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The map label for this gene is thiD [H]

Identifier: 186477082

GI number: 186477082

Start: 2613894

End: 2614754

Strand: Direct

Name: thiD [H]

Synonym: Bphy_2331

Alternate gene names: 186477082

Gene position: 2613894-2614754 (Clockwise)

Preceding gene: 186477072

Following gene: 186477083

Centisome position: 75.13

GC content: 66.67

Gene sequence:

>861_bases
ATGGCCAGCGACACCCCTCCGATCGTACTCACCTTCGGCCTGTCCGACCCGACGGGCGGCGCCGGGCTGCAAGCCGACCT
GATGACGCTTGCCAGCATGGGCTGCCACGGCGTTTCCGTGCTGACGGGCTACACGGTGCGCGACTCGGCGAGCTGCGACG
AAGTCACCGGGCTCGACCCGGAGGTCGTCGCGACGCAAGCGCGGATGCTGCTGGAAGACATGCCGATCGCCGCCTTCAAG
GTCGGCGCAGCGACGCGTGCCGAAGTGGTCAGCGCGATCGCCGAAGTGGTCGCCGATTACGACGACATCCCCCTCATCCT
GGCGCCCGACTTCACGCTCGACGACGAGCACGTGCTCGCCGCCGACGAACTGCGCGAAGCGATCGCCGACCTGCTCGCGC
CGCAAACCACATTGCTGGTTGCGGACACGGCTGCCCTGCTTGCGCTCGCGCAACCGGACGGCGACGCGGAAGCCCCGTCG
CTGGATGCCGCGATTTCCCATCTGCTGTCGCAGGGTTGTGAATACATCCTTTCGACGGAAACGGGCACGCACCGGCTCGT
GAATACCCTGTTCAGCGAAGACGGCCAGTTGCGGCAAGACATGTGGGACCGCACGCAGCAGCGGATCATGGGCATCACCG
ACACACTCGGCGCCGCGATTGCCGCGCTGCTGGCCAACGGTCAGGAACCGGCCGAAGCCGTGCGCGAAGCGCAGGAGTAT
CTCTTCCAGGCGACGCAGGCCGCCTTCCGTCCCGGTATGGGCGCTTATCTTCCCGATCGTTTCTTCTGGGCGAGAAGCAG
CGATGACGAAGTGCCGCTGTCAGGCGGGACGGATGCATCGCCGGGCGAGGCACGGCATTAG

Upstream 100 bases:

>100_bases
TATATGGCCGCATAATTGAGCCGTCTGTGCAGGCCGCGCGGACGCGTGTGCGCGCCGAACGGCCTGCGAATGTTTCGCTC
AACGACCCCATCACAACTTC

Downstream 100 bases:

>100_bases
TTTGCGCGGTTGATGGACCGGAACCGAAGACCCCCCTTTAGTCAAGGGGTAACTCGCAAGCGAAACGTTACCGCCGTAAT
CGACTGTTACAGCACGGGCA

Product: phosphomethylpyrimidine kinase type-1

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MASDTPPIVLTFGLSDPTGGAGLQADLMTLASMGCHGVSVLTGYTVRDSASCDEVTGLDPEVVATQARMLLEDMPIAAFK
VGAATRAEVVSAIAEVVADYDDIPLILAPDFTLDDEHVLAADELREAIADLLAPQTTLLVADTAALLALAQPDGDAEAPS
LDAAISHLLSQGCEYILSTETGTHRLVNTLFSEDGQLRQDMWDRTQQRIMGITDTLGAAIAALLANGQEPAEAVREAQEY
LFQATQAAFRPGMGAYLPDRFFWARSSDDEVPLSGGTDASPGEARH

Sequences:

>Translated_286_residues
MASDTPPIVLTFGLSDPTGGAGLQADLMTLASMGCHGVSVLTGYTVRDSASCDEVTGLDPEVVATQARMLLEDMPIAAFK
VGAATRAEVVSAIAEVVADYDDIPLILAPDFTLDDEHVLAADELREAIADLLAPQTTLLVADTAALLALAQPDGDAEAPS
LDAAISHLLSQGCEYILSTETGTHRLVNTLFSEDGQLRQDMWDRTQQRIMGITDTLGAAIAALLANGQEPAEAVREAQEY
LFQATQAAFRPGMGAYLPDRFFWARSSDDEVPLSGGTDASPGEARH
>Mature_285_residues
ASDTPPIVLTFGLSDPTGGAGLQADLMTLASMGCHGVSVLTGYTVRDSASCDEVTGLDPEVVATQARMLLEDMPIAAFKV
GAATRAEVVSAIAEVVADYDDIPLILAPDFTLDDEHVLAADELREAIADLLAPQTTLLVADTAALLALAQPDGDAEAPSL
DAAISHLLSQGCEYILSTETGTHRLVNTLFSEDGQLRQDMWDRTQQRIMGITDTLGAAIAALLANGQEPAEAVREAQEYL
FQATQAAFRPGMGAYLPDRFFWARSSDDEVPLSGGTDASPGEARH

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=245, Percent_Identity=29.7959183673469, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 30161; Mature: 30030

Theoretical pI: Translated: 3.86; Mature: 3.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASDTPPIVLTFGLSDPTGGAGLQADLMTLASMGCHGVSVLTGYTVRDSASCDEVTGLDP
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCEECCCCCCCHHCCCCH
EVVATQARMLLEDMPIAAFKVGAATRAEVVSAIAEVVADYDDIPLILAPDFTLDDEHVLA
HHHHHHHHHHHHHCCHHHHECCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHH
ADELREAIADLLAPQTTLLVADTAALLALAQPDGDAEAPSLDAAISHLLSQGCEYILSTE
HHHHHHHHHHHHCCCCEEEEEHHHHHHEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECC
TGTHRLVNTLFSEDGQLRQDMWDRTQQRIMGITDTLGAAIAALLANGQEPAEAVREAQEY
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LFQATQAAFRPGMGAYLPDRFFWARSSDDEVPLSGGTDASPGEARH
HHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ASDTPPIVLTFGLSDPTGGAGLQADLMTLASMGCHGVSVLTGYTVRDSASCDEVTGLDP
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCEECCCCCCCHHCCCCH
EVVATQARMLLEDMPIAAFKVGAATRAEVVSAIAEVVADYDDIPLILAPDFTLDDEHVLA
HHHHHHHHHHHHHCCHHHHECCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHH
ADELREAIADLLAPQTTLLVADTAALLALAQPDGDAEAPSLDAAISHLLSQGCEYILSTE
HHHHHHHHHHHHCCCCEEEEEHHHHHHEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECC
TGTHRLVNTLFSEDGQLRQDMWDRTQQRIMGITDTLGAAIAALLANGQEPAEAVREAQEY
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LFQATQAAFRPGMGAYLPDRFFWARSSDDEVPLSGGTDASPGEARH
HHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]