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The map label for this gene is acdA [H]

Identifier: 186475449

GI number: 186475449

Start: 768512

End: 769651

Strand: Direct

Name: acdA [H]

Synonym: Bphy_0684

Alternate gene names: 186475449

Gene position: 768512-769651 (Clockwise)

Preceding gene: 186475448

Following gene: 186475452

Centisome position: 22.09

GC content: 65.44

Gene sequence:

>1140_bases
ATGCATAAGCGGCTGGGTATCGAACACGGCGACCTCGAAATCGCCGATGCGGTTGCGCGCTTTGCGCAAAGCGAACTCGC
GCCAGGTGCGGCGCAAGTGGACCGCGAAGAACTGTCGACGGTGCGCTATGTCGCGCAGCTCGCCGAGCTGGGCATGATGG
GCATGAACCTGCCGCAGCGGTGGGGCGGCGTCGACGCGTCGCCGGTCGCGATCGTGCTCTCGCTGGTGGAGATCGCGAAA
GCGTGTGCATCGACGTCGTCGATGATCGGTGCGCATTATCTTGCGACCGACTCGATTCTGATTGGGGGCGACGATGCGTT
GCGCGATCGCTATCTTCCCGACGCGGCCAGCGGCAAGAAGGTCGGCGCGTTCGCGCTGACGGAGCCGCGCGCCGGCTCCC
ATCCCGCCGACATGGCGACCCGCGCGAGGCGCGAAGGTGACGGCTACCGGATCATGGGCGTGAAGCACTTCATCTCGAAC
GCCGATGCGGCAGGCTTCATCGTCGTGTTTGCGAAGACCGATGTCGACGCGGGCACGCGCGGCATCAGCGCGTTCGTGGT
CGACAGGCACACGCCCGGCGTCGACGTTGCGCCCGCCGAGAAGCTGATGGGCATTCGCGGCGCACCCGCGCATGAAGTCG
CGCTCGACTGCTTCGTTCCCGCTGCGAACCGGCTCGGCGCAGAGGGCAGCGGATTCAGGACGGCCATGAAAGTGCTCGAC
AACAGCCGGCTCGATGTGGCCGCAACGAGTCTCGGTATTGCAGAAGCGGCGTTGTCCGCGGCCATCGGCTGGTTGAAGGA
GCGGCAGGTGGGCGGCGAGCCGTTGTCGAACCGGCAAGGTTTGCAGTGGACGATCGCCGATATGAAGACCAGACTCGAGG
CCGCGTGGTTGCTGACTTTGCAAGCGGCCGCAAAGCGCGGGGCGGGCGTGCCGTTCACGCAGGACGCGTCGATGGCGAAG
CTTTATGCATCCGAGATGGTTGCGTTCGTCACCGATGCTGCGTTGCAGATGCACGGCGGCTATGGTTTCACGCGCGAGAT
GCCGCTGGAGCGCCTGATTCGCGATGCGCGGATTCTGCGGATCTACGAGGGGTCCTCGGAAATCCAGCGGACGGTGATCG
CGCGGACGGTGCTGGAATGA

Upstream 100 bases:

>100_bases
GGTTACGACGCGCAAGACATTGAGGCGTTGCGCGTGCGCGGCGCGTTTGGCGCGAGCGTGCCGACAAGGAACGACGCCGA
TTGCCGACAGGAGCGGGACC

Downstream 100 bases:

>100_bases
ACGAAAGGAAGGGCTCGCCGATCGTTTCTCTGTGCGCACATCGATCCGTGAGCAGAAAACAAAAAGCCCAGTCGCGATGA
CTGGGCTTTTTGTTTGATTC

Product: acyl-CoA dehydrogenase domain-containing protein

Products: 2-butenoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MHKRLGIEHGDLEIADAVARFAQSELAPGAAQVDREELSTVRYVAQLAELGMMGMNLPQRWGGVDASPVAIVLSLVEIAK
ACASTSSMIGAHYLATDSILIGGDDALRDRYLPDAASGKKVGAFALTEPRAGSHPADMATRARREGDGYRIMGVKHFISN
ADAAGFIVVFAKTDVDAGTRGISAFVVDRHTPGVDVAPAEKLMGIRGAPAHEVALDCFVPAANRLGAEGSGFRTAMKVLD
NSRLDVAATSLGIAEAALSAAIGWLKERQVGGEPLSNRQGLQWTIADMKTRLEAAWLLTLQAAAKRGAGVPFTQDASMAK
LYASEMVAFVTDAALQMHGGYGFTREMPLERLIRDARILRIYEGSSEIQRTVIARTVLE

Sequences:

>Translated_379_residues
MHKRLGIEHGDLEIADAVARFAQSELAPGAAQVDREELSTVRYVAQLAELGMMGMNLPQRWGGVDASPVAIVLSLVEIAK
ACASTSSMIGAHYLATDSILIGGDDALRDRYLPDAASGKKVGAFALTEPRAGSHPADMATRARREGDGYRIMGVKHFISN
ADAAGFIVVFAKTDVDAGTRGISAFVVDRHTPGVDVAPAEKLMGIRGAPAHEVALDCFVPAANRLGAEGSGFRTAMKVLD
NSRLDVAATSLGIAEAALSAAIGWLKERQVGGEPLSNRQGLQWTIADMKTRLEAAWLLTLQAAAKRGAGVPFTQDASMAK
LYASEMVAFVTDAALQMHGGYGFTREMPLERLIRDARILRIYEGSSEIQRTVIARTVLE
>Mature_379_residues
MHKRLGIEHGDLEIADAVARFAQSELAPGAAQVDREELSTVRYVAQLAELGMMGMNLPQRWGGVDASPVAIVLSLVEIAK
ACASTSSMIGAHYLATDSILIGGDDALRDRYLPDAASGKKVGAFALTEPRAGSHPADMATRARREGDGYRIMGVKHFISN
ADAAGFIVVFAKTDVDAGTRGISAFVVDRHTPGVDVAPAEKLMGIRGAPAHEVALDCFVPAANRLGAEGSGFRTAMKVLD
NSRLDVAATSLGIAEAALSAAIGWLKERQVGGEPLSNRQGLQWTIADMKTRLEAAWLLTLQAAAKRGAGVPFTQDASMAK
LYASEMVAFVTDAALQMHGGYGFTREMPLERLIRDARILRIYEGSSEIQRTVIARTVLE

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=360, Percent_Identity=41.6666666666667, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4501859, Length=369, Percent_Identity=36.8563685636856, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI7656849, Length=380, Percent_Identity=35.7894736842105, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=34.0425531914894, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4557231, Length=360, Percent_Identity=33.3333333333333, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI187960098, Length=360, Percent_Identity=33.3333333333333, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI226958414, Length=351, Percent_Identity=33.9031339031339, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4557235, Length=373, Percent_Identity=35.1206434316354, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI76496475, Length=373, Percent_Identity=35.1206434316354, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI21361497, Length=372, Percent_Identity=32.258064516129, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI4501857, Length=365, Percent_Identity=27.1232876712329, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI4503943, Length=372, Percent_Identity=26.6129032258064, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI7669494, Length=358, Percent_Identity=26.8156424581006, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI48976061, Length=401, Percent_Identity=26.9326683291771, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI211971008, Length=401, Percent_Identity=26.9326683291771, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38505218, Length=286, Percent_Identity=26.5734265734266, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786223, Length=353, Percent_Identity=29.4617563739377, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI87081958, Length=339, Percent_Identity=29.4985250737463, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87082384, Length=291, Percent_Identity=30.2405498281787, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17508101, Length=366, Percent_Identity=34.4262295081967, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17570075, Length=365, Percent_Identity=35.3424657534247, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17534899, Length=383, Percent_Identity=34.2036553524804, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=33.2439678284182, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17569725, Length=370, Percent_Identity=34.3243243243243, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=31.6622691292876, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71985184, Length=342, Percent_Identity=37.1345029239766, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=31.5649867374005, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=32.9931972789116, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71985192, Length=287, Percent_Identity=34.1463414634146, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=33.6099585062241, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71982178, Length=271, Percent_Identity=29.8892988929889, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17534353, Length=361, Percent_Identity=26.5927977839335, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17551932, Length=381, Percent_Identity=27.2965879265092, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=31.4410480349345, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17505929, Length=365, Percent_Identity=26.8493150684932, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=31.8181818181818, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI86563383, Length=349, Percent_Identity=26.0744985673352, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=349, Percent_Identity=26.0744985673352, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562446, Length=283, Percent_Identity=28.6219081272085, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356377, Length=361, Percent_Identity=39.612188365651, Blast_Score=258, Evalue=7e-69,
Organism=Drosophila melanogaster, GI24646207, Length=359, Percent_Identity=38.7186629526462, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24666513, Length=366, Percent_Identity=35.2459016393443, Blast_Score=227, Evalue=8e-60,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=32.1899736147757, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=32.2834645669291, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI281363737, Length=347, Percent_Identity=34.5821325648415, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI19920834, Length=383, Percent_Identity=28.9817232375979, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.2

Molecular weight: Translated: 40359; Mature: 40359

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKRLGIEHGDLEIADAVARFAQSELAPGAAQVDREELSTVRYVAQLAELGMMGMNLPQR
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHH
WGGVDASPVAIVLSLVEIAKACASTSSMIGAHYLATDSILIGGDDALRDRYLPDAASGKK
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEECCCHHHHHCCCCCCCCCCC
VGAFALTEPRAGSHPADMATRARREGDGYRIMGVKHFISNADAAGFIVVFAKTDVDAGTR
CEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCEEEEEEEECCCCCCCC
GISAFVVDRHTPGVDVAPAEKLMGIRGAPAHEVALDCFVPAANRLGAEGSGFRTAMKVLD
CEEEEEEECCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHC
NSRLDVAATSLGIAEAALSAAIGWLKERQVGGEPLSNRQGLQWTIADMKTRLEAAWLLTL
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
QAAAKRGAGVPFTQDASMAKLYASEMVAFVTDAALQMHGGYGFTREMPLERLIRDARILR
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEEE
IYEGSSEIQRTVIARTVLE
EECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHKRLGIEHGDLEIADAVARFAQSELAPGAAQVDREELSTVRYVAQLAELGMMGMNLPQR
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHH
WGGVDASPVAIVLSLVEIAKACASTSSMIGAHYLATDSILIGGDDALRDRYLPDAASGKK
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEECCCHHHHHCCCCCCCCCCC
VGAFALTEPRAGSHPADMATRARREGDGYRIMGVKHFISNADAAGFIVVFAKTDVDAGTR
CEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCEEEEEEEECCCCCCCC
GISAFVVDRHTPGVDVAPAEKLMGIRGAPAHEVALDCFVPAANRLGAEGSGFRTAMKVLD
CEEEEEEECCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHC
NSRLDVAATSLGIAEAALSAAIGWLKERQVGGEPLSNRQGLQWTIADMKTRLEAAWLLTL
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
QAAAKRGAGVPFTQDASMAKLYASEMVAFVTDAALQMHGGYGFTREMPLERLIRDARILR
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEEE
IYEGSSEIQRTVIARTVLE
EECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: butanoyl-CoA; acceptor

Specific reaction: butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]