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The map label for this gene is pyrH [H]

Identifier: 183221974

GI number: 183221974

Start: 2705737

End: 2706483

Strand: Reverse

Name: pyrH [H]

Synonym: LEPBI_I2615

Alternate gene names: 183221974

Gene position: 2706483-2705737 (Counterclockwise)

Preceding gene: 183221975

Following gene: 183221973

Centisome position: 75.19

GC content: 43.24

Gene sequence:

>747_bases
GTGGGAACTAGTCCGCGTTTCAAACGAATCCTCATTAAAATCTCCGGCGAGGCACTCGCCGGTGAGGGTGAACTTGGTAT
TGATACCAACAAAACATTCTCACTTGCCGGACAAATCAAAGAAGTTCATGACTTAGGTCTCGAGGTTGCTGTGGTTGTTG
GCGGTGGGAATATGATCCGCGGCGAAACATTAGCAAAGTCGGGAATGGACCGAGCCACTGCCGATTATATGGGTATGCTT
GGTACCATCATGAATGGACTCGCCTTACAAGATGCATGCGAAAAACAAGGGATGTTTACCCGGGTTCTTTCCGCCATCGA
AATGAAATCTGTTGCAGAACCTTACATTCGTAGACGAGCGGTTCGCCACTTAGAAAAAAATCGTGTGATTATTTTTGCTG
GTGGAACAGGAAATCCATACTTTACAACAGACACAACGGCCTCTTTACGGGCAGTGGAAGTTGGTTGTGAAGTAATTTTA
AAGGCAACGAAAGTGGATGGTGTGTACACAGCCGATCCAAAAAAAGATCCAAGTGCAAAACGGTATTTACAAGTTTCCTT
TATGGAGTCCATCAAACACCGCTTAAAGGTAATGGATTCAACTGCACTCAGTCTATGTATGGATAATAATATGCCCATCA
TAGTGTTTGATATTTTTAAAGCAGGTAATTTAAGAAAATTGATCGATGGGGAACCAATTGGTACACTCATCTCCAATTCA
GAGGAAGTGATTCTAGATGGTAGATGA

Upstream 100 bases:

>100_bases
ATCCGTGACAACTCCAAAACCATCAATGACCTGCTCCAAGAGGCCATTGCAAAATTTGGAGAGAACATTACTGTTGGTAG
GTTCTCGAGGTTCCAAGTAG

Downstream 100 bases:

>100_bases
AATTATAAAATCCATGCAGTCCAAAATGGACAAAACAGTTGATGCCTTAAAAAAAGATTTTGGTACAATTCGTACGGGAA
AAGCAAACCCTATGATGGTG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MGTSPRFKRILIKISGEALAGEGELGIDTNKTFSLAGQIKEVHDLGLEVAVVVGGGNMIRGETLAKSGMDRATADYMGML
GTIMNGLALQDACEKQGMFTRVLSAIEMKSVAEPYIRRRAVRHLEKNRVIIFAGGTGNPYFTTDTTASLRAVEVGCEVIL
KATKVDGVYTADPKKDPSAKRYLQVSFMESIKHRLKVMDSTALSLCMDNNMPIIVFDIFKAGNLRKLIDGEPIGTLISNS
EEVILDGR

Sequences:

>Translated_248_residues
MGTSPRFKRILIKISGEALAGEGELGIDTNKTFSLAGQIKEVHDLGLEVAVVVGGGNMIRGETLAKSGMDRATADYMGML
GTIMNGLALQDACEKQGMFTRVLSAIEMKSVAEPYIRRRAVRHLEKNRVIIFAGGTGNPYFTTDTTASLRAVEVGCEVIL
KATKVDGVYTADPKKDPSAKRYLQVSFMESIKHRLKVMDSTALSLCMDNNMPIIVFDIFKAGNLRKLIDGEPIGTLISNS
EEVILDGR
>Mature_247_residues
GTSPRFKRILIKISGEALAGEGELGIDTNKTFSLAGQIKEVHDLGLEVAVVVGGGNMIRGETLAKSGMDRATADYMGMLG
TIMNGLALQDACEKQGMFTRVLSAIEMKSVAEPYIRRRAVRHLEKNRVIIFAGGTGNPYFTTDTTASLRAVEVGCEVILK
ATKVDGVYTADPKKDPSAKRYLQVSFMESIKHRLKVMDSTALSLCMDNNMPIIVFDIFKAGNLRKLIDGEPIGTLISNSE
EVILDGR

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=234, Percent_Identity=50, Blast_Score=242, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 26947; Mature: 26816

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTSPRFKRILIKISGEALAGEGELGIDTNKTFSLAGQIKEVHDLGLEVAVVVGGGNMIR
CCCCCCEEEEEEEECCCEEECCCCCCCCCCCEEEHHHHHHHHHHCCCEEEEEECCCCEEE
GETLAKSGMDRATADYMGMLGTIMNGLALQDACEKQGMFTRVLSAIEMKSVAEPYIRRRA
CHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
VRHLEKNRVIIFAGGTGNPYFTTDTTASLRAVEVGCEVILKATKVDGVYTADPKKDPSAK
HHHHHHCCEEEEECCCCCCCEECCCCCHHHHHHHHHHHEEEEECCCCEEECCCCCCCCHH
RYLQVSFMESIKHRLKVMDSTALSLCMDNNMPIIVFDIFKAGNLRKLIDGEPIGTLISNS
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCHHHCCCCCCHHHHCCC
EEVILDGR
CEEEEECC
>Mature Secondary Structure 
GTSPRFKRILIKISGEALAGEGELGIDTNKTFSLAGQIKEVHDLGLEVAVVVGGGNMIR
CCCCCEEEEEEEECCCEEECCCCCCCCCCCEEEHHHHHHHHHHCCCEEEEEECCCCEEE
GETLAKSGMDRATADYMGMLGTIMNGLALQDACEKQGMFTRVLSAIEMKSVAEPYIRRRA
CHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
VRHLEKNRVIIFAGGTGNPYFTTDTTASLRAVEVGCEVILKATKVDGVYTADPKKDPSAK
HHHHHHCCEEEEECCCCCCCEECCCCCHHHHHHHHHHHEEEEECCCCEEECCCCCCCCHH
RYLQVSFMESIKHRLKVMDSTALSLCMDNNMPIIVFDIFKAGNLRKLIDGEPIGTLISNS
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCHHHCCCCCCHHHHCCC
EEVILDGR
CEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA