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The map label for this gene is ilvR [H]

Identifier: 186476971

GI number: 186476971

Start: 2492609

End: 2493562

Strand: Reverse

Name: ilvR [H]

Synonym: Bphy_2220

Alternate gene names: 186476971

Gene position: 2493562-2492609 (Counterclockwise)

Preceding gene: 186476974

Following gene: 186476970

Centisome position: 71.67

GC content: 68.13

Gene sequence:

>954_bases
ATGAATCTGCCCCCGATGCCCGATCTGCGCCAACTGCGTTACTTCGTGACCGTCGCCGAAGAGAAGCATTTCGGACGCGC
CGCGGCGCGGCTGTCGATGACGCAGCCGCCCCTGTCGCAGGCCATCCGGGCGCTCGAGGACACGCTTGGTGTGGAACTGT
TAGCGCGCACGAAGCGCTCGGTCGAGCTGACGCCTGTCGGCGCGGATCTGCTGCCGGAGGTGAGGCGGTTGCTCGCGGGC
GCGGAAGGGCTGCGGCCGTTCGCGCAGAGCCTGGCGCGCGGCGAGGCAGGCGTGCTGTCGCTGGCGTTCGTGTCGACGGC
AGACTACGGGCTGCTGCCGCCGCTATTGCGCGAATTCGGCACGCGTCATCCGCGGGTGCGGCTCGAATTGCTCGAAGCGA
CCAGCGACGTGCAGATCGACGAACTGGTGGCGGGGCGTATTGACGCGGGTCTCGTGATCGGGCCGCTACCGCCGCGCTAC
GCGTCGCACCTGTCGTGGCTGCCGCTCGCGCGCGAGCCCCTCGTGATCGCGATGTCGACGGAGATGGCGGCGCGCATCGA
GGGCGCCGGCGAGGGTGCTGCCGAATGGCGTGACGAACCCTTGAGCCTCGCGCAAGCGAGCGATGCGCCGCTCGTCGTTT
TCCCAAGGCGTTTGGCCCCAGGCTTTTATGACATCATTATGGATTGCTACGGCGCAGCCGGTCTCACGCCGCGCGTCGGC
CAGGAAGCGATCCAGATGCAGACGATCGTGAGCCTCGTGTCGGCGGGCATGGGCGTCGCACTGGTGCCGCAATCGTTGCG
TAACCTGCGGCGCACGGGCGTGGTGTATCGTCCGTTGCGCGAGGCGGTGCCTGCCGTAGTCACGGGCCTCGTGTGGCGCA
CGGAGGAAGTGAGTCCCGTGCTGGCCGGCTTCATCGACATCGTGCGTGCGCATGCCGATGCACTCGCCAGCTAG

Upstream 100 bases:

>100_bases
TTTCCAGTCTAGTCCGGGCGGCGCGTGGGGCAAGAATGGAGTGCAGAGAGAGGAATGTCCAATATATTATTCATGCTCTA
TTAGGTCGTAAAATGTATCA

Downstream 100 bases:

>100_bases
AGAACGCTTTGCCGTGGCAAGCGTCCAATGCGCTTGAGTCCCGGATTTCCCGAACCCCTATAACGATACGATGCACATCC
ATCCGAATTTCGATCCCGTC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MNLPPMPDLRQLRYFVTVAEEKHFGRAAARLSMTQPPLSQAIRALEDTLGVELLARTKRSVELTPVGADLLPEVRRLLAG
AEGLRPFAQSLARGEAGVLSLAFVSTADYGLLPPLLREFGTRHPRVRLELLEATSDVQIDELVAGRIDAGLVIGPLPPRY
ASHLSWLPLAREPLVIAMSTEMAARIEGAGEGAAEWRDEPLSLAQASDAPLVVFPRRLAPGFYDIIMDCYGAAGLTPRVG
QEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLREAVPAVVTGLVWRTEEVSPVLAGFIDIVRAHADALAS

Sequences:

>Translated_317_residues
MNLPPMPDLRQLRYFVTVAEEKHFGRAAARLSMTQPPLSQAIRALEDTLGVELLARTKRSVELTPVGADLLPEVRRLLAG
AEGLRPFAQSLARGEAGVLSLAFVSTADYGLLPPLLREFGTRHPRVRLELLEATSDVQIDELVAGRIDAGLVIGPLPPRY
ASHLSWLPLAREPLVIAMSTEMAARIEGAGEGAAEWRDEPLSLAQASDAPLVVFPRRLAPGFYDIIMDCYGAAGLTPRVG
QEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLREAVPAVVTGLVWRTEEVSPVLAGFIDIVRAHADALAS
>Mature_317_residues
MNLPPMPDLRQLRYFVTVAEEKHFGRAAARLSMTQPPLSQAIRALEDTLGVELLARTKRSVELTPVGADLLPEVRRLLAG
AEGLRPFAQSLARGEAGVLSLAFVSTADYGLLPPLLREFGTRHPRVRLELLEATSDVQIDELVAGRIDAGLVIGPLPPRY
ASHLSWLPLAREPLVIAMSTEMAARIEGAGEGAAEWRDEPLSLAQASDAPLVVFPRRLAPGFYDIIMDCYGAAGLTPRVG
QEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLREAVPAVVTGLVWRTEEVSPVLAGFIDIVRAHADALAS

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=305, Percent_Identity=36.0655737704918, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI2367136, Length=301, Percent_Identity=34.21926910299, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1788887, Length=306, Percent_Identity=32.0261437908497, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1790399, Length=294, Percent_Identity=29.5918367346939, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI145693105, Length=259, Percent_Identity=25.4826254826255, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787806, Length=306, Percent_Identity=26.4705882352941, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI157672245, Length=261, Percent_Identity=28.735632183908, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787589, Length=140, Percent_Identity=38.5714285714286, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788748, Length=255, Percent_Identity=27.4509803921569, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787530, Length=258, Percent_Identity=25.5813953488372, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790208, Length=148, Percent_Identity=32.4324324324324, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788297, Length=263, Percent_Identity=25.4752851711027, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI145693193, Length=152, Percent_Identity=33.5526315789474, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787601, Length=317, Percent_Identity=23.6593059936909, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87081904, Length=146, Percent_Identity=30.1369863013699, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788296, Length=265, Percent_Identity=26.7924528301887, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34226; Mature: 34226

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLPPMPDLRQLRYFVTVAEEKHFGRAAARLSMTQPPLSQAIRALEDTLGVELLARTKRS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
VELTPVGADLLPEVRRLLAGAEGLRPFAQSLARGEAGVLSLAFVSTADYGLLPPLLREFG
EEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEHHHHCCCCCCCHHHHHHHC
TRHPRVRLELLEATSDVQIDELVAGRIDAGLVIGPLPPRYASHLSWLPLAREPLVIAMST
CCCCCEEHHHHHCCCCCCHHHHHHCCCCCCEEECCCCCHHHHHCCCCCCCCCCEEEEECH
EMAARIEGAGEGAAEWRDEPLSLAQASDAPLVVFPRRLAPGFYDIIMDCYGAAGLTPRVG
HHHHHHCCCCCCHHHHCCCCHHHHHCCCCCEEEECHHHCCHHHHHHHHHHCCCCCCCHHH
QEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLREAVPAVVTGLVWRTEEVSPV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
LAGFIDIVRAHADALAS
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLPPMPDLRQLRYFVTVAEEKHFGRAAARLSMTQPPLSQAIRALEDTLGVELLARTKRS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
VELTPVGADLLPEVRRLLAGAEGLRPFAQSLARGEAGVLSLAFVSTADYGLLPPLLREFG
EEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEHHHHCCCCCCCHHHHHHHC
TRHPRVRLELLEATSDVQIDELVAGRIDAGLVIGPLPPRYASHLSWLPLAREPLVIAMST
CCCCCEEHHHHHCCCCCCHHHHHHCCCCCCEEECCCCCHHHHHCCCCCCCCCCEEEEECH
EMAARIEGAGEGAAEWRDEPLSLAQASDAPLVVFPRRLAPGFYDIIMDCYGAAGLTPRVG
HHHHHHCCCCCCHHHHCCCCHHHHHCCCCCEEEECHHHCCHHHHHHHHHHCCCCCCCHHH
QEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLREAVPAVVTGLVWRTEEVSPV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
LAGFIDIVRAHADALAS
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]