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The map label for this gene is proC [H]

Identifier: 18311615

GI number: 18311615

Start: 3006605

End: 3007405

Strand: Reverse

Name: proC [H]

Synonym: CPE2633

Alternate gene names: 18311615

Gene position: 3007405-3006605 (Counterclockwise)

Preceding gene: 18311616

Following gene: 18311614

Centisome position: 99.21

GC content: 31.34

Gene sequence:

>801_bases
ATGAATAAAAAAATTGGATTCATAGGCTGTGGTAACATGGGAAGTGCTATGGTTTTAGGAATATTAAAGTCAGGTATTGT
ATGCAAAGAAAATATTATTGCATCATGTTCAAGAGAATCAAGTGCAGAAAGAATAAAAAATGAATTAGGAATAAACACAA
CTCTTGATAACAAAGAAGTTTGTAATAACAGTGACATAATATTTCTTGCGGTAAAGCCATATATGTATGAAAAAGTTATA
AAAGAAATAAGAGATTGTGTAGACTTAAATAAGACTATTGTTACTATAGCAGCAGGAATTAATTTAAGTGATGTTGAAAA
ATGGTTTAAGAAAGAAACAAAAATAGTTAAGACTATGCCAAATACTCCAGCTTTAATAGGAGAAGCAATGAGCGCTATTT
GTCCTAATGAATTAGTAAATGAAGAAGAATTAAAAGAAGTTATGGATATATTTAATGCTTTTGGAAAATCAGAAGTGTTA
AGTGAGAAAGATTTCCATGGATTTATAGCACTTTGTGGGTCATCACCAGCTTATGTTTATATGTTTATAGAAGCTATGGC
AGATGCTGCTGTTAGAGAGGGAATAAGTAGAGATAAGGCTTATAAATTAGCTGCTCAATCAGTATTAGGATCAGCTAAGA
TGGTTTTAGAAACTGGAGAGCATCCAGCTAAGTTAAAAGACAATGTTTGCTCACCGGGAGGAACAACTATTGAAGCTGTT
TTAGAGTTAGAAGAGACTGGATTTAGAAGCTCTGTAATGAGTGCCATGAAAAAATGTTCAAAAAAATCTAAAAAAATGTA
A

Upstream 100 bases:

>100_bases
AATTAAAGTATTTATAATTAGATACTAAATAGTTAAAATGACTATTAAGAAATTAAGTTAATAAAATAATTACCATCTGT
ATTAAAAAGGAGAGGATAAT

Downstream 100 bases:

>100_bases
TGTTTTTTATTGACAAAAAATAAAAAAACATATATACTTTAATCATGATAATCATTATCAATTAGAGATTGATTATTATT
CATGAACTGGATAAAGACAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MNKKIGFIGCGNMGSAMVLGILKSGIVCKENIIASCSRESSAERIKNELGINTTLDNKEVCNNSDIIFLAVKPYMYEKVI
KEIRDCVDLNKTIVTIAAGINLSDVEKWFKKETKIVKTMPNTPALIGEAMSAICPNELVNEEELKEVMDIFNAFGKSEVL
SEKDFHGFIALCGSSPAYVYMFIEAMADAAVREGISRDKAYKLAAQSVLGSAKMVLETGEHPAKLKDNVCSPGGTTIEAV
LELEETGFRSSVMSAMKKCSKKSKKM

Sequences:

>Translated_266_residues
MNKKIGFIGCGNMGSAMVLGILKSGIVCKENIIASCSRESSAERIKNELGINTTLDNKEVCNNSDIIFLAVKPYMYEKVI
KEIRDCVDLNKTIVTIAAGINLSDVEKWFKKETKIVKTMPNTPALIGEAMSAICPNELVNEEELKEVMDIFNAFGKSEVL
SEKDFHGFIALCGSSPAYVYMFIEAMADAAVREGISRDKAYKLAAQSVLGSAKMVLETGEHPAKLKDNVCSPGGTTIEAV
LELEETGFRSSVMSAMKKCSKKSKKM
>Mature_266_residues
MNKKIGFIGCGNMGSAMVLGILKSGIVCKENIIASCSRESSAERIKNELGINTTLDNKEVCNNSDIIFLAVKPYMYEKVI
KEIRDCVDLNKTIVTIAAGINLSDVEKWFKKETKIVKTMPNTPALIGEAMSAICPNELVNEEELKEVMDIFNAFGKSEVL
SEKDFHGFIALCGSSPAYVYMFIEAMADAAVREGISRDKAYKLAAQSVLGSAKMVLETGEHPAKLKDNVCSPGGTTIEAV
LELEETGFRSSVMSAMKKCSKKSKKM

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=33.4586466165414, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=36.8029739776952, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=32.3308270676692, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=32.3308270676692, Blast_Score=166, Evalue=2e-41,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=50.7518796992481, Blast_Score=279, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=37.7862595419847, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17540664, Length=277, Percent_Identity=36.8231046931408, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320861, Length=285, Percent_Identity=25.2631578947368, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=37.4545454545455, Blast_Score=190, Evalue=7e-49,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=34.8314606741573, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=36.3095238095238, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29018; Mature: 29018

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00521 P5CR ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
8.3 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
8.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKIGFIGCGNMGSAMVLGILKSGIVCKENIIASCSRESSAERIKNELGINTTLDNKEV
CCCCEEEEECCCCHHHHHHHHHHCCCEEHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHH
CNNSDIIFLAVKPYMYEKVIKEIRDCVDLNKTIVTIAAGINLSDVEKWFKKETKIVKTMP
CCCCCEEEEEECHHHHHHHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHHHHHHCCC
NTPALIGEAMSAICPNELVNEEELKEVMDIFNAFGKSEVLSEKDFHGFIALCGSSPAYVY
CCHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEEECCCCHHHH
MFIEAMADAAVREGISRDKAYKLAAQSVLGSAKMVLETGEHPAKLKDNVCSPGGTTIEAV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHH
LELEETGFRSSVMSAMKKCSKKSKKM
HHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKKIGFIGCGNMGSAMVLGILKSGIVCKENIIASCSRESSAERIKNELGINTTLDNKEV
CCCCEEEEECCCCHHHHHHHHHHCCCEEHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHH
CNNSDIIFLAVKPYMYEKVIKEIRDCVDLNKTIVTIAAGINLSDVEKWFKKETKIVKTMP
CCCCCEEEEEECHHHHHHHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHHHHHHCCC
NTPALIGEAMSAICPNELVNEEELKEVMDIFNAFGKSEVLSEKDFHGFIALCGSSPAYVY
CCHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEEECCCCHHHH
MFIEAMADAAVREGISRDKAYKLAAQSVLGSAKMVLETGEHPAKLKDNVCSPGGTTIEAV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHH
LELEETGFRSSVMSAMKKCSKKSKKM
HHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]