Click here to switch to the map view.

The map label for this gene is gpsA

Identifier: 186475039

GI number: 186475039

Start: 312788

End: 313786

Strand: Direct

Name: gpsA

Synonym: Bphy_0270

Alternate gene names: 186475039

Gene position: 312788-313786 (Clockwise)

Preceding gene: 186475038

Following gene: 186475040

Centisome position: 8.99

GC content: 67.87

Gene sequence:

>999_bases
ATGAAGGTCGCCGTTCTCGGCGCCGGTGCATGGGGCACCGCGCTCGCTGGCCATCTGGCCGCGCGGCACGACACGGTGCT
CTGGGCGCGCGATGCCACGCTCATCAGCGAACTTTCCACATCGCACGAAAACGCCCGCTATCTGGCGGGCGTTGCGTTGC
CCTCCACGCTTCGCTTCCAGGCGAATCTCGAACTCGCACTGAATCACGCGCTCGACGACGCGGCGCTGTGCGTCGTGGCG
ACGCCCGTCGCGGGTTTGCGCGCGATGCTGCGCACGATGCGCGACATGCGCAAGGTGCCATCGCACATCGTGTGGCTGTG
CAAGGGTTTCGAGGCGGACTCGCAGCTGATGCCGCATCAGGTCGTCGCACAGGAGTTGAGCGGCCACACCAGCAACGGGC
CGCTGTCGGGGCCGAGCTTTGCGCGCGAGGTGGGGCAGGGGCTGCCCGTCGCGCTGACGGTGGCGAGCGCGTCCGCAGCG
TGCCGCGAACGCACGGTCGCGGCCTTCCATCATGGCGCGATGCGCATCTATAGCGGCGATGATGTCGTCGGTGTGGAAGT
GGGCGGCGCGGTGAAGAATGTGCTGGCGATCGCCACGGGCATCGCCGACGGTCTCGGCCTTGGCCTGAATGCACGTGCGG
CGTTGATCACCCGTGGGCTTGCCGAGATGTCGCGTCTCGGCGCGGCGCTCGGCGGACGGGCGGAAACGTTCACGGGGCTC
ACGGGTCTCGGCGATCTGATCCTGACCGCCACGGGTGATCTGTCGCGCAACCGCACGGTCGGCATGCAACTCGCAAGCGG
CCGTTCACTCGACGACATTCTCAATGCGCTCGGGCATGTCGCCGAGGGCGTGCGCTGCGCGCGCAGCGTGCTGTCACTCG
CGCAATCGCATGCCATCGACATGCCGATCACGCAAGCCGTTTGCGACGTGCTGTTCAATGGCGTCGCGCCGCGCGATGCC
GTGAGCGCGCTGCTGCGCCGTGATGCGAAGCCCGAATAG

Upstream 100 bases:

>100_bases
CTTCCAGGCGCTGTACGAGCAACGTCTCGCGCAGATCGCGACGCAGGAAACGGGCGCGGGCAGCGCAGCCCACCACTGAC
GCGTGCAGGCGGTGCCGGGT

Downstream 100 bases:

>100_bases
GGGCCGTTCTGCAAGCGGGCTTCACGGCCCGTTGCCCATCGCCGCACATTGCTTGAAAGTCTTTTACGCAGCCGGTAAAG
GCTAGCGCCGAACGGCTCGC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKVAVLGAGAWGTALAGHLAARHDTVLWARDATLISELSTSHENARYLAGVALPSTLRFQANLELALNHALDDAALCVVA
TPVAGLRAMLRTMRDMRKVPSHIVWLCKGFEADSQLMPHQVVAQELSGHTSNGPLSGPSFAREVGQGLPVALTVASASAA
CRERTVAAFHHGAMRIYSGDDVVGVEVGGAVKNVLAIATGIADGLGLGLNARAALITRGLAEMSRLGAALGGRAETFTGL
TGLGDLILTATGDLSRNRTVGMQLASGRSLDDILNALGHVAEGVRCARSVLSLAQSHAIDMPITQAVCDVLFNGVAPRDA
VSALLRRDAKPE

Sequences:

>Translated_332_residues
MKVAVLGAGAWGTALAGHLAARHDTVLWARDATLISELSTSHENARYLAGVALPSTLRFQANLELALNHALDDAALCVVA
TPVAGLRAMLRTMRDMRKVPSHIVWLCKGFEADSQLMPHQVVAQELSGHTSNGPLSGPSFAREVGQGLPVALTVASASAA
CRERTVAAFHHGAMRIYSGDDVVGVEVGGAVKNVLAIATGIADGLGLGLNARAALITRGLAEMSRLGAALGGRAETFTGL
TGLGDLILTATGDLSRNRTVGMQLASGRSLDDILNALGHVAEGVRCARSVLSLAQSHAIDMPITQAVCDVLFNGVAPRDA
VSALLRRDAKPE
>Mature_332_residues
MKVAVLGAGAWGTALAGHLAARHDTVLWARDATLISELSTSHENARYLAGVALPSTLRFQANLELALNHALDDAALCVVA
TPVAGLRAMLRTMRDMRKVPSHIVWLCKGFEADSQLMPHQVVAQELSGHTSNGPLSGPSFAREVGQGLPVALTVASASAA
CRERTVAAFHHGAMRIYSGDDVVGVEVGGAVKNVLAIATGIADGLGLGLNARAALITRGLAEMSRLGAALGGRAETFTGL
TGLGDLILTATGDLSRNRTVGMQLASGRSLDDILNALGHVAEGVRCARSVLSLAQSHAIDMPITQAVCDVLFNGVAPRDA
VSALLRRDAKPE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=337, Percent_Identity=27.893175074184, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI24307999, Length=349, Percent_Identity=25.7879656160458, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1790037, Length=332, Percent_Identity=42.1686746987952, Blast_Score=238, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI17507425, Length=338, Percent_Identity=27.5147928994083, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193210136, Length=365, Percent_Identity=25.4794520547945, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI32564399, Length=355, Percent_Identity=25.3521126760563, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI32564403, Length=365, Percent_Identity=25.4794520547945, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193210134, Length=350, Percent_Identity=24, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324513, Length=370, Percent_Identity=28.6486486486486, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320181, Length=355, Percent_Identity=28.4507042253521, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281362270, Length=300, Percent_Identity=26.6666666666667, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45551945, Length=300, Percent_Identity=26.6666666666667, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17136202, Length=350, Percent_Identity=25.1428571428571, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136200, Length=350, Percent_Identity=25.1428571428571, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136204, Length=348, Percent_Identity=25.2873563218391, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24648969, Length=257, Percent_Identity=27.2373540856031, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI22026922, Length=308, Percent_Identity=23.7012987012987, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_BURP8 (B2JC99)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001856509.1
- ProteinModelPortal:   B2JC99
- SMR:   B2JC99
- GeneID:   6241772
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_0270
- HOGENOM:   HBG586392
- OMA:   SQTLRGN
- ProtClustDB:   PRK00094
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 34423; Mature: 34423

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 192-192 BINDING 108-108 BINDING 108-108 BINDING 141-141 BINDING 256-256 BINDING 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAVLGAGAWGTALAGHLAARHDTVLWARDATLISELSTSHENARYLAGVALPSTLRFQ
CEEEEEECCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCEEEEECCCCCEEEE
ANLELALNHALDDAALCVVATPVAGLRAMLRTMRDMRKVPSHIVWLCKGFEADSQLMPHQ
ECHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
VVAQELSGHTSNGPLSGPSFAREVGQGLPVALTVASASAACRERTVAAFHHGAMRIYSGD
HHHHHHCCCCCCCCCCCHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCEEEEECCC
DVVGVEVGGAVKNVLAIATGIADGLGLGLNARAALITRGLAEMSRLGAALGGRAETFTGL
CEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCH
TGLGDLILTATGDLSRNRTVGMQLASGRSLDDILNALGHVAEGVRCARSVLSLAQSHAID
HHHCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MPITQAVCDVLFNGVAPRDAVSALLRRDAKPE
CCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKVAVLGAGAWGTALAGHLAARHDTVLWARDATLISELSTSHENARYLAGVALPSTLRFQ
CEEEEEECCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCEEEEECCCCCEEEE
ANLELALNHALDDAALCVVATPVAGLRAMLRTMRDMRKVPSHIVWLCKGFEADSQLMPHQ
ECHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
VVAQELSGHTSNGPLSGPSFAREVGQGLPVALTVASASAACRERTVAAFHHGAMRIYSGD
HHHHHHCCCCCCCCCCCHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCEEEEECCC
DVVGVEVGGAVKNVLAIATGIADGLGLGLNARAALITRGLAEMSRLGAALGGRAETFTGL
CEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCH
TGLGDLILTATGDLSRNRTVGMQLASGRSLDDILNALGHVAEGVRCARSVLSLAQSHAID
HHHCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MPITQAVCDVLFNGVAPRDAVSALLRRDAKPE
CCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA