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The map label for this gene is apaH

Identifier: 186477072

GI number: 186477072

Start: 2605714

End: 2606562

Strand: Direct

Name: apaH

Synonym: Bphy_2321

Alternate gene names: 186477072

Gene position: 2605714-2606562 (Clockwise)

Preceding gene: 186477055

Following gene: 186477082

Centisome position: 74.89

GC content: 67.26

Gene sequence:

>849_bases
ATGACTGCTTCCACCGCTTCCGCCCCCCTCGCCTTCGGCGATCTGCAGGGCTGCCGCACGCAATTCCAGCAACTGCTCGC
AAAGGCCGCGCCGCCTGCCGACGCGCCACTCTGGTTCGCGGGCGACCTGATCAACCGCGGCGGCGAGTCGCTCGCGATGC
TGCGCGACATCATCGCGCTCGGCGATCGCGCGGTGCCCGTGCTGGGCAATCACGATCTGCATCTGCTGTCCGTGTCGGCG
GGAATCAGAAAGTCGAAGAAAGGCGACACGATCGATGAGATCCTCGCCGCGCCCGACGCAGACGATATGCTGCACTGGAT
CCGCCACCGGCCGCTCGCCCACTACGAGAACGGCATGCTGCTCGTGCATGCGGGCGTGCTGCCGCAATGGGATGTCGATT
TGACGCTGGAACTCGCCGACGAACTGCAGCGCGCGTTGCGCGCGCCTGGCTGGAAGGAAACGCTGGCGGGGCTGTACGGC
AACGAGCCAAACCGCTGGAAGCCGGGCCTCAAGGGCATCGACCGGCTGCGCCTCACGTGCACGGCGCTCACACGGATGCG
CTTCTGCAACGCCGACGGCGTGATGGATTTCTCGTCGAGCGGCGGCATCGGTTCAGCGCCCGCGGGCTTCATGCCGTGGT
TCGACGTGCCGGGCCGCAAGACCGAGGAGATCACGGTCGTCTTCGGGCACTGGGCTGCCCTCGGCCTCCTGATCCGCGAC
AATCTGATCGGGCTCGATTCGGGCTGCGTGTGGGGCGAGCAGCTGTCGGCCGTCCGGCTGGCTCAGTCGGCCGCCGAACG
CACGGTCACGCAAGTCGAATGCGAAGGTTGCCGCGCCGACGTGCATTGA

Upstream 100 bases:

>100_bases
ACGCAGTTAAGCTGCATGCGCATCGAATGTATGCCGGGCGAGTCATGACAGAGCGAGAACCGCTCGCCACTTCGCCCCTT
CGAACCACCACTTCTTGCCG

Downstream 100 bases:

>100_bases
GCGCGGCCGACACGCTACGCGTGGCGCGTCATGTCGACGCCCGAACCCGGCAACGGCTCTTGTGGGTTCGCTGAAGCGGC
GTCGATAAACTGCTGCGTAC

Product: diadenosine tetraphosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MTASTASAPLAFGDLQGCRTQFQQLLAKAAPPADAPLWFAGDLINRGGESLAMLRDIIALGDRAVPVLGNHDLHLLSVSA
GIRKSKKGDTIDEILAAPDADDMLHWIRHRPLAHYENGMLLVHAGVLPQWDVDLTLELADELQRALRAPGWKETLAGLYG
NEPNRWKPGLKGIDRLRLTCTALTRMRFCNADGVMDFSSSGGIGSAPAGFMPWFDVPGRKTEEITVVFGHWAALGLLIRD
NLIGLDSGCVWGEQLSAVRLAQSAAERTVTQVECEGCRADVH

Sequences:

>Translated_282_residues
MTASTASAPLAFGDLQGCRTQFQQLLAKAAPPADAPLWFAGDLINRGGESLAMLRDIIALGDRAVPVLGNHDLHLLSVSA
GIRKSKKGDTIDEILAAPDADDMLHWIRHRPLAHYENGMLLVHAGVLPQWDVDLTLELADELQRALRAPGWKETLAGLYG
NEPNRWKPGLKGIDRLRLTCTALTRMRFCNADGVMDFSSSGGIGSAPAGFMPWFDVPGRKTEEITVVFGHWAALGLLIRD
NLIGLDSGCVWGEQLSAVRLAQSAAERTVTQVECEGCRADVH
>Mature_281_residues
TASTASAPLAFGDLQGCRTQFQQLLAKAAPPADAPLWFAGDLINRGGESLAMLRDIIALGDRAVPVLGNHDLHLLSVSAG
IRKSKKGDTIDEILAAPDADDMLHWIRHRPLAHYENGMLLVHAGVLPQWDVDLTLELADELQRALRAPGWKETLAGLYGN
EPNRWKPGLKGIDRLRLTCTALTRMRFCNADGVMDFSSSGGIGSAPAGFMPWFDVPGRKTEEITVVFGHWAALGLLIRDN
LIGLDSGCVWGEQLSAVRLAQSAAERTVTQVECEGCRADVH

Specific function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Ap4A hydrolase family

Homologues:

Organism=Escherichia coli, GI1786234, Length=256, Percent_Identity=42.1875, Blast_Score=209, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APAH_BURP8 (B2JFC8)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001858542.1
- ProteinModelPortal:   B2JFC8
- SMR:   B2JFC8
- GeneID:   6243807
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_2321
- HOGENOM:   HBG724457
- OMA:   LVFGHWA
- ProtClustDB:   PRK00166
- HAMAP:   MF_00199
- InterPro:   IPR004617
- InterPro:   IPR004843
- PIRSF:   PIRSF000903
- TIGRFAMs:   TIGR00668

Pfam domain/function: PF00149 Metallophos

EC number: =3.6.1.41

Molecular weight: Translated: 30538; Mature: 30407

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASTASAPLAFGDLQGCRTQFQQLLAKAAPPADAPLWFAGDLINRGGESLAMLRDIIAL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHHH
GDRAVPVLGNHDLHLLSVSAGIRKSKKGDTIDEILAAPDADDMLHWIRHRPLAHYENGML
CCCCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCEE
LVHAGVLPQWDVDLTLELADELQRALRAPGWKETLAGLYGNEPNRWKPGLKGIDRLRLTC
EEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
TALTRMRFCNADGVMDFSSSGGIGSAPAGFMPWFDVPGRKTEEITVVFGHWAALGLLIRD
HHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHC
NLIGLDSGCVWGEQLSAVRLAQSAAERTVTQVECEGCRADVH
CEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TASTASAPLAFGDLQGCRTQFQQLLAKAAPPADAPLWFAGDLINRGGESLAMLRDIIAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHHH
GDRAVPVLGNHDLHLLSVSAGIRKSKKGDTIDEILAAPDADDMLHWIRHRPLAHYENGML
CCCCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCEE
LVHAGVLPQWDVDLTLELADELQRALRAPGWKETLAGLYGNEPNRWKPGLKGIDRLRLTC
EEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
TALTRMRFCNADGVMDFSSSGGIGSAPAGFMPWFDVPGRKTEEITVVFGHWAALGLLIRD
HHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHC
NLIGLDSGCVWGEQLSAVRLAQSAAERTVTQVECEGCRADVH
CEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA