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The map label for this gene is erg3 [H]

Identifier: 183220524

GI number: 183220524

Start: 1172581

End: 1173708

Strand: Reverse

Name: erg3 [H]

Synonym: LEPBI_I1125

Alternate gene names: 183220524

Gene position: 1173708-1172581 (Counterclockwise)

Preceding gene: 183220525

Following gene: 183220523

Centisome position: 32.61

GC content: 44.77

Gene sequence:

>1128_bases
TTGAATGATTCGATTGCTGACTTGAGTACGGGAATCATTTCCCAGATTTGGGGTCTCTTCCAAAAAGGTGTGGGCTTATA
TGCCTACTTTTATATCTACGAACACTTTCGTTTTTTTGAATTTGCCATGACAAACCCTTGGGCTTGGGTGCTTTGCATCG
TGGGTCAGGATTTTTGTTACTACTGGTCCCACCGTTTGGCCCATGAAGTGAATTTCCTATGGGCAGGGCATGTGATCCAC
CACCATAGCGAAGAATACAACTTAGTGGTCGCTCTGAGACAAACCGGTCTCGGAGGACTTGTTTCCTGGATTTTTTATGT
GCCTCTTGCCCTCTTTGGATTCCACCCTTGGATGTATCTTGCCAGTGGACAGATCAATTTGATTTACCAATTTTGGGTGC
ATACCAAAGCCGTTGGGAAAATTGGAAAGATTGGAGAGTATCTCTTATCGACCCCTTCCCACCACCGAGTGCACCATGCG
ATCAACCCCATCTACATCGACAAAAACCATGGGGGCATTTTCATCATTTTCGACCGTATGTTTGGGACCTTCCGTGAAGA
AACAGAACCCTGTGTGTATGGAACGGTAAAACCACTGCGAAGTTTTAATCCCGTTTATGCCAACTTCCATTACTATTGGG
AACTGTTAAAACAGGCCTTCCAAGCGGAGTATTTCTTAGACAAAATCCTTGTGTTCTTCAAACCACCAGGTTGGATCCCA
AGACAAGGGCAAAAACCCGCAGGATTTTTACCGATCCCTGAAGTGAGCCCAACAAGTTTTCAAAAATACGACCCAAAACC
TGCATCGGAAGTGAAGGCCTATACCACCACTTGGTTTGTTTTGGTATTACTACTTTCCTTTGCCTTTTTACTATTTGTTC
CCAAATTCAGTATGGTCTCCCAAATCCTTGTGACAATTTGGGTGACCCTCTCCCTTGTTGCCATCAATGCCCTGATCGAA
AACAAATCATGGGCTGGGGCCATGGAGATCACTCGGTTACTTTTTGGATTTTTAGTCCTTGGTTACTTTGATGTGAACTG
GGCTTATTATGCGATTGGTATTGTTTGCCTTGTTGTGGCTGGGATTTACCTCTACCGCACGGGCCAACAAAAAACCCAAG
CCGTCTAA

Upstream 100 bases:

>100_bases
CAGAGCCCCTCAAATTGTAACCTTTGCCATCCCAGTTTTTTTCCTTCTCATCGGGATTGAAGTGTACATCGGTTACCGGA
GGAACAAAGACCTCTACCGA

Downstream 100 bases:

>100_bases
ACCAGAACAAAAGTGGGAGATCGGATCGGTTTCAAACCTATCCGTTTCCACCTCTCTTTTTCAAAAGAACGCAACAGATC
CCTCACGTTTTCCTCTCCCC

Product: putative sterol desaturase protein

Products: NA

Alternate protein names: Sterol-C5-desaturase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MNDSIADLSTGIISQIWGLFQKGVGLYAYFYIYEHFRFFEFAMTNPWAWVLCIVGQDFCYYWSHRLAHEVNFLWAGHVIH
HHSEEYNLVVALRQTGLGGLVSWIFYVPLALFGFHPWMYLASGQINLIYQFWVHTKAVGKIGKIGEYLLSTPSHHRVHHA
INPIYIDKNHGGIFIIFDRMFGTFREETEPCVYGTVKPLRSFNPVYANFHYYWELLKQAFQAEYFLDKILVFFKPPGWIP
RQGQKPAGFLPIPEVSPTSFQKYDPKPASEVKAYTTTWFVLVLLLSFAFLLFVPKFSMVSQILVTIWVTLSLVAINALIE
NKSWAGAMEITRLLFGFLVLGYFDVNWAYYAIGIVCLVVAGIYLYRTGQQKTQAV

Sequences:

