGGCGGGAAGCGTGTTCGACTTT
CGCACGGGCGCCCCCATCGGCGCACGCCTCGACTGGCCCGATGCGCAACTCGCGCGCGCGGGCGGCTTCGATCATTGCTA
CGTGCTGCGCGACAGCGGCGCGGCCCTGCGTACGGCTGCCACGCTGTACGATCCCGCAACCGGACGCGAACTGACGGTGT
CCACGGACGCGAGAGGCATGCAGTTCTACTCGGGCAACTTTCTCGCGGACGTCAACGGGCGCAGCGGCAGGACGTATGGC
AAGCACGCAGCGTTGTGCCTTGAAACAGGCGCGTTTCCGAATCAGGTGAACATGCCCGATGCCGAAGACGTCGTGCTGCG
CCCGGGCGCGCGCTATCGCCACACGACGGTCTACCGCCTCGGCGTGCGCTGA

Upstream 100 bases:

>100_bases
CAGGAGCGACTGCACGCGGCGCAGTCCGTACCATCCGCGCCGTCCACACCCGATGCGCCCTCCGCCCAAATGCCTTAATC
TGGTTCGATCCGCGACCGAC

Downstream 100 bases:

>100_bases
ACTTGCATGCTCGTCACGTAATCTGTCGAAACATTGCCATTGTTGTAAATCGCGTCCGGCGATTGCGGCATTCATGACGC
CGTGAAATCATAAACGGCTT

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MNLADMHSTDTSLSPSVQVERWGTLPGLGDVRLFTLRNAHGMRAAISDLGATLVSWHAPDRAGRVADVLLGHDTPADYLA
SRWFFGSTIGRWANRIAQARFTLDGVTYQLDRNDGDNLLHGGASGFHKALWQAREVDGALVLSHESPEGDAGFPGAVSAT
VRYALDDDGALTIDYDATADAPTPVSLTNHAYFNLSGDALAEAPDIRGHVISIDADAFFAVDDTMIPIERREVAGSVFDF
RTGAPIGARLDWPDAQLARAGGFDHCYVLRDSGAALRTAATLYDPATGRELTVSTDARGMQFYSGNFLADVNGRSGRTYG
KHAALCLETGAFPNQVNMPDAEDVVLRPGARYRHTTVYRLGVR

Sequences:

>Translated_363_residues
MNLADMHSTDTSLSPSVQVERWGTLPGLGDVRLFTLRNAHGMRAAISDLGATLVSWHAPDRAGRVADVLLGHDTPADYLA
SRWFFGSTIGRWANRIAQARFTLDGVTYQLDRNDGDNLLHGGASGFHKALWQAREVDGALVLSHESPEGDAGFPGAVSAT
VRYALDDDGALTIDYDATADAPTPVSLTNHAYFNLSGDALAEAPDIRGHVISIDADAFFAVDDTMIPIERREVAGSVFDF
RTGAPIGARLDWPDAQLARAGGFDHCYVLRDSGAALRTAATLYDPATGRELTVSTDARGMQFYSGNFLADVNGRSGRTYG
KHAALCLETGAFPNQVNMPDAEDVVLRPGARYRHTTVYRLGVR
>Mature_363_residues
MNLADMHSTDTSLSPSVQVERWGTLPGLGDVRLFTLRNAHGMRAAISDLGATLVSWHAPDRAGRVADVLLGHDTPADYLA
SRWFFGSTIGRWANRIAQARFTLDGVTYQLDRNDGDNLLHGGASGFHKALWQAREVDGALVLSHESPEGDAGFPGAVSAT
VRYALDDDGALTIDYDATADAPTPVSLTNHAYFNLSGDALAEAPDIRGHVISIDADAFFAVDDTMIPIERREVAGSVFDF
RTGAPIGARLDWPDAQLARAGGFDHCYVLRDSGAALRTAATLYDPATGRELTVSTDARGMQFYSGNFLADVNGRSGRTYG
KHAALCLETGAFPNQVNMPDAEDVVLRPGARYRHTTVYRLGVR

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=350, Percent_Identity=41.1428571428571, Blast_Score=245, Evalue=4e-65,
Organism=Escherichia coli, GI1786971, Length=333, Percent_Identity=40.8408408408408, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17557428, Length=332, Percent_Identity=32.8313253012048, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI115533334, Length=332, Percent_Identity=32.8313253012048, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6319493, Length=358, Percent_Identity=28.2122905027933, Blast_Score=109, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6322004, Length=364, Percent_Identity=26.9230769230769, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324399, Length=357, Percent_Identity=25.2100840336134, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24659048, Length=345, Percent_Identity=40.5797101449275, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24583720, Length=340, Percent_Identity=37.3529411764706, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24668278, Length=339, Percent_Identity=34.2182890855457, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24668282, Length=343, Percent_Identity=33.8192419825073, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24641876, Length=348, Percent_Identity=29.5977011494253, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 39095; Mature: 39095

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLADMHSTDTSLSPSVQVERWGTLPGLGDVRLFTLRNAHGMRAAISDLGATLVSWHAPD
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHCCCEEEECCCC
RAGRVADVLLGHDTPADYLASRWFFGSTIGRWANRIAQARFTLDGVTYQLDRNDGDNLLH
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEECCCCCCEEE
GGASGFHKALWQAREVDGALVLSHESPEGDAGFPGAVSATVRYALDDDGALTIDYDATAD
CCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCC
APTPVSLTNHAYFNLSGDALAEAPDIRGHVISIDADAFFAVDDTMIPIERREVAGSVFDF
CCCCEEECCEEEEEECCCHHCCCCCCCCEEEEECCCEEEEECCCCCCCHHHHHCCCCEEC
RTGAPIGARLDWPDAQLARAGGFDHCYVLRDSGAALRTAATLYDPATGRELTVSTDARGM
CCCCCCCCEECCCCHHHHHCCCCCEEEEEECCCCEEEEEEEEECCCCCCEEEEECCCCCE
QFYSGNFLADVNGRSGRTYGKHAALCLETGAFPNQVNMPDAEDVVLRPGARYRHTTVYRL
EEECCCEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEECCCCCCEEEEEEEE
GVR
CCC
>Mature Secondary Structure
MNLADMHSTDTSLSPSVQVERWGTLPGLGDVRLFTLRNAHGMRAAISDLGATLVSWHAPD
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHCCCEEEECCCC
RAGRVADVLLGHDTPADYLASRWFFGSTIGRWANRIAQARFTLDGVTYQLDRNDGDNLLH
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEECCCCCCEEE
GGASGFHKALWQAREVDGALVLSHESPEGDAGFPGAVSATVRYALDDDGALTIDYDATAD
CCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCC
APTPVSLTNHAYFNLSGDALAEAPDIRGHVISIDADAFFAVDDTMIPIERREVAGSVFDF
CCCCEEECCEEEEEECCCHHCCCCCCCCEEEEECCCEEEEECCCCCCCHHHHHCCCCEEC
RTGAPIGARLDWPDAQLARAGGFDHCYVLRDSGAALRTAATLYDPATGRELTVSTDARGM
CCCCCCCCEECCCCHHHHHCCCCCEEEEEECCCCEEEEEEEEECCCCCCEEEEECCCCCE
QFYSGNFLADVNGRSGRTYGKHAALCLETGAFPNQVNMPDAEDVVLRPGARYRHTTVYRL
EEECCCEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEECCCCCCEEEEEEEE
GVR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]