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The map label for this gene is envZ [H]

Identifier: 186476910

GI number: 186476910

Start: 2421088

End: 2422428

Strand: Reverse

Name: envZ [H]

Synonym: Bphy_2159

Alternate gene names: 186476910

Gene position: 2422428-2421088 (Counterclockwise)

Preceding gene: 186476911

Following gene: 186476907

Centisome position: 69.63

GC content: 67.56

Gene sequence:

>1341_bases
ATGGCGAGCAACATGCGTCGTCCAATTGATTCATTGTTCGGGCGGCTCGCGCTGCTTGTCGTGTGCGTGTTGCTGGTGTC
GCATTTCGCATGGTACTTGCTGGTCCGTTTTGAACGGAACCAGTCGCAGACGCGCTATGCCGTCGAAGAGGCCGTGTTCC
TCGTCGATGCGGTGCGCGATCACGTAAGACGTGAGCCGGATCAGCCGTTGCCGTCGCGTGTGCGCCTCGTCGATCCCGCC
AGCACCGACGTCCCGCCTGAGGTGCCCAATCTGCCCGCGCCGCTCGACCGTTTCGTCGACGACGTGCGCGACCGTCTGCC
CGCTTCGACACAAGTGCGCGTCGGCACGCCCGGCAAGCCGCCCACGCTGTGGGTGCGCGCCGCGAGCGATGCCAGTTGGA
TCGTCGTGCCCGTGCAGCCGCTGCGTCCGCCGCGCTCGCTCGACCGGATGGTGTTGTGGCTCGGCATCATTTTCTCGGCG
GGCGTGATGGCCGCGCTGTTCGCCGCGTGGCAGTTGCAGCAGCCGCTGCGTTCGCTCGCGCAGGCAGTGACCCGTTTCGG
ACGCGGTCTGCCCGTGCCGCCCGTGCGCGAGCGCGGTCCGCGTGAGTTGCGTCAACTCACGCACGGCTTCAACCAGATGG
TGCAGGAAGTCGCGCGCACCGAGCATGACCGCGCGGTGATGCTGGCGGGCGTCGCGCACGATCTCAAGACGCCGCTTGCG
CGTCTGCGCCTGCGGGCCGAGATGATGGAAGAAGCGAAGATGCGCGACGGCGTCGTGCGCGACGTGGATTCGATGACGCA
CATCGTCGAGCAGTTTCTCGTGTTCGCGCACGACGGTGCGGATCGAAGCGAACCCGTCGAGGTGGACGGCCAGTGCGAGC
GCGTGGTGCGCAGTTATCGGGCCGTCTCGGGCGGTACGCCGACCGTGCTGACCGATCTGCGCGCCGGCGACGGGTTCAGG
CTGCCTGCCGCTACGCTCGACCGCATCCTGTCCAACCTGCTCGACAACGCGCATGCGTACGGTGCGCCGCCCATTGTCGT
CGCGACGGCGCGCACACCGCAAGGCTTCACGCTAACGGTTACCGATAACGGCAACGGCATTGCCGCGCAGGACCTGATCA
ACGCGAGCCGTCCGTTCGTGCGGCTCGATCCGGCGCGCGGCGGCAACGGTCACAGCGGGCTCGGCCTCGCGATCGTCGAA
CGGCTCGTGCGGCGTGCGGGCGGTGAATGGCAGATCGGCAACAACGACTCAGGGAGTGGCGGGAGCGGCTTGCGTGTCCA
GATGACTTTCCCGCTCGAGGCGGTGCCGCGCACAGCGGCAGCGTCGGAAAGCGTCTGGTGA

Upstream 100 bases:

>100_bases
GACGTGCAGGTGTGGCGCCTGCGGCGCATTCTCGAAACCGATCCGTCCGTGCCGCGCTTCATTCAGACAGTGCGCGGACG
CGGATACGTGTTCGTCCCGG

Downstream 100 bases:

>100_bases
GTGCACGTGCCGCGCAATCCACTGCGCGGCGTAGCAAGAAAGAAAAAGAAACGGCGGGGCGAGCAGAGCGTGCGATCGGG
CCTGGCACCGCAACGTGCTC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MASNMRRPIDSLFGRLALLVVCVLLVSHFAWYLLVRFERNQSQTRYAVEEAVFLVDAVRDHVRREPDQPLPSRVRLVDPA
STDVPPEVPNLPAPLDRFVDDVRDRLPASTQVRVGTPGKPPTLWVRAASDASWIVVPVQPLRPPRSLDRMVLWLGIIFSA
GVMAALFAAWQLQQPLRSLAQAVTRFGRGLPVPPVRERGPRELRQLTHGFNQMVQEVARTEHDRAVMLAGVAHDLKTPLA
RLRLRAEMMEEAKMRDGVVRDVDSMTHIVEQFLVFAHDGADRSEPVEVDGQCERVVRSYRAVSGGTPTVLTDLRAGDGFR
LPAATLDRILSNLLDNAHAYGAPPIVVATARTPQGFTLTVTDNGNGIAAQDLINASRPFVRLDPARGGNGHSGLGLAIVE
RLVRRAGGEWQIGNNDSGSGGSGLRVQMTFPLEAVPRTAAASESVW

Sequences:

>Translated_446_residues
MASNMRRPIDSLFGRLALLVVCVLLVSHFAWYLLVRFERNQSQTRYAVEEAVFLVDAVRDHVRREPDQPLPSRVRLVDPA
STDVPPEVPNLPAPLDRFVDDVRDRLPASTQVRVGTPGKPPTLWVRAASDASWIVVPVQPLRPPRSLDRMVLWLGIIFSA
GVMAALFAAWQLQQPLRSLAQAVTRFGRGLPVPPVRERGPRELRQLTHGFNQMVQEVARTEHDRAVMLAGVAHDLKTPLA
RLRLRAEMMEEAKMRDGVVRDVDSMTHIVEQFLVFAHDGADRSEPVEVDGQCERVVRSYRAVSGGTPTVLTDLRAGDGFR
LPAATLDRILSNLLDNAHAYGAPPIVVATARTPQGFTLTVTDNGNGIAAQDLINASRPFVRLDPARGGNGHSGLGLAIVE
RLVRRAGGEWQIGNNDSGSGGSGLRVQMTFPLEAVPRTAAASESVW
>Mature_445_residues
ASNMRRPIDSLFGRLALLVVCVLLVSHFAWYLLVRFERNQSQTRYAVEEAVFLVDAVRDHVRREPDQPLPSRVRLVDPAS
TDVPPEVPNLPAPLDRFVDDVRDRLPASTQVRVGTPGKPPTLWVRAASDASWIVVPVQPLRPPRSLDRMVLWLGIIFSAG
VMAALFAAWQLQQPLRSLAQAVTRFGRGLPVPPVRERGPRELRQLTHGFNQMVQEVARTEHDRAVMLAGVAHDLKTPLAR
LRLRAEMMEEAKMRDGVVRDVDSMTHIVEQFLVFAHDGADRSEPVEVDGQCERVVRSYRAVSGGTPTVLTDLRAGDGFRL
PAATLDRILSNLLDNAHAYGAPPIVVATARTPQGFTLTVTDNGNGIAAQDLINASRPFVRLDPARGGNGHSGLGLAIVER
LVRRAGGEWQIGNNDSGSGGSGLRVQMTFPLEAVPRTAAASESVW

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=333, Percent_Identity=31.8318318318318, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787894, Length=277, Percent_Identity=28.8808664259928, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=29.7794117647059, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790551, Length=304, Percent_Identity=27.6315789473684, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786600, Length=242, Percent_Identity=28.9256198347107, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082128, Length=275, Percent_Identity=26.1818181818182, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790861, Length=299, Percent_Identity=27.0903010033445, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87081816, Length=257, Percent_Identity=24.9027237354086, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48942; Mature: 48811

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASNMRRPIDSLFGRLALLVVCVLLVSHFAWYLLVRFERNQSQTRYAVEEAVFLVDAVRD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
HVRREPDQPLPSRVRLVDPASTDVPPEVPNLPAPLDRFVDDVRDRLPASTQVRVGTPGKP
HHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCC
PTLWVRAASDASWIVVPVQPLRPPRSLDRMVLWLGIIFSAGVMAALFAAWQLQQPLRSLA
CEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVTRFGRGLPVPPVRERGPRELRQLTHGFNQMVQEVARTEHDRAVMLAGVAHDLKTPLA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHH
RLRLRAEMMEEAKMRDGVVRDVDSMTHIVEQFLVFAHDGADRSEPVEVDGQCERVVRSYR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
AVSGGTPTVLTDLRAGDGFRLPAATLDRILSNLLDNAHAYGAPPIVVATARTPQGFTLTV
HHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEE
TDNGNGIAAQDLINASRPFVRLDPARGGNGHSGLGLAIVERLVRRAGGEWQIGNNDSGSG
ECCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCC
GSGLRVQMTFPLEAVPRTAAASESVW
CCCEEEEEECCHHHCCCHHCCCCCCC
>Mature Secondary Structure 
ASNMRRPIDSLFGRLALLVVCVLLVSHFAWYLLVRFERNQSQTRYAVEEAVFLVDAVRD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
HVRREPDQPLPSRVRLVDPASTDVPPEVPNLPAPLDRFVDDVRDRLPASTQVRVGTPGKP
HHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCC
PTLWVRAASDASWIVVPVQPLRPPRSLDRMVLWLGIIFSAGVMAALFAAWQLQQPLRSLA
CEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVTRFGRGLPVPPVRERGPRELRQLTHGFNQMVQEVARTEHDRAVMLAGVAHDLKTPLA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHH
RLRLRAEMMEEAKMRDGVVRDVDSMTHIVEQFLVFAHDGADRSEPVEVDGQCERVVRSYR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
AVSGGTPTVLTDLRAGDGFRLPAATLDRILSNLLDNAHAYGAPPIVVATARTPQGFTLTV
HHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEE
TDNGNGIAAQDLINASRPFVRLDPARGGNGHSGLGLAIVERLVRRAGGEWQIGNNDSGSG
ECCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCC
GSGLRVQMTFPLEAVPRTAAASESVW
CCCEEEEEECCHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]