>Translated_375_residues
MNDSIADLSTGIISQIWGLFQKGVGLYAYFYIYEHFRFFEFAMTNPWAWVLCIVGQDFCYYWSHRLAHEVNFLWAGHVIH
HHSEEYNLVVALRQTGLGGLVSWIFYVPLALFGFHPWMYLASGQINLIYQFWVHTKAVGKIGKIGEYLLSTPSHHRVHHA
INPIYIDKNHGGIFIIFDRMFGTFREETEPCVYGTVKPLRSFNPVYANFHYYWELLKQAFQAEYFLDKILVFFKPPGWIP
RQGQKPAGFLPIPEVSPTSFQKYDPKPASEVKAYTTTWFVLVLLLSFAFLLFVPKFSMVSQILVTIWVTLSLVAINALIE
NKSWAGAMEITRLLFGFLVLGYFDVNWAYYAIGIVCLVVAGIYLYRTGQQKTQAV
>Mature_375_residues
MNDSIADLSTGIISQIWGLFQKGVGLYAYFYIYEHFRFFEFAMTNPWAWVLCIVGQDFCYYWSHRLAHEVNFLWAGHVIH
HHSEEYNLVVALRQTGLGGLVSWIFYVPLALFGFHPWMYLASGQINLIYQFWVHTKAVGKIGKIGEYLLSTPSHHRVHHA
INPIYIDKNHGGIFIIFDRMFGTFREETEPCVYGTVKPLRSFNPVYANFHYYWELLKQAFQAEYFLDKILVFFKPPGWIP
RQGQKPAGFLPIPEVSPTSFQKYDPKPASEVKAYTTTWFVLVLLLSFAFLLFVPKFSMVSQILVTIWVTLSLVAINALIE
NKSWAGAMEITRLLFGFLVLGYFDVNWAYYAIGIVCLVVAGIYLYRTGQQKTQAV

Specific function: Unknown

COG id: COG3000

COG function: function code I; Sterol desaturase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sterol desaturase family [H]

Homologues:

Organism=Homo sapiens, GI51972212, Length=382, Percent_Identity=37.696335078534, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI25144659, Length=394, Percent_Identity=31.7258883248731, Blast_Score=193, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006694 [H]

Pfam domain/function: PF04116 FA_hydroxylase [H]

EC number: NA

Molecular weight: Translated: 43347; Mature: 43347

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSIADLSTGIISQIWGLFQKGVGLYAYFYIYEHFRFFEFAMTNPWAWVLCIVGQDFCY
CCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHH
YWSHRLAHEVNFLWAGHVIHHHSEEYNLVVALRQTGLGGLVSWIFYVPLALFGFHPWMYL
HHHHHHHHHHHHEEECHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCHHHEE
ASGQINLIYQFWVHTKAVGKIGKIGEYLLSTPSHHRVHHAINPIYIDKNHGGIFIIFDRM
ECCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEECCCCCEEEEHHHH
FGTFREETEPCVYGTVKPLRSFNPVYANFHYYWELLKQAFQAEYFLDKILVFFKPPGWIP
HHHHHHCCCCEEECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
RQGQKPAGFLPIPEVSPTSFQKYDPKPASEVKAYTTTWFVLVLLLSFAFLLFVPKFSMVS
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
QILVTIWVTLSLVAINALIENKSWAGAMEITRLLFGFLVLGYFDVNWAYYAIGIVCLVVA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
GIYLYRTGQQKTQAV
HHHHHCCCCHHHCCC
>Mature Secondary Structure
MNDSIADLSTGIISQIWGLFQKGVGLYAYFYIYEHFRFFEFAMTNPWAWVLCIVGQDFCY
CCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHH
YWSHRLAHEVNFLWAGHVIHHHSEEYNLVVALRQTGLGGLVSWIFYVPLALFGFHPWMYL
HHHHHHHHHHHHEEECHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCHHHEE
ASGQINLIYQFWVHTKAVGKIGKIGEYLLSTPSHHRVHHAINPIYIDKNHGGIFIIFDRM
ECCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEECCCCCEEEEHHHH
FGTFREETEPCVYGTVKPLRSFNPVYANFHYYWELLKQAFQAEYFLDKILVFFKPPGWIP
HHHHHHCCCCEEECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
RQGQKPAGFLPIPEVSPTSFQKYDPKPASEVKAYTTTWFVLVLLLSFAFLLFVPKFSMVS
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
QILVTIWVTLSLVAINALIENKSWAGAMEITRLLFGFLVLGYFDVNWAYYAIGIVCLVVA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
GIYLYRTGQQKTQAV
HHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]