Click here to switch to the map view.

The map label for this gene is nhaA [H]

Identifier: 186475587

GI number: 186475587

Start: 922585

End: 923595

Strand: Direct

Name: nhaA [H]

Synonym: Bphy_0822

Alternate gene names: 186475587

Gene position: 922585-923595 (Clockwise)

Preceding gene: 186475586

Following gene: 186475590

Centisome position: 26.52

GC content: 61.03

Gene sequence:

>1011_bases
ATGTCCGACAATCTGACTCCCGATCCGAAGGAACCTGCTGCGGCGAGCCGTGAAGCGCGCCGGGTATCTGGCGACGAGCC
GAACTGGGAGCGCGCCGCACTCGAGCGGGTCGCGCTTGCAGCCATCAACGAACAGCGCACTGCCCGGCGTTGGCGCATTT
TCTTCCGCTTCGTCTTTCTCGGCGTACTCGTCCTGATCGCATGGGCGGTGCTCGATTTCAGCGGCGAGAAGGTGGCCACG
AGTGGGCGACATACGGCGCTCGTGACACTTGACGGCGAAATCGCGTCGGATACTAACGCGAACGCTGAAGATATCGACAT
GGCGCTGGCCAATGCGTTTGACGACGCAGGTACGGCAGGCGTCGTCCTTCGCTGCAACAGTCCGGGTGGCAGTCCTGTCC
AGGCGGGCATCATTTACCGTGAAATCCGGCGATTGCGCGGCAAGTATCCGGCAATACCGCTTTATGTCGTCGTCGGCGAC
ATGTGCGCTTCGGGCGGTTACTACGCCGCGGCGGCGGCCGACAAGATCTACGTCGACAAGGCCAGCATCGTCGGATCAAT
CGGCGTGCTGATGGACGGCTTCGGCTTCACAGGGCTGATGGATAAGCTCGGCATTCAGCGCCGGATGCGCACTTCTGGGG
AGAACAAGGGCTTTTATGATCCGTTCTCCCCCGATACGCCGAAGATGGACTCCCACGCGCAGGTGATGCTGGACGAAATC
CATGCGCAATTCATCGATGCAGTGAAACAGGGGCGCGGAAAGCGGCTCCAGGACAACCCTGACATTTTTTCCGGTCTCTT
CTGGACTGGGGAAAAGAGCGTCGAGTTGGGTCTCGCCGACGGCTTCGGCGACACGAACTACGTCGCTCGCGAAATCATCA
AGGCGCCCGACGTGGTCGATTACACGGTGAAAGAGAGCATCACGGATCGTGTGGCGCGCAAGTTCGGCGCGGCTGTCGGC
GGCGGTGCCGTGCGCGCGATGGCTACGATCGGGAAATTGAACCTGCGATAA

Upstream 100 bases:

>100_bases
AGGCCGTGCCGTATTTTGGCTGCCCGAAGCTGATCTGCGTCCGGCGTCTGCCTGATTTCCCCGCAGTCTTTCCCAACTCG
ATTTCAATCGGCGGCAACGC

Downstream 100 bases:

>100_bases
GTGCTCGTGGGAGCCTGGGAGCGGCGGCCGACATCTGGCGGCCGCCTTCCTGGGCGTCAGTTCGCCAGAATCAGAAAAAT
CGCCGGGCGCTTGTGGAGTT

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSDNLTPDPKEPAAASREARRVSGDEPNWERAALERVALAAINEQRTARRWRIFFRFVFLGVLVLIAWAVLDFSGEKVAT
SGRHTALVTLDGEIASDTNANAEDIDMALANAFDDAGTAGVVLRCNSPGGSPVQAGIIYREIRRLRGKYPAIPLYVVVGD
MCASGGYYAAAAADKIYVDKASIVGSIGVLMDGFGFTGLMDKLGIQRRMRTSGENKGFYDPFSPDTPKMDSHAQVMLDEI
HAQFIDAVKQGRGKRLQDNPDIFSGLFWTGEKSVELGLADGFGDTNYVAREIIKAPDVVDYTVKESITDRVARKFGAAVG
GGAVRAMATIGKLNLR

Sequences:

>Translated_336_residues
MSDNLTPDPKEPAAASREARRVSGDEPNWERAALERVALAAINEQRTARRWRIFFRFVFLGVLVLIAWAVLDFSGEKVAT
SGRHTALVTLDGEIASDTNANAEDIDMALANAFDDAGTAGVVLRCNSPGGSPVQAGIIYREIRRLRGKYPAIPLYVVVGD
MCASGGYYAAAAADKIYVDKASIVGSIGVLMDGFGFTGLMDKLGIQRRMRTSGENKGFYDPFSPDTPKMDSHAQVMLDEI
HAQFIDAVKQGRGKRLQDNPDIFSGLFWTGEKSVELGLADGFGDTNYVAREIIKAPDVVDYTVKESITDRVARKFGAAVG
GGAVRAMATIGKLNLR
>Mature_335_residues
SDNLTPDPKEPAAASREARRVSGDEPNWERAALERVALAAINEQRTARRWRIFFRFVFLGVLVLIAWAVLDFSGEKVATS
GRHTALVTLDGEIASDTNANAEDIDMALANAFDDAGTAGVVLRCNSPGGSPVQAGIIYREIRRLRGKYPAIPLYVVVGDM
CASGGYYAAAAADKIYVDKASIVGSIGVLMDGFGFTGLMDKLGIQRRMRTSGENKGFYDPFSPDTPKMDSHAQVMLDEIH
AQFIDAVKQGRGKRLQDNPDIFSGLFWTGEKSVELGLADGFGDTNYVAREIIKAPDVVDYTVKESITDRVARKFGAAVGG
GAVRAMATIGKLNLR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=218, Percent_Identity=33.0275229357798, Blast_Score=92, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 36345; Mature: 36213

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNLTPDPKEPAAASREARRVSGDEPNWERAALERVALAAINEQRTARRWRIFFRFVFL
CCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVLVLIAWAVLDFSGEKVATSGRHTALVTLDGEIASDTNANAEDIDMALANAFDDAGTAG
HHHHHHHHHHHCCCCCEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCE
VVLRCNSPGGSPVQAGIIYREIRRLRGKYPAIPLYVVVGDMCASGGYYAAAAADKIYVDK
EEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCCCEEEEECCCEEEEEH
ASIVGSIGVLMDGFGFTGLMDKLGIQRRMRTSGENKGFYDPFSPDTPKMDSHAQVMLDEI
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
HAQFIDAVKQGRGKRLQDNPDIFSGLFWTGEKSVELGLADGFGDTNYVAREIIKAPDVVD
HHHHHHHHHHCCCCCCCCCCCHHHCEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCCCH
YTVKESITDRVARKFGAAVGGGAVRAMATIGKLNLR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDNLTPDPKEPAAASREARRVSGDEPNWERAALERVALAAINEQRTARRWRIFFRFVFL
CCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVLVLIAWAVLDFSGEKVATSGRHTALVTLDGEIASDTNANAEDIDMALANAFDDAGTAG
HHHHHHHHHHHCCCCCEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCE
VVLRCNSPGGSPVQAGIIYREIRRLRGKYPAIPLYVVVGDMCASGGYYAAAAADKIYVDK
EEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCCCEEEEECCCEEEEEH
ASIVGSIGVLMDGFGFTGLMDKLGIQRRMRTSGENKGFYDPFSPDTPKMDSHAQVMLDEI
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
HAQFIDAVKQGRGKRLQDNPDIFSGLFWTGEKSVELGLADGFGDTNYVAREIIKAPDVVD
HHHHHHHHHHCCCCCCCCCCCHHHCEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCCCH
YTVKESITDRVARKFGAAVGGGAVRAMATIGKLNLR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA