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The map label for this gene is pyrH [H]

Identifier: 186476094

GI number: 186476094

Start: 1495639

End: 1496352

Strand: Reverse

Name: pyrH [H]

Synonym: Bphy_1336

Alternate gene names: 186476094

Gene position: 1496352-1495639 (Counterclockwise)

Preceding gene: 186476095

Following gene: 186476093

Centisome position: 43.01

GC content: 64.57

Gene sequence:

>714_bases
ATGCCCACTGCCTATAAACGCGTCCTCCTCAAACTCTCTGGCGAAGCCCTGATGGGCGATGATGCATTCGGCATCAATCG
CGCGACGATCGAAAGAATGGTGGCGGACGTGGCCGAGGTGGTGCGGCTCGGTACGCAGCTGGCCGTAGTGATCGGCGGCG
GCAATATCTTTCGTGGCGTCGCAGGCGGCGCAGCGGGCATGGACCGTGCGACGGCTGACTACATGGGCATGCTGGCCACG
ATGATGAACGCGCTGGCGCTGCAGGACGCAATGCGTCACGCCGGCATCGAGGCGCGCGTGCAGTCGGCGCTGCGCATGGA
CCAGGTGGTCGAGCCTTACATCCGTCCGCGCGCGATCCGCCAGCTGGAAGAGGGCAAGGTTGTGATTTTCGCGGCCGGCA
CGGGCAATCCGTTCTTCACGACCGACACGGCGGCTGCCCTGCGCGGCTCGGAAGTGGGCGCCGAAGTGGTGTTGAAGGCG
ACCAAGGTCGACGGCGTCTATTCCGCCGACCCGAAGAAGGACCCGTCCGCGACGCGTTACACCACGATCAGTTTTGACGA
GGCAATTGGCCGCAACCTGCAGGTGATGGACGCGACGGCGTTCGCGCTGTGCCGCGACCAGAAGCTGCCGATCCGCGTGT
TTTCGATCGTGAAGCCGGGCGCGCTCAAGCGCATCGTGCAAGGCGAAGACGAAGGCACGCTCGTCCACGTGTAA

Upstream 100 bases:

>100_bases
CAATTTGGCGGCGCTTGCCCGAACCCGTATTTCACCCCTACAGTTAGTTCCTTGTTGTTTGGCGGCTTTTTGCCCTGCTC
AGCGCGATCTGGATATCTCT

Downstream 100 bases:

>100_bases
ACTCTCTAGCATTCTGTGGGCTTGAACGCGGGCTCAGGCTGCGCCTCGCGCGCTGGCGGCTCGCATCGTTTTGAAGGTTC
GGAGGTTTAATCATGTCTGT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MPTAYKRVLLKLSGEALMGDDAFGINRATIERMVADVAEVVRLGTQLAVVIGGGNIFRGVAGGAAGMDRATADYMGMLAT
MMNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIRQLEEGKVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKA
TKVDGVYSADPKKDPSATRYTTISFDEAIGRNLQVMDATAFALCRDQKLPIRVFSIVKPGALKRIVQGEDEGTLVHV

Sequences:

>Translated_237_residues
MPTAYKRVLLKLSGEALMGDDAFGINRATIERMVADVAEVVRLGTQLAVVIGGGNIFRGVAGGAAGMDRATADYMGMLAT
MMNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIRQLEEGKVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKA
TKVDGVYSADPKKDPSATRYTTISFDEAIGRNLQVMDATAFALCRDQKLPIRVFSIVKPGALKRIVQGEDEGTLVHV
>Mature_236_residues
PTAYKRVLLKLSGEALMGDDAFGINRATIERMVADVAEVVRLGTQLAVVIGGGNIFRGVAGGAAGMDRATADYMGMLATM
MNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIRQLEEGKVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKAT
KVDGVYSADPKKDPSATRYTTISFDEAIGRNLQVMDATAFALCRDQKLPIRVFSIVKPGALKRIVQGEDEGTLVHV

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=56.7099567099567, Blast_Score=275, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 25316; Mature: 25184

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTAYKRVLLKLSGEALMGDDAFGINRATIERMVADVAEVVRLGTQLAVVIGGGNIFRGV
CCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEHHC
AGGAAGMDRATADYMGMLATMMNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHH
QLEEGKVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKATKVDGVYSADPKKDPSATRY
HHCCCCEEEEEECCCCCCEECCHHHHHCCCCCCHHHEEEEECCCCEECCCCCCCCCCCEE
TTISFDEAIGRNLQVMDATAFALCRDQKLPIRVFSIVKPGALKRIVQGEDEGTLVHV
EEEEHHHHHCCCEEEEHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCEEEC
>Mature Secondary Structure 
PTAYKRVLLKLSGEALMGDDAFGINRATIERMVADVAEVVRLGTQLAVVIGGGNIFRGV
CHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEHHC
AGGAAGMDRATADYMGMLATMMNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHH
QLEEGKVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKATKVDGVYSADPKKDPSATRY
HHCCCCEEEEEECCCCCCEECCHHHHHCCCCCCHHHEEEEECCCCEECCCCCCCCCCCEE
TTISFDEAIGRNLQVMDATAFALCRDQKLPIRVFSIVKPGALKRIVQGEDEGTLVHV
EEEEHHHHHCCCEEEEHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA