Click here to switch to the map view.

The map label for this gene is engD [H]

Identifier: 183221493

GI number: 183221493

Start: 2205386

End: 2206483

Strand: Reverse

Name: engD [H]

Synonym: LEPBI_I2111

Alternate gene names: 183221493

Gene position: 2206483-2205386 (Counterclockwise)

Preceding gene: 183221494

Following gene: 183221486

Centisome position: 61.3

GC content: 42.08

Gene sequence:

>1098_bases
ATGGCTTTGAATTGTGGAATTGTAGGTCTCCCGAACGTCGGTAAGTCGACTATTTTTAATGCACTCACGAAAGCAGGCGC
GCAGGCTGCCAACTATCCTTTTTGTACCATTGAACCAAATACGGGTGTTGTGGAAGTACCTGACGAAAGACTGAATCGTC
TTGCTGAAATTTATAAACCAAAACGAACCGTTCCCACAATGATTGAATTTGTGGACATTGCAGGCCTTGTGAAAGGGGCA
AGCCAAGGAGAGGGGTTAGGCAACCAATTTTTATCCCATATCCGCGAAGTGGATGCCATTTGTCATGTGGTACGCGCCTT
CCAAGATGAGAACATAACGCATGTTCATGGAAAAGTAGATCCCATCGAAGACATCACTGTCATCAATTATGAATTGATTT
TAGCTGATTTGGATAGTTTAGAAAAACAACAACAACGAGTTTCCAAAACTGCCAAAACAGGAAATAAAGAGGCAGGAGAA
ATTTTATCCGTTATGGATCAAATTTTAGAAGCCTTAAAAAAAGGAAACAGAGCCTCCACCGTGGAACTTTCGGAAGAAGA
ACTCAAAATTGCCAAAAAGTTTAATCTTATTACCATTAAACCAGTGTTATATGTTGCTAATATTTTAGACTCTGATGTCA
AATCCACTGAAAATCCACTCGTAAAAGTCATCACAGATTTTGCAAAAAAAGAAGGTGCACCGGTCGTTGTGTTATGTGGT
CGTTTTGAAGAAGAAATTTCTGGTTTGGAAAAAGAAGACCAATTGGCCTTTTTGGAAGAGATCGGAGAAAAGGAATCTGG
CCTTTCTCGAATGATCCGCGCCTCCTACCAACTTCTTGGCCTCCTCACATTTTTTACAGCGGGTGTGGAAGAAGTGAGAG
CCTGGACTACCAAACAAGGAAGCACAGGCCCTATTGCTGCCAGTGTGATCCATTCTGATTTTGAAAAGGGATACATCCGT
GCAGAAGTGATGCGGTATGAAGACCTGGATCGCACTGGGGATGCAACCAAAGTCAAAGACGAAGGGAAACTCCGTGTGGA
AGGAAAAGAATACATAGTCCAAGATGGGGATGTGATTTATTTCCGAGTGAATGCTTAA

Upstream 100 bases:

>100_bases
TTCCGTGTATTACCTGACTTCTGTTTATTTGGAAACCGGATTTCAAAACTAAGACAACAATTTTCCTTGTCCTAGTGCTT
CGTTCCAAAATCCTATCCCT

Downstream 100 bases:

>100_bases
AAAAAATCCCGACTTTCGTCGGGATGTCTTTAAGTGTGAACTAGTTTGGAAAAAGAAAGTGGTTTCCTACAGGTAGGGAC
CATTTCTCACAGTATCAATT

Product: GTP-dependent nucleic acid-binding protein EngD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MALNCGIVGLPNVGKSTIFNALTKAGAQAANYPFCTIEPNTGVVEVPDERLNRLAEIYKPKRTVPTMIEFVDIAGLVKGA
SQGEGLGNQFLSHIREVDAICHVVRAFQDENITHVHGKVDPIEDITVINYELILADLDSLEKQQQRVSKTAKTGNKEAGE
ILSVMDQILEALKKGNRASTVELSEEELKIAKKFNLITIKPVLYVANILDSDVKSTENPLVKVITDFAKKEGAPVVVLCG
RFEEEISGLEKEDQLAFLEEIGEKESGLSRMIRASYQLLGLLTFFTAGVEEVRAWTTKQGSTGPIAASVIHSDFEKGYIR
AEVMRYEDLDRTGDATKVKDEGKLRVEGKEYIVQDGDVIYFRVNA

Sequences:

>Translated_365_residues
MALNCGIVGLPNVGKSTIFNALTKAGAQAANYPFCTIEPNTGVVEVPDERLNRLAEIYKPKRTVPTMIEFVDIAGLVKGA
SQGEGLGNQFLSHIREVDAICHVVRAFQDENITHVHGKVDPIEDITVINYELILADLDSLEKQQQRVSKTAKTGNKEAGE
ILSVMDQILEALKKGNRASTVELSEEELKIAKKFNLITIKPVLYVANILDSDVKSTENPLVKVITDFAKKEGAPVVVLCG
RFEEEISGLEKEDQLAFLEEIGEKESGLSRMIRASYQLLGLLTFFTAGVEEVRAWTTKQGSTGPIAASVIHSDFEKGYIR
AEVMRYEDLDRTGDATKVKDEGKLRVEGKEYIVQDGDVIYFRVNA
>Mature_364_residues
ALNCGIVGLPNVGKSTIFNALTKAGAQAANYPFCTIEPNTGVVEVPDERLNRLAEIYKPKRTVPTMIEFVDIAGLVKGAS
QGEGLGNQFLSHIREVDAICHVVRAFQDENITHVHGKVDPIEDITVINYELILADLDSLEKQQQRVSKTAKTGNKEAGEI
LSVMDQILEALKKGNRASTVELSEEELKIAKKFNLITIKPVLYVANILDSDVKSTENPLVKVITDFAKKEGAPVVVLCGR
FEEEISGLEKEDQLAFLEEIGEKESGLSRMIRASYQLLGLLTFFTAGVEEVRAWTTKQGSTGPIAASVIHSDFEKGYIRA
EVMRYEDLDRTGDATKVKDEGKLRVEGKEYIVQDGDVIYFRVNA

Specific function: GTP-dependent nucleic acid-binding protein which may act as a translation factor [H]

COG id: COG0012

COG function: function code J; Predicted GTPase, probable translation factor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI58761500, Length=369, Percent_Identity=43.360433604336, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI58761502, Length=185, Percent_Identity=38.9189189189189, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI24308117, Length=112, Percent_Identity=33.9285714285714, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787454, Length=364, Percent_Identity=54.3956043956044, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1789574, Length=129, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17509631, Length=367, Percent_Identity=42.7792915531335, Blast_Score=298, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6319499, Length=372, Percent_Identity=41.1290322580645, Blast_Score=271, Evalue=9e-74,
Organism=Saccharomyces cerevisiae, GI6321773, Length=378, Percent_Identity=37.037037037037, Blast_Score=237, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6321649, Length=349, Percent_Identity=28.6532951289398, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24640873, Length=367, Percent_Identity=43.0517711171662, Blast_Score=297, Evalue=6e-81,
Organism=Drosophila melanogaster, GI24640877, Length=367, Percent_Identity=43.0517711171662, Blast_Score=297, Evalue=6e-81,
Organism=Drosophila melanogaster, GI24640875, Length=367, Percent_Identity=43.0517711171662, Blast_Score=297, Evalue=6e-81,
Organism=Drosophila melanogaster, GI24640879, Length=329, Percent_Identity=40.4255319148936, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24585318, Length=228, Percent_Identity=28.5087719298246, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI20129375, Length=187, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR004396
- InterPro:   IPR013029
- InterPro:   IPR006073
- InterPro:   IPR002917
- InterPro:   IPR012676
- InterPro:   IPR023192 [H]

Pfam domain/function: PF01926 MMR_HSR1; PF06071 YchF-GTPase_C [H]

EC number: NA

Molecular weight: Translated: 40247; Mature: 40116

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALNCGIVGLPNVGKSTIFNALTKAGAQAANYPFCTIEPNTGVVEVPDERLNRLAEIYKP
CEECCCEEECCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCHHHHHHHHHHHCC
KRTVPTMIEFVDIAGLVKGASQGEGLGNQFLSHIREVDAICHVVRAFQDENITHVHGKVD
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
PIEDITVINYELILADLDSLEKQQQRVSKTAKTGNKEAGEILSVMDQILEALKKGNRAST
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCE
VELSEEELKIAKKFNLITIKPVLYVANILDSDVKSTENPLVKVITDFAKKEGAPVVVLCG
EEECHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECC
RFEEEISGLEKEDQLAFLEEIGEKESGLSRMIRASYQLLGLLTFFTAGVEEVRAWTTKQG
CCHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCC
STGPIAASVIHSDFEKGYIRAEVMRYEDLDRTGDATKVKDEGKLRVEGKEYIVQDGDVIY
CCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCEECCCCCEEECCCEEEEECCCEEE
FRVNA
EEECC
>Mature Secondary Structure 
ALNCGIVGLPNVGKSTIFNALTKAGAQAANYPFCTIEPNTGVVEVPDERLNRLAEIYKP
EECCCEEECCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCHHHHHHHHHHHCC
KRTVPTMIEFVDIAGLVKGASQGEGLGNQFLSHIREVDAICHVVRAFQDENITHVHGKVD
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
PIEDITVINYELILADLDSLEKQQQRVSKTAKTGNKEAGEILSVMDQILEALKKGNRAST
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCE
VELSEEELKIAKKFNLITIKPVLYVANILDSDVKSTENPLVKVITDFAKKEGAPVVVLCG
EEECHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECC
RFEEEISGLEKEDQLAFLEEIGEKESGLSRMIRASYQLLGLLTFFTAGVEEVRAWTTKQG
CCHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCC
STGPIAASVIHSDFEKGYIRAEVMRYEDLDRTGDATKVKDEGKLRVEGKEYIVQDGDVIY
CCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCEECCCCCEEECCCEEEEECCCEEE
FRVNA
EEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]