Click here to switch to the map view.

The map label for this gene is pyrD

Identifier: 186476422

GI number: 186476422

Start: 1878867

End: 1879901

Strand: Direct

Name: pyrD

Synonym: Bphy_1664

Alternate gene names: 186476422

Gene position: 1878867-1879901 (Clockwise)

Preceding gene: 186476421

Following gene: 186476426

Centisome position: 54.0

GC content: 67.15

Gene sequence:

>1035_bases
GTGTTCAGTTCTCTTTATCCGCTCGTACGCGCCCAACTCTTCCGCATGGATGCGGAAGACGCTCACCATCTCACCCTGCG
CCTGCTGCGCGCGGCCGGACGTACCGGCCTGGCAGGCGCGCTCGCGCCGCGTGTGCCCGACTCGCCGCGCACCGTGATGG
GCCTGACGTTCCGGAACCCCGTCGGTCTCGCGGCAGGGCTCGACAAGGACGGCGCGTGCATCGACGGACTGGCCGCGCTC
GGCTTTGGCTTCATCGAAGTCGGCACGGTGACGCCGCGCGCGCAGCCAGGCAATCCGCGCCCGCGCATGTTCCGTCTGCC
GCAGGCGGACGCCGTGATCAACCGGATGGGCTTCAACAACGCAGGCGTCGACCAGTTCGTGAAGAACGTGCAGGCTGCGC
GCTATCGCGGCACGCTCGGGCTGAACATCGGCAAGAACGCCGACACGCCGATCGAGCGCGCCGCCGACGACTACCTCTAC
TGCCTGGAACGCGTGTATCCGTTCGCGAGCTACGTGACCGTCAATATCTCGTCGCCGAACACGAAGAACCTGCGCCAGCT
GCAAGGCGCGGGCGAACTCGATGCGTTGCTCGCCGCGCTCAAGGACAAGCAGCAGCGTCTCGCGGATCTGCACGGCAAGC
TCGTGCCGCTCGCGCTGAAGATCGCGCCGGATCTCGACGACGAACAGGTGAAGTCGATCGCCGACACGCTGCTGCGTCAC
CAGTTCGAAGGCGTGATCGCGACCAACACGACGCTCTCGCGCACCGCCGTGCAAGGTTTGCCGCACGCTGACGAAGCAGG
TGGCCTGTCGGGACGGCCGGTGTTCGATGCATCGAACGAAGTGATCCGCAAGCTGCGCGCGGAAGTCGGCGGCGACGTGC
CCATCATCGGCGTGGGCGGGATTTTCTCCGGCGCGGATGCGCAGGCCAAGCTCGACGCGGGCGCATCGCTCGTTCAGCTC
TACACGGGCTTCATCTATCGGGGCCCCGCCCTCGTCGCCGAATGCGCACAGGCGCTGGCGATGCGCGCAGCGTAG

Upstream 100 bases:

>100_bases
GACGCACGCACGGCACGCACGTACATCGAAACGCCCGTCGCCGCGCTGCCGACCCGTTAAAATAGCGGGTTTTCATTTTT
CAGCCGCCAGGCGTCCCGCC

Downstream 100 bases:

>100_bases
GCCTTTGCGCAGCCGCGGCGCACGGGGACGACGTCAGGCGCGTAGCCGGGCCTCAGTGCGCCGCCACCGCATCGAGCCGC
ACACCGAACCGCTCGAAACG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MFSSLYPLVRAQLFRMDAEDAHHLTLRLLRAAGRTGLAGALAPRVPDSPRTVMGLTFRNPVGLAAGLDKDGACIDGLAAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPQADAVINRMGFNNAGVDQFVKNVQAARYRGTLGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTVNISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQVKSIADTLLRH
QFEGVIATNTTLSRTAVQGLPHADEAGGLSGRPVFDASNEVIRKLRAEVGGDVPIIGVGGIFSGADAQAKLDAGASLVQL
YTGFIYRGPALVAECAQALAMRAA

Sequences:

>Translated_344_residues
MFSSLYPLVRAQLFRMDAEDAHHLTLRLLRAAGRTGLAGALAPRVPDSPRTVMGLTFRNPVGLAAGLDKDGACIDGLAAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPQADAVINRMGFNNAGVDQFVKNVQAARYRGTLGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTVNISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQVKSIADTLLRH
QFEGVIATNTTLSRTAVQGLPHADEAGGLSGRPVFDASNEVIRKLRAEVGGDVPIIGVGGIFSGADAQAKLDAGASLVQL
YTGFIYRGPALVAECAQALAMRAA
>Mature_344_residues
MFSSLYPLVRAQLFRMDAEDAHHLTLRLLRAAGRTGLAGALAPRVPDSPRTVMGLTFRNPVGLAAGLDKDGACIDGLAAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPQADAVINRMGFNNAGVDQFVKNVQAARYRGTLGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTVNISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQVKSIADTLLRH
QFEGVIATNTTLSRTAVQGLPHADEAGGLSGRPVFDASNEVIRKLRAEVGGDVPIIGVGGIFSGADAQAKLDAGASLVQL
YTGFIYRGPALVAECAQALAMRAA

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=336, Percent_Identity=44.6428571428571, Blast_Score=247, Evalue=1e-65,
Organism=Escherichia coli, GI1787177, Length=329, Percent_Identity=57.1428571428571, Blast_Score=394, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17509475, Length=338, Percent_Identity=41.4201183431953, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI281361352, Length=298, Percent_Identity=43.2885906040268, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI17137316, Length=298, Percent_Identity=43.2885906040268, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_BURP8 (B2JKL9)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001857892.1
- GeneID:   6243155
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_1664
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- ProtClustDB:   PRK05286
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 36609; Mature: 36609

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSSLYPLVRAQLFRMDAEDAHHLTLRLLRAAGRTGLAGALAPRVPDSPRTVMGLTFRNP
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCEEEEEEECCC
VGLAAGLDKDGACIDGLAALGFGFIEVGTVTPRAQPGNPRPRMFRLPQADAVINRMGFNN
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCC
AGVDQFVKNVQAARYRGTLGLNIGKNADTPIERAADDYLYCLERVYPFASYVTVNISSPN
CCHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
TKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQVKSIADTLLRH
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
QFEGVIATNTTLSRTAVQGLPHADEAGGLSGRPVFDASNEVIRKLRAEVGGDVPIIGVGG
HHCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECC
IFSGADAQAKLDAGASLVQLYTGFIYRGPALVAECAQALAMRAA
CCCCCCCCHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFSSLYPLVRAQLFRMDAEDAHHLTLRLLRAAGRTGLAGALAPRVPDSPRTVMGLTFRNP
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCEEEEEEECCC
VGLAAGLDKDGACIDGLAALGFGFIEVGTVTPRAQPGNPRPRMFRLPQADAVINRMGFNN
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCC
AGVDQFVKNVQAARYRGTLGLNIGKNADTPIERAADDYLYCLERVYPFASYVTVNISSPN
CCHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
TKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQVKSIADTLLRH
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
QFEGVIATNTTLSRTAVQGLPHADEAGGLSGRPVFDASNEVIRKLRAEVGGDVPIIGVGG
HHCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECC
IFSGADAQAKLDAGASLVQLYTGFIYRGPALVAECAQALAMRAA
CCCCCCCCHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA