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The map label for this gene is manB [H]

Identifier: 183221690

GI number: 183221690

Start: 2384512

End: 2386266

Strand: Direct

Name: manB [H]

Synonym: LEPBI_I2315

Alternate gene names: 183221690

Gene position: 2384512-2386266 (Clockwise)

Preceding gene: 183221687

Following gene: 183221691

Centisome position: 66.24

GC content: 39.94

Gene sequence:

>1755_bases
ATGTTGAAACCAGAAGACAATATCCTATCTTGGACGAAATCACCTTTTTCTACAGAAATCCAATCCGAGGCCAAAAAGGC
TTACGAAGATTGGCAAAAAGGAATCACCTCGGATCTCGTCGATTCATACGCACATCCTTTGAGTTTTGGGACAGGTGGGA
TCCGAGGGAAAATTGGTTATGGCATCGGCAAAATGAACCTCTATACAGTCGGCCGAGCTGCACTTGGTTTTTTAAGTTAT
CTGCGTGACACAAAAAAGTCTCCATCAATCGTGATTGCCTACGACTCACGGAGGATGTCCAAAGAATTTGCAGAACTCTC
TGCTGGCATTGGTGCTACACTCGGTGTCAAAGTGTATTTATTTCCAAAAGTCACACCCACACCTCTACTCTCCTATGCCA
TTCGTTATTTCGAAGCCAGTGGTGGGATTGTCATCACGGCTTCACACAACCCCCCAGAATACAACGGTTTCAAAGCCTAT
CTGGCTGATGGTGGACAACTTGTCCCTCCAGATGACTCACTCATCATCCAAAGGATCAGCGGGATAGAAGATTGGACTAG
TATTCCGATGATCTCCAAAACAGATAAAGTATACAAAAAATTTGTGAAAACCGTCGGTCCAGATTGTTTCCAAAATTATT
TAAAAGAATTAAAAAAAGCAGGGATCCAGTCCCAAGCAAAACCAAAAACACGAAACAATCTAAAAATCGTTTATTCTCCG
TTACACGGCACTGGTGGAGAGTATATGAAGGAGATGTTTCAGTATTTCGGATACAAATCTGTATTTTTAGTACCAGAACA
GAAAAAACCAGATGGCGAATTCCCAACAGTCAAATACCCTAACCCAGAAGAAAAAGAAGCCCTCGCCTTATGTGAGTTTC
ATGCCAAAAAGAAAAAAGCAGAAGTTTTCATCGCCACAGACCCTGATGCAGATAGACTCGGTGTAGGTGTTCGTAAACCC
GATGGAGAATATGAATACTTAAATGGAAACCAAATTGGTTCTATTATGGCCGCATATCTTTCCGAAAGAAAAAAACAAAA
GGGAAAAGTGTATCATTTGGTCAAAACCATCGTGACAACGGACTTACAAGAAGCCATTGCCAAAAAAAATGGAATCAAAA
TTAAAAATGTCCTCACTGGTTTTAAATACATTGCAGAAGAAATGAAACAAATTGAATCCAAAAAAAACAACTTGTTTCTG
TTTGGTGGTGAAGAATCTTATGGATACTTACCCGTTCCCTTCGTTCGTGATAAGGATTCCTTATCGAGTGCCCTTCTCTT
CATTGAAATATTAGCAGAAAAAACGGACCTACTCACTTATCTCAATGAAATTTATCTGAAATACGGACTCTATCGTGAAA
GCCTGTATTCCTTAACCTTAGAAGGAAGTTCGGGTCAGGAAAAAATCAAACAATCTATTGAGTCCTTACGAACCAAAAAC
TTAATTGGAAAACTGATAGGTGGCAGAAAGGTCATTTCTGTCCTTGATTATGAAACACAAAAAGCAGATGGAAAAGGAAA
ATCCTCTGTCTTCAAAGGAATGCCTAAATCCAATGTCATCCAAGTGGAATTGGAAGGAAATGCCAAACTGACCATCCGGC
CTTCCGGGACAGAACCAAAAGTAAAAGTATACTCTTCTTTTGCTTCGCGAAAAAAACCGAAAAAATCTTCAGAGATCCCT
AGTTTATGGAAAACTTTGGGAGATGAGATTGTTTCCGCAGAAACTGAATTTTTACAACTAGCAGGCCTACTATGA

Upstream 100 bases:

>100_bases
CTCTAATCGGAATCGTTCCAGGCGGTCTTCGATGAAAAATTCTCTCGGTTCCAAAATTGATTTCCATTCAACTTAGCTTC
AAAAGATTAGTATGTAAGCT

Downstream 100 bases:

>100_bases
GTTCCGAAACAAAAACCAAATTCGAAAGTATCAAAAATCTTTCTGACAAATACCTACTCAATACTTATAACAGATATCCA
ATCGCCTTCTCCTATGGTGT

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MLKPEDNILSWTKSPFSTEIQSEAKKAYEDWQKGITSDLVDSYAHPLSFGTGGIRGKIGYGIGKMNLYTVGRAALGFLSY
LRDTKKSPSIVIAYDSRRMSKEFAELSAGIGATLGVKVYLFPKVTPTPLLSYAIRYFEASGGIVITASHNPPEYNGFKAY
LADGGQLVPPDDSLIIQRISGIEDWTSIPMISKTDKVYKKFVKTVGPDCFQNYLKELKKAGIQSQAKPKTRNNLKIVYSP
LHGTGGEYMKEMFQYFGYKSVFLVPEQKKPDGEFPTVKYPNPEEKEALALCEFHAKKKKAEVFIATDPDADRLGVGVRKP
DGEYEYLNGNQIGSIMAAYLSERKKQKGKVYHLVKTIVTTDLQEAIAKKNGIKIKNVLTGFKYIAEEMKQIESKKNNLFL
FGGEESYGYLPVPFVRDKDSLSSALLFIEILAEKTDLLTYLNEIYLKYGLYRESLYSLTLEGSSGQEKIKQSIESLRTKN
LIGKLIGGRKVISVLDYETQKADGKGKSSVFKGMPKSNVIQVELEGNAKLTIRPSGTEPKVKVYSSFASRKKPKKSSEIP
SLWKTLGDEIVSAETEFLQLAGLL

Sequences:

>Translated_584_residues
MLKPEDNILSWTKSPFSTEIQSEAKKAYEDWQKGITSDLVDSYAHPLSFGTGGIRGKIGYGIGKMNLYTVGRAALGFLSY
LRDTKKSPSIVIAYDSRRMSKEFAELSAGIGATLGVKVYLFPKVTPTPLLSYAIRYFEASGGIVITASHNPPEYNGFKAY
LADGGQLVPPDDSLIIQRISGIEDWTSIPMISKTDKVYKKFVKTVGPDCFQNYLKELKKAGIQSQAKPKTRNNLKIVYSP
LHGTGGEYMKEMFQYFGYKSVFLVPEQKKPDGEFPTVKYPNPEEKEALALCEFHAKKKKAEVFIATDPDADRLGVGVRKP
DGEYEYLNGNQIGSIMAAYLSERKKQKGKVYHLVKTIVTTDLQEAIAKKNGIKIKNVLTGFKYIAEEMKQIESKKNNLFL
FGGEESYGYLPVPFVRDKDSLSSALLFIEILAEKTDLLTYLNEIYLKYGLYRESLYSLTLEGSSGQEKIKQSIESLRTKN
LIGKLIGGRKVISVLDYETQKADGKGKSSVFKGMPKSNVIQVELEGNAKLTIRPSGTEPKVKVYSSFASRKKPKKSSEIP
SLWKTLGDEIVSAETEFLQLAGLL
>Mature_584_residues
MLKPEDNILSWTKSPFSTEIQSEAKKAYEDWQKGITSDLVDSYAHPLSFGTGGIRGKIGYGIGKMNLYTVGRAALGFLSY
LRDTKKSPSIVIAYDSRRMSKEFAELSAGIGATLGVKVYLFPKVTPTPLLSYAIRYFEASGGIVITASHNPPEYNGFKAY
LADGGQLVPPDDSLIIQRISGIEDWTSIPMISKTDKVYKKFVKTVGPDCFQNYLKELKKAGIQSQAKPKTRNNLKIVYSP
LHGTGGEYMKEMFQYFGYKSVFLVPEQKKPDGEFPTVKYPNPEEKEALALCEFHAKKKKAEVFIATDPDADRLGVGVRKP
DGEYEYLNGNQIGSIMAAYLSERKKQKGKVYHLVKTIVTTDLQEAIAKKNGIKIKNVLTGFKYIAEEMKQIESKKNNLFL
FGGEESYGYLPVPFVRDKDSLSSALLFIEILAEKTDLLTYLNEIYLKYGLYRESLYSLTLEGSSGQEKIKQSIESLRTKN
LIGKLIGGRKVISVLDYETQKADGKGKSSVFKGMPKSNVIQVELEGNAKLTIRPSGTEPKVKVYSSFASRKKPKKSSEIP
SLWKTLGDEIVSAETEFLQLAGLL

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=574, Percent_Identity=33.7979094076655, Blast_Score=285, Evalue=1e-76,
Organism=Homo sapiens, GI31377548, Length=605, Percent_Identity=31.7355371900826, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI21361621, Length=480, Percent_Identity=24.375, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI290463102, Length=488, Percent_Identity=23.9754098360656, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1786904, Length=448, Percent_Identity=26.3392857142857, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71993870, Length=528, Percent_Identity=32.1969696969697, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71993878, Length=283, Percent_Identity=35.3356890459364, Blast_Score=166, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6323934, Length=599, Percent_Identity=30.2170283806344, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6323752, Length=486, Percent_Identity=25.7201646090535, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20129809, Length=594, Percent_Identity=29.6296296296296, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24651977, Length=492, Percent_Identity=30.6910569105691, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24653722, Length=602, Percent_Identity=27.7408637873754, Blast_Score=202, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 65064; Mature: 65064

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKPEDNILSWTKSPFSTEIQSEAKKAYEDWQKGITSDLVDSYAHPLSFGTGGIRGKIGY
CCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCC
GIGKMNLYTVGRAALGFLSYLRDTKKSPSIVIAYDSRRMSKEFAELSAGIGATLGVKVYL
CCCCEEEEHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCEECEEEEE
FPKVTPTPLLSYAIRYFEASGGIVITASHNPPEYNGFKAYLADGGQLVPPDDSLIIQRIS
ECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCEECCCCHHHHHHHHC
GIEDWTSIPMISKTDKVYKKFVKTVGPDCFQNYLKELKKAGIQSQAKPKTRNNLKIVYSP
CCCHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
LHGTGGEYMKEMFQYFGYKSVFLVPEQKKPDGEFPTVKYPNPEEKEALALCEFHAKKKKA
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
EVFIATDPDADRLGVGVRKPDGEYEYLNGNQIGSIMAAYLSERKKQKGKVYHLVKTIVTT
EEEEEECCCCHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
DLQEAIAKKNGIKIKNVLTGFKYIAEEMKQIESKKNNLFLFGGEESYGYLPVPFVRDKDS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHH
LSSALLFIEILAEKTDLLTYLNEIYLKYGLYRESLYSLTLEGSSGQEKIKQSIESLRTKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHH
LIGKLIGGRKVISVLDYETQKADGKGKSSVFKGMPKSNVIQVELEGNAKLTIRPSGTEPK
HHHHHHCCHHHHHHHCCCHHCCCCCCHHHHHCCCCCCCEEEEEECCCEEEEEECCCCCCH
VKVYSSFASRKKPKKSSEIPSLWKTLGDEIVSAETEFLQLAGLL
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKPEDNILSWTKSPFSTEIQSEAKKAYEDWQKGITSDLVDSYAHPLSFGTGGIRGKIGY
CCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCC
GIGKMNLYTVGRAALGFLSYLRDTKKSPSIVIAYDSRRMSKEFAELSAGIGATLGVKVYL
CCCCEEEEHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCEECEEEEE
FPKVTPTPLLSYAIRYFEASGGIVITASHNPPEYNGFKAYLADGGQLVPPDDSLIIQRIS
ECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCEECCCCHHHHHHHHC
GIEDWTSIPMISKTDKVYKKFVKTVGPDCFQNYLKELKKAGIQSQAKPKTRNNLKIVYSP
CCCHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
LHGTGGEYMKEMFQYFGYKSVFLVPEQKKPDGEFPTVKYPNPEEKEALALCEFHAKKKKA
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
EVFIATDPDADRLGVGVRKPDGEYEYLNGNQIGSIMAAYLSERKKQKGKVYHLVKTIVTT
EEEEEECCCCHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
DLQEAIAKKNGIKIKNVLTGFKYIAEEMKQIESKKNNLFLFGGEESYGYLPVPFVRDKDS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHH
LSSALLFIEILAEKTDLLTYLNEIYLKYGLYRESLYSLTLEGSSGQEKIKQSIESLRTKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHH
LIGKLIGGRKVISVLDYETQKADGKGKSSVFKGMPKSNVIQVELEGNAKLTIRPSGTEPK
HHHHHHCCHHHHHHHCCCHHCCCCCCHHHHHCCCCCCCEEEEEECCCEEEEEECCCCCCH
VKVYSSFASRKKPKKSSEIPSLWKTLGDEIVSAETEFLQLAGLL
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]