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The map label for this gene is kefC [H]

Identifier: 183221505

GI number: 183221505

Start: 2214881

End: 2216698

Strand: Reverse

Name: kefC [H]

Synonym: LEPBI_I2123

Alternate gene names: 183221505

Gene position: 2216698-2214881 (Counterclockwise)

Preceding gene: 183221506

Following gene: 183221502

Centisome position: 61.58

GC content: 40.04

Gene sequence:

>1818_bases
ATGGGTGAAGTTAATTTTTTCATTCAGGCCATCATCTATCTCACAAGTGCCATCATCATTGTTCCAATCGCCAATCGTTT
GGGTCTTGGTTCCGTGCTTGGTTATTTGGTGGCAGGGATCGTGATCGGTCCATTTGTATTTGGTTTTGTGGGTACGGAAG
GGAAAGACCTTTTACACTTCGCAGAGTTTGGTGTTGTGATGATGTTATTTGCCATTGGATTGGAATTAGAGCTCAACTTA
CTTTGGCGATTGAAGTTTTGGTTACTTGGACTTGGAGGTTTGCAACTTTTACTCACAACTCTATTTGTCTTTTTGTTTTC
CATCGGATTTCAATTTTCTTGGAAATCATCGCTTGCCCTTGGATTTATTTTATCTTTGTCTTCGACTGCGATCGTATTAC
AAACGTTAAAAGAAAAAGGACTCATGAAATCGGTATCAGGACAAGCATCCTTTTCCATCCTTTTATTCCAAGATATGGCA
GTGATTCCAATACTTGCCATTTTCCCAATGTTAAGTGATGGTGAGATAAACTCAAATGATCACGGACATTCACTCGTAGA
CCATTTACCAGGATACCAAAAAACTTTCGTTGTCCTTTTTGTCGTTTTGGGAATAATTTTGATTGGTAGGTATGTTCTCA
GTCCCATCTTTCGATTGATTGCAAAATCGGGAAGCCGTGAGATTTTTACGGGAGCAAGTTTATTACTCGTCATTGCAATC
TCGGTACTTATGGGAGCTGTTGGTGTTTCGGCAGCTCTCGGAACTTTCCTTGCGGGAGTGGTGCTTGCCAGTAGTGAATT
TCGTCATGAATTGGAGAGTAATATCGAACCCTTCAAAGGATTACTTCTCGGTTTATTTTTTTTAAGTGTTGGTGCTTCCA
TGGAACTTCCTGTCGTAATGGAAGAACCTTTGAAGATCATCTCCATCGTTTTCGGAATCATATTCATGAAAGCCATCGTT
TTACTGACACTTGGATTTTTATTCAAACTCCCTTTGGATCAGAATTTATACATGTCACTTGCCTTATCGCAAGTGGGTGA
ATTTTCCTTTGTTTTGTTTGGTTATTCTGAAGGCCTTGGAATCTTTGATAAGGGGACTGTAGTGATCCTAGTTGCATGTG
TGGCATTGAGTATGGCATTTACTCCCATATTGCTATTGTTATACGAAAAGACAGTCTTTGAAGCCCTTCAATCAAAAGCT
CCCAAAAAACAAACAACAAATACAATTGAAAGAGAAGAAAACCCCGTCATCATCTGTGGGTTTGGTCGATTTGGAAATAT
GGTGGGTCGATTTTTACGATCCAATGGTGTGGGCATCACCATTTTAGATTACGATGCCGATCGAGTGGAGATGCTTGGAC
GGTTTGGGTTTAAGGTATTCTTTGGTGATGCAACACGTTTGGAACTTTTGGAAAATGTTGGATTGGAACATGCCAAAATT
CTTGTGGCGGCCCTTGACCATCCAGAAAAACAACAAGAACTCATTCGCAATGTCAAACACCATTACCCTAATATCAAAAT
TGTTGCACGTGCTGGGGACAGAGAAGAAGCCTATGATTTAAAGGAGATGGGACTTTCCTTTATCTACCGAGAAACTAGGG
AAACCGCTGTGAAACTAGGAAGTGATGTATTAAAAATTTTAGGCACAAGATCCTATACTGCGGAACGAGCCAAAAATTTA
TTCTTGGCCCATGATGATGAAACCTTCCAAGAACTTTTTTCTTTGCGTAAAGATCGGGTGCAATACATAAGCCTAGCCAA
ACAAAGGAACTTAGAATTGGAACGATTGATGTTTGTGGATTTAGGAAAGGAAGACTAG

Upstream 100 bases:

>100_bases
TTTTTAGTCCAAGGTACATTCCAATTGAAAGAAGAGGAGTTCCAAAAAGAATCCATCCGTTATCGAAATTTCATTCTCTC
TCATTTAGAGGAGGTTTACA

Downstream 100 bases:

>100_bases
TTAGAATTAGATACTTGGAGTGAGATGGAACGTTAATCAAATCATGAGATCGGAAACGGATTTTGTTTTAATGAAGTGGA
AAAAAGATTCGAGCTGGATT

Product: K(+) efflux antiporter

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 605; Mature: 604

Protein sequence:

>605_residues
MGEVNFFIQAIIYLTSAIIIVPIANRLGLGSVLGYLVAGIVIGPFVFGFVGTEGKDLLHFAEFGVVMMLFAIGLELELNL
LWRLKFWLLGLGGLQLLLTTLFVFLFSIGFQFSWKSSLALGFILSLSSTAIVLQTLKEKGLMKSVSGQASFSILLFQDMA
VIPILAIFPMLSDGEINSNDHGHSLVDHLPGYQKTFVVLFVVLGIILIGRYVLSPIFRLIAKSGSREIFTGASLLLVIAI
SVLMGAVGVSAALGTFLAGVVLASSEFRHELESNIEPFKGLLLGLFFLSVGASMELPVVMEEPLKIISIVFGIIFMKAIV
LLTLGFLFKLPLDQNLYMSLALSQVGEFSFVLFGYSEGLGIFDKGTVVILVACVALSMAFTPILLLLYEKTVFEALQSKA
PKKQTTNTIEREENPVIICGFGRFGNMVGRFLRSNGVGITILDYDADRVEMLGRFGFKVFFGDATRLELLENVGLEHAKI
LVAALDHPEKQQELIRNVKHHYPNIKIVARAGDREEAYDLKEMGLSFIYRETRETAVKLGSDVLKILGTRSYTAERAKNL
FLAHDDETFQELFSLRKDRVQYISLAKQRNLELERLMFVDLGKED

Sequences:

>Translated_605_residues
MGEVNFFIQAIIYLTSAIIIVPIANRLGLGSVLGYLVAGIVIGPFVFGFVGTEGKDLLHFAEFGVVMMLFAIGLELELNL
LWRLKFWLLGLGGLQLLLTTLFVFLFSIGFQFSWKSSLALGFILSLSSTAIVLQTLKEKGLMKSVSGQASFSILLFQDMA
VIPILAIFPMLSDGEINSNDHGHSLVDHLPGYQKTFVVLFVVLGIILIGRYVLSPIFRLIAKSGSREIFTGASLLLVIAI
SVLMGAVGVSAALGTFLAGVVLASSEFRHELESNIEPFKGLLLGLFFLSVGASMELPVVMEEPLKIISIVFGIIFMKAIV
LLTLGFLFKLPLDQNLYMSLALSQVGEFSFVLFGYSEGLGIFDKGTVVILVACVALSMAFTPILLLLYEKTVFEALQSKA
PKKQTTNTIEREENPVIICGFGRFGNMVGRFLRSNGVGITILDYDADRVEMLGRFGFKVFFGDATRLELLENVGLEHAKI
LVAALDHPEKQQELIRNVKHHYPNIKIVARAGDREEAYDLKEMGLSFIYRETRETAVKLGSDVLKILGTRSYTAERAKNL
FLAHDDETFQELFSLRKDRVQYISLAKQRNLELERLMFVDLGKED
>Mature_604_residues
GEVNFFIQAIIYLTSAIIIVPIANRLGLGSVLGYLVAGIVIGPFVFGFVGTEGKDLLHFAEFGVVMMLFAIGLELELNLL
WRLKFWLLGLGGLQLLLTTLFVFLFSIGFQFSWKSSLALGFILSLSSTAIVLQTLKEKGLMKSVSGQASFSILLFQDMAV
IPILAIFPMLSDGEINSNDHGHSLVDHLPGYQKTFVVLFVVLGIILIGRYVLSPIFRLIAKSGSREIFTGASLLLVIAIS
VLMGAVGVSAALGTFLAGVVLASSEFRHELESNIEPFKGLLLGLFFLSVGASMELPVVMEEPLKIISIVFGIIFMKAIVL
LTLGFLFKLPLDQNLYMSLALSQVGEFSFVLFGYSEGLGIFDKGTVVILVACVALSMAFTPILLLLYEKTVFEALQSKAP
KKQTTNTIEREENPVIICGFGRFGNMVGRFLRSNGVGITILDYDADRVEMLGRFGFKVFFGDATRLELLENVGLEHAKIL
VAALDHPEKQQELIRNVKHHYPNIKIVARAGDREEAYDLKEMGLSFIYRETRETAVKLGSDVLKILGTRSYTAERAKNLF
LAHDDETFQELFSLRKDRVQYISLAKQRNLELERLMFVDLGKED

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=418, Percent_Identity=25.5980861244019, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI1786232, Length=598, Percent_Identity=40.133779264214, Blast_Score=443, Evalue=1e-125,
Organism=Escherichia coli, GI1789749, Length=601, Percent_Identity=39.7670549084859, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1786685, Length=533, Percent_Identity=29.4559099437148, Blast_Score=200, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 66933; Mature: 66802

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEVNFFIQAIIYLTSAIIIVPIANRLGLGSVLGYLVAGIVIGPFVFGFVGTEGKDLLHF
CCCHHHHHHHHHHHHHHHHEEECHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AEFGVVMMLFAIGLELELNLLWRLKFWLLGLGGLQLLLTTLFVFLFSIGFQFSWKSSLAL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
GFILSLSSTAIVLQTLKEKGLMKSVSGQASFSILLFQDMAVIPILAIFPMLSDGEINSND
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCC
HGHSLVDHLPGYQKTFVVLFVVLGIILIGRYVLSPIFRLIAKSGSREIFTGASLLLVIAI
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHH
SVLMGAVGVSAALGTFLAGVVLASSEFRHELESNIEPFKGLLLGLFFLSVGASMELPVVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHH
EEPLKIISIVFGIIFMKAIVLLTLGFLFKLPLDQNLYMSLALSQVGEFSFVLFGYSEGLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEEECCCCC
IFDKGTVVILVACVALSMAFTPILLLLYEKTVFEALQSKAPKKQTTNTIEREENPVIICG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHCCCCCEEEEE
FGRFGNMVGRFLRSNGVGITILDYDADRVEMLGRFGFKVFFGDATRLELLENVGLEHAKI
CCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCEEEECCCHHHHHHHHCCCHHHHH
LVAALDHPEKQQELIRNVKHHYPNIKIVARAGDREEAYDLKEMGLSFIYRETRETAVKLG
HHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SDVLKILGTRSYTAERAKNLFLAHDDETFQELFSLRKDRVQYISLAKQRNLELERLMFVD
HHHHHHHCCCCHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEE
LGKED
CCCCC
>Mature Secondary Structure 
GEVNFFIQAIIYLTSAIIIVPIANRLGLGSVLGYLVAGIVIGPFVFGFVGTEGKDLLHF
CCHHHHHHHHHHHHHHHHEEECHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH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CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA