Click here to switch to the map view.

The map label for this gene is fbp1

Identifier: 186475450

GI number: 186475450

Start: 769912

End: 770928

Strand: Reverse

Name: fbp1

Synonym: Bphy_0685

Alternate gene names: 186475450

Gene position: 770928-769912 (Counterclockwise)

Preceding gene: 186475451

Following gene: 186475447

Centisome position: 22.16

GC content: 61.06

Gene sequence:

>1017_bases
ATGTCTTTGCAACGTCGTACCACTCTCACGAAGTACCTGATCGAGCAGCAGCGCGAAAACAACAATCTGCCTGCCGATCT
GCGCCTGCTGATCGAAGTCGTCGCGCGCGCGTGCAAGGCCATCAGCTATCACGTCAGCAAGGGCGCGCTCGGCGACGCGC
TCGGCACGGCCGGCAGCGAGAACGTGCAGGGCGAAGTGCAGAAGAAGCTCGACATCCTGTCGAACGAAATCCTGCTCGAA
GCCAACGAATGGGGCGGCAACCTCGCCGGCATGGCGTCGGAGGAGATGGAACAGTTCTTCCCGATCCCTGCGAATTATCC
GAAAGGCGAATACCTGCTGGTGTTCGATCCGCTCGACGGCTCGTCGAACATCGACGTCAATGTGTCGATCGGCACGATCT
TCTCGGTGCTGCGCTGCCCGGACGGCCAGCAGCCCACGGAACAATCGTTCCTTCAAAAGGGCACGCAGCAGGTCGCAGCC
GGTTATGCCGTGTACGGCCCGCAAACGGTGCTCGTGCTGACAACGGGCAACGGCGTCAACTGCTTCACGCTCGATCGCGA
ACTGGGCTCGTGGGTGCTCACGCAAAGCGACATGCGCATCCCCGTCGAAACGCGCGAATACGCGATCAACGCATCGAACC
AGCGCCACTGGTATGAGCCCGTGCAGCAGTACATCGGCGAACTGAATGCGGGCAAGGACGGTCCGCGCCAGGCCGACTTC
AACATGCGCTGGATCGCATCGATGGTCGCCGACGTGCACCGCATCCTGAACCGCGGCGGCATCTTCATGTACCCCGCCGA
CAAGCGCGATCCGTCGAAGCCCGGCAAGCTGCGCCTGATGTACGAGGCGAACCCGATGTCGTTCATCGTCGAACAGGCGG
GCGGCGCAGCAACCAACGGCGAGAAGCGCATTCTCGACATCCAGCCGAAGAGCCTGCACGAACGCGTCGCCGTATTCCTC
GGCTCAAAAAACGAAGTTGATCGCGTGACCCGCTATCATCTCGAAAAGAAAAGTTGA

Upstream 100 bases:

>100_bases
CCGCGGGGCCTACGGCAACACCCGGATTATTGAAAGTCACGGAACCCGAACATCGAAAGGTTAAAATCGGGGAATTCCCA
AGCCTCTCCGGAGTACTGCA

Downstream 100 bases:

>100_bases
GAAACCACTTGCCAAGCGGGAAAATAGGCTACATAATCCCACTTCTTCGTTGCTGACGAACAAAACGAACGCAACAACGG
AGCCGGAATAGCTCAGACGG

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 1

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSLQRRTTLTKYLIEQQRENNNLPADLRLLIEVVARACKAISYHVSKGALGDALGTAGSENVQGEVQKKLDILSNEILLE
ANEWGGNLAGMASEEMEQFFPIPANYPKGEYLLVFDPLDGSSNIDVNVSIGTIFSVLRCPDGQQPTEQSFLQKGTQQVAA
GYAVYGPQTVLVLTTGNGVNCFTLDRELGSWVLTQSDMRIPVETREYAINASNQRHWYEPVQQYIGELNAGKDGPRQADF
NMRWIASMVADVHRILNRGGIFMYPADKRDPSKPGKLRLMYEANPMSFIVEQAGGAATNGEKRILDIQPKSLHERVAVFL
GSKNEVDRVTRYHLEKKS

Sequences:

>Translated_338_residues
MSLQRRTTLTKYLIEQQRENNNLPADLRLLIEVVARACKAISYHVSKGALGDALGTAGSENVQGEVQKKLDILSNEILLE
ANEWGGNLAGMASEEMEQFFPIPANYPKGEYLLVFDPLDGSSNIDVNVSIGTIFSVLRCPDGQQPTEQSFLQKGTQQVAA
GYAVYGPQTVLVLTTGNGVNCFTLDRELGSWVLTQSDMRIPVETREYAINASNQRHWYEPVQQYIGELNAGKDGPRQADF
NMRWIASMVADVHRILNRGGIFMYPADKRDPSKPGKLRLMYEANPMSFIVEQAGGAATNGEKRILDIQPKSLHERVAVFL
GSKNEVDRVTRYHLEKKS
>Mature_337_residues
SLQRRTTLTKYLIEQQRENNNLPADLRLLIEVVARACKAISYHVSKGALGDALGTAGSENVQGEVQKKLDILSNEILLEA
NEWGGNLAGMASEEMEQFFPIPANYPKGEYLLVFDPLDGSSNIDVNVSIGTIFSVLRCPDGQQPTEQSFLQKGTQQVAAG
YAVYGPQTVLVLTTGNGVNCFTLDRELGSWVLTQSDMRIPVETREYAINASNQRHWYEPVQQYIGELNAGKDGPRQADFN
MRWIASMVADVHRILNRGGIFMYPADKRDPSKPGKLRLMYEANPMSFIVEQAGGAATNGEKRILDIQPKSLHERVAVFLG
SKNEVDRVTRYHLEKKS

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI22907028, Length=319, Percent_Identity=42.3197492163009, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI189083692, Length=319, Percent_Identity=41.692789968652, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI16579888, Length=319, Percent_Identity=41.692789968652, Blast_Score=244, Evalue=1e-64,
Organism=Escherichia coli, GI1790679, Length=327, Percent_Identity=44.954128440367, Blast_Score=278, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17508131, Length=325, Percent_Identity=41.5384615384615, Blast_Score=257, Evalue=8e-69,
Organism=Saccharomyces cerevisiae, GI6323409, Length=322, Percent_Identity=41.304347826087, Blast_Score=261, Evalue=1e-70,
Organism=Drosophila melanogaster, GI45550998, Length=325, Percent_Identity=44.9230769230769, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI19921562, Length=325, Percent_Identity=44.9230769230769, Blast_Score=263, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16A1_BURP8 (B2JEJ7)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001856920.1
- ProteinModelPortal:   B2JEJ7
- SMR:   B2JEJ7
- GeneID:   6244633
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_0685
- HOGENOM:   HBG731261
- OMA:   HWEAPVQ
- ProtClustDB:   PRK09293
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 37623; Mature: 37492

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00124 FBPASE; PS00659 GLYCOSYL_HYDROL_F5

Important sites: BINDING 210-210 BINDING 276-276

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQRRTTLTKYLIEQQRENNNLPADLRLLIEVVARACKAISYHVSKGALGDALGTAGSE
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCC
NVQGEVQKKLDILSNEILLEANEWGGNLAGMASEEMEQFFPIPANYPKGEYLLVFDPLDG
CCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCCC
SSNIDVNVSIGTIFSVLRCPDGQQPTEQSFLQKGTQQVAAGYAVYGPQTVLVLTTGNGVN
CCCEEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEECCCEEEEEECCCCEE
CFTLDRELGSWVLTQSDMRIPVETREYAINASNQRHWYEPVQQYIGELNAGKDGPRQADF
EEEECCCCCCEEEECCCCCCCEEHHHEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
NMRWIASMVADVHRILNRGGIFMYPADKRDPSKPGKLRLMYEANPMSFIVEQAGGAATNG
CHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCC
EKRILDIQPKSLHERVAVFLGSKNEVDRVTRYHLEKKS
CCEEEECCCHHHHHHHHHEECCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLQRRTTLTKYLIEQQRENNNLPADLRLLIEVVARACKAISYHVSKGALGDALGTAGSE
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCC
NVQGEVQKKLDILSNEILLEANEWGGNLAGMASEEMEQFFPIPANYPKGEYLLVFDPLDG
CCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCCC
SSNIDVNVSIGTIFSVLRCPDGQQPTEQSFLQKGTQQVAAGYAVYGPQTVLVLTTGNGVN
CCCEEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEECCCEEEEEECCCCEE
CFTLDRELGSWVLTQSDMRIPVETREYAINASNQRHWYEPVQQYIGELNAGKDGPRQADF
EEEECCCCCCEEEECCCCCCCEEHHHEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
NMRWIASMVADVHRILNRGGIFMYPADKRDPSKPGKLRLMYEANPMSFIVEQAGGAATNG
CHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCC
EKRILDIQPKSLHERVAVFLGSKNEVDRVTRYHLEKKS
CCEEEECCCHHHHHHHHHEECCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA