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The map label for this gene is lpxA [H]

Identifier: 183219775

GI number: 183219775

Start: 351768

End: 352574

Strand: Reverse

Name: lpxA [H]

Synonym: LEPBI_I0352

Alternate gene names: 183219775

Gene position: 352574-351768 (Counterclockwise)

Preceding gene: 183219777

Following gene: 183219774

Centisome position: 9.79

GC content: 41.88

Gene sequence:

>807_bases
ATGAAAATTCACCCCACTGCCATCATCGATCCAAAAGCGGAATTACATGAATCCGTTGAAGTTGGACCATTTTGTATCAT
CGAAAAAGATGTCAAAATCGGAGAAGGAACTGTTATCGAATCCCATGTAAAAATCCTATCTGGGACCAGAATCGGTAAAT
TTAATAAAATTTCTTCTGGCGGTAGTTTCGGCGGATTACCTCAAGATTTGGCTTTCAAACCCGAAACCAAAACCTACTTA
GAAATTGGGGATCACAATCATTTTAGAGAAAACGTAATCTTTCATAGAGGAACCATCGAAGGCAAAGGAACTGTCATCGG
AAGTCACAATTACCTAATGGGAAATGTACACATTGCCCACGATGTCATTGTTGGTGATCATAACATCATGGTTCAAAATA
CAATGCTTGCAGGTCACGTTGTGATTGGGAACAAAGTATTCATTTCTGGATCTGTAGGAGTCCACCAATTTGTGCGAGTT
GCCGATTATGCGATGTTAGCAGGACTAACGAAAGTTGTGAAAGATGTCCCTCCTTATGCCACAGTCGATGGCCATCCAGG
CCTCATCGTAAGTTTGAATGTGGTTGGTATGAAACGAGCGGGAATCTCTGCCGATGTTCGCCTTGCCATCAAAAGAGTCT
ACAAGGTGATTTATCACAGTGGATTCAACACAAAACAAGCTTTAGCTGAACTTAAGAAAGATCCAAACCCTGCACCAGAA
GTGCAAAAGGTAATCGAATTCTTCGAAACAAGCAAACGTGGTGTTGTGGACCACCGTTTTGTTTCTGGTGGATCCGACGA
AGAATGA

Upstream 100 bases:

>100_bases
CACCACCCTTCCAAAAGATAACAGACGCTGAAAACCGTGTAAATTACATTTTAAAAAATCATTTGCAGGTCTTTCCAATT
GGTTTTTTTTGTAATTCAAT

Downstream 100 bases:

>100_bases
GAGTTCTCGTTACCGGGGGAGCCGGATATATCGGAAGTCATATTGTCCTCGAACTTATGGAACTAGGACATGAAATCATC
ATTGTAGATGATATGGAAAA

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MKIHPTAIIDPKAELHESVEVGPFCIIEKDVKIGEGTVIESHVKILSGTRIGKFNKISSGGSFGGLPQDLAFKPETKTYL
EIGDHNHFRENVIFHRGTIEGKGTVIGSHNYLMGNVHIAHDVIVGDHNIMVQNTMLAGHVVIGNKVFISGSVGVHQFVRV
ADYAMLAGLTKVVKDVPPYATVDGHPGLIVSLNVVGMKRAGISADVRLAIKRVYKVIYHSGFNTKQALAELKKDPNPAPE
VQKVIEFFETSKRGVVDHRFVSGGSDEE

Sequences:

>Translated_268_residues
MKIHPTAIIDPKAELHESVEVGPFCIIEKDVKIGEGTVIESHVKILSGTRIGKFNKISSGGSFGGLPQDLAFKPETKTYL
EIGDHNHFRENVIFHRGTIEGKGTVIGSHNYLMGNVHIAHDVIVGDHNIMVQNTMLAGHVVIGNKVFISGSVGVHQFVRV
ADYAMLAGLTKVVKDVPPYATVDGHPGLIVSLNVVGMKRAGISADVRLAIKRVYKVIYHSGFNTKQALAELKKDPNPAPE
VQKVIEFFETSKRGVVDHRFVSGGSDEE
>Mature_268_residues
MKIHPTAIIDPKAELHESVEVGPFCIIEKDVKIGEGTVIESHVKILSGTRIGKFNKISSGGSFGGLPQDLAFKPETKTYL
EIGDHNHFRENVIFHRGTIEGKGTVIGSHNYLMGNVHIAHDVIVGDHNIMVQNTMLAGHVVIGNKVFISGSVGVHQFVRV
ADYAMLAGLTKVVKDVPPYATVDGHPGLIVSLNVVGMKRAGISADVRLAIKRVYKVIYHSGFNTKQALAELKKDPNPAPE
VQKVIEFFETSKRGVVDHRFVSGGSDEE

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=255, Percent_Identity=41.5686274509804, Blast_Score=200, Evalue=9e-53,
Organism=Escherichia coli, GI1786376, Length=184, Percent_Identity=23.9130434782609, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: NA

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 29146; Mature: 29146

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHPTAIIDPKAELHESVEVGPFCIIEKDVKIGEGTVIESHVKILSGTRIGKFNKISSG
CCCCCCEEECCHHHHHHCCCCCCEEEEECCCCCCCCCEEHHHHHHHCCCCCCCCCCCCCC
GSFGGLPQDLAFKPETKTYLEIGDHNHFRENVIFHRGTIEGKGTVIGSHNYLMGNVHIAH
CCCCCCCCCCCCCCCCCEEEEECCCCCHHHCEEEECCEECCCCEEEECCCEEEEEEEEEE
DVIVGDHNIMVQNTMLAGHVVIGNKVFISGSVGVHQFVRVADYAMLAGLTKVVKDVPPYA
EEEECCCEEEEEEEEEEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
TVDGHPGLIVSLNVVGMKRAGISADVRLAIKRVYKVIYHSGFNTKQALAELKKDPNPAPE
EECCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHH
VQKVIEFFETSKRGVVDHRFVSGGSDEE
HHHHHHHHHCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MKIHPTAIIDPKAELHESVEVGPFCIIEKDVKIGEGTVIESHVKILSGTRIGKFNKISSG
CCCCCCEEECCHHHHHHCCCCCCEEEEECCCCCCCCCEEHHHHHHHCCCCCCCCCCCCCC
GSFGGLPQDLAFKPETKTYLEIGDHNHFRENVIFHRGTIEGKGTVIGSHNYLMGNVHIAH
CCCCCCCCCCCCCCCCCEEEEECCCCCHHHCEEEECCEECCCCEEEECCCEEEEEEEEEE
DVIVGDHNIMVQNTMLAGHVVIGNKVFISGSVGVHQFVRVADYAMLAGLTKVVKDVPPYA
EEEECCCEEEEEEEEEEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
TVDGHPGLIVSLNVVGMKRAGISADVRLAIKRVYKVIYHSGFNTKQALAELKKDPNPAPE
EECCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHH
VQKVIEFFETSKRGVVDHRFVSGGSDEE
HHHHHHHHHCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA