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The map label for this gene is fumC [H]

Identifier: 186475560

GI number: 186475560

Start: 892538

End: 893938

Strand: Reverse

Name: fumC [H]

Synonym: Bphy_0795

Alternate gene names: 186475560

Gene position: 893938-892538 (Counterclockwise)

Preceding gene: 186475561

Following gene: 186475555

Centisome position: 25.69

GC content: 64.6

Gene sequence:

>1401_bases
ATGACCGAAGATGTACGCATGGAACGCGATACGTTCGGCGAAATCGCCGTACCGAATGCGAAATTGTGGGGGGCGCAGAC
GCAGCGTTCGCTGCAGAACTTCAAGATTTCGACGGAGAAGCAGTCGCCTGAACTGATCACCGCGCTCGCGGTCATCAAGC
GCGCCGCCGCCGAAGTGAACCTGAGCCTCGGCGTGCTCGACGCGACCAAGGCGAAAGCGATCATGGCCGCCGCCGACGAG
ATCATCGACGGCAAGCATCCCGACGAATTCCCGCTCGCGGTCTGGCAGACGGGCTCCGGCACGCAGACCAACATGAACCT
CAACGAGGTGATCGCGAACCGCGCGAGCGAGTTGATGGGCGGCGAGCGTGGCGAAGCGCGCCTCGTGCATCCGAACGATG
ACGTGAATCGCGGGCAATCGTCGAACGACGTGTTTCCGACCGCGATGCATGTGGCGGCGGCTGTCGGCATCGTCAAGCAT
CTGCTGCCCGCGCTCAGGACGCTGCGCGACACGCTCGATAACAAGTCGAAGGCGTTCGCCGATATCGTGAAGATCGGCCG
CACGCACCTGCAGGATGCGACGCCGCTCACGCTCGGCCAGGAATTCTCCGGCTACGTCGCGCAGCTCGACCAGAACGCAA
AGCACATCGAGTCGACGCTCGCGCATCTGTACGAACTCGCGCAGGGCGGGACGGCCGTCGGCACGGGACTCAACGCACAT
CCGAAGTTCGCCGCCGAGGTGGCGGCCGCGATCGGACGGCTGACGGGCCTGCCCTTCGTGTCAGCACCGAACAAGTTCGA
GGTCATGGCGGCCGCCGACGCGCTGGTCTTCGCGCACGGCGCATTGAAGACGCTCGCGGCGAGCATGATGAAGATCGCCA
ACGACATCCGCTGGCTCGCGAGCGGCCCGCGCTGCGGCCTCGGCGAGCTGTCGATTCCCGAAAACGAGCCGGGTAGCTCA
ATCATGCCGGGCAAGGTGAACCCGACGCAATCGGAAGCGGTGACGATGCTGTGCTGCCAGGTGTTCGGCAACGACGTCGC
CGTGAACGTGGGCGGCGCGAGCGGCAACTTCGAACTGAACGTATTCCGGCCGATGGTCGCGCATAACGTGCTGCAGTCGG
TGCGCCTGCTCGCTGACGGGATGCACAGCTTCAACGACAACTGCGCGGTCGGGATCGAGCCGAACCGTGAGCGCGTCGAC
CAGCTGCTCAACGAATCGCTGATGCTCGTGACGGCGCTCAATCCGCACATCGGCTACGACAGGGCCGCGCAGATCGCAAA
GAAAGCGCACAAGGAAGGCACGACGCTGAAGGCGGCCGCGCTGGCGCTCGGCCATGTCACCGAACAGCAGTTCGACGAAT
GGGTGCGCCCGCACGACATGGTCGGCAACGCGAAGCGCTAA

Upstream 100 bases:

>100_bases
CGAGCAGTTATAGCCGCACAGTCATACGGCGCAGTCGAGGAGCGCGTGCTGCGCCGCTTTCCCGGAAGCCTTCCGATCAC
CCAGTCAAGCGGAGTAGAAC

Downstream 100 bases:

>100_bases
AAGTCTTTCCATTGCCGGGATGCTCTCGTTCGGGACCGCGGGGAGAGCATCCGTCCCGGCGCATTACACCTTGCCCTGCG
CCACTTCCTCGGGTTTCAGG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTEDVRMERDTFGEIAVPNAKLWGAQTQRSLQNFKISTEKQSPELITALAVIKRAAAEVNLSLGVLDATKAKAIMAAADE
IIDGKHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELMGGERGEARLVHPNDDVNRGQSSNDVFPTAMHVAAAVGIVKH
LLPALRTLRDTLDNKSKAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQNAKHIESTLAHLYELAQGGTAVGTGLNAH
PKFAAEVAAAIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTLAASMMKIANDIRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELNVFRPMVAHNVLQSVRLLADGMHSFNDNCAVGIEPNRERVD
QLLNESLMLVTALNPHIGYDRAAQIAKKAHKEGTTLKAAALALGHVTEQQFDEWVRPHDMVGNAKR

Sequences:

>Translated_466_residues
MTEDVRMERDTFGEIAVPNAKLWGAQTQRSLQNFKISTEKQSPELITALAVIKRAAAEVNLSLGVLDATKAKAIMAAADE
IIDGKHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELMGGERGEARLVHPNDDVNRGQSSNDVFPTAMHVAAAVGIVKH
LLPALRTLRDTLDNKSKAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQNAKHIESTLAHLYELAQGGTAVGTGLNAH
PKFAAEVAAAIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTLAASMMKIANDIRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELNVFRPMVAHNVLQSVRLLADGMHSFNDNCAVGIEPNRERVD
QLLNESLMLVTALNPHIGYDRAAQIAKKAHKEGTTLKAAALALGHVTEQQFDEWVRPHDMVGNAKR
>Mature_465_residues
TEDVRMERDTFGEIAVPNAKLWGAQTQRSLQNFKISTEKQSPELITALAVIKRAAAEVNLSLGVLDATKAKAIMAAADEI
IDGKHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELMGGERGEARLVHPNDDVNRGQSSNDVFPTAMHVAAAVGIVKHL
LPALRTLRDTLDNKSKAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQNAKHIESTLAHLYELAQGGTAVGTGLNAHP
KFAAEVAAAIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTLAASMMKIANDIRWLASGPRCGLGELSIPENEPGSSI
MPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELNVFRPMVAHNVLQSVRLLADGMHSFNDNCAVGIEPNRERVDQ
LLNESLMLVTALNPHIGYDRAAQIAKKAHKEGTTLKAAALALGHVTEQQFDEWVRPHDMVGNAKR

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=459, Percent_Identity=64.7058823529412, Blast_Score=593, Evalue=1e-170,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=48.0519480519481, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=73.9696312364425, Blast_Score=695, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=464, Percent_Identity=39.2241379310345, Blast_Score=347, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=62.8260869565217, Blast_Score=591, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=65.7407407407407, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6324993, Length=464, Percent_Identity=58.4051724137931, Blast_Score=549, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=60.7758620689655, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=60.7758620689655, Blast_Score=589, Evalue=1e-168,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=60.7375271149675, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=59.8272138228942, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=53.1317494600432, Blast_Score=498, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49903; Mature: 49772

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDVRMERDTFGEIAVPNAKLWGAQTQRSLQNFKISTEKQSPELITALAVIKRAAAEVN
CCCCCCCCHHCCCCEECCCCHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
LSLGVLDATKAKAIMAAADEIIDGKHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELMG
CEEEEECHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GERGEARLVHPNDDVNRGQSSNDVFPTAMHVAAAVGIVKHLLPALRTLRDTLDNKSKAFA
CCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
DIVKIGRTHLQDATPLTLGQEFSGYVAQLDQNAKHIESTLAHLYELAQGGTAVGTGLNAH
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEECCCCCCC
PKFAAEVAAAIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTLAASMMKIANDIRWLA
CHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGLGELSIPENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPMVAHNVLQSVRLLADGMHSFNDNCAVGIEPNRERVDQLLNESLMLVTALNPHIGYD
EHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHCCCEEEEEECCCCCCHH
RAAQIAKKAHKEGTTLKAAALALGHVTEQQFDEWVRPHDMVGNAKR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure 
TEDVRMERDTFGEIAVPNAKLWGAQTQRSLQNFKISTEKQSPELITALAVIKRAAAEVN
CCCCCCCHHCCCCEECCCCHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
LSLGVLDATKAKAIMAAADEIIDGKHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELMG
CEEEEECHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GERGEARLVHPNDDVNRGQSSNDVFPTAMHVAAAVGIVKHLLPALRTLRDTLDNKSKAFA
CCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
DIVKIGRTHLQDATPLTLGQEFSGYVAQLDQNAKHIESTLAHLYELAQGGTAVGTGLNAH
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEECCCCCCC
PKFAAEVAAAIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTLAASMMKIANDIRWLA
CHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGLGELSIPENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPMVAHNVLQSVRLLADGMHSFNDNCAVGIEPNRERVDQLLNESLMLVTALNPHIGYD
EHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHCCCEEEEEECCCCCCHH
RAAQIAKKAHKEGTTLKAAALALGHVTEQQFDEWVRPHDMVGNAKR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]