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The map label for this gene is tpiA [H]

Identifier: 186476766

GI number: 186476766

Start: 2261177

End: 2261956

Strand: Reverse

Name: tpiA [H]

Synonym: Bphy_2011

Alternate gene names: 186476766

Gene position: 2261956-2261177 (Counterclockwise)

Preceding gene: 186476767

Following gene: 186476765

Centisome position: 65.01

GC content: 64.23

Gene sequence:

>780_bases
ATGGCGAAACAACGAGCAAAACTGGTAGTCGGTAACTGGAAGATGCATGGCCGGCTTGCCGACAATCGCGTGCTGCTGCA
AGCGGTCTCGCGCGGCGCAGACGATCTTCCGGACGATGTGCGGGTGGGTGTGTGTGTGCCGTGCCTCTATCTGGCGCAGG
CGCAAACGCTGCTCGAAAGCGGTCGCGTCGCGTGGGGCGTGCAGGATATCTCCGCGTACACGCAGGGCGCCTACACGGGC
GAAGTCGCGGCCGAGATGGCTGCCGAATTCGGCGCCACACTTGCGATCGTCGGGCACTCCGAGCGGCGTGCGTATCATCG
CGAAAGCGCTGAGGTCGTCGCGCTGAAGACGCAACGCGCGCTCGAAGCAGGTTTGACGCCGATCGTCTGCGTCGGTGAGA
CGCTCGAAGAGCGCGAATGCGGCAAGACGGAGCAGATTGTCGGCGAGCAGATCGATGTTGTGCTCGCGAAACTGTCGGTT
GAAGATGCCGCTCGCATCGTCATCGCTTACGAGCCTGTGTGGGCGATCGGCACCGGCAAGAGCGCGACGGCGCAGCAGGC
GCAAGACGTGCACGCGTTTCTGCGCGCACGTCTCGTGGCGAAGGGCGGCGATGCCGCGAACGTGTCGCTGCTGTACGGCG
GCAGCGTGAAACCGGAGAACGCGGAAGAGCTGTTCGGCCAGCCGGACATCGATGGCGGTTTGATCGGCGGAGCGTCGTTG
AAGGACAAGGATTTCCTGGCAATCTGCAGTGCAGCTGTCGCGGCAACGGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
GTTTTGCGCGTTCTGCATGGTTTTTGCATGCGGACCGGGTACCGGGCGCCGACGAAACGGACGCGTTCATCACCCGCACC
ACGATAAATCAGGCGAGACG

Downstream 100 bases:

>100_bases
TATCAAGGCAGAATGCCCGGGCGAGGATGACCCATTGCGTGCAGCATGCGGTGCTGTGCGGTTAAATAAAGACTCAGGTG
AGTGTGATGCTGTATTTGAA

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MAKQRAKLVVGNWKMHGRLADNRVLLQAVSRGADDLPDDVRVGVCVPCLYLAQAQTLLESGRVAWGVQDISAYTQGAYTG
EVAAEMAAEFGATLAIVGHSERRAYHRESAEVVALKTQRALEAGLTPIVCVGETLEERECGKTEQIVGEQIDVVLAKLSV
EDAARIVIAYEPVWAIGTGKSATAQQAQDVHAFLRARLVAKGGDAANVSLLYGGSVKPENAEELFGQPDIDGGLIGGASL
KDKDFLAICSAAVAATAAR

Sequences:

>Translated_259_residues
MAKQRAKLVVGNWKMHGRLADNRVLLQAVSRGADDLPDDVRVGVCVPCLYLAQAQTLLESGRVAWGVQDISAYTQGAYTG
EVAAEMAAEFGATLAIVGHSERRAYHRESAEVVALKTQRALEAGLTPIVCVGETLEERECGKTEQIVGEQIDVVLAKLSV
EDAARIVIAYEPVWAIGTGKSATAQQAQDVHAFLRARLVAKGGDAANVSLLYGGSVKPENAEELFGQPDIDGGLIGGASL
KDKDFLAICSAAVAATAAR
>Mature_258_residues
AKQRAKLVVGNWKMHGRLADNRVLLQAVSRGADDLPDDVRVGVCVPCLYLAQAQTLLESGRVAWGVQDISAYTQGAYTGE
VAAEMAAEFGATLAIVGHSERRAYHRESAEVVALKTQRALEAGLTPIVCVGETLEERECGKTEQIVGEQIDVVLAKLSVE
DAARIVIAYEPVWAIGTGKSATAQQAQDVHAFLRARLVAKGGDAANVSLLYGGSVKPENAEELFGQPDIDGGLIGGASLK
DKDFLAICSAAVAATAAR

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=253, Percent_Identity=43.8735177865613, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI226529917, Length=253, Percent_Identity=43.8735177865613, Blast_Score=186, Evalue=2e-47,
Organism=Escherichia coli, GI1790353, Length=257, Percent_Identity=45.5252918287938, Blast_Score=203, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI17536593, Length=250, Percent_Identity=44.4, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320255, Length=249, Percent_Identity=40.1606425702811, Blast_Score=181, Evalue=7e-47,
Organism=Drosophila melanogaster, GI28572008, Length=249, Percent_Identity=44.1767068273092, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI28572006, Length=249, Percent_Identity=44.1767068273092, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI28572004, Length=249, Percent_Identity=44.1767068273092, Blast_Score=182, Evalue=3e-46,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 27314; Mature: 27183

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00107 PROTEIN_KINASE_ATP ; PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQRAKLVVGNWKMHGRLADNRVLLQAVSRGADDLPDDVRVGVCVPCLYLAQAQTLLES
CCCCCCEEEEECEEEECEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GRVAWGVQDISAYTQGAYTGEVAAEMAAEFGATLAIVGHSERRAYHRESAEVVALKTQRA
CCEEECHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEEECHHHHHHHHCCCEEEEEEHHHH
LEAGLTPIVCVGETLEERECGKTEQIVGEQIDVVLAKLSVEDAARIVIAYEPVWAIGTGK
HHHCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEECCC
SATAQQAQDVHAFLRARLVAKGGDAANVSLLYGGSVKPENAEELFGQPDIDGGLIGGASL
CHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHCCCCCCCCCEECCCCC
KDKDFLAICSAAVAATAAR
CCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKQRAKLVVGNWKMHGRLADNRVLLQAVSRGADDLPDDVRVGVCVPCLYLAQAQTLLES
CCCCCEEEEECEEEECEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GRVAWGVQDISAYTQGAYTGEVAAEMAAEFGATLAIVGHSERRAYHRESAEVVALKTQRA
CCEEECHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEEECHHHHHHHHCCCEEEEEEHHHH
LEAGLTPIVCVGETLEERECGKTEQIVGEQIDVVLAKLSVEDAARIVIAYEPVWAIGTGK
HHHCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEECCC
SATAQQAQDVHAFLRARLVAKGGDAANVSLLYGGSVKPENAEELFGQPDIDGGLIGGASL
CHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHCCCCCCCCCEECCCCC
KDKDFLAICSAAVAATAAR
CCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA