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The map label for this gene is iscS [H]

Identifier: 186476216

GI number: 186476216

Start: 1639832

End: 1641055

Strand: Reverse

Name: iscS [H]

Synonym: Bphy_1458

Alternate gene names: 186476216

Gene position: 1641055-1639832 (Counterclockwise)

Preceding gene: 186476217

Following gene: 186476215

Centisome position: 47.17

GC content: 61.68

Gene sequence:

>1224_bases
ATGAATAACGACATTCCCCACCTGCCCATTTACATGGACTACAGCGCGACGACCCCGGTCGATCCGCGCGTGGTGGACAA
GATGATCCCGTATCTGCGCGAGCAATTCGGCAATCCGGCGTCGCGCAGCCACGCGTATGGCTGGGATGCGGAGCGTGCCG
TCGAGGAAGCGCGCGAGAACGTCGCAGCGCTGGTCAACGCCGACCCGCGCGAAATCATCTGGACGTCGGGCGCGACGGAA
TCGGACAACCTCGCCATCAAGGGCGCGGCGCACTTCTACAAAAGCAAAGGCAAGCACATCGTCACGGTGAAGACCGAGCA
CAAGGCCGTACTCGACACCACGCGCGAACTGGAGCGCGAAGGCTACGAAGTGACGTACCTCGACGTGAAGGACGACGGCC
TGCTCGATCTCGAAGTCTTCAAGGCAGCGCTGCGTCCCGATACGATCCTGGTTTCCGTGATGCACGTGAACAACGAGATC
GGTGTCATCCAGGACATCGAGACCATCGGTGAAATCTGCCGCGAAAAGGGCATCATTTTCCACGTCGACGCGGCGCAGGC
CACGGGCAAGGTCGAAATCGACCTGCAGAAGCTCAAGGTCGACCTGATGTCGTTTTCGGCGCACAAGACGTATGGCCCCA
AGGGCATTGGCGCGCTGTATGTGCGCCGCAAGCCGCGCGTGCGCATCGAAGCGCAGATGCACGGCGGCGGTCACGAGCGC
GGCATGCGTTCGGGCACGCTCGCCACGCACCAGATCGTCGGCATGGGCGAAGCGTTCCGTATCGCCCGTGAAGAAATGGC
GACCGAAAACGAACGCATCCGCATGCTGCGCGACAAGCTACTGCGCGGCCTGCAGGAAATCGAAGAAACGTACGTGAACG
GCGACATGGAGCAGCGCGTCCCGCACAACCTGAACATCAGCTTCAACTTCGTCGAAGGCGAGTCGCTGATCATGGCAGTG
AAGGACGTGGCCGTGTCGTCGGGTTCGGCCTGCACGTCGGCTTCGCTGGAGCCGTCATATGTGCTGCGCGCGCTAGGCCG
CAACGACGAGCTGGCGCACAGCTCGATCCGCTTCACGGTCGGCCGCTTCACGACGGAGCAGGACGTCGATTACGTCATCA
ACCTGCTGAAGAGCAAGATTGCGAAGCTGCGCGATCTGTCGCCGCTGTGGGAAATGCACAAGGACGGCATCGATCTGTCG
ACCATCCAGTGGGCTGCGCACTGA

Upstream 100 bases:

>100_bases
GCCGAATTCCGTTTTCAACATGGCCGGCTGAAAGAGCGCGCAAGAGACGCGAACGCCAGAACCGAGAAGCCATTAGCACT
GATGTCCCCCGGAGCGATTG

Downstream 100 bases:

>100_bases
GCGCGCGTCGCGGCGGGTCGAACACGAACGCAGGTTGAATCGAATCAAGGAGTGACAACATGGCATACAGCGATAAGGTC
CTGGACCACTACGAAAACCC

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MNNDIPHLPIYMDYSATTPVDPRVVDKMIPYLREQFGNPASRSHAYGWDAERAVEEARENVAALVNADPREIIWTSGATE
SDNLAIKGAAHFYKSKGKHIVTVKTEHKAVLDTTRELEREGYEVTYLDVKDDGLLDLEVFKAALRPDTILVSVMHVNNEI
GVIQDIETIGEICREKGIIFHVDAAQATGKVEIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
GMRSGTLATHQIVGMGEAFRIAREEMATENERIRMLRDKLLRGLQEIEETYVNGDMEQRVPHNLNISFNFVEGESLIMAV
KDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQDVDYVINLLKSKIAKLRDLSPLWEMHKDGIDLS
TIQWAAH

Sequences:

>Translated_407_residues
MNNDIPHLPIYMDYSATTPVDPRVVDKMIPYLREQFGNPASRSHAYGWDAERAVEEARENVAALVNADPREIIWTSGATE
SDNLAIKGAAHFYKSKGKHIVTVKTEHKAVLDTTRELEREGYEVTYLDVKDDGLLDLEVFKAALRPDTILVSVMHVNNEI
GVIQDIETIGEICREKGIIFHVDAAQATGKVEIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
GMRSGTLATHQIVGMGEAFRIAREEMATENERIRMLRDKLLRGLQEIEETYVNGDMEQRVPHNLNISFNFVEGESLIMAV
KDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQDVDYVINLLKSKIAKLRDLSPLWEMHKDGIDLS
TIQWAAH
>Mature_407_residues
MNNDIPHLPIYMDYSATTPVDPRVVDKMIPYLREQFGNPASRSHAYGWDAERAVEEARENVAALVNADPREIIWTSGATE
SDNLAIKGAAHFYKSKGKHIVTVKTEHKAVLDTTRELEREGYEVTYLDVKDDGLLDLEVFKAALRPDTILVSVMHVNNEI
GVIQDIETIGEICREKGIIFHVDAAQATGKVEIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
GMRSGTLATHQIVGMGEAFRIAREEMATENERIRMLRDKLLRGLQEIEETYVNGDMEQRVPHNLNISFNFVEGESLIMAV
KDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQDVDYVINLLKSKIAKLRDLSPLWEMHKDGIDLS
TIQWAAH

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=400, Percent_Identity=58.25, Blast_Score=515, Evalue=1e-146,
Organism=Homo sapiens, GI156713448, Length=418, Percent_Identity=33.0143540669856, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI48994898, Length=402, Percent_Identity=72.636815920398, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI1787970, Length=225, Percent_Identity=28, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1789175, Length=229, Percent_Identity=28.3842794759825, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=401, Percent_Identity=60.0997506234414, Blast_Score=510, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17533177, Length=327, Percent_Identity=32.7217125382263, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319831, Length=399, Percent_Identity=57.6441102756892, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI20129463, Length=400, Percent_Identity=56, Blast_Score=480, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45623; Mature: 45623

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNDIPHLPIYMDYSATTPVDPRVVDKMIPYLREQFGNPASRSHAYGWDAERAVEEAREN
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
VAALVNADPREIIWTSGATESDNLAIKGAAHFYKSKGKHIVTVKTEHKAVLDTTRELERE
HHEEECCCCHHEEEECCCCCCCCEEEEEHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHC
GYEVTYLDVKDDGLLDLEVFKAALRPDTILVSVMHVNNEIGVIQDIETIGEICREKGIIF
CCEEEEEEECCCCEEEHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEE
HVDAAQATGKVEIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
EEECCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHC
GMRSGTLATHQIVGMGEAFRIAREEMATENERIRMLRDKLLRGLQEIEETYVNGDMEQRV
CCCCCCCHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
PHNLNISFNFVEGESLIMAVKDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTV
CCCCCEEEEEECCCEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCHHHCEEEEEE
GRFTTEQDVDYVINLLKSKIAKLRDLSPLWEMHKDGIDLSTIQWAAH
ECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MNNDIPHLPIYMDYSATTPVDPRVVDKMIPYLREQFGNPASRSHAYGWDAERAVEEAREN
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
VAALVNADPREIIWTSGATESDNLAIKGAAHFYKSKGKHIVTVKTEHKAVLDTTRELERE
HHEEECCCCHHEEEECCCCCCCCEEEEEHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHC
GYEVTYLDVKDDGLLDLEVFKAALRPDTILVSVMHVNNEIGVIQDIETIGEICREKGIIF
CCEEEEEEECCCCEEEHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEE
HVDAAQATGKVEIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
EEECCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHC
GMRSGTLATHQIVGMGEAFRIAREEMATENERIRMLRDKLLRGLQEIEETYVNGDMEQRV
CCCCCCCHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
PHNLNISFNFVEGESLIMAVKDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTV
CCCCCEEEEEECCCEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCHHHCEEEEEE
GRFTTEQDVDYVINLLKSKIAKLRDLSPLWEMHKDGIDLSTIQWAAH
ECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA