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The map label for this gene is proC [H]

Identifier: 183220726

GI number: 183220726

Start: 1390654

End: 1391397

Strand: Direct

Name: proC [H]

Synonym: LEPBI_I1336

Alternate gene names: 183220726

Gene position: 1390654-1391397 (Clockwise)

Preceding gene: 183220725

Following gene: 183220727

Centisome position: 38.63

GC content: 48.12

Gene sequence:

>744_bases
ATGGGAGGTGCTGTGGCAAAGGCGCTGGTAAACCAAGGAACAAAAGTGTTTGCCTTTGATCCAAACCTGAAAGTATCACC
GGTGGAAGGAGTGACTCTTGTATCCACCTTGGAACGATTGGAAGAGGAAGCGGGTCTTTTTGTCATCGCCGTAAAACCAA
ACCTGGTAGGACCAGTACTCTCTGAATTCAAAAAACCATCGATCTTTGTTTCGATTGCGGCGGGGATTACTTATGAACAA
TTACTTTCCTTTTCTCCCAAAGCTTCCACTTGTGTTCGGGTCATGCCAAACCTTCCTTTGGTTTCCAAACGTGGGGCCAT
GGGGTATTATTGTAACGATGAAGCTGTCTCTCACGTCGAACGTCTGTTTTATGGAATGGGGGAATGTGTAAGGATTTCCA
AGGAATCTTTAATGGATGCGGTCACTGGGTTATCGGGTTCTGGCCCTGCTTATGTACTCACGTTTTTACAAGCAATGGCG
GAAGCTGGGTTACAAGAGGGACTCGGTTATGAGGAATCTTTGGCTCTCTCTCTTGAGACCATCGAAGGAACTCTTGTGTA
TTTCAGGGAATTGAGAACAAAAGACCACGCCATCCATCCAATGGAAGTGCGAAATTGGGTGACGTCTCCAGGTGGGACAA
CCATCCACGGACTTGATGCTTTGGAACGTGGTGGGTTTTCCACCGCGGTGCGGGATGCCGTGAAGCGGGCAACCGAGAGA
AGTAAGGAATTGGGAAAGGGATGA

Upstream 100 bases:

>100_bases
CTTGGATCCAACTTTGTTCGGATCGGATCAAAAATTTTTGGAGATAGGGATTATGGCACACACTCCGTTTAAAACAGTGG
GAATGGTAGGACTTGGGAAA

Downstream 100 bases:

>100_bases
TAACGGTTGCGCGGACAGGATTCGAACCTGTGGCCTTTGGGTTATGAGCCCAACGAGCTACCAGCTGCTCCACCGCGCGG
TATAAGACCATTGTTTTTAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MGGAVAKALVNQGTKVFAFDPNLKVSPVEGVTLVSTLERLEEEAGLFVIAVKPNLVGPVLSEFKKPSIFVSIAAGITYEQ
LLSFSPKASTCVRVMPNLPLVSKRGAMGYYCNDEAVSHVERLFYGMGECVRISKESLMDAVTGLSGSGPAYVLTFLQAMA
EAGLQEGLGYEESLALSLETIEGTLVYFRELRTKDHAIHPMEVRNWVTSPGGTTIHGLDALERGGFSTAVRDAVKRATER
SKELGKG

Sequences:

>Translated_247_residues
MGGAVAKALVNQGTKVFAFDPNLKVSPVEGVTLVSTLERLEEEAGLFVIAVKPNLVGPVLSEFKKPSIFVSIAAGITYEQ
LLSFSPKASTCVRVMPNLPLVSKRGAMGYYCNDEAVSHVERLFYGMGECVRISKESLMDAVTGLSGSGPAYVLTFLQAMA
EAGLQEGLGYEESLALSLETIEGTLVYFRELRTKDHAIHPMEVRNWVTSPGGTTIHGLDALERGGFSTAVRDAVKRATER
SKELGKG
>Mature_246_residues
GGAVAKALVNQGTKVFAFDPNLKVSPVEGVTLVSTLERLEEEAGLFVIAVKPNLVGPVLSEFKKPSIFVSIAAGITYEQL
LSFSPKASTCVRVMPNLPLVSKRGAMGYYCNDEAVSHVERLFYGMGECVRISKESLMDAVTGLSGSGPAYVLTFLQAMAE
AGLQEGLGYEESLALSLETIEGTLVYFRELRTKDHAIHPMEVRNWVTSPGGTTIHGLDALERGGFSTAVRDAVKRATERS
KELGKG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=247, Percent_Identity=33.1983805668016, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI198041662, Length=261, Percent_Identity=32.183908045977, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI24797097, Length=262, Percent_Identity=33.206106870229, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI24797095, Length=262, Percent_Identity=33.206106870229, Blast_Score=118, Evalue=5e-27,
Organism=Escherichia coli, GI1786585, Length=258, Percent_Identity=31.3953488372093, Blast_Score=108, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=34.3511450381679, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17540664, Length=231, Percent_Identity=31.1688311688312, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320861, Length=217, Percent_Identity=33.1797235023041, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=32.9545454545455, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24648116, Length=222, Percent_Identity=31.981981981982, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24647700, Length=175, Percent_Identity=36, Blast_Score=97, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 26532; Mature: 26401

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGAVAKALVNQGTKVFAFDPNLKVSPVEGVTLVSTLERLEEEAGLFVIAVKPNLVGPVL
CCHHHHHHHHHCCCEEEEECCCCEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHH
SEFKKPSIFVSIAAGITYEQLLSFSPKASTCVRVMPNLPLVSKRGAMGYYCNDEAVSHVE
HHCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHCCCCCCEECCCCCCEEECHHHHHHHH
RLFYGMGECVRISKESLMDAVTGLSGSGPAYVLTFLQAMAEAGLQEGLGYEESLALSLET
HHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHEEEHHH
IEGTLVYFRELRTKDHAIHPMEVRNWVTSPGGTTIHGLDALERGGFSTAVRDAVKRATER
HHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCEEEHHHHHHHCCCHHHHHHHHHHHHHH
SKELGKG
HHHCCCC
>Mature Secondary Structure 
GGAVAKALVNQGTKVFAFDPNLKVSPVEGVTLVSTLERLEEEAGLFVIAVKPNLVGPVL
CHHHHHHHHHCCCEEEEECCCCEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHH
SEFKKPSIFVSIAAGITYEQLLSFSPKASTCVRVMPNLPLVSKRGAMGYYCNDEAVSHVE
HHCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHCCCCCCEECCCCCCEEECHHHHHHHH
RLFYGMGECVRISKESLMDAVTGLSGSGPAYVLTFLQAMAEAGLQEGLGYEESLALSLET
HHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHEEEHHH
IEGTLVYFRELRTKDHAIHPMEVRNWVTSPGGTTIHGLDALERGGFSTAVRDAVKRATER
HHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCEEEHHHHHHHCCCHHHHHHHHHHHHHH
SKELGKG
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]