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The map label for this gene is fadA [H]

Identifier: 186475795

GI number: 186475795

Start: 1161473

End: 1162651

Strand: Direct

Name: fadA [H]

Synonym: Bphy_1030

Alternate gene names: 186475795

Gene position: 1161473-1162651 (Clockwise)

Preceding gene: 186475794

Following gene: 186475797

Centisome position: 33.38

GC content: 65.48

Gene sequence:

>1179_bases
ATGACTGACGCCGTAATCGTATCGACTGCCCGCACGGGCCTGGCCAAATCGTGGCGCGGCGCGTTCAACATGACGCATGG
CGCGACGCTCGGCGGACATGTGACGCAAGCCGCCGTCGAACGCGCGAAGATCGACCCGGCCCGCGTCGAGGACGTGATCA
TGGGTTGCGCGAATCCCGAAGGCGCGACGGGCTCGAATATCGCGCGGCAGATCGCGCTGCGCGGCGGCTTGCCCGTCACG
GTGCCGGGTATGACTGTGAACCGCTTCTGCTCGTCAGGCCTGCAGACCATCGCACTCGCTGCGCAACGCGTGATGGTCGG
CGAAGGTGACGTGTACGTCGCGGGCGGCGTCGAGTCGATCTCGTGCGTGCAGAACGAAATGAATCAGCACATGCTGCGCG
AGGGCTGGCTGATGGAGCACAAGCCGGAAATCTACTGGTCGATGCTGGAGACGGCCGAAAACGTCGCGAAGCGCTACGGC
ATCTCGAGGGATCGTCAGGACGAGTACGGCGTGCAGTCGCAGCAGCGCGCGGCCGCCGCGCAGCAAGCCGGGCGCTTCAA
CGACGAAATCGTGCCGCTGACGGTGCTTGCCGGCGTCGCCGACAAGGAAACCGGGCGCATGTTCACGAAGGAGGTGACCA
TCGCCGCCGACGAAGGCATCCGCGCGGATACGACGCTTGAAGGCGTGTCGAAGATCCGTACCGCGGTCCCTGGCGGCGTG
ATCACCGCGGGCAATGCGAGCCAGTTTTCGGATGGCGCATCGGCGTGCGTGGTGATGAACGCAAAGGTCGCCGAGCGCGA
AGGCCTGCAGCCGATGGGCATTTTCCGCGGCTTTGCCGTCGCCGGATGCGAACCGGACGAAATGGGCATCGGCCCGGTGT
TTGCCGTGCCTAAGCTGCTGAAGCAGGCGGGCCTCAAGGTCGACGATATCGGTCTGTGGGAACTGAACGAGGCATTCGCC
GTGCAGGTGCTGTATTGCCGCGACAAGCTCGGCATTCCGAACGAACGGCTGAACGTGAATGGCGGCGCGATTGCCGTCGG
GCACCCGTATGGCGTATCGGGTGCGCGTCTGACGGGGCATGCGCTGATCGAAGGCAAGCGGCGCGGCGCGAAATTCGTCG
TGGTGACGATGTGCATCGGCGGCGGGCAGGGCGCGGCGGGGCTGTTCGAGGTCGTCTGA

Upstream 100 bases:

>100_bases
GAGCAGCGCGAACCGCACACATTCAATTTAAAGAGTTAATCGTTACGTCGGACGGGAGCCAGCGCTCAAGCCACCGCTTC
CATCGACATTGGAGAGATGC

Downstream 100 bases:

>100_bases
TACGCCTGCGATTCGCACGTCGAGGAAAGCCCGCGTACGAAAGTGCGCGGGCTTTTTCTTGCGCGTGCTTGTTCGGGCGT
CAACGAGCGGGCAGTTTGTG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTDAVIVSTARTGLAKSWRGAFNMTHGATLGGHVTQAAVERAKIDPARVEDVIMGCANPEGATGSNIARQIALRGGLPVT
VPGMTVNRFCSSGLQTIALAAQRVMVGEGDVYVAGGVESISCVQNEMNQHMLREGWLMEHKPEIYWSMLETAENVAKRYG
ISRDRQDEYGVQSQQRAAAAQQAGRFNDEIVPLTVLAGVADKETGRMFTKEVTIAADEGIRADTTLEGVSKIRTAVPGGV
ITAGNASQFSDGASACVVMNAKVAEREGLQPMGIFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLKVDDIGLWELNEAFA
VQVLYCRDKLGIPNERLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKFVVVTMCIGGGQGAAGLFEVV

Sequences:

>Translated_392_residues
MTDAVIVSTARTGLAKSWRGAFNMTHGATLGGHVTQAAVERAKIDPARVEDVIMGCANPEGATGSNIARQIALRGGLPVT
VPGMTVNRFCSSGLQTIALAAQRVMVGEGDVYVAGGVESISCVQNEMNQHMLREGWLMEHKPEIYWSMLETAENVAKRYG
ISRDRQDEYGVQSQQRAAAAQQAGRFNDEIVPLTVLAGVADKETGRMFTKEVTIAADEGIRADTTLEGVSKIRTAVPGGV
ITAGNASQFSDGASACVVMNAKVAEREGLQPMGIFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLKVDDIGLWELNEAFA
VQVLYCRDKLGIPNERLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKFVVVTMCIGGGQGAAGLFEVV
>Mature_391_residues
TDAVIVSTARTGLAKSWRGAFNMTHGATLGGHVTQAAVERAKIDPARVEDVIMGCANPEGATGSNIARQIALRGGLPVTV
PGMTVNRFCSSGLQTIALAAQRVMVGEGDVYVAGGVESISCVQNEMNQHMLREGWLMEHKPEIYWSMLETAENVAKRYGI
SRDRQDEYGVQSQQRAAAAQQAGRFNDEIVPLTVLAGVADKETGRMFTKEVTIAADEGIRADTTLEGVSKIRTAVPGGVI
TAGNASQFSDGASACVVMNAKVAEREGLQPMGIFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLKVDDIGLWELNEAFAV
QVLYCRDKLGIPNERLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKFVVVTMCIGGGQGAAGLFEVV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=42.8205128205128, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=37.7833753148615, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI4557237, Length=402, Percent_Identity=36.318407960199, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI148539872, Length=395, Percent_Identity=35.4430379746835, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4504327, Length=399, Percent_Identity=31.5789473684211, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=32.3907455012853, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1787663, Length=413, Percent_Identity=39.225181598063, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=42.1182266009852, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=39.1959798994975, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=38.3663366336634, Blast_Score=237, Evalue=8e-64,
Organism=Escherichia coli, GI1788683, Length=420, Percent_Identity=30.4761904761905, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=37.9052369077307, Blast_Score=241, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI17535921, Length=404, Percent_Identity=35.8910891089109, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI25147385, Length=397, Percent_Identity=32.7455919395466, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=438, Percent_Identity=29.9086757990868, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=389, Percent_Identity=29.0488431876607, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=36.6161616161616, Blast_Score=223, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6325229, Length=402, Percent_Identity=32.089552238806, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24655093, Length=400, Percent_Identity=40.25, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI17648125, Length=360, Percent_Identity=38.8888888888889, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24640423, Length=401, Percent_Identity=35.4114713216958, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI17137578, Length=409, Percent_Identity=31.7848410757946, Blast_Score=184, Evalue=8e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41329; Mature: 41198

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAVIVSTARTGLAKSWRGAFNMTHGATLGGHVTQAAVERAKIDPARVEDVIMGCANPE
CCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCC
GATGSNIARQIALRGGLPVTVPGMTVNRFCSSGLQTIALAAQRVMVGEGDVYVAGGVESI
CCCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHH
SCVQNEMNQHMLREGWLMEHKPEIYWSMLETAENVAKRYGISRDRQDEYGVQSQQRAAAA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHH
QQAGRFNDEIVPLTVLAGVADKETGRMFTKEVTIAADEGIRADTTLEGVSKIRTAVPGGV
HHHCCCCCCEEEEEEEECCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCE
ITAGNASQFSDGASACVVMNAKVAEREGLQPMGIFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCCCEEEEEECHHHHHCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHH
KQAGLKVDDIGLWELNEAFAVQVLYCRDKLGIPNERLNVNGGAIAVGHPYGVSGARLTGH
HHCCCCEECCCEEECCHHHEEEEEEEECCCCCCCCEEECCCCEEEECCCCCCCCCEEECH
ALIEGKRRGAKFVVVTMCIGGGQGAAGLFEVV
HEEECCCCCCEEEEEEEEECCCCCCCCCEECC
>Mature Secondary Structure 
TDAVIVSTARTGLAKSWRGAFNMTHGATLGGHVTQAAVERAKIDPARVEDVIMGCANPE
CCEEEEECHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCC
GATGSNIARQIALRGGLPVTVPGMTVNRFCSSGLQTIALAAQRVMVGEGDVYVAGGVESI
CCCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHH
SCVQNEMNQHMLREGWLMEHKPEIYWSMLETAENVAKRYGISRDRQDEYGVQSQQRAAAA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHH
QQAGRFNDEIVPLTVLAGVADKETGRMFTKEVTIAADEGIRADTTLEGVSKIRTAVPGGV
HHHCCCCCCEEEEEEEECCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCE
ITAGNASQFSDGASACVVMNAKVAEREGLQPMGIFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCCCEEEEEECHHHHHCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHH
KQAGLKVDDIGLWELNEAFAVQVLYCRDKLGIPNERLNVNGGAIAVGHPYGVSGARLTGH
HHCCCCEECCCEEECCHHHEEEEEEEECCCCCCCCEEECCCCEEEECCCCCCCCCEEECH
ALIEGKRRGAKFVVVTMCIGGGQGAAGLFEVV
HEEECCCCCCEEEEEEEEECCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]